| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Safecracker | PC | | Rerelease |  | |  |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Schizm: Mysterious Journey (Side B) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Side A) | PC | | DVD-ROM Edition | | | |
 | The Scroll
Daughter of Serpents | PC | | Original | | | |
| Seal of Evil | PC | | Original | | 904066DVD | |
| The Secret of the Silver Earring (Disc 1)
Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of the Silver Earring (Disc 2)
Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Sentient | PC | | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Original | | CD-W58-1103-0 | |
| Shadowgrounds Survivor | PC | 1.0 | Original | | 000152 DVD | |
 | Shannara | PC | 1.0.0 | Original | | | |
| Sherlock Holmes: The Awakened | PC | 3.0 | Original | | Art. Number PF0903/US2 | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.0.0.2 | Rerelease | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original, Rerelease | | | |
| Sid Meier's Civilization Chronicles (Disc 1) | PC | | Original | | 31074-1.1 | |
| Sid Meier's Civilization Chronicles (Disc 2) | PC | | Original | | 31074-1.2 | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Rerelease, Sid Meier's Civilization Chronicles | | 31074-1.3 | |
 | Sid Meier's Civilization III Complete (Disc 2) (Play the World) | PC | | PC Gamer Presents, Rerelease, Sid Meier's Civilization Chronicles | | 31074-1.4 | |
| Sid Meier's Civilization III Complete (Disc 3) (Conquests) | PC | | PC Gamer Presents, Rerelease, Sid Meier's Civilization Chronicles | | 31074-1.5 | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization IV (Disc 2) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.7 | |
 | Silverfall | PC | 1.15.46 | Original | | | |
| Silverfall: Earth Awakening | PC | | Original | | | |
| Solid State Pinball: Crystal Caliburn | PC | | Rerelease | | 517-05-232 | |
 | Sorcerian Forever
魔域傳說 永恆之書 | PC | | Game Box Taiwan Release |  | | |
| Spider-Man | PC | | Original | | 31131.101.US | |
| Star Wars: Dark Forces | PC | 1.0 Build 1 | Rerelease, LucasArts Archives Vol. IV, The: Star Wars Collection II | | 3064130, 8061835 | |
| Star Wars: Pit Droids | PC | | Original | | 3513030 | |
| Star Wars: Rogue Squadron 3D | PC | 1.3 | Rerelease | | 6521830 | |
| Steel Harbinger | PSX | | Original | | SLUS-00093 | |
| The Sting! | PC | v2.0e | Original | | ROTHESTING0004USLAB | |
| Symbiocom | PC | | Original | | | |
