Region | Title | System | Version | Edition | Languages | Serial | Status |
| Le Secret du Templier | MAC | 1.0 | Covermount | | | |
| Seven Kingdoms: Artwork | MAC | | Art Assets | | | |
| SimCity 2000: CD Collection | MAC | 1.20 | Original | | 1074-029-0601-A | |
| Les Sims: Superstar (Disc 1) (Disque Additionnel) | MAC | | Original | | | |
| Les Sims: Superstar (Disc 2) (Disque Additionnel) | MAC | | Original | | | |
| Space Quest 6: Roger Wilco in the Spinal Frontier | MAC | | Original | | S4330250Z12ZZ | |
| Star Trek: New Worlds: Ad | MAC | | Art Assets | | | |
| Star Trek: Starfleet Command II: Empires at War: Ad | MAC | | Art Assets | | | |
| Star Wars: Dark Forces | MAC | 1.00 | Original | | | |
| Star Wars: Episode I: Racer | MAC | 1.0 | Original | | | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630 | |
| StarCraft | MAC | 1.05 | Original | | S0013318 | |
| StarCraft: Brood War (Expansion Set) | MAC | 1.05 | Original | | S0015019 | |
| The Sims 2: Open for Business (Expansion Pack) | MAC | | Original | | 11392-1DDA | |
| Sail to Win! A Rules and Tactics Challenge | CDI | | Original | | 819 0042 | |
| Sälis Cirkus Äventyr | CDI | | Original | | 817 0011 | |
| Salvat Enciclopedia Interactiva: Nueva Versión '98 | CDI | L.01.01 | Original | | | |
| Salzburger Land | CDI | 1.05 | Original | | 810 0149 | |
| Sandy's Circus Adventure | CDI | | Original | | 690 0222 | |
| Sandy's Circus Avontuur | CDI | | Original | | 814 0008 | |
| Sandy's Zirkus Abenteuer | CDI | | Original, For Demonstration Only | | 813 0015 | |
| Santa Claus' Mice Les Souris du Pere Noel | CDI | | Original | | 811 0012, 812 0023 | |
| Sargon Chess | CDI | | Original | | 310690030-2, 690 030-2, 690 0302, 699 030-2, 812 0024, 814 0042 | |
| Say What You Want | CDI | | Original | | | |
| Scan & Teach: Thema 1-6: Klasse 3 | CDI | | Original | | | |
| Scan & Teach: Thema 7-12: Klasse 3 | CDI | | Original | | | |
| Die Schöne und das Tier | CDI | | Original | | 813 0040 | |
| Les Schtroumpfs: Le Téléportaschtroumpf | CDI | | Original | | SCHTRFR4011 | |
| Scotland Yard Interactif | CDI | 1.04 | Original | | 812 0070 | |
| Scotland Yard Interactive | CDI | 1.03 | Original | | 810 0139 | |
| Scotland Yard Interactive | CDI | 1.09 | Original | | 813 0042 | |
| Seasons Greetings from Philips Media | CDI | | Original | | | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Secret Mission | CDI | 1.01 | Beta | | 810 0272 | |
| Secret Mission | CDI | 1.07 | Original | | 812 0053 | |
| Secret Mission | CDI | 1.06 | Original | | 813 0160 | |
| Secret Mission | CDI | | Original | | 814 0133 | |
| Secrets of Tatjana | CDI | | Original | | 810 0046 | |
| Sell It to Me! Part One: Preparing The Way | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Handling Telephone Sales Enquiries and Making Appraisals Pay | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Paperwork, Bloody Paperwork and Selling to Women | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Selling You to You and Taking Personal Control | CDI | | Original | | | |
| Serie Privélessen: Klassieke Gitaar: Handleiding voor Beginners | CDI | 1.06 | Original | | 814 0067 | |
| Serum-Werk Bernburg AG: Veterinärpharmaka: Vol. 1 | CDI | | Original | | | |
| Shadoan Kingdom II: Shadoan | CDI | 1.03 | Original | | 810 0280 | |
| Shaolin's Road | CDI | | Original | | SHAOLM24011 | |
| Shipwreck | CDI | | Original | | 811 0025 | |
| Si Balla! | CDI | 1.01 | Beta | | 815 0066 | |
| Si Balla! | CDI | 1.03 | Original | | 815 0066 | |
| Sieben Schritte zum Erfolg | CDI | | | | | |
| Sieben Schritte zum Erfolg II | CDI | | | | | |
| Silhouette: CD-i Demo Version | CDI | | Original | | | |
| Sipa Image: First Image Catalog on CD-I | CDI | | Original | | | |
| Smilde | CDI | | Original | | | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2, 699 011-2, 812 0031 | |
| Solar Crusade | CDI | | Original | | SOLARGB5511 | |
| Solar System | CDI | 1.10 | Original | | 811 0039 | |
| Solitaire | CDI | | Prototype | | | |
| Somewhere: Une Envie de Naturel | CDI | | | | | |
| Somewhere: Une Envie de Naturel: Printemps 96 | CDI | | Original | | | |
| Soundtrap | CDI | 1.06 | Original | | 811 0032 | |
| Space Ace | CDI | | Original, For Demonstration Only | | 810 0073, 818 0017 | |
| Space Safari | CDI | 01.08 | Original | | 811 0035 | |
| Sport Freaks | CDI | | Original | | 819 1033 | |
| St. Petersbourg et les Trésors de l'Ermitage: The Art of the Czars | CDI | | Original | | 812 0056 | |
| Het Staat in de Sterren | CDI | 1.05 | Original | | 814 0108 | |
| Standaard Interactieve Encyclopedie | CDI | | Demonstratie-Exemplaar | | 818 0081 | |
| Star Trek VI: Das unentdeckte Land (Disc 1) | CDI | 1.04 | Original | | 813 1023 | |
| Star Trek VI: Das unentdeckte Land (Disc 2) | CDI | 1.01 | Original | | 813 1024 | |
| Star Trek VI: Terre Inconnue (Disc 1) | CDI | 1.02 | Original | | 812 1032 | |
| Star Trek VI: Terre Inconnue (Disc 2) | CDI | 1.01 | Original | | 812 1033 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 811 1007 | |
| Starring You: BZN Starring You: Zing Mee met Bekende Duetten van BZN | CDI | | Original | | 2700586 | |
| Stars on CD-i: Ad Peters | CDI | | Original | | | |
| Stars on CD-I: Rob Peetoom | CDI | | Original | | | |
| Steel Machine | CDI | 1.14 | Original | | 810 0160 | |
| Stichting voor de Technische Wetenschappen: Jaarverslag 91 Technology Foundation: Annual Report 91 | CDI | | Original | | 2036.001 | |
| Sticks 'n' Fire: Stop That Train | CDI | | Original | | CMC 24020-2CD-I | |
| Stickybear Family Fun | CDI | | Original | | 810 0237 | |
| Stickybear Maths | CDI | 1.08 | Original, For Demonstration Only | | 810 0064, 818 0043 | |
| Stickybear Preschool | CDI | 1.03 | Beta | | 690 2572 | |
| Stickybear Preschool | CDI | 1.05 | Original | | 810 0218 | |
| Sting: Ten Summoner's Tales | CDI | 1.03 | Original | | 089 5664 | |
| Stomach in Motion | CDI | | Original | | WIM 060792 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2, 699 025-2 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Story Maschine: Galaxis | CDI | | Original | | 813 0032 | |
| Story Maschine: Märchenzauber | CDI | | Original | | 813 0026 | |
| Stretch-Top System: Wasserbett-Information Stretch-Top System: Waterbed-Information | CDI | | Original | | | |
| Striker Pro | CDI | 1.14 | Original | | 810 0186, 810 0187, 811 0044 | |
| Strip Poker Live | CDI | 1.04 | Original | | 810 0257 | |
| Strip Poker Live | CDI | | Original | | IM99002 | |
| Strip-Poker Pro | CDI | | Original | | 8120142 | |
| Die Stunde der Patrioten (Disc 1) | CDI | | Original | | 813 1004 | |
| Die Stunde der Patrioten (Disc 2) | CDI | | Original | | 813 1004 | |
| SuperTest | CDI | 1.01 | Beta | | 810 0168 | |
| SuperTest | CDI | 1.03 | Original | | 810 0168 | |
| Surf City | CDI | 1.07 | Original | | 810 0091 | |
| SVO: Opleiding voor de Vleessector: Het Bewerken van Varkensvlees SVO Opleiding voor de Vleessector te Utrecht | CDI | | Original | | | |
| SVO: Opleiding voor de Vleessector: Hygiëne en Verse Voeding SVO Opleiding voor de Vleessector te Utrecht | CDI | | Original | | | |
| Swiss Click | CDI | | Original | | | |
| Synthelabo: Cardio-Vasculaire Dausse 1995: Cours de Perfectionnement en Imagerie Cardiaque | CDI | | Original | | | |
| Schoenbrunn | PHOTO-CD | | Original | | | |
| Die Schönsten Hotels der Welt | PHOTO-CD | | Original | | 813 0060 | |
| Sexy Bytes: Housewives 2 | PHOTO-CD | | Original | | | |
| Sexy Bytes: Lacquer & Leather | PHOTO-CD | | Original | | | |
| Sexy Bytes: Office Sex | PHOTO-CD | | Original | | | |
| Sexy Bytes: Outside Dreams | PHOTO-CD | | Original | | | |
| Sexy Bytes: Rolling Mountains | PHOTO-CD | | Original | | | |
| Sexy Bytes: Studio Girls 1 | PHOTO-CD | | Original | | | |
| Snake II | FPP | | Service Release Update 2001 | | 7710117 | |
| Science & Nature: Elements Science 1: Elements | ARCH | 1.00 | Original | | | |
| Science & Nature: Materials Science Series II: Materials | ARCH | 1.00 | Original | | | |
| Science: Electricity and Magnetism: Secondary Edition Science 3: Electricity and Magnetism | ARCH | 1.0 | Original | | | |
| Seashore Life | ARCH | 1.0 | Original | | | |
| Simon the Sorcerer | ARCH | | Original | | | |
| The Soft Rock Games Collection CD | ARCH | | Original | | | |
| The Soft Rock Software Collection | ARCH | Edition 1 | Original | | | |
| The StrongARM CD-ROM | ARCH | | Original | | | |
| Scooby-Doo: Viaje al Pasado | VFLASH | | Original | | 093087(SP) | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093083(UK) | |
| Scooby-Doo! Les Civilisations Perdues | VFLASH | | Original | | 093085(FR) | |
| Shrek der Dritte: Die Suche nach Arthus | VFLASH | | Original | | 093144(GER) | |
| Shrek Le Troisième: En quête d'Artur | VFLASH | | Original | | 093145(FR) | |
| Shrek Tercero: ¿Dónde Está Arturo? | VFLASH | | Original | | 093147(SP) | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093143(UK) | |
| Spider-Man Course-Poursuite à Manhattan | VFLASH | | Original | | 093065(FR) | |
| Spider-Man: Angriff der Super-Schurken | VFLASH | | Original | | 093064(GER) | |