Region | Title | System | Version | Edition | Languages | Serial | Status |
| Universe at War: Earth Assault | PC | 1.0 | Original | | | |
| Universe at War: Earth Assault | PC | 1.0 (86418) | Original, Covermount | | SEGA-PC058 | |
| Ultimate Spider-Man | PC | 1.0.0.1 | Original, Best of Activision | | 32857.101.00, 32857.101.5E | |
| USA Raser: Mit Highspeed durch Amerika! | PC | 1.0.0 | Original | | USRAC | |
| US Racer | PC | 1.0.0.21 | Original | | USRAC, USRACDE, USRACUK | |
| Uru: The Path of the Shell Myst: Uru Expansion Pack: The Path of the Shell | PC | | Original | | 652021-CD | |
| Uru: The Path of the Shell | PC | | Original | | | |
| Uru: Complete Chronicles (Disc 1) | PC | | Original | | 652038-CD1 | |
| Uru: Complete Chronicles (Disc 1) | PC | | Original | | 751830-CD1 | |
| Uru: Ages Beyond Myst | PC | 1.0 | Original | | 651093-CD | |
| Uru: Ages Beyond Myst | PC | | Original, OEM Bundle, Collector's Edition | | G71-URGA001 | |
| Urban Chaos | PC | 2.63 | Original | | | |
| Urban Chaos | PC | | Original | | | |
| Urban Chaos | PC | 2.69 | Original | | | |
| Upptäck Rymden med Mulle Meck | PC | 1.3 | Rerelease | | | |
| Upptäck Rymden med Mulle Meck | PC | 1.3 | Original | | KS0061 | |
| Unter schwarzer Flagge | PC | | Original | | | |
| Unreal Tournament (Disc 1) (Game) | PC | 400 | Original | | 04-18115CD1 | |
| Unreal Tournament (Disc 1) (Game) | PC | 400 | Original, Rerelease | | 04-18115CD1A | |
| Unreal Tournament | PC | 428 | Bundle Version Creative Labs OEM | | 04-18115CD | |
| Unreal Tournament (Disc 1) (Game) 언리얼 토너먼트 | PC | 400 | Best of Infogrames | | | |
| Unreal Tournament (Disc 1) (Game) | PC | 400 | Original | | | |
| Universal Combat | PC | | Original | | PCO404CD | |
| Uncommon Valour: Campaign for the South Pacific | PC | | Original | | JFC000417 | |
| Ultimate Spider-Man (Disc 1) | PC | 1.0 | Original | | 32857.101.US | |
| Ultima IX: Ascension (Disc 2) (Game Disc) | PC | | Ultima Online 7th Anniversary Edition | | 1487227 | |
| Ultima IX: Ascension (Play Disc) | PC | 1.03F, 1.18F | Original, Ultima: Best of Both Worlds: Special Value Edition | | 1051017 | |
| Ultima IX: Ascension (Game Disc) | PC | 1.03F | Dragon Edition | | 1051017 | |
| Ultima IX: Ascension (Install Disc) | PC | 1.03F | Original, Dragon Edition | | 1051007 | |
| Ultima IX: Ascension (Install Disc) 創世紀IX | PC | 1.03f | Original | | 1051007 | |
| Ultima IX: Ascension (Disc 2) (Game Disc) | PC | 1.03F | Covermount | | | |
| Ultima IX: Ascension (Disc 1) (Install Disc) | PC | 1.03F | Covermount | | | |
| Ultima IX: Ascension (Game Disc) ウルティマ Ⅸ アセンション | PC | | Original, Premium Edition | | EMW-4060, EMWS-401 | |
| Ultima IX: Ascension (Spiel-CD) | PC | 1.18F | Special Limited Gamers Edition | | ORG08901538D1 | |
| Ultima IX: Ascension (Game Disc) | PC | 1.18F | Original | | ORE08901538D2 | |
| Ultima IX: Ascension (Game Disc) 創世紀IX | PC | 1.03f | Original | | 1051017 | |
| UEFA Euro 2004: Portugal (Disc 2) ยูฟ่า ยูโร 2004: โปรตุเกส | PC | | Original | | | |
| UEFA Euro 2000 | PC | | Original | | EAG08902998D | |
| UEFA Champions League 2004-2005 (Disc 2) | PC | | Original | | EAI08004461D2 | |