Region | Title | System | Version | Edition | Languages | Serial | Status |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scholastic's The Magic School Bus: Volcano Adventure: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0401 Part No. X08-06054 | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| SeaWorld Adventure Parks Tycoon | PC | | Original | | 31711.101.US | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | GC | | Original | | DL-DOL-GJZE-USA | |
| Seek & Find Adventures | PC | | Original | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Sesame Street Search & Learn Adventures | PC | | Original, Software for the fun of it | | EOA844AE-CD, KES005 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS3E-USA-B0 | |
| Sesame Street: Elmo's Letter Adventure | PSX | | Original, Twin Pack | | SLUS-00621 … | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Skylanders: Spyro's Adventure | WII | | Starter Pack | | RVL-SSPY-BRA-B0 | |
| Skylanders: Spyro's Adventure | PC | | Press Kit | | | |
| Skylanders: Spyro's Adventure | WII | | Starter Pack | | RVL-SSPE-USA-B0 | |
| Smart Series Presents: Jaja's Adventure | WII | | Original | | RVL-R67E-USA-B0 | |
| Snapshot Adventures: Secret of Bird Island | PC | | Original | | P/N 61191-CD | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| Sonic Adventure 2: Battle | GC | | Original, Player's Choice | | DL-DOL-GSNE-USA | |
| Sonic Adventure DX: Director's Cut | GC | | Original, Player's Choice | | DL-DOL-GXSE-USA | |
| Sorting Adventures: Interactive Activities | PC | | Original | | AAP899, PP463 | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015 | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 Rev.1 | |
| Spy Kids Learning Adventures: The Candy Conspiracy | PC | | Original | | 03962 | |
| Spy Kids Learning Adventures: The Nightmare Machine | PC | | Original | | 03963 | |
| Star Fox Adventures | GC | | Original | | DL-DOL-GSAE-USA | |
| Star Fox Adventures: Game Preview CD | PC | | Promo | | | |
| Star Trek: Klingon (Disc 1) (Installation) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Star Trek: Klingon (Disc 2) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Star Wars Galaxies: The Complete Online Adventures (Disc 1) | PC | | Original | | 8131830 | |
| Story Hour: Adventures | WII | | Original | | RVL-R3AE-USA | |
| Strange Adventures in Infinite Space | PC | | Cheapass Games | | | |
| Stuart Little: Big City Adventures Stuart Little: Big City Adventures CD-ROM Game | PC | | Original | | Product # 99716 | |
| Super Monkey Ball Adventure | GC | | Original | | DL-DOL-G3LE-USA | |
| The Sims 3: World Adventures (Expansion Pack) | PC | 0.2.0.56 | Original, The Sims 3 Expansion Bundle | | 1539307 | |
| Skylanders: Spyro's Adventure | PS3 | 01.00 | Starter Pack | | BLUS-30779 | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.0 | Original | | PCO519CD | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.0 | Original | | | |
| SeaWorld Adventure Parks Tycoon 2 SeaWorld Adventure Parks Tycoon 3D | PC | 1.0 | Original | | 35077.101.US | |
| Skylanders: Spyro's Adventure | PC | 1.0 | Starter Pack | | 33366010US | |
| Slots Adventure: War for Olympus | PC | 1.0 | Original | | | |
| Spore: Galactic Adventures | PC | 1.0 | Original | | 1535407 | |
| Star Wars: Jar Jar's Journey Adventure Book | PC | 1.0 | Original | | #3520530 | |
| Stuart Little Learning Adventures: His Adventures in Wordland (Disc 2) | PC | 1.0 | Original | | 381676-CD2 | |
| Shutter Island: The Adventure Game | PC | 1.0.0 | Original | | | |
| Sonic Adventure DX: Director's Cut (Disc 1) | PC | 1.0.0.9 | Original | | 35033.101.US | |
| Sonic Adventure DX: Director's Cut (Disc 2) | PC | 1.0.0.9 | Original | | 35033.102.US | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | PS2 | 1.00 | Original | | SLUS 21289 | |
| Sonic Adventure | DC | 1.000 | Trial Version for E3 | | HDR-0001 | |
| Sonic Adventure: Limited Edition | DC | 1.002 | Limited Edition, Hollywood Video Rental | | SDC-51014 | |
| Sonic Adventure | DC | 1.004 | Original | | 51000 | |
| Sonic Adventure | DC | 1.005 | Original, Sega All Stars | | 51000 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | 51117 | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.01 | Original | | PCO519CD | |
| Sea Monsters: A Prehistoric Adventure | PS2 | 1.01 | Original | | SLUS-21741 | |
| Shonen Jump's One Piece: Grand Adventure | PS2 | 1.01 | Original | | SLUS 21435 | |
| Stuart Little 3: Big Photo Adventure | PS2 | 1.01 | Original | | SLUS 21341 | |
| Super Monkey Ball Adventure | PS2 | 1.01 | Original | | SLUS 21272 | |
| Super Monkey Ball Adventure | PSP | 1.02 | Original | | ULUS-10132 | |
| Scooby-Doo! Ancient Adventure | VFLASH | Rev 1 | Original | | 093080(US) | |
| Skylanders: Spyro's Adventure | WII | Rev 1 | Starter Pack | | RVL-SSPE-USA-B1 | |
| Star Fox Adventures | GC | Rev 1 | Player's Choice | | DL-DOL-GSAE-USA | |