Region | Title | System | Version | Edition | Languages | Serial | Status |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Sanity: Aiken's Artifact | PC | 1.0 | Original, Best Buy | | | |
| Sanitarium (Disc 3) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 1) | PC | 1.00 RC15 / Build 836 | Original | | | |
| Sanitarium | PC | | Demo | | | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| San Francisco Rush: Extreme Racing | PSX | | Original | | SLUS-00505 | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| San Francisco Rush 2049 | DC | 1.001 | Original | | T-9707N | |
| San Francisco Rush 2049 | DC | 1.000 | Demo | | T-9707ND | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-87015 | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | 170121 | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| Samurai Western | PS2 | 1.01 | Original | | SLUS 21187 | |
| Samurai Western | PS2 | 1.00 | Trade Demo | | SLUS-28051 | |
| Samurai Warriors: Xtreme Legends | PS2 | 1.00 | Original | | SLUS-21080 | |
| Samurai Warriors: State of War | PSP | 1.01 | Original | | ULUS-10089 | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5E-USA | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59E-USA-E0 | |
| Samurai Warriors 2: Xtreme Legends | PS2 | 1.02 | Original | | SLUS 21726 | |
| Samurai Warriors 2: Empires | PS2 | 1.00 | Original | | SLUS 21585 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Samurai Warriors 2 | PS2 | 1.01 | Original | | SLUS-21462 | |
| Samurai Warriors | PS2 | 1.00 | Original | | SLUS-20878 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Shodown: Warriors Rage | PSX | | Original | | SLUS-01039 | |
| Samurai Shodown V | XBOX | | Original | | SN-004 | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Shodown III: Blades of Blood | PSX | | Original | | SCUS-94206 | |
| Samurai Shodown II | PC | | Dual Jewel | | CD-C95-1302-0 | |
| Samurai Shodown II | PC | | Original | | CD-C95-1166-0 | |
| Samurai Shodown Anthology | PS2 | 1.01 | Original | | SLUS 21629 | |
| Samurai Shodown Anthology | PSP | 1.02 | Original | | ULUS 10401 … | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| Samurai Jack: The Shadow of Aku | PS2 | 1.03 | Original | | SLUS-20899 | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Champloo: Sidetracked | PS2 | 1.00 | Original | | SLUS 21343 | |
| Sampler Disc for PSP Vol. 1 | PSP | 1.00 | Demo | | UCJB-98301 | |
| Sammy's Science House | PC | 3.0 | Southwestern Kids' Collection | | R2522/8612a.7.01 | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Sammy's Science House | PC | 1.0 | Original | | | |
| Sammy Soza Softball Slam | PC | | Original | | PCD-5048-001 | |
| Sammy Sosa Softball Slam | PSX | | Original | | SLUS-01064 | |
| Sammy Sosa High Heat Baseball 2001 | PSX | | Original | | SLUS-01063 | |
| Samba de Amigo | DC | 1.001 | Original | | 51092 | |
| Samba de Amigo | WII | | Original | | RVL-R3BE-USA | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Sam & Max: This Time It's Virtual! | PC | | Limited Run Games | | | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| Sam & Max: Season Two | PC | 1.5.0.0 | Original | | | |
| Sam & Max: Season One | PC | 1.0 | Original | | | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XE-USA | |
| Sam & Max: Season One | WII | | Beta | | | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Sam & Max: Beyond Time and Space | PC | | Original | | 27898CD | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | Original | | 634031 | |
| Sam & Max Hit the Road | PC | | Original | | 634430 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | |
| Saltwater Sportfishing | PSX | | Original | | SLUS-01397 | |
| Salt Lake 2002 | PS2 | 1.01 | Original | | SLUS-20378 | |
| Sakura Wars: So Long, My Love (Disc 2) (Japanese Voice Over) | PS2 | 1.00 | Original | | SLUS-21930 | |
| Sakura Wars: So Long, My Love (Disc 1) (English Voice Over) | PS2 | 1.00 | Original | | SLUS-21927 | |
| Sakura Wars: So Long, My Love | WII | | Original | | RVL-SAKE-USA-E0 | |
| Saiyuki: Journey West | PSX | | Original | | SLUS-01381 | |
| Saints Row: The Third: The Full Package | PS3 | 01.00 | Original | | BLUS-31062 | |
| Saints Row: The Third (Disc 2) | PC | | Original | | | |
| Saints Row: The Third (Disc 1) | PC | | Original | | | |
| Saints Row: The Third | PS3 | 01.01 | Original | | BLUS-30666 | |
| Saints Row: Gat out of Hell | PS3 | 01.00 | Original | | BLUS-31496 | |
| Saints Row IV: National Treasure Edition | PS3 | 01.01 | Greatest Hits | | BLUS-31416 … | |
| Saints Row IV | PS3 | 01.00 | Original, Commander in Chief Edition | | BLUS-31205 | |
| Saints Row 2 | PS3 | 01.00 | Original, Greatest Hits | | BLUS-30201 … | |
| Saints Row 2 | PC | | Original | | | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Saints of Virtue | PC | 1.1 | Original | | | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Saint | WII | | Original | | RVL-RZCE-USA-B0 | |
| Sailing | CDI | | Original, Demonstration Disc | | 310-690-101-2, 310690101-2 | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Sail 2000 | PC | 1.04 | Original | | | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| SaGa Frontier 2 | PSX | | Original | | SLUS-00933 | |
| SaGa Frontier | PSX | | Original | | SCUS-94230 | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.01 | Original | | PCO519CD | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.0 | Original | | PCO519CD | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Sacrifice (Scapex Tutorial Video) | PC | | Preproduction | | | |
| Sacrifice | PC | | Bundle Version Hewlett Packard OEM | | CD-C951041-PC2E | |
| Sacrifice (Editors Press Kit) | PC | | Press Kit | | | |
| The Sacred Rings (Disc 4) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 3) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 2) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 1) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| Sacred Gold (Disc 3) | PC | 1.0 | Original | | 10130-CD3 | |
| Sacred Gold (Disc 2) | PC | 1.0 | Original | | 10130-CD2 | |
| Sacred Gold (Disc 1) | PC | 1.0 | Original | | 10130-CD1 | |
| Sacred 3 | PS3 | 01.02 | Original | | BLUS-30876 | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 3) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 2) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 1) | PC | | Beta | | | |
| Sacred 2: Fallen Angel | PS3 | 01.00 | Original | | BLUS-30312 | |
| Sacred 2 (Disc 2) | PC | | Original | | | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| Sacred (Disc 2) | PC | 1.8 | Rerelease | | 10153-CD2 | |
| Sacred (Disc 2) | PC | 1.2.0.10 | Original | | 28302-CD2 v1.0 | |
| Sacred (Disc 1) | PC | 1.8 | Rerelease | | 10153-CD1 | |
| Sacred (Disc 1) | PC | 1.2.0.10 | Original | | 28302-CD1 v1.0 | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sabrina the Teenage Witch: Spellbound | PC | 1.0c | Original | | S03836 | |
| Sabrina the Teenage Witch: Brat Attack | PC | | Original | | S02560 | |
| Sabrina the Teenage Witch: A Twitch in Time! | PSX | | Original | | SLUS-01208 | |
| Sabre Ace: Conflict over Korea | PC | 1.0 | Original | | D83115 | |
| Sabre Ace | PC | 1.0 | Covermount | | | |
| The Saboteur | PC | 1.0 | Original | | | |
| The Saboteur | PS3 | 01.00 | Original | | BLUS-30407 | |
| The Saboteur | XBOX360 | | Original | | EA-2191 | |
| Saban's Power Rangers: Time Force | PSX | | Original | | SLUS-01351 | |
| Saban's Power Rangers: Lightspeed Rescue | PSX | | Original | | SLUS-01114 | |
| Saban's Power Rangers Zeo: Full Tilt Battle Pinball | PSX | | Original | | SLUS-00256 | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 2) | PC | 1.0 | Original | | 28015-CD2 | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 1) | PC | 1.0 | Original | | 28015-CD1 | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl | PC | 1.0 | Original | | 109310 | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| S.T.A.L.K.E.R.: Clear Sky | PC | 1.0 | Original | | ECD950001D | |
| S.T.A.L.K.E.R.: Call of Pripyat | PC | 1.6.02 | Collector's Edition | | | |
| S.L.A.I.: Steel Lancer Arena International | PS2 | 1.02 | Original | | SLUS-20969 | |
| S.L.A.I.: Steel Lancer Arena International S.L.A.I.: Phantom Crash | PS2 | 0.11 | Beta | | SLUS 29132 | |
| S.C.A.R.S. | PSX | | Original | | SLUS-00692 | |
| S.C.A.R.S. | PC | | Original | | | |
| S!Zone for SimCity 2000 | PC | | Original | | | |