Region | Title | System | Version | Edition | Languages | Serial | Status |
| Samurai Shodown | 3DO | | Original | | | |
| Samurai Spirits ~ Samurai Shodown サムライ・スピリッツ | NGCD | | Original | | NGCD-045 | |
| Samurai Spirits: Amakusa Kourin ~ Samurai Shodown IV: Amakusa's Revenge サムライ・スピリッツ ~天草降臨~ | NGCD | | Original | | NGCD-222, NGCD-222E | |
| Samurai Spirits: Zankurou Musouken ~ Samurai Shodown III サムライ・スピリッツ 斬紅郎無双剣 | NGCD | | Original | | NGCD-087, NGCD-087E | |
| Sega Classics Arcade Collection | MCD | 1.01 | Bundled with Sega CD (Ecco the Dolphin / Sega Classics Arcade Collection Bundle) | | 4126 | |
| Sexy Idol Mahjong: Yakyuuken no Uta セクシー・アイドル麻雀 ~野球拳の詩~ | PCE | | Original | | NBCD4007 | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | PCE | | Original | | JCCD2008 | |
| Sherlock Holmes: Consulting Detective | PCE | | Original | | TGXCD1011 | |
| Shin Samurai Spirits: Haoumaru Jigokuhen ~ Samurai Shodown II 真サムライ・スピリッツ ~覇王丸地獄変~ | NGCD | | Original | | NGCD-063, NGCD-063E | |
| Shining Force CD | MCD | | Original | | 4656 | |
| Shining Force III | SS | 1.001 | Original | | 81383 | |
| Shining Force III Premium Disc シャイニング・フォースⅢ プレミアム・ディスク | SS | 1.000 | Hibaihin | | 610-6979 | |
| Shining Force III: Scenario 2: Nerawareta Miko シャイニング・フォースⅢ シナリオ2 ~狙われた神子~ | SS | 1.003 | Original | | GS-9188 | |
| Shining Force III: Scenario 3: Hyouheki no Jashinguu シャイニング・フォースⅢ シナリオ3 ~氷壁の邪神宮~ | SS | 1.001 | Original | | GS-9203 | |
| Shinsetsu Samurai Spirits: Bushidou Retsuden 真説サムライ・スピリッツ ~武士道烈伝~ | NGCD | | Original | | NGCD-0850 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silpheed | MCD | | Original | | 4423 | |
| Sky Target | SS | 1.003 | Original | | 81051 | |
| Snatcher | MCD | | Original | | T-95035 | |
| Snatcher CD-ROMantic スナッチャー・シーディロマンティック | PCE | | Original | | KMCD2002 | |
| Snatcher CD-ROMantic: Pilot Disk スナッチャー・シーディロマンティック パイロット・デイスク | PCE | | Original | | KMCD2001 | |
| SNK vs. Capcom: SVC Chaos | XBOX | | Original | | SN-001 | |
| Solar Eclipse | SS | 1.000 | Original | | T-15911H | |
| Sonic Adventure 2: Battle | GC | | Original, Player's Choice | | DL-DOL-GSNE-USA | |
| Sonic Adventure DX: Director's Cut | GC | | Original, Player's Choice | | DL-DOL-GXSE-USA | |
| Sonic CD | MCD | | Bundled with Sega CD | | 4407 | |
| Sonic Mega Collection Plus ソニック メガコレクション プラス | XBOX | | Original, Classics | | SE-060 | |
| Sonic Rivals | PSP | 1.00 | Original, Greatest Hits | | ULUS 10195 … | |
| Sonic Wings 2 ~ Aero Fighters 2 ソニック・ウイングス2 | NGCD | | Original | | NGCD-075, NGCD-075E | |
| Soulcalibur II | XBOX | | Original, Platinum Hits | | NM-003 | |
| Soulcalibur II | GC | | Original, Player's Choice | | DL-DOL-GRSE-USA | |
| Space Jam | SS | 1.000 | Original | | T-8125H | |
| Stakes Winner: GI Kanzen Seiha e no Michi ステークス・ウィナー ~GI完全制覇への道~ | NGCD | | Original | | NGCD-088 | |
| Star Ocean: First Departure | PSP | 1.00 | Original | | ULUS-10374 | |
| Star Ocean: Second Evolution | PSP | 1.00 | Original | | ULUS-10375 | |
| Star Wars: Knights of the Old Republic | XBOX | | Original | | LA-003 | |
| Star Wars: Rebel Assault | MCD | | Original | | T-60075 | |
| Star Wars: Rogue Squadron II: Rogue Leader | GC | | Original, Player's Choice | | DL-DOL-GSWE-USA | |
| Star Wars: Rogue Squadron III: Rebel Strike | GC | | Original | | DL-DOL-GLRE-USA | |
| Street Fighter Alpha 3 Max | PSP | 1.00 | Original | | ULUS-10062 | |
| Street Fighter X Tekken ストリートファイター Ⅹ 鉄拳 | XBOX360 | | Original, Collector's Package, Street Fighter 25th Anniversary Collector's Set | | CC-2063 | |
| Street Fighter: The Movie | SS | 1.003 | Original | | T-8105H | |
| Super Mario Galaxy | WII | | Original, Nintendo Selects | | RVL-RMGE-USA, RVL-RMGE-USA-B0 | |
| Super Mario Galaxy 2 | WII | | Original, Nintendo Selects | | RVL-SB4E-USA-B0 | |
| Super Mario Sunshine | GC | | Original, Player's Choice | | DL-DOL-GMSE-USA | |
| Super Paper Mario | WII | | Original | | RVL-R8PE-USA | |
| Super Smash Bros. Brawl | WII | Rev 2 | Original | | RVL-RSBE-USA-2, RVL-RSBE-USA-E0 | |
| The Super Spy ザ・スーパー・スパイ | NGCD | | Original | | NGCD-011 | |
| Super Street Fighter II Turbo | 3DO | RE2 | Original | | FZ-SM3851 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Sega CD 32X | | T-16203F | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | MCD | | Sega CD 32X | | T-16203F | |
| Syphon Filter: Dark Mirror | PSP | 1.01 | Original, Greatest Hits, UMD Dual Pack | | UCUS-98641 | |