Region | Title | System | Version | Edition | Languages | Serial | Status |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| Saban's Power Rangers: Lightspeed Rescue | PSX | | Original | | SLUS-01114 | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| Sacred 2 (Disc 2) | PC | | Original | | | |
| Sacred 2: Fallen Angel (Disc 1) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 2) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 3) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| The Sacred Amulet | PC | | Original | | | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| Sacrifice | PC | | Bundle Version Hewlett Packard OEM | | CD-C951041-PC2E | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Saints Row: The Third (Disc 1) | PC | | Original | | | |
| Saints Row: The Third (Disc 2) | PC | | Original | | | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | Original | | 634031 | |
| Sam & Max Hit the Road | PC | | Original | | 634430 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | |
| Sam & Max: Beyond Time and Space | PC | | Original | | 27898CD | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Samba de Amigo | WII | | Original | | RVL-R3BE-USA | |
| Sammy Soza Softball Slam | PC | | Original | | PCD-5048-001 | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Shodown II | PC | | Dual Jewel | | CD-C95-1302-0 | |
| Samurai Shodown II | PC | | Original | | CD-C95-1166-0 | |
| Samurai Shodown III: Blades of Blood | PSX | | Original | | SCUS-94206 | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Shodown V | XBOX | | Original | | SN-004 | |
| Samurai Shodown: Warriors Rage | PSX | | Original | | SLUS-01039 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-87015 | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Original | | | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| Scaler | GC | | Original | | DL-DOL-GKUE-USA | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| SCEA Gamers Day 2002: Press Info | PC | | Press Kit | | | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scholastic's The Magic School Bus Explores the World of Animals | PC | | Original, The Magic School Bus: Bonus Pack | | 0299 Part No. X03-94114, 1001 Part No. X08-51052 | |
| Scholastic's The Magic School Bus Lands on Mars: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0400 Part No. X05-64212 | |
| Scholastic's The Magic School Bus: Volcano Adventure: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0401 Part No. X08-06054 | |
| Scholastic's The Magic School Bus: Whales & Dolphins: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3, The Magic School Bus: Bonus Pack | | 0201 Part No. X06-15571 | |
| School Tycoon | PC | | Scholastic | | P/N: CDR 21661-1R | |
| School Zone Flash Action Software: Multiplication/Division | PC | | Original | | 08021 | |
| School Zone Math: First & Second Grade | PC | | Original | | 08020 | |
| Schoolhouse Rock! 1st & 2nd Grade (Disc 2) (2nd Grade) | PC | | Original | | 21330CD-2, SGE744AE-CD2 | |
| Schoolhouse Rock! 1st & 2nd Grade Essentials (Disc 1) | PC | | Original | | 21330CD-1 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! Grammar Rock | PC | | SmartSaver | | SGR744AE-CD | |
| Schoolhouse Rock! Math Rock | PC | | Original | | 21010CD | |
| Schoolhouse Rock! Math Rock | PC | | Smart Saver | | SHR744AE-CD | |
| Schoolhouse Rock! Thinking Games | PC | | Original | | BBT844AE-CD | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744BE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744AE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 2) (Learning Adventures) | PC | | Original | | SRT744AE-CD2 | |
| Science Arcade | PC | | Original | | Part No.: MAR476 | |
| Scooby-Doo and the Cyber Chase | PSX | | Demo | | SLUS-90098 | |
| Scooby-Doo and the Cyber Chase | PSX | | Original, Greatest Hits | | SLUS-01396 … | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Scooby-Doo! and the Spooky Swamp | WII | | Original | | RVL-SJ2E-USA-B0 | |
| Scooby-Doo! First Frights | WII | | Original | | RVL-RQNE-USA-B0 | |
| Scooby-Doo! Mystery Mayhem | GC | | Original | | DL-DOL-GC3E-USA | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Night of 100 Frights | XBOX | | Original | | TQ-031 | |
| Scooby-Doo! Night of 100 Frights | PSX | | Prototype | | | |
| Scooby-Doo! Night of 100 Frights | GC | | Original | | DL-DOL-GIHE-USA | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DE-USA | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Scorched Planet | PC | | Bundle Version Matrox OEM | | /MYST-CD/GA1/01 | |
| Scorched Planet | PC | | Original | | | |
| Scorcher | PC | | Original | | 04-11264CD | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| ScottForesman Wide World of Mathematics | PC | | Original | | 45678910 ET 030201009998 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Scholastic, Classic Value Series | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002, 99002● | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble Complete | PC | | Cosmi | | CDRZ652D1, SJ122005 | |
| Scrabble Complete | PC | | Original, Monopoly & Scrabble Complete, Scrabble Complete/Jeopardy 2003 | | 11290-CD, Part # 23970CD | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble: Champion Edition | PC | | Original | | 11191A-CD v1.0 S | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Rerelease | | | |
| Screamer 2 Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Scribblenauts Unlimited | PC | | Original | | 5000145356 | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Sea-Doo Hydro Cross | PSX | | Original | | SLUS-01149 | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Seal of Evil | PC | | Original | | 904066DVD | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| SeaWorld Adventure Parks Tycoon | PC | | Original | | 31711.101.US | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | GC | | Original | | DL-DOL-GJZE-USA | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| The Second AMUC CD | ACD | | | | CDRM1251610 | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| The Secret of Googol 2b: Reshaping Googol: Under the Ocean | PSX | | Original | | LSP-020170 … | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PSX | | Original | | LSP-020260 … | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PSX | | Original | | LSP-020570 … | |
| The Secret of Googol 7: Eggs All Around: Egg Trek / Balloon Picnic | PSX | | Original | | LSP-020650 … | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PSX | | Original | | LSP-020780 … | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The Secret of Monkey Island | MCD | | Original | | T-60035 | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| The Secret of the Silver Earring (Disc 1) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of the Silver Earring (Disc 2) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| Secret Weapons of the Luftwaffe | PC | | Original | | 2156010-590001/I042, CDRM1003790 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Atlantis (Disc 1) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 2) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 3) | PC | | Original | | PC0549CD SNY 2.0 | |
| Secrets of the East | PC | | Scholastic | | P/N CDR9909538 | |
| Seek & Find Adventures | PC | | Original | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Seek and Destroy Seek & Destroy | PC | | Original | | EPSAD01 | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega Soccer Slam | GC | | Original | | DL-DOL-GSSE-USA | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| Sesame Street Search & Learn Adventures | PC | | Original, Software for the fun of it | | EOA844AE-CD, KES005 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS4E-USA-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | PC | | Original | | | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS3E-USA-B0 | |
| Sesame Street: Elmo's Art Workshop | PC | | Original | | EAW844AE-CD | |
| Sesame Street: Elmo's Letter Adventure | PSX | | Original, Twin Pack | | SLUS-00621 … | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Elmo's Preschool | PC | | | | 11040CD | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 1) (Reading Basics) | PC | | Original | | EPK-744AE-CD1 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: Learn, Play and Grow Preschool / Sesame Street: Let's Go to Preschool / Sesame Street: First Steps | PC | | Southwestern Kids' Collection | | 05SS3-R01 | |
| Sesame Street: Let's Make a Word! | PC | | Original, Software for the fun of it | | KES006 | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Sesame Street: Let's Make a Word! | PC | | Bundle Version Creative Labs OEM | | 1713310119-1 | |
| Sesame Street: Reading Basics | PC | | Encore | | 10200 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| Shade: Wrath of Angels (Press Disc) | PC | | Press Kit | | | |
| Shadoan (Disc 1) | PC | | Original | | CD-ICD-228-0 | |
| Shadoan (Disc 2) | PC | | Original | | CD-ICD-228-1 | |
| Shadow Company: Left for Dead (Digital Press Kit) | PC | | Press Kit | | 5051895 | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow Force: Razor Unit | PC | | Special Forces Pack | | SFRU-0414 | |
| Shadow Madness | PSX | | Demo | | SLUS-90031 | |
| Shadow Madness (Disc 1) | PSX | | Original | | SLUS-00468 | |
| Shadow Madness (Disc 2) | PSX | | Original | | SLUS-00718 | |
| Shadow Man | PC | | Demo | | | |
| Shadow Man | PC | | Original | | | |
| Shadow Man | PSX | | Original | | SLUS-00895 | |
| Shadow Master | PSX | | Original | | SLUS-00545 | |
| Shadow of the Beast | PCE | | Original | | TGXCD1018 | |
| Shadow of the Beast II | MCD | | Original | | T-113045 | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-037 | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Gold Medal 12 CD Pack | | MQ 13-004-116 | |
| Shadow the Hedgehog | XBOX | | Original | | SE-134 | |
| Shadow the Hedgehog | GC | | Original | | DL-DOL-GUPE-USA | |
| Shadow Tower | PSX | | Original | | SLUS-00863 | |
| SHADOW: War of Succession | 3DO | | Original | | | |
| Shadowbane: The Rise of Chaos | PC | | Original | | 651727-CD | |
| ShadowCaster | PC | | CD-ROM Classics | | 5393 | |
| ShadowCaster | PC | | Top Ten Pak II | | 5454 | |
| Shadowlands | PC | | Megapak 2 | | | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| Shadowrun Returns (Game Disc) | PC | | Original | | | |
| Shadows of Cairn | PC | | Rerelease | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shanghai Double Pack | PC | | Original | | | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shape Shifter | PCE | | Original | | TGXCD1021 | |
| Shattered Union | XBOX | | Original | | TT-131 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shaun White Skateboarding | WII | | Original | | RVL-SHNE-USA-B0 | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Shaun White Snowboarding: Road Trip | WII | | Target Limited Edition | | RVL-RW7E-USA | |
| Shaun White Snowboarding: Road Trip | WII | | Original | | RVL-RDFE-USA | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NE-USA-B0 | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| ShellShock 2: Blood Trails | PC | | Original | | 5000026211 | |
| ShellShock 2: Blood Trails | XBOX360 | | Original | | SC-2021 | |
| Sherlock Holmes and the Hound of the Baskervilles | PC | | Collector's Edition | | 33369101US | |
| Sherlock Holmes: Consulting Detective | PCE | | Original | | TGXCD1011 | |
| Sherlock Holmes: Consulting Detective | MCD | | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | T-4501 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Rerelease | | CDRM 835400 | |
| Sherlock Holmes: Consulting Detective: Vol. I Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | 5 ft. 10 PAK Vol. 2 | | | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. II | PCE | | Original | | TGXCD1039 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 1) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 2) | MCD | | Original | | 4653 | |
| Shift 2: Unleashed | PC | | Limited Edition | | 1948307 | |
| Shining Force CD | MCD | | Original | | 4656 | |
| Shining Force CD | MCD | | Original | | 4656 | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shiren the Wanderer | WII | | Original | | RVL-RFSE-USA-B0 | |
| Shockwave 2: Beyond the Gate (Disc 01) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 02) | 3DO | | Original | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shonen Jump's One Piece: Grand Battle | GC | | Original | | DL-DOL-GOPE-USA | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shopmania | PC | | Original | | P/N 61227-CD | |
| Showdown: Legends of Wrestling | XBOX | | Original | | AC-029 | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| Shrek 2 | GC | | Original, Player's Choice | | DL-DOL-G3RE-USA, DL-DOL-G3RE-USA-02 | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9E-USA | |
| Shrek Game Land Activity Center | PC | | Original | | 32053.101.US | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYE-USA | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093140(US) | |
| Sid Meier's Alien Crossfire | PC | | Original | | 1405807 | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Linux | | | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Sid Meier's Civilization Chronicles (Disc 1) | PC | | Original | | 31074-1.1 | |
| Sid Meier's Civilization Chronicles (Disc 2) | PC | | Original | | 31074-1.2 | |
| Sid Meier's Civilization Chronicles (Disc 3) (Sid Meier's Civilization III Complete: Disc 1) | PC | | Original | | 31074-1.3 | |
| Sid Meier's Civilization II: Fantastic Worlds | PC | | Original | | 0-529-47-101 | |
| Sid Meier's Civilization III (Bonus CD) | PC | | Game of the Year Edition | | Part # 24356CD2 | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Original | | 25766CD1 | |
| Sid Meier's Civilization III Complete (Disc 2) (Play the World) | PC | | Original | | 25766CD2 | |
| Sid Meier's Civilization III Complete (Disc 3) (Conquests) | PC | | Original | | 25766CD3 | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization IV (Disc 1) (Install) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 2) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.7 | |
| Sid Meier's Civilization IV (Disc 2) (Play) | PC | | Original | | | |
| Sid Meier's Civilization IV: Beyond the Sword | MAC | | Original | | 12090-1DDA | |
| Sid Meier's Civilization IV: Colonization | PC | | Original | | 31491-1 | |
| Sid Meier's Civilization Revolution | XBOX360 | | Original | | TT-2021 | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| Sid Meier's Civilization VI | PC | | Original | | 41829-1 | |
| Sid Meier's Civilization: Beyond Earth | PC | | Original | | 41403-1 | |
| Sid Meier's Gettysburg! | PC | | CD-ROM Classics | | 1187707 | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDE-USA-B0 | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Sid Meier's SimGolf | PC | | Rerelease | | 1641547 | |
| Silent Hill 2: Restless Dreams | XBOX | | Platinum Hits | | KN-004 | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-R5WE-USA-B0 | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| Silpheed | MCD | | Original | | 4423 | |
| Silverload | PSX | | Original | | SLUS-00050 | |
| Silverload | PC | | | | | |
| SimCity 2000 Special Edition | PC | | Original | | 0126-000-0601-A | |
| SimCity 3000 Unlimited | PC | | Bundle Version Compaq OEM | | 1500907, 239478-001 | |
| SimCity 3000 Unlimited | PC | | Rerelease | | 1446307, 1641507 | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | | Original | | 1474007 | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | | SimCity Box | | 1907327 | |
| SimCity Enhanced CD-ROM | PC | | Rerelease | | CD-ICD-204-0 | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| SimCity Enhanced CD-ROM | PC | | Original | | CD-ICD-041-0 | |
| SimEarth | PC | | Scholastic | | 5675434C, DP19 | |
| SimEarth: The Living Planet | PCE | | Original | | TGXCD1036 | |
| SimLife SimLife: The Genetic Playground | PC | | Scholastic Clubs and Fairs | | 1111707, P1 | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQE-USA | |
| The Simpsons: Road Rage | XBOX | | Platinum Hits | | EA-019 | |
| The Simpsons: Road Rage | GC | | Original | | DL-DOL-GSPE-USA | |
| The Sims 2 | GC | | Original | | DL-DOL-G4ZE-USA | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | The Sims 2: Double Deluxe | | 1597017 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | Original | | 1672917 | |
| The Sims 2: Double Deluxe (Bonus DVD) | PC | | Original | | 1597027 | |
| The Sims 2: Double Deluxe | PC | | Original | | 1597007 | |
| The Sims 2: Happy Holiday Stuff | PC | | Original | | 1527707 | |
| The Sims 2: Insider Preview CD | PC | | Original | | 1625207 | |
| The Sims 2: Kitchen & Bath Interior Design Stuff | PC | | Original | | 1578007 | |
| The Sims 2: Nightlife (Expansion Pack) | MAC | | Original | | 11330-1DDA | |
| The Sims 2: Open For Business (Expansion Pack) | MAC | | Original | | 11390-1DDA | |
| The Sims 2: Pets | GC | | Original | | DL-DOL-G4OE-USA | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| The Sims 2: Seasons (Expansion Pack) | MAC | | Original | | 11610-1DDA | |
| The Sims 2: Sneak Preview CD | PC | | Original | | 1472027 | |
| The Sims 2: Sneak Preview CD | PC | | Original | | 1472027 | |
| The Sims 2: University (Expansion Pack) | MAC | | Original | | 11110-1DDA | |
| The Sims 3: Dragon Valley | PC | | Original | | 7312803402 | |
| The Sims 3: Hidden Springs | PC | | Original, The Sims 3: Worlds Bundle | | 1979707 | |
| The Sims 4: Discover University (Expansion Pack) | PC | | Original | | 3765903401 | |
| The Sims 4: Island Living | PC | | Original, Rerelease | | 3765703401, 3765703402 | |
| The Sims Strategy Guide and SimFan Pack | PC | | Pre-Order Bonus | | 1414407 | |
| The Sims | GC | | Original, Player's Choice | | DL-DOL-GCIE-USA-01 | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| The Sims: Bustin' Out | GC | | Original | | DL-DOL-G4ME-USA | |
| The Sims: Double Deluxe (Bonus CD) | PC | | Double Deluxe, Mega Deluxe | | 1474107 | |
| The Sims: Hot Date (Expansion Pack) | MAC | | Original | | 10150-1CDA | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | MAC | | Original | | 10430-1CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | MAC | | Original | | 10430-2CDA | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | | Original | | 1640617 | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| SiN Episodes: Emergence | PC | | Original | | 984707 | |
| SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| SiN Gold | MAC | | MacPlay | | | |
| Sing 4: The Hits Edition | WII | | Original | | RVL-SIHE-USA-B0 | |
| Sing-Along Kids: Vol. 2 | PC | | | | | |
| Sinistar: Unleashed | PC | | Original | | | |
| Ski and Shoot | WII | | Original | | RVL-RUME-USA | |
| Ski Park Manager 2003: Gold Edition Val d'Isère Ski Park Manager 2003: Gold Edition | PC | | | | 71102221 | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Ski-Doo Snowmobile Challenge | WII | | Original | | RVL-R87E-USA-B0 | |
| Ski-Doo Snowmobile Challenge | XBOX360 | | Original | | VG-2001 | |
| Skies of Arcadia Legends | GC | | Original | | DL-DOL-GEAE-USA | |
| The Skins Game at Bighorn | PC | | Original | | CD-MPC-126-0 | |
| Skydiving Extreme | PSX | | Original | | SLUS-01392 | |
| Skylanders: Giants | WII | | Starter Pack | | RVL-SKYY-USA-B0 | |
| Skylanders: Giants | WII | | Starter Pack | | RVL-SKYE-USA-B0 | |
| Skylanders: Imaginators | XBOX360 | | Original | | AV-2352 | |
| Skylanders: Spyro's Adventure | WII | | Starter Pack | | RVL-SSPY-BRA-B0 | |
| Skylanders: Spyro's Adventure | PC | | Press Kit | | | |
| Skylanders: Spyro's Adventure | WII | | Starter Pack | | RVL-SSPE-USA-B0 | |
| Skylanders: SuperChargers | XBOX360 | | Original | | AV-2335 | |
| Skylanders: SuperChargers Racing | WII | | Starter Pack | | RVL-SKNE-USA-B0 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXX-LTN-E0 | |
| Skylanders: Swap Force | XBOX360 | | Original | | AV-2281 | |
| Skylanders: Swap Force | XBOX360 | | Starter Pack | | AV-2281 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXE-USA-B0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8X-LTN-E0 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8E-USA-B0 | |
| SkyMaze X3D SkyMaze | PC | | X3D | | | |
| Slam Dunk Typing All-Star Typing: Ages 9-12: Slam Dunk Typing | PC | | Original | | WTY744AE-CD | |
| Sled Shred featuring the Jamaican Bobsled Team | WII | | Original | | RVL-R9YE-USA-B0 | |
| Sled Storm | PSX | | Original, Greatest Hits, Collectors' Edition | | SLUS-00955 … | |
| Sled Storm & Medal of Honor Demo CD | PSX | | | | SLUS-90072 | |
| Sleeping Dogs | XBOX360 | | Original, Ultimate Action Triple Pack | | SQ-2065 | |
| Slingo Deluxe | PC | | Original | | | |
| Slingo Mystery: Who's Gold | PC | | Big Fish Games Backup CD | | | |
| Slingo: 15th Anniversary Edition | PC | | Original | | | |
| Slingo: Wild 7's | PC | | Oregon Lottery | | | |
| Slot City Jackpot Games (120 Slot Machines) | PC | | Jackpot Games | | CD-4700 | |
| Slots 100 | PC | | Cosmi | | CDR712D1, SJ 062001 | |
| Slots Dual Pack Best of Slots from Bally Gaming / Best of Slots II | PC | | Original | | | |
| Small Soldiers | PSX | | Original | | SLUS-00781 | |
| Small Soldiers | PSX | | Preview | | | |
| Small Soldiers: Globaltech Design Lab | PC | | | | Product# 99144 | |
| Small Soldiers: Squad Commander | PC | | | | Product# 99264 | |
| Smart Games: Challenge 1 | PC | | Original | | P/N:DSGC1CD0001 | |
| Smart Series Presents: Jaja's Adventure | WII | | Original | | RVL-R67E-USA-B0 | |
| Smart Steps: Kindergarten | PC | | Rerelease | | P/N: LDSMASTKIJ | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |
| Smashing Drive | XBOX | | Original | | NM-001 | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDE-USA-B0 | |
| Smilingüido em: Desafio na Floresta | PC | | Original | | | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| Smuggler's Run: Warzones | GC | | Original | | DL-DOL-GSRE-USA | |
| The Smurfs: Dance Party | WII | | Toys R Us | | RVL-SDUX-USA-B0 | |
| The Smurfs: Dance Party | WII | | Original | | RVL-SDUE-USA-B0 | |
| Snap! 3D Bowling | PC | | Original | | | |
| Snap! 400 Word Searches | PC | | Original | | CS-296 | |
| Snapshot Adventures: Secret of Bird Island | PC | | Original | | P/N 61191-CD | |
| Sniper: Ghost Warrior 3 (Disc 1) | PC | | Season Pass Edition | | TCIU01221UND | |
| Sniper: Ghost Warrior 3 (Disc 2) | PC | | Season Pass Edition | | TCIU01221UND2 | |
| Sniper: Ghost Warrior 3 (Disc 3) | PC | | Season Pass Edition | | TCIU01221UND3 | |
| Sniper: Ghost Warrior 3 (Disc 4) | PC | | Season Pass Edition | | TCIU01221UND4 | |
| SNK Arcade Classics Vol. 1 | WII | | Original | | RVL-RNCE-USA | |
| Snoopy vs. the Red Baron | PC | | Original | | | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| Snow Drop | PC | | Original | | P-002 | |
| Snowboard Park Tycoon | PC | | | | 30983.101.US | |
| Snowboarding | PSX | | Original | | SLUS-01287 | |
| Snowmobile Racing | PC | | Original | | 04-17527CD | |
| So Who's Dr. Rabbit? | PC | | Original | | | |
| So You Wanna Be a Redneck | PC | | Original | | | |
| Soccer Kid | 3DO | | Original, 3DO Action Pak, Demo Disc (3DO Demo Disc Program) | | | |
| Soccer Kid Soccer Kid: Feets of Fury!! | PC | | Original | | D134 | |
| SODA Off-Road Racing | PC | | Original | | 7056640/S7056614 | |
| Software JukeBox: Home & Entertainment Edition: Vol. 1 No. 1 | PC | | Original | | CDRM1006830 | |
| The Software Toolworks CD Deluxe Pack 4 | PC | | Bundle Version OEM | | 2192610-590001/1034100, CDRM1170920 | |
| The Software Toolworks CD Deluxe Pack: Version 2 | PC | | Bundle Version Packard Bell OEM | | 2192611-590001 170122 | |
| The Software Toolworks CD Game Pack | PC | | Original | | | |
| Sol Divide | PSX | | Original | | SLUS-01519 | |
| Soldier of Fortune II: Double Helix | XBOX | | Original | | AV-027 | |
| Soldier of Fortune II: Double Helix (Disc 1) | PC | | Original | | 31147.101.US | |
| Soldier of Fortune: Payback | XBOX360 | | Original | | AV-2050 | |
| Soldiers at War | PC | | Preview | | | |
| Soldiers of Anarchy | PC | | Original | | S5280010 | |
| A Sombra do Zorro | PC | | Original | | INFOG 095 | |
| Sonic & Garfield Pack | PC | | Original | | 85090 | |
| Sonic 3D Blast | PC | | Expert Software | | 6822 01 | |
| Sonic Adventure 2: Battle | GC | | Original, Player's Choice | | DL-DOL-GSNE-USA | |
| Sonic Adventure DX: Director's Cut | GC | | Original, Player's Choice | | DL-DOL-GXSE-USA | |
| Sonic and the Black Knight | WII | | Original | | RVL-RENE-USA, RVL-RENE-USA-B0 | |
| Sonic and the Secret Rings | WII | | Original, Target Exclusive | | RVL-RSRE-USA | |
| Sonic and the Secret Rings Comic Book DVD from Archie Comics | PC | | | | | |
| Sonic CD | MCD | | Original | | 4407 | |
| Sonic CD | PC | | Original | | 85015 | |
| Sonic CD | MCD | | Original | | 4407 | |
| Sonic CD | MCD | | Bundled with Sega CD | | 4407 | |
| Sonic CD | MCD | | Original | | 4407 | |
| Sonic CD | PC | | Expert Software | | 6805 02 | |
| Sonic Gems Collection | GC | | Original, Player's Choice | | DL-DOL-G2XE-USA | |
| Sonic Heroes | GC | | Original, Player's Choice | | DL-DOL-G9SE-USA | |
| Sonic Mega Collection | GC | | Original, Player's Choice | | DL-DOL-GSOE-USA | |
| Sonic Riders | XBOX | | Original | | SE-135 | |
| Sonic Riders | GC | | Original, Player's Choice | | DL-DOL-GXEE-USA | |
| Sonic Riders: Zero Gravity | WII | | Original | | RVL-RS9E-USA | |
| Sonic Unleashed | WII | | Original | | RVL-RSVE-USA | |
| Sonic Unleashed | XBOX360 | | Original, Platinum Hits | | SE-2066 | |
| Sorry / Boggle / Yahtzee: Triple Pack of Fun | PC | | Original | | Part # 26023CD | |
| Sorting Adventures: Interactive Activities | PC | | Original | | AAP899, PP463 | |
| Soul Blade | PSX | | Original | | SLUS-00240 | |
| Soulbringer (Disc 1) | PC | | Original | | CD-C95-1077-0 | |
| Soulcalibur II | GC | | Demo | | DL-DOL-DRSE-USA | |
| Soulcalibur II | GC | | Original, Player's Choice | | DL-DOL-GRSE-USA | |
| Soulcalibur Legends | WII | | Original | | RVL-RSLE-USA | |
| Soundtrack1: The Definitive Xbox Compilation (Disc 2) | PC | | Original | | 314 584 098 2 | |
| South Park: The Fractured But Whole (Disc 1) | PC | | Gold Edition | | UBP60802045-DISC1 | |
| South Park: The Fractured But Whole (Disc 2) | PC | | Gold Edition | | UBP60802045-DISC2 | |
| South Park: The Fractured But Whole (Disc 3) | PC | | Gold Edition | | UBP60802045-DISC3 | |
| South Park: The Stick of Truth | PC | | Original | | 689058-DVD | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM (PC and Compatibles) Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM (For Macintosh Computers) Don Bluth's Space Ace | MAC | | Original | | | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015 | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| The Space Bar (Disc 1) | MAC | | Original | | 115-7D | |
| Space Bunnies Must Die! | PC | | Demo | | MSDE-37216 | |
| Space Bunnies Must Die! | PC | | Original | | CD-RC004 | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | 7373 | |
| Space Hulk: Vengeance of the Blood Angels | PSX | | Original | | SLUS-00205 | |
| Space Invaders | PSX | | Original | | SLUS-00928 | |
| Space Invaders | PSX | | Review | | | |
| Space Invaders XL | NUON | | Original | | 11109 | |
| Space Quest: Collector's Edition Space Quest: 15th Anniversary Collector's Edition | PC | | Original | | | |
| Space Raiders | GC | | Original | | DL-DOL-GIJE-USA | |
| Space Ranger | CDI | | Unlicensed | | OGCDI-1180 | |
| Space Shuttle | PC | | Original | | CDRM1109910 | |
| Space Shuttle | MAC | | Original | | CDRM1087300 | |
| Spacebound Space Bound | PC | | Original | | | |
| Spaceship Warlock | MAC | | Original | | CDRM 403300 | |
| Spaguetti Party: La Familia Pomodoro | PC | | Covermount | | | |
| Spartan: Total Warrior | GC | | Original | | DL-DOL-GWAE-USA | |
| Spawn: Armageddon | XBOX | | Original | | NM-012 | |
| Spawn: Armageddon | GC | | Original | | DL-DOL-GPWE-USA | |
| Spear of Destiny | PC | | Ultimate Game Collection | | | |
| Spear of Destiny: Super CD Pack | PC | | Super CD Pack | | | |
| Spec Ops: Airborne Commando | PSX | | Original | | SLUS-01447 | |
| Spec Ops: Ranger Assault | PC | | Covermount | | CDE30_CDA | |
| Spec Ops: Ranger Team Bravo | PC | | Original | | CD-RC010 | |
| Speed | WII | | Original | | RVL-SPEE-USA-B0 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 Rev.1 | |
| Speed Busters: American Highways | PC | | Original | | | |
| Speed Freaks (Misc Artwork: PC-CD 2nd July '99) | PC | | Press Kit | | | |
| Speed Kings | XBOX | | Original | | AC-011 | |
| Speed Kings | GC | | Original | | DL-DOL-GDCE-USA | |
| Speed Punks | PSX | | Original | | SCUS-94563 | |
| Speed Punks | PSX | | Demo | | SCUS-94572 | |
| Speed Racer | PSX | | Original | | SLUS-00613 | |
| Speed Racer: The Videogame | WII | | Original | | RVL-R3PE-USA | |
| Speed Thief X3D Speed Thief | PC | | X3D | | | |