| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Spiritual Soul 2: The Blue-Eyed Elementaler
スピリチュアル ソウル ２ ～蒼き瞳の精霊使い～ | PC | | Original |  | | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
 | Spiritual Warfare | PC | | Original | | |  |
 | Spirou | PC | | Original |       | SPIROM65511 | |
 | Spirou | PC | | Promo | | SPIROM65511 | |
 | Split Screen Soccer Managers | PC | | Soccer Superstars | | | |
 | Spokojnye igry: krug, shashki, shaxmaty, ugolki i...
Спокойные игры: круг, шашки, шахматы, уголки и... | PC | | Original |  | | |
 | Spongebob Squarepants: Licht Uit, Camera Aan! | PC | | Original |  | | |
 | Spore: Creature Creator | PC | | Original | | 1586407 | |
| Sport Image: World Cup 1994
1994 International Soccer | PC | 2.0 | Soccer Superstars | | | |
| Sport Image: World Cup 1994 | PC | 2.0 | SoftKey | | WCF344AE-CD | |
| Sporting Clays
スポーティング クレー | PC | | Original | | TORM-6257 | |
| Sporting Clays: Interactive Shooting Simulation | PC | 1.0 | Original | | P/N 7407 | |
 | Sportowe Zmagania bez Wysiłku i Biegania | PC | | |  | | |
| Sports Car GT | PC | 1.52m | Collector, Dice | | DCG 012729, DMM 012767, WWE08803703D | |
| Sports Car GT | PC | 1.52m | Original, EA Classics | | WWE08801952D, WWE08803054D | |
 | Sports Car GT | PC | 1.52m | Play the Games Vol. 3 | | | |
| Sports Car GT | PC | 1.52m | EA Classics | | WWG08801952D | |
 | Sports Car GT (Manuale Elettronico) | PC | | Original | | ECA430 DK2 | |
 | Sports Car GT | PC | 1.52m | Rerelease | | WWE08801952D | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | CD-C951932-LOE | |
| Sports Car GT | PC | 1.52US | CD-ROM Classics | | 1187207 | |
 | Sports Challenge Pack 2 | PC | | Encyclopedia Games 2009-10 Deluxe Edition | | | |
| Sports Illustrated Kids: Baseball | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Basketball | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Skateboarding | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Soccer | PC | | Wendy's Kids' Meal | | | |
| Sports Mania: 10 Top Games Deluxe (Disc 3) | PC | | Original | | CD01973/A | |
| Sports Wurx 1 | PC | | Original | | CDO226 | |
| Sportsman's Double Play | PC | 1.0.0 | Original | | | |
| Sportsman's Paradise II | PC | 1.0 | Original | | P/N 4-19599CDSL | |
| SportzFreakz | PC | 1.0 | Original | | | |
| SPQR: The Empire's Darkest Hour | PC | | Original | | | |
| SPQR: The Empire's Darkest Hour | PC | | Hemming All Stars | | | |
| SPQR: The Empire's Darkest Hour | PC | | Original | | MMICDR 5188 | |
 | SPQR: The Empire's Darkest Hour | PC | 1.0.001 | Original, Platinum PC | | 04-11315CD, 04-11568CD, GTI-13-0003-1 CD, GTI-13-0005-1 | |
| Sprill: Wodne Przygody | PC | | | | | |
 | Springdale: Höga berg och djupa dalar | PC | | Original |     | 16837KS0194 | |
| Springdale: Stallets Hemlighet | PC | 1.1 | Original | | KN0062, KS0111 | |
 | Springy | PC | | Original | | | |
| Sproink | PC | | | | | |
| Sproink | PC | | Cosmi | | SJ031609 | |
| Spy Fox 2: "Some Assembly Required" | PC | 1.0.0.1 | Original | | Part No. 04-17571CD | |
| Spy Fox 2: Operatie "Robot-Knop" | PC | | Original | | | |
| Spy Fox 2: Operatie "Robot-Knop" | PC | | CD-ROM Toppers | | | |
| Spy Fox 2: Operatie "Robot-Knop"
Spy Fox: Operatie Robot-Knop | PC | 1.0.0.1 | Rerelease | | 04DSILK16n | |
| Spy Fox in "Cheese Chase" | PC | 2.00 | Rerelease | | Part No. 04-15244CD | |
| Spy Fox in "Das Milchkartell" | PC | | Rerelease | | 1003163 | |
| Spy Fox in "Das Milchkartell" | PC | | Kellogg's | | | |
| Spy Fox in "Dry Cereal" | PC | | Rerelease | | 23563CD | |
| Spy Fox in "Dry Cereal" | PC | | Rerelease | | Part # 001407 | |
| Spy Fox in "Dry Cereal" | PC | | Rerelease | | Part # 0001407 | |
| Spy Fox in "Dry Cereal" | PC | | Demo | | | |
| Spy Fox in "Dry Cereal" | PC | 1.0 | Original | | 04-70281, Part # 0001407, Part No. 04-00000H1529 | |
| Spy Fox in "Dry Cereal" | PC | 2.00 | Original | | Part #04-00000H1407 | |
| Spy Fox in "Hold the Mustard" | PC | 1.0 | Original | | Part No. 04-17574CD | |
| Spy Fox in "Operation Robohund" | PC | 1.0.0.1 | Rerelease | | SPY2PCMCD/A | |
| Spy Fox in Operatie "Melk Weg" | PC | | Rerelease | | | |
| Spy Fox in Operatie "Melk Weg"
Spy Fox: Operatie Melkweg | PC | | Original | | | |
| Spy Fox in Operatie "Melk Weg"
Spy Fox: Operatie Melkweg | PC | | Taptoe | | 500634 | |
 | Spy Fox: "Operation Milkshake" | PC | | Kellogg's | | | |
| Spy Fox: "Operation Milkshake" | PC | | Rerelease | | | |
| Spy Fox: "Operation Ozone" | PC | | Original | | | |
| Spy Fox: "Operation Ozone" | PC | | Original | | Part No. 04-22394CD | |
| Spy Fox: "Operation Ozone" | PC | | Rerelease | | pvaol008spyo | |
| Spy Fox: "Operation Ozone" | PC | | Original | | | |
| Spy Kids 3-D: Game Over | PC | | Original |   | I6100 | |
| Spy Kids Learning Adventures: The Candy Conspiracy | PC | | Original | | 03962 | |
| Spy Kids Learning Adventures: The Nightmare Machine | PC | | Original | | 03963 | |
| Spy Masters: Training Mission / JumpStart Music | PC | | Great Clips | | W0000946 | |
| Spycraft: La Grande Sfida (Disc 1) | PC | | | | | |
| Spycraft: La Grande Sfida (Disc 2) | PC | | | | | |
| Spycraft: La Grande Sfida (Disc 3) | PC | | | | | |
| Spycraft: The Great Game (Disc 1) | PC | | Original | | CDD-3110-101-U3, CDD-3110-101-UK | |
| Spycraft: The Great Game (Disc 3) | PC | | Original | | CDD-3110-103-U3 | |
| Spycraft: The Great Game | PC | | Interactive Preview | | | |
| Spycraft: The Great Game (Disc 1) | PC | | Original | | CDD-3110-101-U3 | |
| Spycraft: The Great Game (Disc 3) | PC | | Original | | CDD-3110-103-U3 | |
 | Spycraft: The Great Game (Disc 2) | PC | | Original | | CDD-3110-102-U3 | |
| SpyHunter | PC | | Original | | 103201CDA, RUSSOBIT-M 2003/414 | |
| Spyro: A Hero's Tail (Assets) | PC | | Press Kit | | | |
| Squad Leader | PC | 1.0 | Original | | SQUADPCGBFDI/A | |
| Square Enix E3 2004 Media CD | PC | | Press Kit | | | |
| Square Enix E3 2005 Media CD | PC | | Press Kit | | | |
| Square Enix: Final Fantasy VII Advent Children Trailer | PC | | Press Kit | | | |
| Square Europe: Press Kit: E3 2000 | PC | | Press Kit | | | |
| SquareSoft: E3 2001 Media CD | PC | | Press Kit | | | |
 | Srpske Igre
Српске Игре | PC | | Original |  | SI_082004 | |
| SRS: Street Racing Syndicate (Disc 1) | PC | | Serie Maxima | | | |
| SRS: Street Racing Syndicate (Disc 2) | PC | | Serie Maxima | | | |
| SRS: Street Racing Syndicate (Disc 1) | PC | | Original | | | |
| SRS: Street Racing Syndicate (Disc 2) | PC | | Original | | | |
| SSI Strategy Collection: Critic's Choice
Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| SSI Tristar Seihin Catalog Software Lineup Vol. 2 Windows
ＳＳＩトリスター製品カタログ Ｓｏｆｔｗａｒｅ Ｌｉｎｅｕｐ ＶＯＬ．２ Ｗｉｎｄｏｗｓ | PC | | Original | | | |
 | St. Gallen Altenrhein X | PC | 1.0 | Original | | | |
| St. Jeremiah Gakuen for Windows
聖エレミヤ学園 ＦＯＲ ＷＩＮＤＯＷＳ | PC | | Original | | LNR0001 | |
| St. Shirobara Gakuen Petit Mahjong: Enami Rina no Maki
聖白薔薇学園プチ★ＭＡＨＪＯＮＧ ～江波理菜の巻～ | PC | | Original | | FIVD-002 | |
| Stable Masters 2 | PC | | Original | | | |
| Stack Up / Arcade Fruit Machine
Double Fun Pack: Volume 1 | PC | | Original | | | |
| Die Stadt der verlorenen Kinder | PC | | Original, Neon Edition | | | |
