Region | Title | System | Version | Edition | Languages | Serial | Status |
| The Eye of Typhoon (Disc 2) 極超豪拳, 극초호권 | PC | | Limited Edition | | VIC-PS0001K | |
| Eye of the Beholder | MCD | | Original | | 4655-50 | |
| Extreme-G 2 | PC | | Original | | | |
| Extreme Wintersports | PC | 1.1 | Original | | 21203.101.US | |
| Extreme Watersports Mastercraft Extreme Watersports | PC | | Original | | 21189.101.US | |
| Extreme Watersports Mastercraft Extreme Watersports | PC | | Original | | 21189.101.GM | |
| Extreme Tennis | PC | | Original | | 21201.101.US | |
| Extreme Assault | PC | | Demo | | | |
| Extreme Assault | PC | | Tanie Granie, eXtra Klasyka | | | |
| Extreme Assault | PC | | Original | | | |
| Extreme Assault | PC | | Original | | | |
| The Experiment (Disc 1) | PC | 1.0 | Original | | PCO548CD1 | |
| Expendable Lite | PC | | Demo | | | |
| Exhumed | PC | 1.0 | Original | | 76896-421322 | |
| Exciting CD (Disc 2) エキサイティングCD | FMT | | Hibaihin | | HMF-902 | |
| Exciting CD (Disc 2) エキサイティングCD | FMT | | Car Marty (Not for Sale) | | HMF-911-2 | |
| Exciting CD (Disc 1) エキサイティングCD | FMT | | Hibaihin | | HMF-901 | |
| Exciting CD (Disc 1) エキサイティングCD | FMT | | Car Marty (Not for Sale) | | HMF-911-1 | |
| The Even More! Incredible Machine | PC | 1.11 | Original | | 836354000 | |
| Eve: The Lost One (Disc 4) (Extra Disc) イヴ・ザ・ロストワン | SS | 1.000 | Original | | T-15035G, T-15041G | |
| Eve: The Lost One (Disc 4) (Extra Disc) イヴ・ザ・ロストワン | SS | 1.000 | Original | | T-15035G | |
| Eve: The Lost One (Disc 3) (Lost One Disc) イヴ・ザ・ロストワン | SS | 1.000 | Original | | T-15035G, T-15041G | |
| Eve: The Lost One (Disc 3) (Lost One Disc) イヴ・ザ・ロストワン | SS | 1.000 | Original | | T-15035G | |
| Eve: The Lost One (Disc 2) (Snake Disc) イヴ・ザ・ロストワン | SS | 1.000 | Original | | T-15035G, T-15041G | |
| Eve: The Lost One (Disc 1) (Kyoko Disc) イヴ・ザ・ロストワン | SS | 1.000 | Original | | T-15035G, T-15041G | |
| Eve: The Lost One イヴ・ザ・ロストワン | SS | 1.000 | Taikenban (Premium Pack, Eve: Burst Error & Desire Value Pack, Bundled with Book) | | 610-6837, T-15036G, T-15037G | |
| Étude Prologue: Yureugoku Kokoro no Katachi (Omake CD) エチュードプロローグ ~揺れ動く心のかたち~ おまけCD | PC | | PC Game Bundle | | | |
| Etsuko Nishio: Finger by Hajime Sawatari 西尾悦子・フィンガー | PHOTO-CD | | Original | | FZ-JJ1YP0101 | |
| Eternal Melody エターナル・メロディ | SS | 2.000 | Original | | T-27802G | |
| Eternal Melody エターナル・メロディ | SS | 1.002 | Original | | T-27802G | |
| Eternal Champions: Challenge from the Dark Side | MCD | | Original | | 4427 | |
| Eternal Champions: Challenge from the Dark Side | MCD | | Original | | 4427 | |
| Eternal Champions: Challenge from the Dark Side | MCD | | Original | | 4427-50 | |
| ESPN Baseball Tonight | MCD | | Original | | T-93115-50 | |
| eScape | CDI | | Original, Head Crash: Limited Edition Triple Pack | | 810 0117 | |
| Erotic Visions: Foto: Turbo Girls | PHOTO-CD | | Original | | CD 557-S | |
| Eradicator | PC | 1.0 | Original | | 5000-00445 | |
| Eradicator | PC | 1.0 | Original | | | |
| Entomorph: Plague of the Darkfall World of Aden: Entomorph: Plague of the Darkfall | PC | 1.0 | Awesome 4 Pak | | | |
| Enemy Zero (Disc 3) | SS | 1.001 | Original | | 81076 | |
| Enemy Zero (Disc 2) | SS | 1.001 | Original | | 81076 | |
| Enemy Zero (Disc 1) | SS | 1.001 | Original | | 81076 | |
| Enemy Zero (Disc 0) | SS | 1.001 | Original | | 81076 | |
| Enemy Zero (Disc 3) (Game Disc) エネミー・ゼロ | SS | 1.000 | Original | | T-30001G | |
| Enemy Zero (Disc 3) (Game Disc) エネミー・ゼロ | SS | 1.000 | Original | | T-30001G | |
| Enemy Zero (Disc 2) (Game Disc) エネミー・ゼロ | SS | 1.000 | Original | | T-30001G | |
| Enemy Zero (Disc 2) (Game Disc) エネミー・ゼロ | SS | 1.000 | Original | | T-30001G | |
| Enemy Zero (Disc 1) (Game Disc) エネミー・ゼロ | SS | 1.000 | Original | | T-30001G | |
| Enemy Zero (Disc 1) (Game Disc) エネミー・ゼロ | SS | 1.000 | Original | | T-30001G | |
| Enemy Zero (Disc 0) (Opening Disc) エネミー・ゼロ | SS | 1.000 | Original | | T-30001G | |
| Enemy Zero (Disc 0) (Opening Disc) エネミー・ゼロ | SS | 1.000 | Original | | T-30001G | |
| Enemy Engaged: RAH-66 Comanche Versus KA-52 Hokum | PC | 1.0 | Original | | EI-1195 | |
| Emit Vol. 1: Toki no Maigo エミット Vol.1 「時の迷子」 | FMT | | Demo | | HMF-904 | |
| Emergency | PC | | Covermount | | | |
| Emerald Mines | CD32 | | Original | | | |
| Embrace エンブレイス | PC | | TGL 2000 Series | | | |
| Embrace エンブレイス | PC | | Original | | | |
| Elmer's Cut & Build 3D: Spacestation & Hometown USA | PC | | Original | | CD-EST001 | |
| Elmer's Cut & Build 3D: Castle and House | PC | | Original | | | |
| Electro Body | PC | 2.001 | Collector's Edition | | RCP-2201 | |
| The Elder Scrolls Adventures: Redguard (Disc 2) (Play Disc) | PC | | Original | | | |
| Eiyuu Densetsu IV: Akai Shizuku: MIDI Collection 英雄伝説Ⅳ 朱紅い雫MIDIコレクション | PC | | Original | | NF02012 | |
| Eiyuu Densetsu 3 Renewal: Shiroki Majo 英雄伝説ⅢRENEWAL 白き魔女 | PC-98 | | Windows 95 MS-DOS Prompt Taiou-ban | | NF01003 | |
| Eisei Meijin II 永世名人Ⅱ | SS | 2.020 | Original | | T-9516G | |
| Eisei Meijin 永世名人 | SS | 2.000 | Original | | T-9506G | |
| EGWord Ver 2.00 | SS | 2.000 | WoPro Upgrade Kit (Digital Camera Taiouban) | | T-7642G | |
| EGWord | SS | 1.021 | WoPro Set | | T-7626G | |
| EGWord | SS | 1.001 | WoPro Set | | T-7626G | |
| EF2000 | PC | 1.0 | Bundle Version Diamond OEM | | | |
| EF2000 | PC | | Original | | 43331-911EFC | |
| EF2000 | PC | | Bundle Version Diamond OEM | | 75000137-001 | |
| Edge CD1 | PC | | | | EDG/47/07/97 | |
| Ecco: The Tides of Time | MCD | | Original | | 4441 | |
| Ecco: The Tides of Time | MCD | | Original | | 4441-50 | |
| Ecco the Dolphin | PC | 1.1 | Original, Jack in the Box | | 85013 | |
| Ecco the Dolphin | MCD | | Original, Bundled with Sega CD (Ecco the Dolphin / Sega Classics Arcade Collection Bundle) | | 4408 | |
| Ecco the Dolphin | PC | | Original, Family Pack | | MK 85013-50, MK 85086-50 | |
| Eberouge Special: Koi to Mahou no Gakuen Seikatsu エーベルージュ・スペシャル ~恋と魔法の学園生活~ | SS | 1.003 | Original | | T-10315G | |
| Eberouge 2 エーベルージュ2 | PC | | Original | | HMI-345 | |
| Eberouge (Disc 2) エーベルージュ | SS | 1.005 | Original | | T-10309G | |
| Eberouge (Disc 1) エーベルージュ | SS | 1.005 | Original | | T-10309G | |
| Eberouge エーベルージュ | PC | | Original | | A28800F0 HMH-720 | |
| Eberouge エーベルージュ | MAC | | Original | | HMH-721B | |
| Eberouge エーベルージュ | MAC | | Original | | HMH-721A | |
| Earthworm Jim: Special Edition | MCD | | Original | | T-125045 | |
| Earthworm Jim: Special Edition アースワーム・ジム | PC | | Original | | ID No.9403-56-01 | |
| Earthworm Jim: Special Edition | PC | | Original | | CDD-3114-101-GM | |
| Earthworm Jim: Special Edition | PC | 1.0 | Original, The Essential Collection | | 1000142.101.UK, CDD-3114-101-3L | |
| Earthworm Jim: Special Edition | MCD | | Original | | T-125045-50 | |
| Earthworm Jim 2 アースワーム・ジム2 | SS | 1.001 | Original | | T-10304G | |
| Earthworm Jim 2 | PC | | Silver Games 1 | | SPI 027-01 | |
| Earthworm Jim 2 | PC | | Eine Dose voll Würmer | | | |
| Earthworm Jim 2 | PC | | Eine Dose voll Würmer | | | |
| Earthworm Jim 2 | PC | | Earthworm Jim 1 & 2: The Whole Can O'Worms, Ubisoft Classique Collection | | | |
| Earthworm Jim Earthworm Jim 1 | PC | | Earthworm Jim 1 & 2: The Whole Can 'O Worms | | Item No. 6563 | |
| Earthworm Jim Earthworm Jim 1 | PC | | Eine Dose voll Würmer | | | |
| Earthworm Jim Earthworm Jim 1 | PC | | Tewi | | Bestell-Nr. 27913 | |
| Earthworm Jim Earthworm Jim 1 | PC | | Eine Dose voll Würmer | | | |
| Earthworm Jim Earthworm Jim 1 | PC | | Earthworm Jim 1 & 2: The Whole Can O'Worms | | | |
| EarthSiege 2 | PC | 1.1 | 3 Free | | W0735220 | |
| EarthSiege 2 | PC | 1.00 | Rerelease | | | |
| EarthSiege 2 EarthSiege II | PC | 1.13 | Covermount | | | |
| EarthSiege 2 EarthSiege II | PC | 1.11 | Gold Games 2 (CD 2), Rerelease | | S4510210Z12Z1, S4510510Z12ZZ, S4520520Z12ZZ, SPI 046 | |
| Earth 2140: Mission Pack 1 | PC | | Earth 2140 3. Edition | | SPI 044 | |
| Earth 2140 | PC | | Covermount | | | |
| Earth 2140 | PC | 1.50.005 | Original | | CD-C95-682-0 | |
| Earth 2140 | PC | 1.32 | Original | | | |