Region | Title | System | Version | Edition | Languages | Serial | Status |
| Expendable | PC | 1.0 | Sold Out Software | | | |
| Excessive Speed | PC | | Sold Out Software | | | |
| Excessive Speed | PC | | Rerelease | | | |
| EverQuest II (Disc 2) | PC | | Original | | 5003644-2 (DVD2) | |
| EverQuest II (Disc 1) | PC | | Original | | 5003644-1 (DVD1) | |
| Eurofighter Typhoon | PC | 1.0.4.4 | Sold Out Software | | | |
| Euro Truck Simulator Gold | PC | 1.3 | Original | | | |
| Escape from Paradise City | PC | 1.0.0 | Original | | | |
| The Entente: World War I Battlefields | PC | 1.0 | Original | | | |
| Enemy Zero (Disc 3) (Game Disc) | PC | | Original | | 500-0021-50, MK85070-50 | |
| Enemy Zero (Disc 2) (Game Disc) | PC | | Original | | 500-0020-50, MK85070-50 | |
| Enemy Zero (Disc 1) (Game Disc) | PC | | Original | | 500-0019-50, MK85070-50 | |
| Enemy Zero (Disc 0) (Opening Disc) | PC | | Original | | 500-0016-50, MK85070-50 | |
| Enemy Engaged: Apache/Havoc | PC | | Xplosiv | | EI-1170 | |
| Empire Earth: The Art of Conquest Expansion | PC | | Original | | S0026749 | |
| Empire Earth III | PC | 1.1.0.0 | Original | | S2115401 | |
| Empire Earth II: The Art of Supremacy | PC | | Original | | S1003574 | |
| Empire Earth II: The Art of Supremacy | PC | | Sold Out Software (Gold Edition) | | | |
| Empire Earth II (Disc 2) | PC | | Original, Best Seller Series | | S1002684, S1003816 | |
| Empire Earth II (Disc 1) | PC | | Original | | S1002683 | |
| Empire Earth | PC | | Rerelease | | S0027936 | |
| The Emperor's Mahjong | PC | 1.0.2 | SoftKey | | EMZ854AB-CD | |
| The Elder Scrolls IV: Oblivion | PC | 1.0.228 | Original, Collector's Edition, BioShock & The Elder Scrolls IV: Oblivion | | 5039437/DVDENG | |
| eGames Master's Series 151 | PC | 1.0 | Original | | | |
| eGames Galaxy of Games: Yellow Edition | PC | 1.3 | | | | |
| eGames Galaxy of Games: Blue e2 Games: Blue Edition | PC | 1.2g | Original | | 02-9406-10 | |
| eGames Galaxy of Games 201 | PC | 1.0 | Original | | | |
| eGames Collector's Edition 251 | PC | 1.0 | Original | | | |
| Ecco the Dolphin | PC | | Original, Family Pack | | MK 85013-50, MK 85086-50 | |
| Earthworm Jim: Special Edition | PC | | Original | | CDD-3114-01-U3 | |
| e2 Office Games | PC | 1.1 | Original | | | |
| e2 Games: Red Edition | PC | 1.5g | Original | | | |