Region | Title | System | Version | Edition | Languages | Serial | Status |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Serious Sam: The First Encounter | PC | 1.00 | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS3E-USA-B0 | |
| Shiren the Wanderer | WII | | Original | | RVL-RFSE-USA-B0 | |
| Sid Meier's Civilization III | PC | 1.07f | Original, Gold Edition | | CIVIL3PCUS/A, Part # 04-22252CD | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| SimCity 2000 Special Edition | PC | | CD-ROM Classics, Scholastic | | 10365, 1131107, 5710243CSP1, DP10 | |
| SimCity 2000: CD Collection | PC | 1.00 | Windows 95 | | 0026-000-0601-A | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQE-USA | |
| The Sims 2 (Bonus Disk) | PC | | Special DVD Edition | | 1488317 | |
| The Sims 2 (Game Disk) | PC | 1.0.0.932 | Special DVD Edition | | 1488307 | |
| SiN | PC | 1.01 | Rerelease | | 6236-01 | |
| Sin & Punishment: Star Successor | WII | | Original | | RVL-R2VE-USA-B0 | |
| Ski-Doo Snowmobile Challenge | WII | | Original | | RVL-R87E-USA-B0 | |
| The Sky Crawlers: Innocent Aces | WII | | Original | | RVL-RQRE-USA-B0 | |
| SNK Arcade Classics Vol. 1 | WII | | Original | | RVL-RNCE-USA | |
| SOCOM: U.S. Navy SEALs | PS2 | 1.00 | Original | | SCUS 97134 | |
| SOCOM: U.S. Navy SEALs | PS2 | 2.01 | Original | | SCUS-97134 | |
| Sonic Colors | WII | | Original | | RVL-SNCE-USA-B0 | |
| Sorry! | PC | 1.3 | Original | | 99040 | |
| Squeeballs Party | WII | | Original | | RVL-R6YE-USA-B0 | |
| Star Trek Pinball | PC | 1.00 | Original | | CD-C95-675-0 | |
| Star Trek: Starfleet Academy (Disc 1) | PC | 0.99 | Original | | CD-H95-069-0 | |
| Star Trek: Starfleet Academy (Disc 2) | PC | 0.99, 1.1 | Original | | CD-H95-069-1, CD-MCR-069-1 | |
| Star Trek: Starfleet Academy (Disc 3) | PC | 0.99, 1.1 | Original | | CD-H95-069-2, CD-MCR-069-2 | |
| Star Trek: Starfleet Academy (Disc 4) | PC | 0.99, 1.1 | Original | | CD-H95-069-3, CD-MCR-069-3 | |
| Star Trek: Starfleet Academy (Disc 5) | PC | 0.99, 1.1 | Original | | CD-H95-069-4, CD-MCR-069-4 | |
| Star Wars: Jedi Knight II: Jedi Outcast | PC | 1.02a | Original | | 9541830 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 1) (Play Disc) | PC | 1.0 | Rerelease | | 3261830R | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 2) | PC | 1.0 | Original | | 3261831, 3261831R | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 3) | PC | 1.0 | Original | | 3261832, 3261832R | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 4) | PC | 1.0 | Original | | 3261833, 3261833R | |
| Star Wars: The Best of PC (Star Wars: Empire at War & Star Wars: Knights of the Old Republic) | PC | 1.0 | Original | | 8101830 | |
| Star Wars: The Best of PC (Star Wars: Battlefront & Star Wars: Jedi Knight II: Jedi Outcast & Star Wars: Republic Commando) | PC | | Original | | 41153.102.UK, 8101831 | |
| Suikoden III | PS2 | 1.00 | Original | | SLUS-20387 | |
| Super Mario Galaxy 2 | WII | | Original, Nintendo Selects | | RVL-SB4E-USA-B0 | |
| Super Paper Mario | WII | Rev 2 | Original, Nintendo Selects | | RVL-R8PE-USA, RVL-R8PE-USA-B0 | |
| Super Smash Bros. Brawl | WII | Rev 2 | Original | | RVL-RSBE-USA-2, RVL-RSBE-USA-E0 | |
| System Shock 2 | PC | 1.15 | Original | | 796907 | |