Region | Title | System | Version | Edition | Languages | Serial | Status |
| S.L.A.I.: Steel Lancer Arena International S.L.A.I.: Phantom Crash | PS2 | 0.11 | Beta | | SLUS 29132 | |
| Saints Row: The Third (Disc 1) | PC | | Original | | | |
| Saints Row: The Third (Disc 2) | PC | | Original | | | |
| Sam & Max: Season One | WII | | Beta | | | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Samurai Warriors 2: Empires | PS2 | 1.00 | Original | | SLUS 21585 | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Saw | XBOX360 | | Original | | KN-2050 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| Scooby-Doo! Night of 100 Frights | XBOX | | Original | | TQ-031 | |
| Score International Baja 1000: The Official Game | PS2 | 1.00 | Original | | SLUS 21850 | |
| Scrabble | PSP | 1.00 | Original | | ULUS-10412 | |
| SD Gundam Force: Showdown! | PS2 | 1.01 | Original | | SLUS 20698 | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | PS2 | 1.00 | Original | | SLUS 21289 | |
| The Secret Saturdays: Beasts of the 5th Sun | PSP | 1.00 | Original | | ULUS-10443 | |
| Secret Service | PS2 | 1.01 | Original | | SLUS 21836 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Secret Weapons over Normandy | PS2 | 1.01 | Original | | SLUS 20762 | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| The Settlers: Heritage of Kings | PC | 1.01.0163 | Original | | 682011-DVD | |
| Seven Samurai 20XX | PS2 | 1.00 | Original | | SLUS 20621 | |
| Shadow Man | DC | 1.001 | Original | | T-8106N | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shattered Union | XBOX | | Original | | TT-131 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| ShellShock 2: Blood Trails | PC | | Original | | 5000026211 | |
| Shepherd's Crossing | PS2 | 1.00 | Original | | SLUS 21798 | |
| Sherlock Holmes: Crimes & Punishments | XBOX360 | | Original | | FE-2015 | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Short Track Racing: Trading Paint | PS2 | 1.00 | Original | | SLUS 21857 | |
| Showdown: Legends of Wrestling | XBOX | | Original | | AC-029 | |
| Shrek | XBOX | | Original | | TM-001 | |
| Shrek Super Party | XBOX | | Original | | TM-004 | |
| Silent Hill: Downpour | PS3 | 01.01 | Review | | | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| SimEarth: The Living Planet | PCE | | Original | | TGXCD1036 | |
| The Simpsons Skateboarding | PS2 | 1.01 | Original | | SLUS-20114 | |
| The Sims 2 | XBOX | | Original | | EA-907 | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| The Sims 3 | WII | | Beta | | | |
| The Sims 3: Diesel Stuff The Sims 3: Diesel for Successful Living Stuff | PC | 14.0.48.017001 | Original | | 1968807 | |
| The Sims 3: Fast Lane Stuff | PC | 5.0.44.008001 | Original | | 1950207 | |
| The Sims 3: Katy Perry Sweet Treats | PC | | Original | | 1979807 | |
| The Sims 3: Master Suite Stuff | PC | 11.0.84.014001 | Original | | 1962307 | |
| The Sims 3: Outdoor Living Stuff | PC | 7.0.55.010001 | Original | | 1950307 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims 3: Seasons (Expansion Pack) | PC | | Original, Limited Edition | | 1978303301 | |
| The Sims | XBOX | | Original | | EA-047 | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| SingStar '80s | PS2 | 1.00 | Original | | SCUS 97622 | |
| SingStar '90s | PS2 | 1.00 | Original | | SCUS 97626 | |
| SingStar ABBA | PS2 | 1.00 | Original | | SCUS-97642 | |
| SingStar Country | PS2 | 1.00 | Original, Bundled with Microphone | | SCUS 97650 … | |
| SingStar Legends | PS2 | 1.00 | Original | | SCUS 97640 | |
| SingStar Pop Vol. 2 | PS2 | 1.00 | Original | | SCUS 97649 | |
| Singularity | PC | | Press Kit | | | |
| Sitting Ducks | PS2 | 1.00 | Original | | SLUS 20886 | |
| Skate 2 | XBOX360 | | Original | | EA-2175 | |
| Skate It | WII | | Beta | | | |
| Skate. | XBOX360 | | Original | | EA-2067 | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| SkyGunner | PS2 | 1.00 | Trade Demo | | SLUS-28008 | |
| Skylanders: Imaginators | XBOX360 | | Original | | AV-2352 | |
| Skylanders: SuperChargers | XBOX360 | | Original | | AV-2335 | |
| Skylanders: Swap Force | XBOX360 | | Starter Pack | | AV-2281 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Sleeping Dogs | PS3 | 00.00 | Preview | | | |
| Sly 2: Band of Thieves | PS2 | 1.00 | Demo | | SCUS 97415 | |
| Smash Court Tennis: Pro Tournament 2 | PS2 | 1.00 | Original | | SLUS 20933 | |
| Smashing Drive | XBOX | | Original | | NM-001 | |
| The Smurfs 2 | XBOX360 | | Original | | US-2237 | |
| Sneakers | XBOX | | Original | | MS-035 | |
| Sniper Elite | XBOX | | Original | | MI-013 | |
| Sniper: Ghost Warrior 3 (Disc 1) | PC | | Season Pass Edition | | TCIU01221UND | |
| Sniper: Ghost Warrior 3 (Disc 2) | PC | | Season Pass Edition | | TCIU01221UND2 | |
| Sniper: Ghost Warrior 3 (Disc 3) | PC | | Season Pass Edition | | TCIU01221UND3 | |
| Sniper: Ghost Warrior 3 (Disc 4) | PC | | Season Pass Edition | | TCIU01221UND4 | |
| SnoCross 2 featuring Blair Morgan | PS2 | 1.04 | Original | | SLUS 21130 | |
| Snoopy vs. the Red Baron | PS2 | 1.01 | Original | | SLUS 21380 | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| Soldier of Fortune: Payback | XBOX360 | | Original | | AV-2050 | |
| Sonic Adventure | DC | 1.004 | Original | | 51000 | |
| Sonic Mega Collection Plus | PS2 | 0.80 | Beta | | | |
| Sonic's Ultimate Genesis Collection | XBOX360 | | Platinum Hits | | SE-2064 | |
| Soulcalibur II | XBOX | | Demo | | NM-003 | |
| Soulcalibur II | PS2 | 1.00 | Demo | | SLUS 29058 | |
| Space Chimps | XBOX360 | | Original | | BT-2004 Version: 1. | |
| Space Chimps | PS2 | 1.03 | Original | | SLUS 21783 | |
| Space Station Tycoon | WII | | Prototype | | | |
| Spartan: Total Warrior | XBOX | | Original | | SE-139 | |
| Spawn: Armageddon | XBOX | | Original | | NM-012 | |
| Speed Kings | XBOX | | Original | | AC-011 | |
| Spelling Challenges and More! | PSP | 1.00 | Original | | ULUS 10255 | |
| Spider-Man: Friend or Foe | XBOX360 | | Original | | AV-2042 | |
| The Spiderwick Chronicles | XBOX360 | | Bundled with Audiobook | | VU-2022 | |
| Splashdown | XBOX | | Original | | IG-027 | |
| Splashdown | PS2 | 1.00 | Original | | SLUS 20223 | |
| SPRay | WII | | Beta | | | |
| Spring 2012 Refresh Standard: PS3 IDU 4.11 | PS3 | | Kiosk Demo | | | |
| Spring 2013: Standard IDU 4.31 | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2010: 3.21 IDU Update (E-M) | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2011 3.60 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Sprint Cars: Road to Knoxville | PS2 | 1.02 | Original | | SLUS 21418 | |
| Spy vs. Spy | XBOX | | Original | | TT-124 | |
| Spyborgs | WII | | Beta | | | |
| SRS: Street Racing Syndicate | XBOX | | Original | | NM-019 | |
| SRS: Street Racing Syndicate | PS2 | 2.00 | Original | | SLUS 20582 | |
| SSX 3 | XBOX | | Original | | EA-060 | |
| SSX Blur | WII | | Beta | | | |
| SSX Tricky | XBOX | | Platinum Hits | | EA-004 | |
| Star Trek: Deep Space Nine: Dominion Wars | PC | 1.00 | Original | | | |
| Star Wars: Battlefront | MAC | 1.2 | Original | | 10900-1DDA | |
| Star Wars: Empire at War | MAC | 1.05 | Original | | 11490-1DDA | |
| Star Wars: Jedi Knight Gold Pack | MAC | | Original | | 12280-1DDA | |
| Star Wars: Jedi Knight: Dark Forces II: Pathways to the Force | PC | | Bundle Version Diamond OEM | | 646230, 75000202-100, CD-C95-829-DIA | |
| Star Wars: Knights of the Old Republic | MAC | 1.03 | Original | | 10660-1DDA | |
| Star Wars: Mac Pack | MAC | | Original | | 12300-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | MAC | | Original | | 12240-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | MAC | | Original | | 12240-1DDA2 | |
| StarCraft II: Heart of the Swarm | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 1) | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 2) | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original, Collector's Edition | | | |
| Starfighter Assets CD | PC | | Press Kit | | | |
| State of Emergency 2 | PS2 | 1.02 | Original | | SLUS 20966 | |
| Stealth + WipEout Pure | PSP | 2.00 | Original | | ULUS-10058 | |
| Steel Battalion | XBOX | | Original | | CC-002 | |
| Stoked: Big Air Edition | XBOX360 | | Original | | DE-2005 | |
| Street Hoops | XBOX | | Original | | AV-003 | |
| Strike Force Bowling | XBOX | | Original | | CV-008 | |
| Stuart Little 3: Big Photo Adventure | PS2 | 1.01 | Original | | SLUS 21341 | |
| The Suffering | PS2 | 1.01 | Original | | SLUS 20636 | |
| The Suffering: Ties That Bind | PS2 | 1.01 | Original | | SLUS 21189 | |
| Summer Athletics: The Ultimate Challenge | XBOX360 | | Original | | CV-2004 | |
| Summer Athletics: The Ultimate Challenge | PS2 | 1.00 | Original | | SLUS 21786 | |
| Summer Heat Beach Volleyball | PS2 | 1.00 | Original | | SLUS-20634 | |
| Summer Refresh 2011: 3.65 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Super Air Zonk: Rockabilly-Paradise | PCE | | Original | | TGXCD1042 | |
| Super Bender Boot Disc | PS2 | 2.00 | | | | |
| Super Bubble Pop | XBOX | | Original | | JA-004 | |
| Super Magnetic Neo | DC | 1.001 | Demo | | T-40206ND | |
| Super PickUps | PS2 | 1.00 | Original | | SLUS 21450 | |
| Supreme Commander | XBOX360 | | Original | | AY-2001 | |
| Surf's Up | XBOX360 | | Original | | US-2041 | |
| Suzuki TT Superbikes: Real Road Racing Championship | PS2 | 1.00 | Original | | SLUS-21863 | |
| SWAT: Global Strike Team | XBOX | | Original | | VV-037 | |
| SWAT: Global Strike Team | PS2 | 1.00 | Original | | SLUS 20433 | |
| Sword of the New World: Granado Espada | PC | 2.1.18 | | | | |
| Syberia Collection | PS3 | 01.00 | Original | | BLUS-31429 | |
| Space Engineers | PC | | Limited Edition | | | |
| Super Lucky's Tale (Disc 1) | PC | | Original | | | |
| Super Lucky's Tale (Disc 2) | PC | | Original | | | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| SimCity | PC | 1.0 | Original, Limited Edition | | 1971403401 | |
| The Sims 4 (Disc 1) | PC | 1.0 | Limited Edition | | 7303703301, 7303703303 | |
| The Sims 4 (Disc 2) | PC | 1.0 | Limited Edition | | 7303703302, 7303703401 | |
| The Sims 4: Discover University (Expansion Pack) | PC | | Original | | 3765903401 | |
| The Sims 3 | PC | 1.42.130.019037 | The Sims 3 Starter Pack | | 1539003301 | |
| Stardew Valley | PC | 1.4.5 | Fangamer | | | |
| Sid Meier's Civilization VI | PC | | Original | | 41829-1 | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| Sid Meier's Civilization: Beyond Earth | PC | | Original | | 41403-1 | |
| Swap Magic 3 Plus | PS2 | 1.12 | Unlicensed | | | |
| SimCity Societies Destinations | PC | 1.0 | SimCity Box | | 1907307 | |
| The Sims 3 | PC | | Original | | | |
| Spore | PC | 1.0 | Galactic Edition | | 1908007 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | The Sims 2: Double Deluxe | | 1597017 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | Original | | 1672917 | |
| Spore: Creepy & Cute Parts Pack | PC | | Original | | 1907607 | |
| Spore: Galactic Adventures | PC | 1.0 | Original | | 1535407 | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Bundled with Bluetooth Headset | | BCUS-98152 | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Original | | BCUS-98183 | |
| SingStar Dance | PS3 | 01.00 | Original | | BCUS-98266 | |
| SingStar Queen | PS3 | 01.00 | Original | | BCUS-98206 | |
| SingStar | PS3 | 01.01 | Original | | BCUS-98151 … | |
| SingStar ABBA | PS3 | 01.00 | Original | | BCUS-98192 | |
| SingStar Vol. 2 | PS3 | 01.00 | Original | | BCUS-98186 | |
| Skylanders: Spyro's Adventure | PC | 1.0 | Starter Pack | | 33366010US | |
| Saints Row 2 | PC | | Original | | | |
| Saints Row: The Third | PS3 | 01.01 | Original | | BLUS-30666 | |
| Saints Row: The Third: The Full Package | PS3 | 01.00 | Original | | BLUS-31062 | |
| The Sims 3 | PS3 | 01.00 | Original, Greatest Hits | | BLUS-30609 … | |
| The Sims 3: Pets | PS3 | 01.00 | Original | | BLUS-30803 | |
| The Sims Medieval | PC | 1.0.286.00001 | Limited Edition | | 1945407 | |
| The Sims Medieval: Pirates & Nobles | PC | 2.0.109.00001 | Original | | 1962507 | |
| The Sims 2: Castaway | PSP | 1.00 | Original | | ULUS 10296 | |
| The Smurfs 2 | PS3 | 01.00 | Original | | BLUS-31151 | |
| S.L.A.I.: Steel Lancer Arena International | PS2 | 1.02 | Original | | SLUS-20969 | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| Sacred 2 (Disc 2) | PC | | Original | | | |
| Sacred 2: Fallen Angel (Disc 1) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 2) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 3) | PC | | Beta | | | |
| Sacrifice | PC | | Bundle Version Hewlett Packard OEM | | CD-C951041-PC2E | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Saint | WII | | Original | | RVL-RZCE-USA-B0 | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Sakura Wars: So Long, My Love | WII | | Original | | RVL-SAKE-USA-E0 | |
| Sakura Wars: So Long, My Love (Disc 1) (English Voice Over) | PS2 | 1.00 | Original | | SLUS-21927 | |
| Sakura Wars: So Long, My Love (Disc 2) (Japanese Voice Over) | PS2 | 1.00 | Original | | SLUS-21930 | |
| Sam & Max: Season One | PC | 1.0 | Original | | | |
| Sam & Max: Season Two | PC | 1.5.0.0 | Original | | | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| Sam & Max: This Time It's Virtual! | PC | | Limited Run Games | | | |
| Samba de Amigo | DC | 1.001 | Original | | 51092 | |
| Sampler Disc for PSP Vol. 1 | PSP | 1.00 | Demo | | UCJB-98301 | |
| Samurai Champloo: Sidetracked | PS2 | 1.00 | Original | | SLUS 21343 | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Jack: The Shadow of Aku | PS2 | 1.03 | Original | | SLUS-20899 | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Shodown Anthology | PSP | 1.02 | Original | | ULUS 10401 … | |
| Samurai Shodown Anthology | PS2 | 1.01 | Original | | SLUS 21629 | |
| Samurai Warriors | PS2 | 1.00 | Original | | SLUS-20878 | |
| Samurai Warriors 2 | PS2 | 1.01 | Original | | SLUS-21462 | |
| Samurai Warriors 2: Xtreme Legends | PS2 | 1.02 | Original | | SLUS 21726 | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5E-USA | |
| Samurai Warriors: State of War | PSP | 1.01 | Original | | ULUS-10089 | |
| Samurai Warriors: Xtreme Legends | PS2 | 1.00 | Original | | SLUS-21080 | |
| Samurai Western | PS2 | 1.00 | Trade Demo | | SLUS-28051 | |
| Samurai Western | PS2 | 1.01 | Original | | SLUS 21187 | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Satisfashion: Rock the Runway | WII | | Original | | RVL-SS5E-USA-B0 | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Savage Skies | PS2 | 1.02 | Original | | SLUS 20430 | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| SBK: Superbike World Championship | PS3 | 01.01 | Original | | BLUS-30236 | |
| SBK: Superbike World Championship | PS2 | 1.01 | Original | | SLUS-21817 | |
| SBK: Superbike World Championship | PSP | 1.01 | Original | | ULUS-10395 | |
| Scarface: Money. Power. Respect. | PSP | 1.01 | Original | | ULUS-10148 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Scarface: The World Is Yours | PS2 | 1.00 | Collector's Edition | | SLUS 21111 … | |
| Scarface: The World Is Yours | PC | 1.00.1 | Original | | | |
| SCEE Software Brochure + Press Information: E3 2003 | PC | | Press Kit | | | |
| Scene It? Bright Lights! Big Screen! | XBOX360 | | Original | | WR-2037 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCE-USA-B0 | |
| Scene It? Bright Lights! Big Screen! | PS3 | 01.02 | Original | | BLUS-30447 | |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| Schizm: Mysterious Journey (Side A) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Side B) | PC | | DVD-ROM Edition | | | |
| Scooby-Doo! Mystery Mayhem | GC | | Original | | DL-DOL-GC3E-USA | |
| Scooby-Doo! Night of 100 Frights | GC | | Original | | DL-DOL-GIHE-USA | |
| Scooby-Doo! Night of 100 Frights | PS2 | 1.01 | Original, Greatest Hits | | SLUS 20349 … | |
| Scooby-Doo! Night of 100 Frights | GC | Rev 1 | Original | | DL-DOL-GIHE-USA | |
| Scooby-Doo! Who's Watching Who? | PSP | 1.01 | Original | | ULUS-10168 | |
| Scorcher | PC | | Original | | 04-11264CD | |
| Score International Baja 1000: The Official Game | PC | | Original | | 35619./101.US | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Score International Baja 1000: The Official Game | PS3 | 01.00 | Original | | BLUS-30230 | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| The Scorpion King: Rise of the Akkadian | PS2 | 1.03 | Original | | SLUS-20424 | |
| Scratches: Director's Cut | PC | | Rerelease | | | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| Scribblenauts Unlimited | PC | | Original | | 5000145356 | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Seal of Evil | PC | | Original | | 904066DVD | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | GC | | Original | | DL-DOL-GJZE-USA | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| Second Sight | PS2 | 1.00 | Original | | SLUS-21033 | |
| Secret Agent Clank | PSP | 1.00 | Demo | | UCUS 98707 | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| Secret Service | XBOX360 | | Original | | AV-2084 | |
| Secret Weapons over Normandy | PS2 | 1.00 | Review Build | | SLUS-20762 | |
| Seek & Find Adventures | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek and Destroy | PS2 | 1.01 | Original | | SLUS 20606 | |
| Sega Bass Fishing | WII | | Original | | RVL-RBTE-USA | |
| Sega Bass Fishing 2 | DC | 1.080 | Original | | 51166 | |
| Sega Classics Collection | PS2 | 1.01 | Original | | SLUS 21009 | |
| Sega Genesis Collection | PS2 | 1.01 | Original | | SLUS-21542 | |
| Sega Genesis Collection | PSP | 1.01 | Original, SEGA Fun Pack | | ULUS-10192 | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega Marine Fishing | DC | 1.001 | Original | | 51096 | |
| Sega Rally Revo | PSP | 1.00 | Original | | ULUS-10311 | |
| Sega Smash Pack | PC | 1.0 | Expert Software | | 682601.101.US | |
| Sega Soccer Slam | GC | | Original | | DL-DOL-GSSE-USA | |
| Sega Soccer Slam | PS2 | 1.00 | Original | | SLUS-20509 | |
| Sengoku Rance 戦国ランス | PC | 1.07 | Limited Edition | | MG-AS-RE-004 | |
| Serious Sam | XBOX | | Original | | TT-004 | |
| Serious Sam: Next Encounter | PS2 | 1.01 | Original | | SLUS-20907 | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| Serious Sam: The First Encounter | PC | | | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS4E-USA-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS3E-USA-B0 | |
| Sesame Street: Learn, Play and Grow Preschool / Sesame Street: Let's Go to Preschool / Sesame Street: First Steps | PC | | Southwestern Kids' Collection | | 05SS3-R01 | |
| Seven Kingdoms: Conquest | PC | 1.00 | Original | | DVD580CD | |
| Seventh Cross Evolution | DC | 1.000 | Original | | T-41301N | |
| Shadow Hearts | PS2 | 1.00 | Original | | SLUS 20347 | |
| Shadow Hearts: Covenant (Disc 1) | PS2 | 1.00 | Original | | SLUS 21041 | |
| Shadow Hearts: Covenant (Disc 2) | PS2 | 1.00 | Original | | SLUS 21044 | |
| Shadow Hearts: From the New World | PS2 | 1.01 | Original | | SLUS 21326 | |
| Shadow of Destiny | PSP | 1.00 | Original | | ULUS-10459 | |
| Shadow of Destiny | PS2 | 1.10 | Original | | SLUS-20146 | |
| Shadow of Rome | PS2 | 1.00 | Demo | | SLUS 29139 | |
| Shadow of Rome | PS2 | 1.03 | Original | | SLUS-20902 | |
| Shadow of the Beast | PCE | | Original | | TGXCD1018 | |
| Shadow of the Colossus | PS2 | 1.00 | Demo | | SCUS 97505 | |
| Shadow of the Colossus | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97472 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-037 | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Gold Medal 12 CD Pack | | MQ 13-004-116 | |
| Shadowgrounds Survivor | PC | 1.0 | Original | | 000152 DVD | |
| Shadowrun | PC | 1.1.1.0 | Original | | 0307 Part No. X13-37194-01 | |
| Shakedown: Hawaii | PS3 | 01.01 | Original | | BLUS-31622 | |
| Shattered Suns | PC | 1.0 | | | Part # CCS00003-1 | |
| Shaun Palmer's Pro Snowboarder | PS2 | 1.00 | Original | | SLUS-20199 | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| Shaun White Snowboarding | PS2 | 1.01 | Original | | SLUS 21853 | |
| Shaun White Snowboarding | PSP | 1.01 | Original | | ULUS 10399 | |
| ShellShock 2: Blood Trails | PS3 | 01.01 | Original | | BLUS-30225 | |
| ShellShock: Nam '67 | PC | 1.00 | Original | | MSHOCPUS01 | |
| ShellShock: Nam '67 | PS2 | 2.00 | Original | | SLUS-20828 | |
| Shenmue (Shenmue Passport) | DC | 1.004 | Original | | 51059 | |
| Shenmue (Disc 2) | DC | 1.003 | Original | | 51059 | |
| Shenmue (Disc 3) | DC | 1.003 | Original | | 51059 | |
| Shenmue II | XBOX | | Original | | MS-050 | |
| Shepherd's Crossing | PSP | 1.00 | Original | | ULUS-10499 | |
| Sherlock Holmes Chronicles | PC | 1.0 | Original | | DVD732CD | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | PC | | Original | | | |
| Sherlock Holmes: Consulting Detective: Vol. II | PCE | | Original | | TGXCD1039 | |
| Sherlock Holmes: The Awakened | PC | 3.0 | Original | | Art. Number PF0903/US2 | |
| The Shield: The Game | PC | 1.0.0.0 | | | 11451-1DDA | |
| The Shield: The Game | PS2 | 1.01 | Original | | SLUS 21040 | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shin Megami Tensei: Devil Summoner 2: Raidou Kuzunoha vs. King Abaddon | PS2 | 1.00 | Original, Raiho Special Edition | | SLUS 21845 … | |
| Shin Megami Tensei: Devil Summoner: Raidou Kuzunoha vs. the Soulless Army | PS2 | 1.00 | Trade Demo | | SLUS-28064 | |
| Shin Megami Tensei: Devil Summoner: Raidou Kuzunoha vs. the Soulless Army | PS2 | 1.00 | Original | | SLUS-21431 | |
| Shin Megami Tensei: Digital Devil Saga | PS2 | 1.00 | Trade Demo | | SLUS-28049 | |
| Shin Megami Tensei: Digital Devil Saga | PS2 | 1.00 | Original | | SLUS 20974 | |
| Shin Megami Tensei: Digital Devil Saga 2 | PS2 | 1.00 | Trade Demo | | SLUS-28052 | |
| Shin Megami Tensei: Digital Devil Saga 2 | PS2 | 1.00 | Original | | SLUS 21152 | |
| Shin Megami Tensei: Nocturne | PS2 | 1.00 | Trade Demo | | SLUS-28045 | |
| Shin Megami Tensei: Nocturne | PS2 | 1.01 | Original | | SLUS 20911 | |
| Shin Megami Tensei: Persona | PSP | 1.00 | Original | | ULUS-10432 | |
| Shin Megami Tensei: Persona 2: Innocent Sin | PSP | 1.00 | Original | | ULUS-10584 | |
| Shin Megami Tensei: Persona 3 | PS2 | 1.00 | Trade Demo | | SLUS-28067 | |
| Shin Megami Tensei: Persona 3 | PS2 | 1.00 | Original | | SLUS 21569 | |
| Shin Megami Tensei: Persona 3 FES | PS2 | 1.00 | Original | | SLUS 21621 | |
| Shin Megami Tensei: Persona 3 FES | PS2 | 1.00 | Trade Demo | | SLUS-28068 | |
| Shin Megami Tensei: Persona 3 Portable | PSP | 1.00 | Original | | ULUS-10512 | |
| Shin Megami Tensei: Persona 3 Portable | PSP | 1.00 | Trade Demo | | ULUS-80022 | |
| Shin Megami Tensei: Persona 4 | PS2 | 1.00 | Trade Demo | | SLUS-28069 | |
| Shin Megami Tensei: Persona 4 | PS2 | 1.00 | Original | | SLUS 21782 … | |
| Shining Force EXA | PS2 | 1.00 | Original | | SLUS-21567 | |
| Shining Force Neo | PS2 | 1.00 | Original | | SLUS-21206 | |
| Shining Tears | PS2 | 1.00 | Original | | SLUS-21063 | |
| Shinobi | PS2 | 1.00 | Original | | SLUS 20459 | |
| Shinobi | PS2 | 1.00 | Trade Demo | | SLUS-28016 | |
| The Ship | PC | | Original | | | |
| Shiren the Wanderer | WII | | Original | | RVL-RFSE-USA-B0 | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shonen Jump's One Piece: Grand Adventure | PS2 | 1.01 | Original | | SLUS-21435 | |
| Shonen Jump's One Piece: Grand Battle | GC | | Original | | DL-DOL-GOPE-USA | |
| Shonen Jump's One Piece: Grand Battle | PS2 | 1.00 | Original | | SLUS 20975 | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shonen Jump's One Piece: Pirates' Carnival | PS2 | 1.00 | Original | | SLUS-21364 | |
| Shonen Jump's Shaman King: Power of Spirit | PS2 | 1.00 | Original | | SLUS-20953 | |
| Showdown: Legends of Wrestling | PS2 | 1.01 | Original | | SLUS-21017 | |
| Showtime Championship Boxing | WII | | Original | | RVL-RSYE-USA | |
| Shrek 2 | GC | | Original, Player's Choice | | DL-DOL-G3RE-USA, DL-DOL-G3RE-USA-02 | |
| Shrek 2 | PS2 | 1.02 | Original, Greatest Hits | | SLUS 20745 … | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9E-USA | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYE-USA | |
| Sid Meier's Civilization III Complete | MAC | 1.22 | Original | | 11180-1DDA | |
| Silent Heroes: Elite Troops of WWII | PC | 1.0.29.0 | Original | | | |
| Silent Hill: Shattered Memories | PSP | 1.00 | Original | | ULUS-10450 | |
| Silent Hunter III | PC | 1.0 | Original | | 681953-DVD | |
| Silent Hunter III | PC | 1.4 | Encore | | | |
| Silent Hunter: Wolves of the Pacific | PC | 1.2.0.0 | Original | | 683438-DVD1 | |
| Silent Line: Armored Core | PS2 | 1.00 | Original | | SLUS-20644 | |
| Silent Scope | PS2 | 1.00 | Original | | SLUS-20078 | |
| Silver | DC | 1.001 | Original | | T-15108N | |
| SimCity (Preview Disc) | PC | | Target | | 7298103301 | |
| The Simpsons Game | WII | | Original | | RVL-RSNE-USA | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| The Simpsons Game | PS2 | 1.00 | Original | | SLUS-21665 | |
| The Simpsons Game | PSP | 1.00 | Original | | ULUS-10295 | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQE-USA | |
| The Simpsons: Hit & Run | PS2 | 1.01 | Original | | SLUS 20624 … | |
| The Simpsons: Road Rage | XBOX | | Platinum Hits | | EA-019 | |
| The Simpsons: Road Rage | GC | | Original | | DL-DOL-GSPE-USA | |
| The Simpsons: Road Rage | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20305 … | |
| The Simpsons: Road Rage | PS2 | 1.00 | Beta | | SLUS-20305 | |
| The Sims 2 (Bonus Disk) | PC | | Special DVD Edition | | 1488317 | |
| The Sims 2 | GC | | Original | | DL-DOL-G4ZE-USA | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| The Sims 2 | PS2 | 1.00 | Original, Greatest Hits | | SLUS 21265 … | |
| The Sims 2 | PS2 | 1.00 | Demo | | SLUS 29173 | |
| The Sims 2 | PSP | 1.00 | Original | | ULUS-10031 | |
| The Sims 2 | PS2 | 1.00 | Beta | | SLUS-21066 | |
| The Sims 2 | PS2 | 1.00 | Beta | | SLUS-21265 | |
| The Sims 2: Castaway | WII | | Original | | RVL-R42E-USA | |
| The Sims 2: Castaway | PS2 | 1.00 | Original | | SLUS 21664 | |
| The Sims 2: Double Deluxe (Bonus DVD) | PC | | Original | | 1597027 | |
| The Sims 2: Nightlife (Expansion Pack) | MAC | | Original | | 11330-1DDA | |
| The Sims 2: Open For Business (Expansion Pack) | MAC | | Original | | 11390-1DDA | |
| The Sims 2: Pets | GC | | Original | | DL-DOL-G4OE-USA | |
| The Sims 2: Pets | WII | | Original | | RVL-R4PE-USA | |
| The Sims 2: Pets | PSP | 1.00 | Original | | ULUS 10130 | |
| The Sims 2: Pets | PS2 | 1.00 | Original | | SLUS 21536 | |
| The Sims 2: Seasons (Expansion Pack) | MAC | | Original | | 11610-1DDA | |
| The Sims 2: University (Expansion Pack) | MAC | | Original | | 11110-1DDA | |
| The Sims 3: Dragon Valley | PC | | Original | | 7312803402 | |
| The Sims 3: Generations (Expansion Pack) | PC | 1.0.0.1 | Original, The Sims 3 Expansion Bundle | | 1957307 | |
| The Sims 3: Hidden Springs | PC | | Original, The Sims 3: Worlds Bundle | | 1979707 | |
| The Sims 3: High-End Loft Stuff | PC | 0.2.0.84 | The Sims 10th Anniversary | | 1941507 | |
| The Sims 3: Into the Future (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7308903401 | |
| The Sims 3: Island Paradise (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7301203301 | |
| The Sims 3: Late Night (Expansion Pack) | PC | 0.2.0.125 | Original, The Sims 3 Starter Pack | | 1915003301 | |
| The Sims 3: Monte Vista | PC | | Original, The Sims 3: Worlds Bundle | | 7299103401 | |
| The Sims 3: Town Life Stuff | PC | | Original | | 1957907 | |
| The Sims 3: University Life (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 1980803301 | |
| The Sims 3: World Adventures (Expansion Pack) | PC | 0.2.0.56 | Original, The Sims 3 Expansion Bundle | | 1539307 | |
| The Sims | GC | | Original, Player's Choice | | DL-DOL-GCIE-USA-01 | |
| The Sims | PS2 | 1.00 | Original, Greatest Hits | | SLUS-20573 … | |
| The Sims: Bustin' Out | XBOX | | Original | | EA-067 | |
| The Sims: Bustin' Out | GC | | Original | | DL-DOL-G4ME-USA | |
| The Sims: Bustin' Out | PS2 | 1.00 | Original | | SLUS 20842 | |
| Sin & Punishment: Star Successor | WII | | Original | | RVL-R2VE-USA-B0 | |
| SiN Episodes: Emergence | PC | | Original | | 984707 | |
| Sing-Along Kids: Vol. 2 | PC | | | | | |
| SingStar Amped | PS2 | 1.00 | Original | | SCUS-97612 | |
| SingStar Pop | PS2 | 1.00 | Bundled with PS2 | | SCUS 97580 … | |
| SingStar Queen | PS2 | 1.00 | Original | | SCUS-97643 | |
| SingStar Rocks! | PS2 | 1.00 | Original | | SCUS-97571 | |
| Sins of a Solar Empire | PC | | Rerelease | | | |
| Sins of a Solar Empire | PC | 1.00 | Original | | | |
| Sins of a Solar Empire | PC | 1.165 | Game of the Year Edition | | | |
| Sins of a Solar Empire: Trinity | PC | | | | | |
| Sins of a Solar Empire: Trinity | PC | | Rerelease | | | |
| Siren | PS2 | 1.00 | Original | | SCUS 97355 | |
| Siren | PS2 | 1.00 | Demo | | SCUS 97398 | |
| Skate City Heroes | WII | | Original | | RVL-RHUE-USA | |
| Skate. | PS3 | 01.01 | Original | | BLUS-30059 | |
| Ski-Doo Snow X Racing | PS2 | 1.00 | Original | | SLUS-21591 | |
| Skies of Arcadia Legends | GC | | Original | | DL-DOL-GEAE-USA | |
| Sky Odyssey | PS2 | 1.10 | Original | | SLUS 20134 | |
| SkyGunner | PS2 | 1.01 | Original | | SLUS 20384 | |
| Slave Zero | DC | 1.001 | Original | | T-15106N | |
| Sly 2: Band of Thieves | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97316 | |
| Sly 2: Band of Thieves | PS2 | 1.00 | Demo | | SCUS 97457 | |
| Sly 3: Honor Among Thieves | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97464 | |
| Sly 3: Honor Among Thieves | PS2 | 1.00 | Demo | | SCUS 97484 | |
| Sly 3: Honor Among Thieves | PS2 | 1.00 | Demo | | SCUS-97527 | |
| Sly Cooper and the Thievius Raccoonus | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97198 | |
| Smart Bomb | PSP | 1.03 | Original | | ULUS-10016 | |
| Smart Series Presents: Jaja's Adventure | WII | | Original | | RVL-R67E-USA-B0 | |
| Smarty Pants: Trivia Fun for Everyone! | WII | | Original | | RVL-RP2E-USA | |
| Smash Court Tennis 3 | PSP | 1.00 | Original | | ULUS-10269 | |
| Smash Court Tennis: Pro Tournament | PS2 | 1.00 | Original | | SLUS-20286 | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| Smuggler's Run 2: Hostile Territory | PS2 | 1.00 | Original | | SLUS-20204 | |
| Smuggler's Run: Warzones | GC | | Original | | DL-DOL-GSRE-USA | |
| The Smurfs: Dance Party | WII | | Toys R Us | | RVL-SDUX-USA-B0 | |
| The Smurfs: Dance Party | WII | | Original | | RVL-SDUE-USA-B0 | |
| Sneak King | XBOX | | Original | | MS-211 | |
| Sniper Elite | PC | | Original | | 40009 | |
| Sniper Elite | PS2 | 1.02 | Original | | SLUS-21231 | |
| Sniper Elite V2 | XBOX360 | | Original | | FO-2024 | |
| Sniper: Ghost Warrior | PC | | Original | | L0001US | |
| SNK Arcade Classics Vol. 1 | WII | | Original | | RVL-RNCE-USA | |
| SNK Arcade Classics Vol. 1 | PS2 | 1.01 | Original | | SLUS 21724 | |
| SNK Arcade Classics Vol. 1 | PSP | 1.02 | Original | | ULUS-10338 | |
| SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | T-40207N | |
| Snoopy vs. the Red Baron | PSP | 1.00 | Original | | ULUS-10189 | |
| SOCOM 3: U.S. Navy SEALs | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97474 | |
| SOCOM 3: U.S. Navy SEALs | PS2 | 1.00 | Demo | | SCUS 97475 | |
| SOCOM 3: U.S. Navy SEALs | PS2 | 1.00 | Beta | | SCUS 97489 | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.02 | Original, Greatest Hits | | SCUS 97275 … | |
| SOCOM: U.S. Navy SEALs | PS2 | 1.00 | Original | | SCUS-97134 | |
| SOCOM: U.S. Navy SEALs | PS2 | 2.01 | Original | | SCUS-97134 | |
| SOCOM: U.S. Navy SEALs | PS2 | 3.00 | Greatest Hits | | SCUS 97230 | |
| SOCOM: U.S. Navy SEALs: Combined Assault | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97545 | |
| SOCOM: U.S. Navy SEALs: Combined Assault | PS2 | 1.00 | Demo | | SCUS 97560 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo | PSP | 1.00 | Demo | | UCUS 98638 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo | PSP | 1.00 | Public Beta v1.0 | | UCUS 98637 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo | PSP | 1.01 | Original, Greatest Hits, UMD Dual Pack | | UCUS-98615 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 2 | PSP | 1.00 | Demo | | UCUS 98677 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 2 | PSP | 1.00 | Demo | | UCUS 98691 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 2 | PSP | 1.00 | Original, Greatest Hits | | UCUS-98645 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 2 | PSP | 1.00 | Best Buy Demo | | UCUS 98692 | |
| SOCOM: U.S. Navy SEALs: Tactical Strike | PSP | 1.00 | Demo | | UCUS 98714 | |
| SOCOM: U.S. Navy SEALs: Tactical Strike | PSP | 1.00 | Original | | UCUS-98649 | |
| Soldier of Fortune | DC | 1.001 | Original | | T-40212N | |
| Soldier of Fortune II: Double Helix | XBOX | | Original | | AV-027 | |
| Soldier of Fortune: Gold Edition | PS2 | 1.20 | Original | | SLUS 20084 | |