| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Seijo Vampire
聖女ヴァンパイア | PC | | Original |  | MMM-7881 |  |
| Seikai Risshiden: Kimi wa Nihon no Leader ni Nareru ka!
政界立志伝～君は日本のリーダーになれるか！～ | PC | | | | MSDJ-99094 | |
 | Sekrety tvoix koshmarov
Секреты твоих кошмаров | PC | | Original |  | | |
| Sem' Samuraev (Disc 1)
Семь Самураев | PC | | Original | | | |
| Sem' Samuraev (Disc 2)
Семь Самураев | PC | | Original | | | |
 | Semper Fi | PC | | Original |  | | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Sengoku Bishoujo Emaki: Kuu o Kiru!!
戦国美少女絵巻 空を斬る！！ | PC | | Original | | TGL-98 0220 | |
| Sengoku Bishoujo Emaki: Kuu o Kiru!! Harukaze no Shou
戦国美少女絵巻 空を斬る！！ ～春風の章～ | PC | | Original | | | |
| Senjou de Shoujo wa Karada o Kakeru: Briefing Disc
戦場デ少女ハ躰ヲカケル ブリーフィングDISC | PC | | Demo | | | |
| Senshi no Ketsudan: Combat Force
戦士の決断 コンバット フォース | PC | 1.0 | Original | | KN12-12201 | |
| Sensible Soccer '98 | PC | | Original |      | | |
| Sensible Soccer 2006 | PC | 1.00.0000 | Original | | MSS1CDEU00 | |
| Sensible Soccer 2006 | PC | 0.0.0.1 | Original | | | |
| Sensible Soccer: European Club Edition | PC | | Original | | | |
| Sensible World of Soccer | PC | 1.0 | Original | | | |
| Sensible World of Soccer '96/'97 (Upgrade PC CD-ROM Disc) | PC | | Original | | | |
| Sensible World of Soccer '96/'97 | PC | 2.0 | Original | | | |
| Sensible World of Soccer '96/'97 | PC | 2.0 | Replay | | | |
| Sensible World of Soccer: European Championship Edition | PC | 1.2 | White Label | | | |
| Sentimental Graffiti (Disc 1)
センチメンタルグラフティ | PC | | Original | | ID NO.9718-X8-01A | |
| Sentimental Graffiti (Disc 2)
センチメンタルグラフティ | PC | | Original | | ID NO.9718-X8-01B | |
 | Sentimental Graffiti 2 (Disc 1)
青澀寶貝2：青澀之戀 | PC | 1.00 | Original |  | | |
| Sentimental Graffiti 2 (Disc 2)
青澀寶貝2：青澀之戀 | PC | 1.00 | Original | | | |
| Sentinel Returns | PC | | Dice | | DMM 005448 | |
| Sentinel Returns | PC | | Original | | | |
 | Sentinel Returns | PC | 1.0 | Original | | CDAC-148200 | |
 | Sentinel: Il Regno delle Illusioni (Disc 1) | PC | 1.0 | | | | |
| Sentinel: Il Regno delle Illusioni (Disc 2) | PC | 1.0 | | | | |
| Sentinel: Strazh vremeni (Disc 1)
Sentinel: Страж времени | PC | 1.0 | Original | | | |
| Sentinel: Strazh vremeni (Disc 2)
Sentinel: Страж времени | PC | 1.0 | Original | | | |
| Sento Monogatari: Sono I
「占都物語」 そのＩ | PC | | Original | | | |
| Sentou Kokka: Improved
戦闘国家 ＩＭＰＲＯＶＥＤ | PC | | Original | | YP-1001 | |
| Sentou Yousei Yukikaze: Yousei no Mau Sora (Disc 1) (Installation CD-ROM)
戦闘妖精雪風～妖精の舞う空～ | PC | | Original | | SYYi-V1.00 | |
| Sentou Yousei Yukikaze: Yousei no Mau Sora (Disc 2) (Game CD-ROM)
戦闘妖精雪風～妖精の舞う空～ | PC | | Original | | SYYg-V1.00 | |
 | Septerra Core: Legacy of the Creator
赛普特拉战记 | PC | 1.02 | Original | | | |
| Septerra Core: Legacy of the Creator | PC | | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Original | | | |
 | Septerra Core: Legacy of the Creator | PC | | Covermount | | ADB 0103 | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Original | | TWI011 | |
| Septerra Core: Legacy of the Creator | PC | 1.02 | Gold Strategy Games, Rerelease | | TWI011 | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Covermount | | | |
 | Septerra Core: Legacy of the Creator | PC | 1.00I | Covermount | | | |
| Septerra Core: Legacy of the Creator | PC | | Original | | 1CSP OR03 0020 IR | |
 | Septerra Core: Legacy of the Creator | PC | 1.02 | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Rerelease | | CD-W58-1103-1 | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Original | | CD-W58-1103-0 | |
| Septerra Core: Legacy of the Creator | PC | 1.02 | Dual Jewel | | CD-C95-1298-1 | |
| Sequence Palladium
シークエンス パラディウム | PC | | DigiCube, Media Kite Great Series | | DWRPM-00089, MKW-182 | |
| Sequence Palladium Mania Kit: Desktop Accessory
シークエンス・パラディウム マニアキット デスクトップアクセサリ | PC | | Original | | WIC-6346 | |
| Sequence Palladium Premium Digital Novel | PC | | PC Game Bundle | | KGD-06021 | |
 | Seraphim: Master of Legend
세라핌 전설의 지배자 | PC | 1.01 | Rerelease |  | | |
| Seraphim: Saigo no Tenshi
セラフィム 最後の天使 | PC | | Original | | SCR-003 | |
 | Sergei Bubka's Millennium Games
Súper Atletismo | PC | 1.0.0.1 | Covermount | | | |
 | Serial Cleaner | PC | | Polska Kolekcja Gier Indie / Edycja Premium | | | |
 | Serious Sam Gold (Disc 1) | PC | 1.05 | Original | | | |
| Serious Sam Gold (Disc 2) | PC | 1.05 | Original | | | |
| Serious Sam II | PC | | Demo | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Serious Sam: Drugie Starcie
Serious Sam: The Second Encounter | PC | 1.05 | Original |  | | |
| Serious Sam: Pierwsze Starcie
Serious Sam: The First Encounter | PC | 1.00b | Original | | | |
 | Serious Sam: The First Encounter | PC | | | | | |
| Serious Sam: The First Encounter
英雄萨姆 | PC | 1.00 | Original, Zhima Kai Men | | | |
| Serious Sam: The First Encounter | PC | 1.00a | Original, TakeAdvantage |  | | |
| Serious Sam: The First Encounter | PC | 1.05 | Gold Edition (PC Gamer Presents) | | | |
| Serious Sam: The First Encounter | PC | 1.05 | Gold Edition | | | |
| Serious Sam: The First Encounter | PC | 1.00a | Software Pyramide | | | |
| Serious Sam: The First Encounter | PC | 1.00a | Covermount | | | |
| Serious Sam: The First Encounter
シリアス サム | PC | 1.00 | Original | | | |
| Serious Sam: The First Encounter
Крутой Сэм: Первая Кровь | PC | 1.00b | 1C: Kollekciya igrushek | | | |
| Serious Sam: The First Encounter | PC | 1.02 | Bundle Version Gainward OEM | | | |
 | Serious Sam: The First Encounter | PC | 1.00 | Original, Pack 5 Action Games | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Original, TakeAdvantage | | | |
| Serious Sam: The Second Encounter | PC | 1.07 | Gold Edition (PC Gamer Presents) | | | |
| Serious Sam: The Second Encounter | PC | 1.07 | Gold Edition, Covermount | | | |
 | Serious Sam: The Second Encounter | PC | | Original, Rerelease | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Software Pyramide | | | |
| Serious Sam: The Second Encounter
シリアス サム：ザ セカンド エンカウンター | PC | 1.05 | Original | | | |
| Serious Sam: The Second Encounter
Крутой Сэм: Второе пришествие | PC | 1.05 | 1C: Kollekciya igrushek | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Original | | | |
 | Serious Sam: The Second Encounter
英雄萨姆2 | PC | 1.05 | Original | | | |
| Serious Sam: Złota Edycja (Disc 1) | PC | | Kolekcja Klasyki | | CENEGA 395a/PCCD-ROM/2006 | |
| Serious Sam: Złota Edycja (Disc 2) | PC | | Kolekcja Klasyki | | CENEGA 395b/PCCD-ROM/2006 | |
| Serp i Molot (Disc 1)
Серп и Молот | PC | | 1C: Igroteka | | | |
| Serp i Molot (Disc 2)
Серп и Молот | PC | | 1C: Igroteka | | | |
| Serp i Molot (Disc 3)
Серп и Молот | PC | | 1C: Igroteka | | | |
| The Serpent of Isis: The First 2 Chapters
The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Serve & Volley | PC | | Telstar Fun & Games | | TFGD 2178/4 | |
| Sesame Street Reading is Fun! Toddler (Disc 1) (Grover's Travels) | PC | 2.0 | Original | | SRF844AE-CD-1 | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Sesame Street Search & Learn Adventures | PC | | software for the fun of it! | | | |
| Sesame Street Search & Learn Adventures | PC | | Original, Software for the Fun of It! | | EOA844AE-CD, KES005 | |
| Sesame Street Toddler | PC | | Adventure Workshop Tots | | 32180-CD1 v1.0 | |
| Sesame Street Toddler (Disc 1) (Letters & Numbers) | PC | 3.0 | | | STL744AE-CD1 | |
| Sesame Street Toddler (Disc 2) (Elmo's Art Workshop) | PC | 3.0 | Rerelease | | STL744AE-CD2 | |
