Region | Title | System | Version | Edition | Languages | Serial | Status |
| Scorcher | SS | 1.008 | Original | | 81214 | |
| The Secret of Googol 1: Reshaping Googol: Submarine / Tower | PC | 2.0 | Original | | | |
| The Secret of Googol 2: Reshaping Googol: Castle / Ocean | PC | 2.0 | Original | | | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PC | 2.0 | Original | | | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PC | 2.0 | Original | | | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PC | 2.0 | Original | | | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Self Selling Disc | CDI | 3.1 | | | 310-690-049-2 | |
| Sex | 3DO | | Original | | | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shari Lewis Lamb Chop's Play-Along! Action Songs | CDI | | Original | | 310690289-2 | |
| SharkPort: Code and Save Transfer Kit | PC | 1.04 | Original | | | |
| SharkPort: Code and Save Transfer Kit | PS2 | 2.21 | Unlicensed | | | |
| Shining Soul II + Shining Force Assets Shining Soul 2 + Shining Force Assets | PC | | Press Kit | | | |
| Shorelines | CDI | | | | | |
| The Sims 2 | PC | | Press Kit | | | |
| Singularity | PC | | Press Kit | | | |
| Skylanders: Spyro's Adventure | PC | | Press Kit | | | |
| SMBX + Tak 2 Art | PC | | Press Kit | | | |
| The Smithsonian Presents the Riches of Coins | CDI | | Original, Demonstration Disc | | 310-690-088-2, 310690088-2 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| SNK NeoGeo USA Consumer Corporation: E3 2004 Games | PC | | Press Kit | | | |
| SNK Playmore E3 2006 Games | PC | | Press Kit | | | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.00 | Beta | | SCUS 97366 | |
| Sony E3 2004: Press Information | PC | | Press Kit | | | |
| Sony PlayStation 2: SCEA Santa Monica Studios: 2004 Press Information: Press Print | PC | | Press Kit | | | |
| Soulcalibur II | XBOX | | Demo | | NM-003 | |
| SouthPeak Interactive E3 2000 Electronic Press Kit | PC | | Press Kit | | | |
| Space Ace | CDI | | Original, Demonstration Disc | | 310-690-059-2, 310690059-2 | |
| Space Bunnies Must Die! | PC | | Demo | | MSDE-37216 | |
| Speed Freaks (Misc Artwork: PC-CD 2nd July '99) | PC | | Press Kit | | | |
| Spelling Challenges and More! | PSP | 1.00 | Original | | ULUS 10255 | |
| Spider-Man: Web of Shadows (Final Press Kit) | PC | | Press Kit | | | |
| Spring 2012 Refresh Standard: PS3 IDU 4.11 | PS3 | | Kiosk Demo | | | |
| Spring 2013: Standard IDU 4.31 | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2010: 3.21 IDU Update (E-M) | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2011 3.60 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Square Enix E3 2004 Media CD | PC | | Press Kit | | | |
| SquareSoft: E3 2001 Media CD | PC | | Press Kit | | | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 310690304-2 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 310690304-2 | |
| Star Trek: Secret of Vulcan Fury (Non-Interactive Preview) | PC | | | | CD-C95-647-N1 | |
| Star Trek: Secret of Vulcan Fury (Non-Interactive Trailer) | PC | | | | CD-C95-647-N2 | |
| Star Wars: Episode I: Cover Disk 4 | PC | | Press Kit | | | |
| Star Wars: Episode I: Disc #3: Covers | PC | | Press Kit | | | |
| The Story of Jonah | CDI | 2.04 | Original, FPD | | 310-690-067-2, 310690067-2 | |
| The Story of Samson | CDI | | Original, Demonstration Disc | | 310-690-190-2, 310690190-2 | |
| Str.at.e.s. 1: Match-A-Batch | PC | 2.0 | Original | | | |
| Stratosphere: Conquest of the Skies | PC | | Demo | | | |
| Striker Pro | CDI | | Original, Demonstration Disc | | 310-690-143-2, 310690143-2 | |
| Summer Refresh 2011: 3.65 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |
| Super Bender Boot Disc | PS2 | 2.00 | | | | |
| Super Magnetic Neo | DC | 1.001 | Demo | | T-40206ND | |
| Super Stories: Mom is Going to Stop It | CDI | | | | | |
| Super Stories: My Favorite Things | CDI | | | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | MCD | | Original | | T162045 | |
| Surf City | CDI | | Original, Demonstration Disc | | 310-690-131-2, 310690131-2 | |
| SX Superstar | PS2 | 1.00 | Preview | | SLUS-20600 | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Samurai Champloo: Sidetracked | PS2 | 1.00 | Original | | SLUS 21343 | |
| SCEA Gamers Day 2002: Press Info | PC | | Press Kit | | | |
| SCEE Software Brochure + Press Information: E3 2003 | PC | | Press Kit | | | |
| SCI Games E3 2005 Press Kit | PC | | Press Kit | | | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | Rev 1 | Original | | 093080(US) | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| Secret Agent Clank | PSP | 1.00 | Demo | | UCUS 98707 | |
| The Secret of Googol 7: Eggs All Around: Egg Trek / Balloon Picnic | PC | 2.0 | Original | | | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PC | 2.0 | Original | | | |
| Sega Genesis Collection | PSP | 1.01 | Original, SEGA Fun Pack | | ULUS-10192 | |
| Sega Screenshots 2000 Sega E3 2000 | PC | | Press Kit | | | |
| Shadow Company: Left for Dead (Digital Press Kit) | PC | | Press Kit | | 5051895 | |
| Shadow of Rome | PS2 | 1.00 | Demo | | SLUS 29139 | |
| Shadow of the Colossus | PS2 | 1.00 | Demo | | SCUS 97505 | |
| Shark Alert | CDI | | Original, Demonstration Disc | | 310-690-278-2, 310690278-2 | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| Shin Megami Tensei: Persona 3 FES | PS2 | 1.00 | Original | | SLUS 21621 | |
| Shinobi | PS2 | 1.00 | Original | | SLUS 20459 | |
| Shock Wave | 3DO | RE2 | Original, Not for Resale | | | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shonen Jump's One Piece: Grand Battle | PS2 | 1.00 | Demo | | SLUS 29159 | |
| Shrek 2 (Final Press Kit) | PC | | Press Kit | | | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093140(US) | |
| Sierra Press Kit | PC | | Press Kit | | | |
| The Sims 2 | PS2 | 1.00 | Demo | | SLUS 29173 | |
| Siren | PS2 | 1.00 | Demo | | SCUS 97398 | |
| Slayer | 3DO | | 3DO Action Pak | | | |
| Slim Jim | PSX | | | | SCUS-94472 | |
| SOCOM 3: U.S. Navy SEALs | PS2 | 1.00 | Demo | | SCUS 97475 | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.00 | Demo | | SCUS 97368 | |
| SOCOM: U.S. Navy SEALs | PS2 | 1.00 | Demo | | SCUS 97205 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 2 | PSP | 1.00 | Best Buy Demo | | UCUS 98692 | |
| Sol-Feace | MCD | RE | Bundled with Sega CD | | 4130 | |
| Sonic CD | PC | 1.1 | Expert Software | | 6805 02 | |
| Sonic Rivals 2 | PSP | 1.01 | Original, SEGA Fun Pack | | ULUS 10323 | |
| Soundtrack1: The Definitive Xbox Compilation (Disc 2) | PC | | Original | | 314 584 098 2 | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | 7373 | |
| Spawn: The Eternal | PSX | | Preview Version | | SCUS-94204 | |
| SpellForce: The Order of Dawn (Disc 1) | PC | 1.05 | Original, Store Manager Copy | | 28017-CD1 v1.0 F, 28017-SM1 v1.0 F | |
| SpellForce: The Order of Dawn (Disc 2) | PC | 1.05 | Original, Store Manager Copy | | 28017-CD2 v1.0 E, 28017-SM2 v1.0 F | |
| Splashdown: Rides Gone Wild | PS2 | 1.00 | Demo | | SLUS 29054 | |
| Square Enix E3 2005 Media CD | PC | | Press Kit | | | |
| Squaresoft on PlayStation Collector's CD | PSX | | | | SCUS-94256 | |
| Star Trek: Tactical Assault | PSP | 1.02 | Original | | ULUS 10150 | |
| Star Wars: Episode I: The Phantom Menace | PSX | | Trade Demo | | SLUS-80884 | |
| Star Wars: Making Magic | PC | QA1.03 | Original, LucasArts Archives Vol. II, The: Star Wars Collection | | 8031835 | |
| State of Emergency 2 | PS2 | 1.00 | Trade Demo | | SLUS-28056 | |
| Stellar 7: Draxon's Revenge | 3DO | | Original | | | |
| Stickybear Family Fun | CDI | | Original | | 310690258-2 | |
| Str.at.e.s. 1: Match-A-Batch | PC | 2.0 | Rerelease | | | |
| Street Fighter III: Double Impact | DC | 1.001 | Original | | T-1210N | |
| Street Fighter: The Movie | SS | 1.003 | Original | | T-8105H | |
| Stupid Invaders (Disc 2) | DC | 1.001 | Original | | T-17708N | |
| Super Meat Boy: Ultra Edition | PC | | Original | | | |
| Super Monkey Ball Deluxe | PS2 | 1.00 | Original | | SLUS 20918 | |
| Super Street Fighter II Turbo HD Remix (Asset Disc) | PC | | Super Turbo Hyper Champion Special Edition Pack | | | |
| Surgical Strike | MCD | | Original | | 4435 | |
| Symbol Set 1: Fantasy Overland | PC | | Original | | | |
| Symbol Set 2: Fantasy Floorplans | PC | | Original | | | |
| Syphon Filter 2 | PSX | | Demo | | SCUS-94393 | |
| Syphon Filter: The Omega Strain | PS2 | 2.00 | Demo | | SCUS 97377 | |
| Secret Agent Clank | PSP | 1.01 | Original, Greatest Hits, Secret Agent Clank + Daxter UMD Dual Pack | | UCUS 98697 … | |
| Stealth + WipEout Pure | PSP | 2.00 | Original | | ULUS-10058 | |
| Silent Hill 2 | PS2 | 1.20 | Original | | SLUS 20228 | |
| Stickybear Math | CDI | | Original, Demonstration Disc | | 310-690-082-2, 310690082-2 | |
| Stickybear Preschool | CDI | | Pre-Release Demonstration Disc | | 310-690-257-2 | |
| Stickybear Preschool | CDI | | Original, Demonstration Disc | | 310-690-257-2, 310690257-2 | |
| Scene It? Bright Lights! Big Screen! | PS3 | 01.02 | Original | | BLUS-30448 … | |
| Square Enix: Final Fantasy VII Advent Children Trailer | PC | | Press Kit | | | |