Region | Title | System | Version | Edition | Languages | Serial | Status |
| Surasura Gaikokugo Kaiwa for Pocket PC すらすら外国語会話 for Pocket PC | PPC | | Original | | | |
| SuperKarts | PC | | Original | | 04-10242CD | |
| Super Monkey Ball 2 | GC | | Original, Player's Choice | | DL-DOL-GM2E-USA | |
| Sunsoft Classic Games 2 サンソフト クラシック ゲームズ2 | PC | | Ultra 2000/Ultra Series | | MKW-191 | |
| Standard 1500: The Mahjong Joou スタンダード1500 The 麻雀女王 | PC | 1.0 | Original | | SD-100287 | |
| Spyro: Enter the Dragonfly | GC | | Original, Player's Choice | | DL-DOL-GS8E-USA | |
| Spyro: A Hero's Tail | GC | | Original, Player's Choice | | DL-DOL-G5SE-USA | |
| Solid State Pinball: Loony Labyrinth | PC | 1.01 | Original | | LLW-01-001 | |
| Software & Document: Master CD for Video Family | PC | 1.20 | Bundle Version Jaton OEM | | | |
| Sins of a Solar Empire シンズ オブ ア ソーラーエンパイア | PC | | Original | | ZPG-0090 | |
| SimTheme Park (Bonus Rides and Attractions) Sim Theme Park | PC | | Gold Edition, Sim Mania 2 | | 1229817, 1403347, 1641527 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition | | 1403337 | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | 1.0 | Original | | 1459517 | |
| The Sims: Unleashed (Expansion Pack) (Disc 1) | PC | 1.0 | Original | | 1459507 | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) Die Sims: Tierisch gut drauf: Erweiterungspack | PC | 1.7 | Original | | MXX08803906D2, MXX08803906D2/GER | |
| The Sims: Unleashed (Expansion Pack) (Disc 1) Die Sims: Tierisch gut drauf: Erweiterungspack | PC | 1.7 | Original | | MXX08803906D, MXX08803906D/GER | |
| The Sims: House Party (Expansion Pack) | PC | 1.3 | Original | | 62092, MXX08803522D | |
| The Sims: Hot Date (Expansion Pack) | PC | 1.4 | Original | | MXX088003645D | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 2) Die Sims 2: Nightlife: Erweiterungspack | PC | 1.2.0.312 | Original | | MXX08004773D2, MXX08004773D2/GER | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 1) Die Sims 2: Nightlife: Erweiterungspack | PC | 1.2.0.312 | Original | | MXX08004773D, MXX08004773D/GER | |
| SimLife SimLife: The Genetic Playground | PC | | Rerelease | | | |
| Silent Steel | PC | 1.82.42.100 | DVD-ROM | | | |
| Shock Price 500 Game Series: Shougi SHOCK PRICE 500 GAME SERIES 将棋 | PC | 1.0.2 | Rerelease | | SSRX 3027 | |
| Shock Price 500 Game Series: Hit the Block SHOCK PRICE 500 GAME SERIES ヒット・ザ・ブロック | PC | | Original | | SSRX 3018 | |
| Shock Price 500 Game Series: Digital Puzzle Street: Blue SHOCK PRICE 500 GAME SERIES デジタル・パズル・ストリート Blue | PC | | Original | | SSRX 3078 | |
| Shin Seiki Evangelion: Character Box 新世紀エヴァンゲリオン キャラクターBOX | PC | | PCHome | | 506-7036 | |
| Sherlock Holmes: The Mystery of the Mummy | PC | | Original, Reload / White Label | | 1564A | |
| Shattered Union | PC | 1.00x | Sold Out Software | | S0C001010 sov. 3.5 | |
| The Settlers II: 10th Anniversary | PC | | Original | | 5004880 | |
| SD Gundam: GGeneration DA SDガンダム GジェネレーションDA | PC | 1.00 | DigiCube PC Series | | DWRMS-00158 | |
| Scrabble Complete | PC | | Original, Bundle Version Microgistix OEM | | 11290-CD, Part # 23970CD | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Schoolhouse Rock! America Rock | PC | | Original | | 21080CD | |
| Schizm: Mysterious Journey (Side B) スキズム ~謎めく旅路~ | PC | Build: 744 | DVD-ROM Edition | | TSYC-W1012E1-2 | |
| Schizm: Mysterious Journey (Side A) スキズム ~謎めく旅路~ | PC | Build: 744 | DVD-ROM Edition | | TSYC-W1012E1-1 | |
| Savage: The Battle for Newerth | PC | | Bundle Version ASUS OEM | | V471 | |