Region | Title | System | Version | Edition | Languages | Serial | Status |
| StarCraft | PC | 1.0 | Original | | | |
| StarCraft | PC | 1.05b | StarCraft Battle Chest | | S0437070 | |
| StarCraft | PC | 1.15.2 | StarCraft Battle Chest | | | |
| StarCraft II: Heart of the Swarm | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 1) | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 2) | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original, Collector's Edition | | | |
| StarCraft II: Wings of Liberty | PC | | Original | | | |
| StarCraft: Brood War (Expansion Set) | PC | 1.04 | Original | | S03995 | |
| StarCraft: Brood War (Expansion Set) | PC | 1.15.2 | StarCraft Battle Chest | | | |
| Stardew Valley | PC | 1.4.5 | Fangamer | | | |
| The Starfire Soccer Challenge | PC | | Original | | 109-10-2000 | |
| StarFlyers: Royal Jewel Rescue | PC | 1.0 | Original | | 381547A-CD | |
| StarLancer (Disc 1) Microsoft StarLancer | PC | 1.0 | Original, Microsoft Action Pack | | 0200 Part Number X05-67021 | |
| StarLancer (Disc 2) Microsoft StarLancer | PC | 1.0 | Original, Microsoft Action Pack | | 0200 Part Number X05-67023 | |
| Starship Tycoon | PC | Build 2.24 | Original | | | |
| Starsiege | PC | 1.02 | Rerelease | | | |
| Starsiege: Tribes | PC | 1.0 | Original | | | |
| Startopia | PC | 1.00 | Original | | MSTARPUS01 | |
| State of Decay: Year-One Survival Edition | PC | | Original | | | |
| Steel Panthers III: Brigade Command: 1939-1999 | PC | 1.0 | Original | | 2218010-590001 | |
| Steel Panthers III: Campaign Disk | PC | | Original | | 2220210-590001 | |
| Steel Soldiers | PC | | Original | | | |
| Steins;Gate | PC | System 1.20 / Script 1.11 | Limited Edition | | | |
| Stellar Forces Stellar Forces Expansion Pak: Over 50 Add-On Levels for StarCraft | PC | 2.0 | Original | | | |
| Stephen King's F13 Stephen King's F13: Ctrl,Alt, ...Shiver | PC | | Original | | | |
| Steven Spielberg's Director's Chair (Disc 1) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD100CD | |
| Steven Spielberg's Director's Chair (Disc 2) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD200CD | |
| Steven Spielberg's Director's Chair (Disc 3) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD300CD | |
| Stonekeep | PC | 1.2 | Rerelease | | CD-ICD-045-1 | |
| Stories: The Path of Destinies (Installation Disc) | PC | 0.0.18092 | Collector's Edition, GameTrust Collection | | | |
| Stowaway DK Multimedia: Stephen Biesty's Incredible Cross-Section: Stowaway | PC | | | | | |
| Strange Cases: The Tarot Card Mystery / Strange Cases: The Lighthouse Mystery | PC | | The Best of Big Fish Games | | 33364101US | |
| Strategic Command: European Theater | PC | 1.0 | Original | | | |
| Stratego | PC | | Original | | 99032 | |
| Stray Souls: Dollhouse Story | PC | | Original | | | |
| Street Maps & Vacation Planner | PALM | | Cosmi | | PDA051501, PDA631D1 | |
| Street Sports: Jammit | PC | | Super 16 CD Pak Volume 2 | | MQ 13-004-166 | |
| Streets of SimCity | PC | | CD-ROM Classics, 10 Sims for $20 | | 1127517 | |
| Streets of SimCity | PC | 1.0 | Original | | 1040207 | |
| Stronghold FireFly Studios' Stronghold | PC | 1.0 | Original | | | |
| Stronghold FireFly Studios' Stronghold | PC | 1.1 | Original | | | |
| Stronghold FireFly Studios' Stronghold | PC | 1.2 | Original | | | |
| Stronghold 2 (Disc 1) (Install) Firefly Studios' Stronghold 2 | PC | | Original | | | |
| Stronghold 2 (Disc 2) (Play) Firefly Studios' Stronghold 2 | PC | | Original | | | |
| Stronghold 3 Gold Stronghold 3: Gold | PC | | Original | | 50080-LBL | |
| Stronghold Crusader FireFly Studios' Stronghold Crusader | PC | 1.0 | Original | | | |
| Sub Culture | PC | | Original | | | |
| Submarine Titans | PC | 1.0 | Original | | 04-21473CDA | |
| Sudden Strike (Additional Missions) | PC | 1.0.0.1 | Original | | 04-22099CD2 | |
| Sudoku Crunch for Kids! | PC | | Original | | P/N 61081-CD | |
| Sudoku Master | PALM | | Original | | 3340R-2006-03-CDA-US | |
| Super Collapse! 3 | PC | | Original | | | |
| Super Collapse! II | PC | 1.33 | Original | | | |
| Super Game Pak | PALM | | Ultimate Game Collection, Cosmi | | PDA102501, PDA634D1 | |
| Super GameHouse Collection Super Collapse! / Super Glinx! / Super Nisqually | PC | | MacPlay | | | |
| Super Mario Galaxy | WII | | Original, Nintendo Selects | | RVL-RMGE-USA, RVL-RMGE-USA-B0 | |
| Super Mario Galaxy 2 | WII | | Original, Nintendo Selects | | RVL-SB4E-USA-B0 | |
| Super Mario Strikers | GC | | Original, Best Seller | | DL-DOL-G4QE-USA | |
| Super Mario Sunshine | GC | | Original, Player's Choice | | DL-DOL-GMSE-USA | |
| Super Monkey Ball | GC | | Original, Player's Choice | | DL-DOL-GMBE-USA | |
| Super Monkey Ball 2 | GC | | Original, Player's Choice | | DL-DOL-GM2E-USA | |
| Super Paper Mario | WII | Rev 1 | Original | | RVL-R8PE-USA | |
| Super Scattergories | PC | | General Mills | | A50040 | |
| Super Smash Bros. Brawl | WII | Rev 2 | Original | | RVL-RSBE-USA-2, RVL-RSBE-USA-E0 | |
| Super Smash Bros. Melee | GC | Rev 2 | Original, Player's Choice, Original (Best Seller) | | DL-DOL-GALE-USA | |
| Super Solitaire 15 | PALM | | Rerelease | | 332-0204-10 | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.01 | Original | | MEM744CE-CD | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.1 | Original | | GAG744AE-CD | |
| Super Solvers: Spellbound! | PC | 1.12 | Rerelease | | SBO744CE-CD | |
| Super Solvers: Spellbound! | PC | 1.2 | Bonus CD | | SRS744AE-CD | |
| SuperPower | PC | 1.0 | | | PC35320JC | |
| Supreme Commander | PC | | Original | | P/N: 120904-B | |
| Surface: Mystery of Another World | PC | | Collector's Edition | | 33418010US | |
| Survival: The Ultimate Challenge | PC | 1.0 | Original | | 31209.101.US | |
| Survivor: The Interactive Game | PC | 1.0.0.17 | Original | | 04-22709CDSL | |
| SWAT 3: Close Quarters Battle (Tactics CD) | PC | 2.0 | Tactical Game of the Year Edition | | | |
| SWAT 3: Close Quarters Battle (Play CD) | PC | 2.0 | Tactical Game of the Year Edition | | | |
| SWAT: Career Pack (Disc 4) (Police Quest: SWAT) | PC | | Original | | | |
| Sweet Tooth To Go Sweet Tooth Deluxe | PC | 1.1R | Original | | 1586807 | |
| SwiftWare | PALM | | Cosmi | | PDA060501, PDAMC1 | |
| Sword of the New World: Granado Espada | PC | 2.1.18 | | | | |
| Sword of the Stars | PC | 1.0.12 | Original | | P/N 21133-5 | |
| Sword of the Stars: Ultimate Collection | PC | 1.6.7 | Original | | | |
| Syberia (Bonus CD) | PC | 1.0 | Game of the Year Edition | | PCO379CDB | |
| Syberia (Disc 1) | PC | 1.0 | Game of the Year Edition | | PC37820JC | |
| Syberia (Disc 1) | PC | 1.0 | Original | | PC37920JC | |
| Syberia (Disc 2) | PC | 1.0 | Game of the Year Edition | | PC37920JC | |
| Syberia (Disc 2) | PC | 1.0 | Original | | PC37920JC | |
| Syberia II (Disc 2) B. Sokal Syberia II | PC | 1.0 | Original, Viva Media Adventure Anthology | | 71702321 | |
| Systemax Ultimate Software Collection (Disc 1) (Daria's Inferno / Who Wants to Beat Up a Millionaire) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 10) (Deer Avenger / Ski-Doo X-Team Racing) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 11) (Pearl Harbor: Zero Hour / Real War) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 12) (S&S Encyclopedia of Science / Curious George: Reads, Writes and Spells) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 13) (Multimedia Billiards / Astrology Starscopes / Music Match Juke Box Deluxe 6.1 / Extreme Chess / Typing Tutor Jr. / Bumper Wars) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 14) (Darkened Skye: Disc 2) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 18) (M&M's: The Lost Formulas) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 2) (I See Sue... the T. Rex / Amazons & Aliens / Cheerios: Playtime) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 21) (Mob Rule) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 22) (Richard Scarry's: Busy Town) | PC | 2.0 | Original | | | |
| Systemax Ultimate Software Collection (Disc 26) (Sabrina, the Teenage Witch: Brat Attack) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 27) (Star Trek: Deep Space Nine - The Fallen) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 3) (How Many Bugs in a Box? / More Bugs in Boxes / Jim Henson's Muppet Babies: Toyland Train / Miss Spider's Tea Party) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 4) (Forbes: Corporate Warrior / Starwebs: Web Shop / Writing Tutor / Complete Idiots Guide: Marketing Materials Maker) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 5) (S&S Encyclopedia / Typing Tutor 12) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 6) (Women's Fitness / Christina Aguilera: Follow Your Dreams) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 8) (Garfield: Mad About Cats / Money Town) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 9) (Darkened Skye: Disc 1 / Zoboomafoo with the Kratt Brothers Animal Kids) | PC | | Original | | | |
| Scooby-Doo! Case File #1: The Glowing Bug Man | PC | 1.0 | Original, Scholastic | | 381681-CD, 381681-CD SP1 | |
| Siege of Avalon Anthology | PC | 1.7.1.0913 | Rerelease | | | |