| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Silver Gene: The Mutia Chronicle 1
シルバージーン ｔｈｅ ｍｕｔｉａ ｃｈｒｏｎｉｃｌｅ 1 | PC | | Original | | CNDL-0002 |  |
 | Silverload | PC | | |  | | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Simone
Simone: A 64-Bit Memory Game | AJCD | | Unlicensed | | | |
| Simulation Pro Yakyuu '99
シミュレーションプロ野球'９９ | PC | 1.0 | PCHome |  | 506-9801 | |
| Simulation Zoo
シミュレーション・ズー | SS | 1.001 | Original | | T-18611G | |
 | Sinbad in the Lost Land
신밧드의 모험 | PC | 1.0.0.1 | Original |  | | |
 | Skeleton Krew | CD32 | | Original | | | |
| Skeleton Warriors | SS | 1.001 | Original | | T-13204 H | |
| Ski Racing: Extreme Edition
Sierra Sports Ski Racing '99: Extreme Edition | PC | 1.0.0.14 | Sierra Originals: Sports | | S0014001 | |
| Skull Caps | PC | | Original |     | | |
| Sky Target: Daredevil Air Force
スカイ・ターゲット | PC | 1.0.06.19 us | PCHome | | 506-9890 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Sega CD 32X | | T16204F | |
 | Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | 063636, T162035 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | 063636, T162035 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | 063636, T162035 | |
| Slam Tilt | PC | | Original | | | |
| Slayers Royal 2
スレイヤーズろいやる２ | SS | 1.005 | Original | | T-27907G | |
| Slayers Royal 2
スレイヤーズろいやる２ | SS | 1.005 | Original | | T-27907G | |
| The Smurfs | MCD | | Original | | T-151015-50 | |
| Snatcher
スナッチャー | SS | 1.000 | Original | | T-9508G | |
| Soccer Kid | CD32 | | Original | | | |
| Soccer Kid | PC | | Original, Soft Price | | | |
 | Soft-World Magazine No. 139: November 2000
軟體世界雜誌社 ＭｅｇａＤｉｓｃ 第１３９期 | PC | | | | | |
| Software of the Month Club: Volume 245 (Software Showcase) | PC | | | | | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-158025-50 | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-87035 | |
| Sol Divide
ソル・ディバイド | SS | 1.000 | Original | | T-14423G | |
| Soldier of Fortune | PC | 1.03 | Special Tactical Edition | | 1001348.101.US | |
| Soldier of Fortune | PC | 1.03 | Original | | 1000910.101.US | |
| Soldier of Fortune | PC | 1.06 | Gold Edition | | 30173.101.US | |
| Solo Crisis
ソロ・クライシス | SS | 1.000 | Original | | T-23501G | |
| Solo Crisis
ソロ・クライシス | SS | 1.000 | Original | | T-23501G | |
| Solo Crisis
ソロ・クライシス | SS | 1.001 | Taiken Sample-ban | | 610-6802 | |
| Sonic & Garfield Pack | PC | | Original | | 85090 | |
| Sonic 3D Blast | PC | 1.00 | Original | | 85064 | |
 | Sonic 3D: Flickies Island | PC | | ValuSoft | | THQ70487.101 | |
| Sonic 3D: Flickies' Island | PC | | Original | | MK 85064-50 | |
| Sonic CD | PC | | Original, Family Pack | | 500-0014-50, MK 85015-50, MK 85086-50 | |
| Sonic CD | PC | | Original | | MK 85015-50 | |
| Sonic CD | PC | | Expert Software | | 6805 01 | |
| Sonic CD | PC | | Expert Software | | 6805 02 | |
| Sonic CD | PC | 1.1 | Expert Software | | 6805 02 | |
| Sonic Jam | SS | 1.004 | Original | | 81079 | |
| Sonic R | PC | | Original | | MK 85076-50 | |
| Sonic R
ソニックＲ | PC | | Ultra 2000/Ultra Series | | MKW-111 | |
| Sonic R
ソニックＲ | SS | 1.002 | Original | | GS-9170 | |
| Sonic R
ソニックＲ | SS | 1.002 | Original | | GS-9170 | |
| Sonic R | PC | | Expert Software | | 682501.101.US, 682501.101.US 01 | |
| Sonic R | SS | 1.000 | Original, Not for Resale | | 81800, 191306 | |
| Sonic the Hedgehog CD
ソニック・ザ・ヘッジホッグＣＤ | PC | 1.001 | Ultra 2000/Ultra Series | | MKW-160 | |
| Sorcerian Forever
ソーサリアン・フォーエバー | PC | | Premium-ban | | NF03006 | |
| Sotsugyou II: Neo Generation
卒業Ⅱ －Ｎｅｏ ｇｅｎｅｒａｔｉｏｎ－ | SS | 1.000 | Original | | T-5301G | |
| Sotsugyou II: Neo Generation
卒業Ⅱ －Ｎｅｏ ｇｅｎｅｒａｔｉｏｎ－ | SS | 1.000 | Original | | T-5301G | |
| Sotsugyou R: Graduation Real
卒業Ｒ －Ｇｒａｄｕａｔｉｏｎ Ｒｅａｌ－ | PC-FX | | Original | | FXNAV602 | |
| Soul Ride | PC | | | | | |
 | Soul Ride | PC | | Linux (LGP) | | | |
| The Soul
소울 | PC | | Original | | | |
| SoulStar | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 3, Demo) | | T 115035-50 | |
| SoulStar | MCD | | Original | | T-115035-50 | |
| SoulStar / Battlecorps | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 8) | | T 115035-50 / T 115045-50 | |
| Sound Novel Machi (Disc 1) (10.11-10.13 Incl.)
サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Sound Novel Machi (Disc 2) (10.13-10.15 Incl.)
サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Sound Novel Machi (Disc 2) (10.13-10.15 Incl.)
サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Soundtracks of Lipstick Adv.EX
リップスティックアドベンチャーＥＸ サウンドトラック | PC | | PC Game Bundle | | F&C-106 | |
| Souzou Sozai: Umi Vol. 1
創造素材 海 Ｖｏｌ．１ | PHOTO-CD | | Original | | SEVI-1049 | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015-50 | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015 | |
| Space Arcade Collection | PC | 1.0 | Original | | 11-4150-10 | |
 | Space in Motion: Future Trade | PC | 1.01 | Original | | | |
| Space Jam
スペース・ジャム | SS | 1.000 | Original | | T-8119G | |
| Spear of Destiny: Super CD Pack | PC | | Super CD Pack | | | |
 | Speed Demons | PC | | Original | | | |
 | Speedboat Attack | PC | 0.9.9.0 | Covermount | | | |
 | Speedboat Attack | PC | 0.9.9.0 | Best Buys | | BB 004 | |
| Speedster | PC | | Original, Argentum Collection | | | |
 | Spellcross: Poslední Bitva | PC | | Covermount |  | | |
| Spider-Man (Disc 2) | PC | | Original | | 32249.102.US | |
| Spiritual Soul 2: The Blue-Eyed Elementaler
スピリチュアル ソウル ２ ～蒼き瞳の精霊使い～ | PC | | Original | | | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | CD-C951932-LOE | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | | |
| Spot Goes to Hollywood
スポット・ゴーズ・トゥー・ハリウッド | SS | 1.000 | Original | | T-7014G | |
| SSN-21 Seawolf | PC | | EA CD-ROM Classics | | E3205CXD | |
| Stakes Winner 2: Saikyouba Densetsu
ステークス・ウィナー２ ～最強馬伝説～ | SS | 1.006 | Original | | T-3115G | |
| Standard 1500: The Mahjong Joou
スタンダード１５００ Ｔｈｅ 麻雀女王 | PC | 1.0 | Original | | SD-100287 | |
| The Star Bowling (Disc 1)
ザ・スター・ボーリング | SS | 1.001 | Original | | T-21804G | |
| The Star Bowling (Disc 2)
ザ・スター・ボーリング | SS | 1.001 | Original | | T-21804G | |
| Star Command Revolution | PC | 1.0 | Original | | 04-12257CD | |
| Star Fighter | MAC | | | | 03239-001 | |
