Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sanitarium (Disc 2) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 1) | PC | 1.00 RC15 / Build 836 | Original | | | |
| Sanitarium | PC | | Demo | | | |
| Sanitarium (Disc 3) Шизариум | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) Шизариум | PC | 1.01 | Original | | | |
| Sanitarium (Disc 1) Шизариум | PC | 1.01 | Original | | | |
| Sanitarium (Disc 1) Шизариум | PC | 1.01 | Rerelease | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 1) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | 1.0 | Original | | CS090737 | |
| Sangokushi Koumeiden 三國志孔明傳 | PC | | Original | | | |
| Sangokushi Koumeiden 三國志孔明伝 | PC | 1.0 | Value Set Series | | KN11-15101 | |
| Sangokushi Koumeiden 三國志孔明伝 | PC | 1.0 | Original | | KN11-15102 | |
| Sangokushi Koumeiden 三國志孔明伝 | PC | | Original | | KN11-15101 | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sanae-chan wa Torawarete Shimatta! (Disc 1) さなえチャンは囚われてしまった! | PC | | Original | | | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | 170121 | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| Samuraj Po-Xi Super Zabawa | PC | | | | | |
| Samurai Shodown II | PC | | Dual Jewel | | CD-C95-1302-0 | |
| Samurai Shodown II | PC | | Original | | CD-C95-1166-0 | |
| Samurai Shodown II Samurai Spirits | PC | | All You Can Play: 10 Action-Games | | | |
| Samurai Shodown II Samurai Spirits | PC | | Original | | | |
| Samorost 2: Zvezdanutoe priklyuchenie (Igrovoj disk) Саморост 2. Звезданутое приключение | PC | | Podarochnoe izdanie | | | |
| Samogonki Самогонки | PC | | Original | | | |
| Sammy's Science House | PC | 3.0 | Southwestern Kids' Collection | | R2522/8612a.7.01 | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Sammy's Science House | PC | 1.0 | Original | | | |
| Sammy's Science House 泡泡蟲的實驗室 | PC | 1.0.0.0 | Original | | | |
| Sammy 3D Jump 'n' Fun: Gold Edition | PC | 1.02 | Original | | 11022 | |
| Samidare 五月雨 | PC | 1.051 | Original | | PNB-001 | |
| Samidare 五月雨 | PC | 1.05 | Original | | PNB-001 | |
| Samgukji II 2000 Plus 三國志Ⅱ 2000 PLUS | PC | | Original | | | |
| Same or Different | PC | | Book Bundle | | 08028 | |
| Samantha Swift and the Roses of Athena | PC | | Play + Smile | | | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Samanta Svift. Tajna Zolotogo Prikosnoveniya Саманта Свифт. Тайна Золотого Прикосновения | PC | 1.2 | Original | | | |
| Samanta Svift. Tajna Atlantidy' Саманта Свифт. Тайна Атлантиды | PC | 1.3 | Original | | | |
| Sam & Max Hit the Road | PC | | Original | | 634031 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max Hit the Road | PC | | Original | | 634430 | |
| Sam & Max Hit the Road | PC | | LucasArts Classic | | 41117.101.IT | |
| Sam & Max Hit the Road | PC | | Collezione CD-Rom by C.T.O. | | | |
| Sam & Max Hit the Road | PC | 1.0 | LucasArts Classic | | 41117.101.GM | |
| Sam & Max Hit the Road | PC | | Softgold, Rerelease | | | |
| Sam & Max Hit the Road | PC | 2.0 | LucasArts Classic | | 41117.101.UK | |
| Sam & Max Hit the Road | PC | | Kixx XL | | | |
| Sam & Max Hit the Road | PC | | White Label: Doubles | | | |
| Sam & Max Hit the Road | PC | | LucasArts Classic | | 41117.101.AU | |
| Salvage Yard Simulator | PC | | Original | | | |
| Sali Mali 123 | PC | 2.0 Build 216 | Original | | TPPC27 | |
| Salaryman Kintarou: Dai-3-kan Touhoku Dotou-hen サラリーマン金太郎:第3巻東北怒涛篇 | PC | | Original | | | |
| Salaryman Kintarou: Dai-2-kan Netsuai Roman-hen サラリーマン金太郎 第2巻 熱愛浪漫篇 | PC | | Original | | SCR90403 | |
| Salaryman Kintarou サラリーマン金太郎 | PC | | Original | | SCR90402 | |
| Sakura Taisen: Denmaku Club 2 サクラ大戦 電幕倶楽部2 | PC | | Gouka Genteiban | | 673-01444 | |
| Sakura Taisen Monogatari: Mysterious Paris: Special Disc サクラ大戦物語 ~ミステリアス巴里~ Special Disc | PC | | Promo | | | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Desktop Accessories サクラ大戦3 ~巴里は燃えているか~ デスクトップアクセサリーズ | PC | | Tokubetsu Genteiban B | | DWWWC-50121~50123 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 6) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03916 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 5) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03915 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 4) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03914 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 3) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03913 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 2) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03912 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 1) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03911 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 4) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | 1.0.0.0 | Original, Shokai Genteiban | | 673-02560 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 5) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | 1.0.0.0 | Original, Shokai Genteiban | | 673-02561 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02557 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02558 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02559 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Play Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02554 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Play Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02555 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Play Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02556 | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Saikyou Densetsu: Mahjong Haou 2: Kanzenban 最強伝説 麻雀覇王2 完全版 | PC | 1.04 | Best Selections | | MCM-0004 | |
| Die Sage von Nietoom | PC | | Original | | | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic II) | PC | | eXtra Klasyka Next | | | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.01 | Original | | PCO519CD | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.0 | Original | | PCO519CD | |
| Safecracker Safecracker: L'avventura definitiva per aspiranti scassinatori | PC | 1.01 | Original | | SAFEMULTICD1 | |
| Sado Gurumi no Machi: Tada de JK ni Nama Hame Dekiru to Omottara Shasei Shisugite Konsui Joutai ni Natta サドぐるみの町 ~タダでJKに生ハメ出来ると思ったら射精しすぎて昏睡状態になった~ | PC | 1.0.0.0 | Original | | SEA-097 | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Sacrifice: Kamigami no Houkou サクリファイス ~神々の咆哮~ | PC | 0533.01.12 | Original | | | |
| Sacrifice | PC | | Bundle Version MSI OEM | | CD-C951041-MSY4E | |
| Sacred: La Leggenda dell'Arma Sacra (Disco 1) | PC | 1.6.66 | FX Interactive | | IT v.1.6.66 | |
| Sacred: La Leggenda dell'Arma Sacra (Disco 2) | PC | 1.6.66 | FX Interactive | | IT v.1.6.66 | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| Saban's Power Rangers: Time Force | PC | | PC Fun Club, THQ Double Pack (Focus Essential) | | ESS589, PFC024/D | |
| Saban's Power Rangers: Time Force | PC | | Original | | | |
| Saban's Power Rangers Zeo Versus the Machine Empire | PC | | Original | | | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| S³: Silent Storm: Sentinels | PC | | Gold Edition | | ROSILENTST0004lab, ROSILENTST0006lab3 | |
| S²: Silent Storm (Disc 2) | PC | 1.1 | Gold Edition | | ROSILENTST0007lab2 | |
| S²: Silent Storm (Disc 2) | PC | 1.2 | Original | | 28015-CD2 | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | 28015-CD1 | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 2) | PC | 1.1 | | | | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | | | | |
| S²: Silent Storm (Disc 2) | PC | 1.2 | Original | | ROSILENTST0011lab2 | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | ROSILENTST0011lab1 | |
| S²: Silent Storm (Disc 2) | PC | 1.1 | Original | | JW002243 | |
| S²: Silent Storm (Disc 2) | PC | | Gold Edition | | ROSILENTST0006lab2 | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Original | | JW002243 | |
| S²: Silent Storm (Disc 1) | PC | | Gold Edition | | ROSILENTST0006lab1 | |
| S²: Silent Storm (Disc 1) | PC | | Gold Edition | | ROSILENTST0007lab1 | |
| S.C.A.R.S. | PC | 1.1 | Budget | | MMICDR 5259 | |
| S!Zone for SimCity 2000 | PC | | Original | | | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59E-USA-E0 | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59P-EUR-E0 | |
| Suzumiya Haruhi no Heiretsu 涼宮ハルヒの並列 | WII | | Original | | RVL-R44J-JPN | |
| Suzumiya Haruhi no Gekidou 涼宮ハルヒの激動 | WII | | Chou DX Pack | | RVL-RHHJ-JPN | |
| Super Paper Mario | WII | Rev 2 | Original, Nintendo Selects | | RVL-R8PE-USA, RVL-R8PE-USA-B0 | |
| Super Paper Mario | WII | Rev 1 | Original | | RVL-R8PE-USA | |
| Super Paper Mario | WII | | Original | | RVL-R8PE-USA | |
| Super Paper Mario 슈퍼 페이퍼 마리오 | WII | | Original | | RVL-R8PK-KOR | |
| Super Paper Mario スーパーペーパーマリオ | WII | Rev 1 | Original | | RVL-R8PJ-JPN | |
| Super Paper Mario スーパーペーパーマリオ | WII | | Original | | RVL-R8PJ-JPN | |
| Super Paper Mario | WII | | Original | | RVL-R8PP-EUR | |
| Super Paper Mario | WII | Rev 1 | Original, Nintendo Selects | | RVL-R8PP-EUR, RVL-R8PP-EUR-B0 | |
| Super Monkey Ball: Uki Uki Party Daishuugou スーパーモンキーボール ウキウキパーティー大集合 | WII | | Original | | RVL-RSMJ-JPN | |
| Super Monkey Ball: Banana Blitz | WII | | Original | | RVL-RSME-USA | |
| Super Monkey Ball: Banana Blitz | WII | | Original | | RVL-RSMP-EUR | |
| Super Monkey Ball Athletic スーパーモンキーボール アスレチック | WII | | Original | | RVL-SMBJ-JPN-B0 | |
| Super Mario Wii: Galaxy Adventure 슈퍼 마리오 Wii 갤럭시 어드벤처 | WII | | Original, Nintendo Selects | | RVL-RMGK-KOR, RVL-RMGK-KOR-B0 | |
| Super Mario Wii 2: Galaxy Adventure Together 슈퍼 마리오 Wii 2 갤럭시 어드벤처 투게더 | WII | | Original | | RVL-SB4K-KOR-B0 | |
| Super Mario Stadium: Family Baseball スーパーマリオスタジアム ファミリーベースボール | WII | | Original | | RVL-RMBJ-JPN | |
| Super Mario Galaxy 2 | WII | | Original, Nintendo Selects | | RVL-SB4E-USA-B0 | |
| Super Mario Galaxy 2 スーパーマリオギャラクシー2 | WII | | Original | | RVL-SB4J-JPN-B0 | |
| Super Mario Galaxy 2 | WII | | Original, Nintendo Selects | | RVL-SB4P-EUR-B0 | |
| Super Mario Galaxy 2 超級瑪利歐銀河2 | WII | | Original | | RVL-SB4W-CHT-B0 | |
| Super Mario Galaxy | WII | | Original, Nintendo Selects | | RVL-RMGE-USA, RVL-RMGE-USA-B0 | |
| Super Mario Galaxy スーパーマリオギャラクシー | WII | | Original | | RVL-RMGJ-JPN | |
| Super Mario Galaxy | WII | | Original, Nintendo Selects | | RVL-RMGP-EUR, RVL-RMGP-EUR-1, RVL-RMGP-EUR-B0 | |
| Super Mario Collection 슈퍼 마리오 컬렉션 | WII | | Super Mario Bros. 25th Anniversary | | RVL-SVMK-KOR-B0 | |
| Super Mario Collection スーパーマリオコレクション | WII | | Original | | RVL-SVMJ-JPN-B0 | |
| Super Mario All-Stars | WII | | Original, Nintendo Selects | | RVL-SVME-USA-B0 | |
| Super Mario All-Stars | WII | | Original, 25th Anniversary Edition | | RVL-SVMP-EUR-B0 | |
| Summer Sports: Paradise Island | WII | | Original | | RVL-RSUE-USA | |
| Summer Sports Party | WII | | Original | | RVL-RI6P-EUR | |
| Summer Sports 2: Island Sports Party | WII | | Original | | RVL-RI6E-USA-B0 | |
| Summer Challenge: Athletics Tournament | WII | | Original | | RVL-RE6P-EUR-B0 | |
| Summer Athletics: The Ultimate Challenge | WII | | Original | | RVL-RU3E-USA, RVL-RU3E-USA-B0 | |
| Summer Athletics 2009 | WII | | Original | | RVL-R9MP-EUR-B0 | |
| Summer Athletics | WII | Rev 1 | Original | | RVL-RUMP-EUR | |
| Summer Athletics | WII | | Original | | RVL-RUMP-EUR | |
| Sugoro Chronicle: Migite ni Ken o Hidarite ni Saikoro o スゴロクロニクル ~右手に剣を左手にサイコロを~ | WII | | Original | | RVL-RDUJ-JPN | |
| Spy Games: Elevator Mission | WII | | Original | | RVL-RECE-USA-B0 | |
| Spore: Kimi ga Tsukuru Hero スポア キミがつくるヒーロー | WII | | Original | | RVL-RQOJ-JPN-B0 | |
| Spider-Man: Web of Shadows | WII | | Original | | RVL-R3SE-USA | |
| Spider-Man: Web of Shadows | WII | | Original | | RVL-R3SP-EUR, RVL-R3SP-EUR-B0 | |
| Spider-Man: Shattered Dimensions | WII | | Original | | RVL-SPDE-USA-B0 | |
| Spider-Man: Shattered Dimensions | WII | | Original | | RVL-SPDP-EUR-B0 | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOE-USA | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOX-EUR | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOP-UKV | |
| Spider-Man: Edge of Time | WII | | Original | | RVL-SQME-USA-B0 | |
| Spider-Man: Edge of Time | WII | | Original | | RVL-SQMP-EUR-B0 | |
| Spider-Man 3 | WII | | Original | | RVL-RS3E-USA | |
| Spider-Man 3 スパイダーマン3 | WII | | Original | | RVL-RS3J-JPN | |
| Spider-Man 3 | WII | Rev 1 | Original | | RVL-RS3P-UKV | |
| Spider-Man 3 | WII | | Original | | RVL-RS3X-EUR | |
| Speed Racer: The Videogame | WII | | Original | | RVL-R3PE-USA | |
| Speed Racer: The Videogame | WII | | Original | | RVL-R3PP-EUR | |
| Space Chimps | WII | | Original | | RVL-RP9E-USA | |
| Space Chimps | WII | | Original | | RVL-RP9X-EUU | |
| Space Chimps | WII | | Original | | RVL-RP9P-EUR | |
| Space Camp | WII | | Original | | RVL-RIYE-USA | |
| Space Camp | WII | | Original | | RVL-RIYP-EUR | |
| Soul Eater: Monotone Princess ソウルイーター モノトーン プリンセス | WII | | Original | | RVL-RSEJ-JPN | |
| Sonic to Himitsu no Ring ソニックと秘密のリング | WII | | Original | | RVL-RSRJ-JPN | |
| Sonic to Himitsu no Ring ソニックと秘密のリング | WII | | Taikenban | | RVL-DSRJ-JPN | |
| Solitaire & Mahjong | WII | | Original | | RVL-RSOE-USA-B0 | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDE-USA-B0 | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDP-EUR | |
| Smarty Pants: Trivia Fun for Everyone! | WII | | Original | | RVL-RP2E-USA | |
| Smarty Pants: Trivia Fun for Everyone! | WII | | Original | | RVL-RP2P-FRA, RVL-RP2P-NOE | |
| Smart Series Presents: Jaja's Adventure | WII | | Original | | RVL-R67E-USA-B0 | |
| Sled Shred featuring the Jamaican Bobsled Team | WII | | Original | | RVL-R9YE-USA-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8I-EUZ-B0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8I-EUZ-B0 | |
| Ski-Doo Snowmobile Challenge | WII | | Original | | RVL-R87E-USA-B0 | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Ski and Shoot | WII | | Original | | RVL-RUME-USA | |
| Sin Junghwa-daeseon: Michaelgwa Meimeiui Moheom 신중화대선 ~마이클과 메이메이의 모험~ | WII | | Original | | RVL-RTDK-KOR | |
| Sin and Punishment: Successor of the Skies | WII | | Original | | RVL-R2VP-EUR-B0 | |
| Sin & Punishment: Star Successor | WII | | Original | | RVL-R2VE-USA-B0 | |
| The Sims 3 | WII | | Original | | RVL-S3ME-USA-B0 | |
| The Sims 3 | WII | | Beta | | | |
| The Sims 3 | WII | | Original | | RVL-S3MP-EUR-B0 | |
| The Sims 2: Pets | WII | | Original | | RVL-R4PE-USA | |
| The Sims 2: Pets | WII | | Original | | RVL-R4PP-EUR | |
| The Sims 2: Castaway | WII | | Original | | RVL-R42E-USA | |
| The Sims 2: Castaway | WII | Rev 1 | Original | | RVL-R42P-EUR | |
| The Sims 2: Castaway | WII | | Original | | RVL-R42P-EUR, RVL-R42P-NOE | |
| The Sims 2: Castaway | WII | | Beta | | | |
| Die Simpsons: Das Spiel | WII | | Original | | RVL-RSND-NOE | |
| The Simpsons Game | WII | | Original | | RVL-RSNP-UKV | |
| The Simpsons Game | WII | | Original | | RVL-RSNE-USA | |
| The Simpsons Game Los Simpson: El Videojuego / I Simpson: Il Videogioco | WII | | Original | | RVL-RSNX-EUS | |
| Les Simpson: Le Jeu | WII | | Original | | RVL-RSNF-FRA | |
| Simple Wii Series Vol. 6: The Wai Wai Combat SIMPLE Wii シリーズ Vol.6 THE ワイワイ・コンバット | WII | | Original | | RVL-RZ7J-JPN | |
| Simple Wii Series Vol. 5: The Block Kuzushi SIMPLE Wii シリーズ Vol.5 THE ブロックくずし | WII | | Original | | RVL-RZ6J-JPN | |
| Simple Wii Series Vol. 4: The Shooting Action SIMPLE Wii シリーズ Vol.4 THE シューティング・アクション | WII | | Original | | RVL-RZ5J-JPN | |
| Simple Wii Series Vol. 3: Asonde Oboeru: The Party Casino SIMPLE Wii シリーズ Vol.3 遊んで覚える THE パーティー・カジノ | WII | | Original | | RVL-RZ4J-JPN | |
| Simple Wii Series Vol. 2: The Minna de Bass Tsuri Taikai SIMPLE Wii シリーズ Vol.2 THE みんなでバス釣り大会 | WII | | Original | | RVL-RZ3J-JPN | |
| Simple Wii Series Vol. 1: The Minna de Kart Race SIMPLE Wii シリーズ Vol.1 THE みんなでカート・レース | WII | | Original | | RVL-RZ2J-JPN | |
| Simple 2000 Series Wii Vol. 2: The Party Game SIMPLE2000シリーズWii Vol.2 THE パーティーゲーム | WII | | Original | | RVL-RZ9J-JPN | |
| I Simple 2000 Series Wii Vol. 1: The Table Game: Mahjonggo, Shougi, Card, Hanafuda, Reversi, Gomoku Narabe SIMPLE2000シリーズWii Vol.1 THE テーブルゲーム ~麻雀・囲碁・将棋・カード・花札・リバーシ・五目ならべ~ | WII | | Original | | RVL-RZ8J-JPN | |
| SimCity Namanui Dosi 심시티 나만의 도시 | WII | | Original | | RVL-R4CK-KOR | |
| SimCity Creator | WII | | Original | | RVL-R4CE-USA | |
| SimCity Creator シムシティ クリエイター | WII | | Original | | RVL-R4CJ-JPN | |
| SimCity Creator | WII | | Original | | RVL-R4CP-EUR | |
| SimCity Creator | WII | | Beta | | | |
| SimCity Creator | WII | Rev 1 | Original | | RVL-R4CP-AUS | |
| SimAnimals: Africa | WII | | Original | | RVL-R7AE-USA-B0 | |
| SimAnimals: Africa シムアニマル アフリカ | WII | | Original | | RVL-R7AJ-JPN-B0 | |
| SimAnimals: Africa | WII | | Original | | RVL-R7AP-EUR-B0 | |
| SimAnimals | WII | | Original | | RVL-R4AE-USA | |
| SimAnimals シムアニマル | WII | | Original | | RVL-R4AJ-JPN | |
| SimAnimals | WII | | Original | | RVL-R4AP-EUR | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-R5WE-USA-B0 | |
| Silent Hill: Shattered Memories サイレントヒル SHATTERED MEMORIES | WII | | Original | | RVL-R5WJ-JPN-B0 | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-SHLP-EUR-B0 | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDE-USA-B0 | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDP-EUR-B0 | |
| Showtime Championship Boxing | WII | | Original | | RVL-RSYE-USA | |
| Showtime Championship Boxing | WII | | Original | | RVL-RSYP-EUR | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shin Chuuka Taisen: Michael to Meimei no Bouken 新・中華大仙 ~マイケルとメイメイの冒険~ | WII | | Original | | RVL-RTDJ-JPN | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shimano Extreme Fishing | WII | | Original | | RVL-R39P-EUR-B0 | |
| Shikigami no Shiro III 式神の城Ⅲ | WII | | Original | | RVL-RS4J-JPN | |
| Shikakui Atama o Maruku Suru. Wii シカクいアタマをマルくする。 Wii | WII | | Original | | RVL-R4MJ-JPN | |
| Sherlock Holmes: The Silver Earring | WII | | Original | | RVL-SSHP-EUR-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Sesame Street: Ready, Set, Grover! The Videogame | WII | | Original | | RVL-SESU-AUS-B0 | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS3E-USA-B0 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Original | | RVL-SS3U-AUS-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS4E-USA-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Original | | RVL-SS4U-AUS-B0 | |
| Sengoku Basara: Samurai Heroes | WII | | Original | | RVL-SB3E-USA-B0 | |
| Sengoku Basara: Samurai Heroes | WII | | Original | | RVL-SB3P-EUR-B0 | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7P-EUR | |
| SD Gundam: GGeneration World SDガンダム ジージェネレーション ワールド | WII | | Original | | RVL-SDJJ-JPN-B0 | |
| SD Gundam: GGeneration Wars SDガンダム ジージェネレーション ウォーズ | WII | | Original | | RVL-R77J-JPN | |
| Score International Baja 1000: World Championship Off Road Racing | WII | | Original | | RVL-RJCP-EUR-B0 | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Scene It? Lumières ! Action ! | WII | | Original | | RVL-SSCF-FRA-B0 | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5E-USA | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5P-EUR | |
| Samurai Spirits: Rokuban Shoubu サムライスピリッツ 六番勝負 | WII | | Original | | RVL-RSSJ-JPN | |
| Samurai Spirits: 6beonui Seungbu 사무라이 스피리츠 6번의 승부 | WII | | Original | | RVL-RSSK-KOR | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSP-EUR | |
| Samba de Amigo | WII | | Original | | RVL-R3BE-USA | |
| Samba de Amigo サンバDEアミーゴ | WII | | Original | | RVL-R3BJ-JPN | |
| Samba de Amigo | WII | | Original | | RVL-R3BP-EUR | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YP-EUR-B0 | |
| Superman: Shadow of Apokolips | GC | | Original | | DL-DOL-GSUE-USA | |
| Superman: Shadow of Apokolips | GC | | Original | | DL-DOL-GSUP-EUR | |
| Super Monkey Ball 2 スーパーモンキーボール2 | GC | | Taikenban | | DL-DOL-DM2J-DIS | |
| Super Mario Sunshine | GC | | Original, Player's Choice | | DL-DOL-GMSE-USA | |
| Super Mario Sunshine 슈퍼 마리오 선샤인 | GC | | Original | | DL-DOL-GMSE-KOR | |
| Super Mario Sunshine スーパーマリオサンシャイン | GC | Rev 1 | Original | | DL-DOL-GMSJ-JPN | |
| Super Mario Sunshine スーパーマリオサンシャイン | GC | | Original | | DL-DOL-GMSJ-JPN | |
| Super Mario Sunshine | GC | | Original, Player's Choice | | DL-DOL-GMSP-EUR, DL-DOL-GMSP-EUR-01 | |
| Super Mario Strikers | GC | | Original, Best Seller | | DL-DOL-G4QE-USA | |
| Super Mario Strikers スーパーマリオ ストライカーズ | GC | | Original | | DL-DOL-G4QJ-JPN | |
| Super Mario Stadium: Miracle Baseball スーパーマリオスタジアム ミラクルベースボール | GC | | Original | | DL-DOL-GYQJ-JPN | |
| Summoner: La Déesse Réincarnée | GC | | Original | | DL-DOL-GS2F-FRA | |
| SSX on Tour with Mario SSX オン ツアー with マリオ | GC | | Original | | DL-DOL-GXOJ-JPN | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2E-USA | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2I-ITA | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2D-NOE | |
| Spider-Man 2 | GC | | Original, Player's Choice | | DL-DOL-GK2F-FRA | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2P-UKV | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSME-USA | |
| Spider-Man | GC | | Original | | DL-DOL-GSME-USA | |
| Spider-Man スパイダーマン | GC | | Original | | DL-DOL-GSMJ-JPN | |
| Spider-Man | GC | | Original | | DL-DOL-GSMD-NOE | |
| Spider-Man | GC | | Original | | DL-DOL-GSMF-FRA | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSMP-UKV | |
| Spider-Man | GC | | Original | | DL-DOL-GSMP-EUR, DL-DOL-GSMP-UKV | |
| Sphinx and the Cursed Mummy | GC | | Original | | DL-DOL-GXPE-USA | |
| Sphinx and the Cursed Mummy | GC | | Original | | DL-DOL-GXPP-EUR, DL-DOL-GXPP-NOE | |
| Special Jinsei Game Special 人生ゲーム | GC | | Original | | DL-DOL-GLIJ-JPN | |
| Sonic Mega Collection | GC | | Original, Player's Choice | | DL-DOL-GSOE-USA | |
| Sonic Mega Collection ソニック メガコレクション | GC | | Original | | DL-DOL-GSOJ-JPN | |
| Sonic Mega Collection | GC | | Original, Player's Choice | | DL-DOL-GSOP-EUR, DL-DOL-GSOP-EUR-01 | |
| Sonic Gems Collection | GC | | Original, Player's Choice | | DL-DOL-G2XE-USA | |
| Sonic Gems Collection ソニック ジェムズ コレクション | GC | | Original | | DL-DOL-G2XJ-JPN | |
| Sonic Gems Collection | GC | | Original | | DL-DOL-G2XP-EUR | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| SmaBro DX Event-you Disc スマブラDX イベント用ディスク | GC | | Promo | | DL-DOL-D24J-DIS | |
| The Sims: Bustin' Out | GC | | Original | | DL-DOL-G4ME-USA | |
| The Sims: Bustin' Out | GC | | Original, Player's Choice | | DL-DOL-G4MP-EUR-01, DL-DOL-G4MP-NOE, DL-DOL-G4MP-UKV | |
| The Sims | GC | | Original, Player's Choice | | DL-DOL-GCIE-USA-01 | |
| The Sims ザ・シムズ | GC | | Original | | DL-DOL-G4PJ-JPN | |
| The Sims | GC | | Original | | DL-DOL-GCIP-EUR, DL-DOL-GCIP-NOE | |
| The Sims 2: Pets | GC | | Original | | DL-DOL-G4OE-USA | |
| The Sims 2: Pets | GC | | Original | | DL-DOL-G4OP-EUR | |
| The Sims 2 | GC | | Original | | DL-DOL-G4ZE-USA | |
| The Sims 2 | GC | | Original | | DL-DOL-G4ZP-EUR | |
| The Simpsons: Road Rage | GC | | Original | | DL-DOL-GSPE-USA | |
| The Simpsons: Road Rage | GC | | Original | | DL-DOL-GSPP-EUR | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQE-USA | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQP-EUR | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shonen Jump's One Piece: Grand Battle | GC | | Original | | DL-DOL-GOPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shikigami no Shiro II 式神の城Ⅱ | GC | | Original | | DL-DOL-G2SJ-JPN | |
| Shaman King: Soul Fight シャーマンキング ソウルファイト | GC | Rev 1 | Original | | DL-DOL-GSEJ-JPN | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| Serious Sam: Next Encounter | GC | | Original | | DL-DOL-G3BP-EUR | |
| SD Media Launcher for GameCube / Wii SDメディアランチャー Wii用/GC用 | GC | | Unlicensed | | | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCP-EUR | |
| Sturmwind | DC | 1.0 | Unlicensed (Rerelease) | | | |
| Space Channel 5 Theme Music: Mexican Flyer スペース・チャンネル5 | DC | 1.080 | Not for Sale | | | |
| Suzuki Alstare: Extreme Racing | DC | 1.000 | Original | | T-17703N | |
| Suzuki Alstare: Extreme Racing | DC | 1.000 | Original | | T-17703D-50, T-17703D-74 | |
| Super Street Fighter II X for Matching Service スーパーストリートファイターⅡX フォー マッチング サービス | DC | 1.001 | Original | | T-1236M | |
| Super Runabout: San Francisco Edition スーパーランナバウト サンフランシスコエディション | DC | 1.000 | Original | | T-22102M | |
| Super Robot Taisen Alpha スーパーロボット大戦α | DC | 1.016 | Original | | T-20602M | |
| Super Puzzle Fighter II X for Matching Service スーパーパズルファイターⅡX フォー マッチング サービス | DC | 1.001 | Original | | T-1250M | |
| Super Producers: Mezase Show Biz Kai スーパープロデューサーズ 目指せショウビズ界 | DC | 1.001 | Original | | T-14303M | |
| Super Magnetic Niuniu: Promotion Disc スーパーマグネチック ニュウニュウ Promotion Disc | DC | 1.000 | Demo | | 610-7386 | |
| Super Magnetic Niuniu スーパーマグネチックニュウニュウ | DC | 1.002 | Original | | T-30802M | |
| Super Magnetic Neo | DC | 1.001 | Original | | T-40206N | |
| Super Magnetic Neo | DC | 1.001 | Demo | | T-40206ND | |
| Super Magnetic Neo | DC | 1.001 | Original | | T-40206D-50 | |
| Sunrise Eiyuutan サンライズ英雄譚 | DC | 1.000 | Original | | T-41101M | |
| Suika 水夏 ~SUIKA~ | DC | 1.003 | Original, Shokai Genteiban | | T-46508M, T-46509M | |
| Suigetsu: Mayoigokoro (Disc 2) 水月 ~迷心~ | DC | 1.002 | Original | | T-19725M | |
| Suigetsu: Mayoigokoro (Disc 1) 水月 ~迷心~ | DC | 1.002 | Original | | T-19725M | |
| Street Fighter Zero 3: Saikyo-ryu Dojo for Matching Service ストリートファイターZERO3 サイキョー流道場 フォー マッチング サービス | DC | 1.002 | Original | | T-1230M | |
| Street Fighter Zero 3: Saikyo-ryu Dojo ストリート・ファイターZERO3 ~サイキョー流道場~ | DC | 1.007 | Original | | T-1203M | |
| Street Fighter III: W Impact ストリートファイターⅢ Wインパクト | DC | 1.001 | Original | | T-1211M | |
| Street Fighter III: Double Impact | DC | 1.001 | Original | | T-1210N | |
| Street Fighter III: Double Impact | DC | 1.001 | Original | | T-7006D-50 | |
| Street Fighter III: 3rd Strike: Fight for the Future ストリート・ファイターⅢ サードストライク ~ファイト・フォー・ザ・フューチャー~ | DC | 1.003 | Original | | T-1209M | |
| Star Wars: Demolition | DC | 1.001 | Original | | T-23003N | |
| Star Wars: Demolition | DC | 1.000 | Original | | 830-0215-50, T-13010D-50 | |
| Star Gladiator 2: Nightmare of Bilstein スターグラディエイター2 ~ナイトメアオブビルシュタイン~ | DC | 1.002 | Original | | T-1204M | |
| Star Gladiator 2: Nightmare of Bilstein スターグラディエイター2 ~ナイトメアオブビルシュタイン~ | DC | 1.000 | Tentou Taikenban | | 610-7181 | |
| Spirit of Speed 1937 スピリット オブ スピード 1937 | DC | 1.000 | Original | | T-8102M | |
| Spider-Man | DC | 1.000 | Original | | T-13008N | |
| Spider-Man | DC | 1.000 | Original | | T-13011D-50 | |
| Speed Devils スピード・デビル | DC | 1.005 | Original | | T-17702M | |
| Spec Ops II: Omega Squad | DC | 1.008 | Original | | T-41704N | |
| Spec Ops II: Omega Squad | DC | 1.002 | Original | | T-45004D-50 | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-1216N | |
| Spawn: In the Demon's Hand スポーン イン ザ デーモンズ ハンド | DC | 1.003 | Original | | T-1216M | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-36816D-50 | |
| Soulcalibur ソウルキャリバー | DC | 2.000 | Original | | T-1401M | |
| Soukou no Kihei: Space Griffon 蒼鋼の騎兵 -SPACE GRIFFON- | DC | 1.001 | Original | | T-39601M | |
| Sorcerian: Shichisei Mahou no Shito ソーサリアン 七星魔法の使徒 | DC | 1.007 | Genteiban | | T-9102M | |
| Sonic Shuffle | DC | 1.000 | Original | | MK-51060-50 | |
| Sonic Adventure: Limited Edition | DC | 1.002 | Limited Edition, Hollywood Video Rental | | SDC-51014 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | MK-51117-50 | |
| Sonic Adventure 2 | DC | 1.002 | Beta | | MK-5111750 | |
| Sonic Adventure | DC | 1.003 | Original | | MK-51000-50 | |
| SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | T-40207N | |
| SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | 830-0223-50, T-17722D-50 | |
| Skies of Arcadia (Disc 2) | DC | 1.000 | Original | | MK-51052-50 | |
| Skies of Arcadia (Disc 1) | DC | 1.000 | Original | | MK-51052-50 | |
| Sister Princess: Premium Edition (Disc 2) シスター・プリンセス プレミアム・エディション | DC | 1.003 | Original | | T-27802M | |
| Sister Princess: Premium Edition (Disc 1) シスター・プリンセス プレミアム・エディション | DC | 1.003 | Original | | T-27802M | |
| Simple 2000 Series DC Vol. 04: Okaeri! The Ren'ai Adventure SIMPLE2000シリーズDC Vol.04 おかえりっ! THE 恋愛アドベンチャー | DC | 1.003 | Original | | T-47403M | |
| Simple 2000 Series DC Vol. 03: Fureai: The Ren'ai Simulation SIMPLE2000シリーズDC Vol.03 ふれあい THE恋愛シミュレーション | DC | 1.003 | Original | | T-47402M | |
| Simple 2000 Series DC Vol. 02: Natsuiro Celebration: The Ren'ai Simulation SIMPLE2000シリーズDC Vol.02 夏色セレブレーション THE 恋愛シミュレーション | DC | 1.002 | Original | | T-47404M | |
| Simple 2000 Series DC Vol. 01: Bittersweet Fools: The Ren'ai Adventure SIMPLE2000シリーズDC Vol.01 BITTERSWEET FOOLS THE 恋愛アドベンチャー | DC | 1.002 | Original | | T-47401M | |
| Silent Scope サイレント スコープ | DC | 1.002 | Original | | T-9513M | |
| Shirotsumesouwa: Episode of the Clovers 白詰草話 -EPISODE OF THE CLOVERS- | DC | 1.003 | Original, Gouka Tokuten-iri Package | | T-20123M, T-20125M | |
| The Shinri Game ザ・心理ゲーム | DC | 1.004 | Original | | T-43403M | |
| Shinki Sekai Evolution 2: Tooi Yakusoku 神機世界 エヴォリューション 2 遠い約束 | DC | 1.002 | Original | | T-38703M | |
| Shinki Sekai Evolution 神機世界 エヴォリューション | DC | 1.023 | Original | | T-38701M | |
| Shin Seiki Evangelion: Typing Hokan Keikaku 新世紀エヴァンゲリオン タイピング補完計画 | DC | 1.002 | Original | | T-35102M | |
| Shin Seiki Evangelion: Typing E Keikaku 新世紀エヴァンゲリオン タイピング‐E計画 | DC | 1.001 | Original | | T-35101M | |
| Shin Seiki Evangelion: Ayanami Ikusei Keikaku 新世紀エヴァンゲリオン 綾波育成計画 | DC | 1.002 | Original | | T-46303M | |
| Shin Nihon Pro Wrestling: Toukon Retsuden 4 新日本プロレスリング 闘魂烈伝4 | DC | 1.006 | Shokai Genteiban | | T-28202M | |
| Shin Honkaku Hanafuda 真 本格花札 | DC | 1.005 | Original | | T-16601M | |
| Shikigami no Shiro II 式神の城Ⅱ | DC | 1.002 | Original, Shokai Genteiban | | T-47701M, T-47702M | |
| Shenmue: Ichishou Yokosuka (Disc 3) シェンムー 一章 横須賀 | DC | 1.007 | Original, Genteiban | | HDR-0016, HDR-0031 | |
| Shenmue: Ichishou Yokosuka (Disc 2) シェンムー 一章 横須賀 | DC | 1.007 | Original, Genteiban | | HDR-0016, HDR-0031 | |
| Shenmue: Ichishou Yokosuka (Disc 1) シェンムー 一章 横須賀 | DC | 1.007 | Original, Genteiban | | HDR-0016, HDR-0031 | |
| Shenmue: Ichishou Yokosuka (Shenmue Passport) シェンムー 一章 横須賀(シェンムーパスポート) | DC | 1.014 | Original, Genteiban | | HDR-0016, HDR-0031 | |
| Shenmue: Ichishou Yokosuka (Shenmue Passport) シェンムー 一章 横須賀(シェンムーパスポート) | DC | 1.010 | Genteiban | | HDR-0031 | |
| Shenmue II (Disc 4) シェンムーⅡ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0164, HDR-0179 | |
| Shenmue II (Disc 3) シェンムーⅡ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0164, HDR-0179 | |
| Shenmue II (Disc 2) シェンムーⅡ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0164, HDR-0179 | |
| Shenmue II (Disc 1) シェンムーⅡ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0164, HDR-0179 | |
| Shenmue II (Disc 4) | DC | 1.001 | Original | | MK-51184-50 | |
| Shenmue II (Disc 3) | DC | 1.001 | Original | | MK-51184-50 | |
| Shenmue II (Disc 2) | DC | 1.001 | Original | | MK-51184-50 | |
| Shenmue II (Disc 1) | DC | 1.001 | Original | | MK-51184-50 | |
| Shanghai: Dynasty 上海ダイナスティ | DC | 1.010 | Original | | T-9902M | |
| Sentimental Graffiti: Yakusoku センチメンタルグラフティ ~約束~ | DC | 1.003 | Original | | T-20128M | |
| Sentimental Graffiti 2: Third Window センチメンタルグラフティ2 サードウィンドウ | DC | 3.000 | Hibaihin | | 610-7749 | |
| Sentimental Graffiti 2 (Disc 2) センチメンタルグラフティ2 | DC | 1.008 | Original | | T-20104M | |
| Sentimental Graffiti 2 (Disc 1) センチメンタルグラフティ2 | DC | 1.008 | Original | | T-20104M | |
| Sengoku Turb: Fanfan I Love Me Dunce-doublentendre 戦国TURB Fanfan I ♥ me Dunce-doublentendre | DC | 1.001 | Original | | T-38805M | |
| Sekai Fushigi Hakken! Troia 世界ふしぎ発見! トロイア | DC | 1.002 | Original | | T-39701M | |
| Seitai Heiki Expendable 生体兵器 エクスペンダブル | DC | 1.001 | Original | | T-15003M | |
| Seireiki Rayblade 聖霊機ライブレード | DC | 1.003 | Original | | T-42201M | |
| Sega Worldwide Soccer 2000: Euro Edition SWWS 2000: Euro Edition | DC | 1.030 | Original | | MK-51083-50 | |
| Sega Worldwide Soccer 2000 | DC | 1.300 | Original | | MK-51031-50 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.003 | Original | | 51019 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.001 | Original | | MK-51019-50 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.000 | Original | | MK-51019-50 | |
| Sega Marine Fishing | DC | 1.001 | Original | | 51096 | |
| Sega Marine Fishing セガマリンフィッシング | DC | 1.003 | Original | | HDR-0104 | |
| Sega GT: Homologation Special セガGT ホモロゲーションスペシャル | DC | 1.006 | Original | | HDR-0054 | |
| Sega GT: Homologation Special セガGT ホモロゲーションスペシャル | DC | 0.800 | Taikenban | | 610-7727 | |
| Sega Bass Fishing | DC | 1.020 | Original | | MK-51006-50 | |
| Seaman Esa Disc: Kimos Shu no Youchuu Hojuu Kit シーマン えさ ディスク <キモス種の幼虫補充キット> | DC | 1.001 | Bundled with Seaman Ikusei Shien Kit | | 610-7804 | |
| Sangokushi VI with Power-Up Kit 三國志Ⅵ with パワーアップキット | DC | 1.000 | Original | | T-7607M | |
| Sangokushi VI 三國志Ⅵ | DC | 1.000 | Original | | T-7603M | |
| Samba de Amigo Ver. 2000 | DC | 1.001 | Original | | HDR-0131 | |
| Samba de Amigo | DC | 1.001 | Original | | 51092 | |
| Samba de Amigo サンバDEアミーゴ | DC | 1.000 | Original | | HDR-0063 | |
| Samba de Amigo | DC | 1.002 | Bundled with Maracas Controller | | MK-51092-50 | |
| Sakura Taisen: Hanagumi Taisen Columns 2 サクラ大戦 ~花組対戦コラムス2~ | DC | 1.000 | Original | | HDR-0046 | |
| Sakura Taisen Kinematron Hanagumi Mail サクラ大戦 キネマトロン 花組メール | DC | 1.008 | Original | | HDR-0136 | |
| Sakura Taisen Dream Passport 3 サクラ大戦 ドリームパスポート 3 | DC | 1.007 | Original | | 610-7996 | |
| Sakura Taisen 4: Koi seyo Otome: Preview Disc サクラ大戦4 ~恋せよ乙女~ プレビュウDisc | DC | 1.001 | DC Game Bundle | | HDR-0184, HDR-0189 | |
| Sakura Taisen 4: Koi seyo Otome サクラ大戦4 ~恋せよ乙女~ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0191, HDR-0202 | |
| Sakura Taisen 4: Koi seyo Otome サクラ大戦4 ~恋せよ乙女~ | DC | 1.000 | Tentou-you Demo Movie | | 610-8333 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Sakura Taisen 3 Movie Disc サクラ大戦3 ~巴里は燃えているか~ サクラ大戦3 ムービーディスク | DC | 1.002 | Original | | HDR-0136 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Preview Disc サクラ大戦3 ~巴里は燃えているか~ プレビュウディスク | DC | 1.001 | DC Game Bundle | | HDR-0082, HDR-0108 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Drama Download Disc サクラ大戦3 ~巴里は燃えているか~ ドラマダウンロードディスク | DC | 1.000 | Original, Shokai Genteiban, Sakura Wars Complete Box | | HDR-0191, HDR-0201, HDR-0202 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 3) サクラ大戦3 ~巴里は燃えているか~ | DC | 1.003 | Original, Shokai Genteiban A, Shokai Genteiban B, Memorial Pack, Sakura Wars Complete Box | | HDR-0147, HDR-0148, HDR-0152, HDR-0194, HDR-0201 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 2) サクラ大戦3 ~巴里は燃えているか~ | DC | 1.003 | Original, Shokai Genteiban A, Shokai Genteiban B, Memorial Pack, Sakura Wars Complete Box | | HDR-0147, HDR-0148, HDR-0152, HDR-0194, HDR-0201 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 1) サクラ大戦3 ~巴里は燃えているか~ | DC | 1.003 | Original, Shokai Genteiban A, Shokai Genteiban B, Memorial Pack, Sakura Wars Complete Box | | HDR-0147, HDR-0148, HDR-0152, HDR-0194, HDR-0201 | |
| Sakura Taisen 3: Paris wa Moeteiru ka サクラ大戦3 ~巴里は燃えているか~ | DC | 1.000 | Tentou-you Demo Movie | | 610-8022 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.005 | Memorial Pack, Sakura Wars Complete Box | | HDR-0193, HDR-0201 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.002 | Original, Shokai Genteiban Puru Puru Pack Fuzoku Set | | HDR-0082, HDR-0108 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.005 | Memorial Pack, Sakura Wars Complete Box | | HDR-0193, HDR-0201 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.002 | Original, Shokai Genteiban Puru Puru Pack Fuzoku Set | | HDR-0082, HDR-0108 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.005 | Memorial Pack, Sakura Wars Complete Box | | HDR-0193, HDR-0201 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.002 | Original, Shokai Genteiban Puru Puru Pack Fuzoku Set | | HDR-0082, HDR-0108 | |
| Sakura Momoko Gekijou: Coji-Coji さくらももこ劇場 コジコジ | DC | 1.002 | Original | | T-40802M | |
| System-Disc (KD02) JVC | SS | 1.000 | Original | | 610-5732-03 | |
| System-Disc (KD02) Columbia | SS | 1.000 | Original | | 610-5732-06 | |
| Super Real Mahjong PVI スーパーリアル麻雀PⅥ | SS | 1.000 | P's Club Special Edition | | T-16508G | |
| Super Real Mahjong PVI スーパーリアル麻雀PⅥ | SS | 1.000 | Original | | T-16507G | |
| Super Real Mahjong Graffiti スーパーリアル麻雀 グラフィティ | SS | 1.001 | P's Club Special Edition | | T-16506G | |
| Super Real Mahjong Graffiti スーパーリアル麻雀 グラフィティ | SS | 1.001 | Original | | T-16504G | |
| Suikoden: Tenmei no Chikai 水滸伝 ~天命の誓い~ | SS | 1.000 | Original | | T-7624G | |
| Sugoventure: Dragon Master Silk Gaiden すごべんちゃー ~ドラゴン・マスター・シルク外伝~ | SS | 1.000 | Original | | T-19505G | |
| Suchie-Pai Adventure: Doki Doki Nightmare (Disc 2) スーチーパイ・アドベンチャー ~ドキドキナイトメア~ | SS | 1.003 | Original, Special Package-ban | | T-5713G, T-5715G | |
| Suchie-Pai Adventure: Doki Doki Nightmare (Disc 1) スーチーパイ・アドベンチャー ~ドキドキ・ナイトメア~ | SS | 1.003 | Original, Special Package-ban | | T-5713G, T-5715G | |
| Street Fighter: The Movie | SS | 1.003 | Original | | T-8105H | |
| Street Fighter: The Movie | SS | 1.001 | Original | | T-8105H-50 | |
| Street Fighter: The Movie | SS | 1.001 | Original | | T-8105H-50 | |
| Street Fighter: Real Battle on Film ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter: Real Battle on Film ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter: Real Battle on Film ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter II Movie (Disc 2) ストリート・ファイターⅡ ムービー | SS | 1.003 | Original | | T-1204G | |
| Street Fighter II Movie (Disc 1) ストリート・ファイターⅡ ムービー | SS | 1.003 | Original | | T-1204G | |
| Street Fighter Alpha: Warriors' Dreams | SS | 1.000 | Original | | T-1206H | |
| Street Fighter Alpha: Warriors' Dreams | SS | 1.000 | Beta | | | |
| Street Fighter Alpha: Warriors' Dreams | SS | 1.001 | Original | | T-7008H-50 | |
| Strahl: Himerareshi Nanatsu no Hikari シュトラール ~秘められし七つの光~ | SS | 1.004 | Original | | T-20501G | |
| Steep Slope Sliders | SS | 1.00 | Original | | MK81128-50 | |
| Stakes Winner: GI Kanzen Seiha e no Michi ステークス・ウィナー ~GI完全制覇への道~ | SS | 0.108 | Original | | T-3107G | |
| Sound Novel Machi (Disc 2) (10.13-10.15 Incl.) サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Sound Novel Machi (Disc 2) (10.13-10.15 Incl.) サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Sound Novel Machi (Disc 1) (10.11-10.13 Incl.) サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Sonic R | SS | 1.000 | Original | | MK81800-50 | |
| Sonic Jam | SS | 1.004 | Original | | 81079 | |
| Sonic Jam ソニック・ジャム | SS | 1.008 | Satakore | | GS-9200 | |
| Sonic Jam ソニック・ジャム | SS | 1.005 | Original | | GS-9147 | |
| Sonic Jam | SS | 1.000 | Original | | MK81079-50 | |
| Sonic 3D: Flickies' Island | SS | 1.000 | Original | | MK81062-50 | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H-50 | |
| Slam 'n Jam '96 featuring Magic & Kareem マジック・ジョンソン・と・カリーム・アブドュール・ジャバーの スラム・ジャム’96 | SS | 1.000 | Original | | T-15905G | |
| Simulation Zoo シミュレーション・ズー | SS | 1.001 | Original | | T-18611G | |
| Simulation RPG Tkool シミュレーションRPGツクール | SS | 1.003 | Original | | T-2106G | |
| SimCity 2000 | SS | 1.401 | Original | | T-12601H | |
| SimCity 2000 シムシティ2000 | SS | 1.041 | Original | | GS-9027 | |