Region | Title | System | Version | Edition | Languages | Serial | Status |
| S!Zone for SimCity 2000 | PC | | Original | | | |
| S.C.A.R.S. | PC | | Original | | | |
| S.T.A.L.K.E.R.: Call of Pripyat | PC | 1.6.02 | Collector's Edition | | | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| The Saboteur | PC | 1.0 | Original | | | |
| Sabre Ace | PC | 1.0 | Covermount | | | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| Sacred 2 (Disc 2) | PC | | Original | | | |
| The Sacred Amulet | PC | | Original | | | |
| Safecracker | PC | | Rerelease | | | |
| Sail 2000 | PC | 1.04 | Original | | | |
| Saints of Virtue | PC | 1.1 | Original | | | |
| Saints Row 2 | PC | | Original | | | |
| Saints Row: The Third (Disc 1) | PC | | Original | | | |
| Saints Row: The Third (Disc 2) | PC | | Original | | | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max: Season One | PC | 1.0 | Original | | | |
| Sam & Max: Season Two | PC | 1.5.0.0 | Original | | | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| Sam & Max: This Time It's Virtual! | PC | | Limited Run Games | | | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sanitarium (Disc 1) | PC | 1.00 RC15 / Build 836 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitarium (Disc 3) | PC | 1.00.000 | Rerelease | | | |
| Sanity: Aiken's Artifact | PC | 1.0 | Original, Best Buy | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 2) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Original | | | |
| SAS: Secure Tomorrow | PC | 1.0 | Original | | | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Savage Warriors | PC | 1.0 | Original | | | |
| Savage: The Battle for Newerth | PC | 1.0 | Original | | | |
| Scarface: The World Is Yours | PC | 1.00.1 | Original | | | |
| Schizm: Mysterious Journey (Side A) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Side B) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Disc 1) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 2) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 3) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 4) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 5) | PC | 1.0.0.744 | Original | | | |
| School Tycoon | PC | | Original | | | |
| School Tycoon | PC | v1 | Original | | | |
| The Sci-Fi Collection | PC | | Original | | | |
| Sci-Fi Pinball | PC | | Original | | | |
| Scissors 'n' Stones | PC | | Original | | | |
| Scooby-Doo 2: Monsters Unleashed | PC | 3.0 | Original | | | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scorched Planet | PC | | Original | | | |
| Score 4 | PC | | Original | | | |
| Scrabble | PC | | General Mills | | | |
| Scratches | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Rerelease | | | |
| Screamer | PC | | White Label | | | |
| Screamer | PC | | White Label | | | |
| The Scroll | PC | | | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.0 | Original | | | |
| Search & Rescue 3 | PC | 1.0.0.0 | Original | | | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Secret Files: Tunguska (Disc 1) (Play Disc) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 2) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 3) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 4) | PC | 1.0 | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Section Z Capcom Classics: Section Z | PC | 1.0 | PDA | | | |
| Seek & Find Adventures | PC | | Original | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Sega Genesis Classic Collection: Gold Edition | PC | 1.0.019 | Original | | | |
| Sentient | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Serious Sam Gold (Disc 1) | PC | 1.05 | Original | | | |
| Serious Sam Gold (Disc 2) | PC | 1.05 | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Serious Sam: The First Encounter | PC | | | | | |
| Serious Sam: The First Encounter | PALM | | Original | | | |
| Serious Sam: The First Encounter | PC | 1.00 | Original | | | |
| Serious Sam: The First Encounter | PC | 1.02 | Bundle Version Gainward OEM | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Original | | | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | PC | | Original | | | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| The Settlers: Rise of an Empire | PC | 1.0.4140 | Original | | | |
| Seven Games of the Soul (Disc 1) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 2) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 3) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 4) Faust | PC | | Original | | | |
| Seven Kingdoms | PC | 1.1 | Colección 'Juega y Aprende' | | | |
| Shadow Man | PC | | Original | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadow Watch | PC | 1.0 | Original | | | |
| SHADOW: War of Succession | 3DO | | Original | | | |
| Shadowlands | PC | | Megapak 2 | | | |
| Shadowrun Returns (Game Disc) | PC | | Original | | | |
| Shadows of Cairn | PC | | Rerelease | | | |
| Shakii the Wolf | PC | | Original | | | |
| Shanghai Double Pack | PC | | Original | | | |
| Shanghai: Great Moments | PC | 2.00 | Bundle Version Canon OEM | | | |
| Shanghai: Triple-Threat | 3DO | | Original | | | |
| Shanghai: Triple-Threat | 3DO | | 3DO Action Pak | | | |
| Shannara | PC | 1.0.0 | Original | | | |
| Shannara | PC | 1.0 | Original | | | |
| Shape Shifter | PC | | Original | | | |
| Sheep | PC | 1.00.000 | Original | | | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | PC | | Original | | | |
| Sherlock Holmes: Consulting Detective: Vol. I Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | 5 ft. 10 PAK Vol. 2 | | | |
| The Ship | PC | | Original | | | |
| Shivers | PC | 1.02 | Rerelease | | | |
| Shivers | PC | 1.02 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.0.0.2 | Rerelease | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.00 | | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original, Rerelease | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shock Wave | 3DO | | Original, Not for Resale | | | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shogo: Mobile Armor Division 昇剛 | PC | 1.0 | Original | | | |
| Shooting Gallery | PALM | | Original | | | |
| Shutter Island: The Adventure Game | PC | 1.0.0 | Original | | | |
| Sid Meier's Alpha Centauri | PC | 1.0I | CD-ROM Classics | | | |
| Sid Meier's Alpha Centauri | MAC | RELEASE 4.0 | Original | | | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Linux | | | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | 3.0 | Original | | | |
| Sid Meier's Civilization II | PC | 2.42a | Infogrames Rerelease | | | |
| Sid Meier's Civilization III | PC | 1.29f | Game of the Year Edition (Rerelease) | | | |
| Sid Meier's Civilization IV (Disc 1) (Install) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 2) (Play) | PC | | Original | | | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Siege | PC | 1.2 | | | | |
| Siege of Avalon Anthology | PC | 1.1.2001.913 | Original | | | |
| Siege of Avalon Anthology | PC | 1.7.1.0913 | Rerelease | | | |
| Sierra Pro Pilot (Disc 1) | PC | 1.0 | Original | | | |
| Sierra Pro Pilot (Disc 2) | PC | 1.0 | Original | | | |
| Sierra Pro Pilot 98 | PC | 1.0 | Original | | | |
| Silent Heroes: Elite Troops of WWII | PC | 1.0.29.0 | Original | | | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | | |
| Silent Hill 4: The Room | PC | 1.0 | Original | | | |
| Silent Hunter | PC | 1.0.324 | Original | | | |
| Silent Hunter III | PC | 1.4 | Encore | | | |
| Silent Steel | PC | 1.82.42.100 | DVD-ROM | | | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.00 | Original | | | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.01 | Rerelease | | | |
| Silver (Disc 1) | PC | 1.08C | | | | |
| Silver (Disc 2) | PC | 1.08C | | | | |
| The Silver Case | PC | 1.01 | Limited Run Games Limited Edition | | | |
| Silverload | PC | | | | | |
| SimCity 2000 SimCity 2000: The Ultimate City Simulator | PC | | Bundle Version Creative Labs OEM | | | |
| SimCity 2000 for Pocket PC | PPC | 1.0 | Original | | | |
| SimCity 2000: CD Collection | PC | 1.0 | Original | | | |
| SimCity 3000 | PC | | Linux | | | |
| Simon the Sorcerer | PC | 1.00 | Original | | | |
| The Sims 3 | PC | | Original | | | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims Mandrake Linux Gaming Edition (The Sims for Linux) | PC | | Linux (Mandrake Linux Gaming Edition) | | | |
| The Sims | MAC | | | | | |
| The Sims | MAC | | | | | |
| SiN | PC | | Linux | | | |
| SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| SiN Gold | MAC | | MacPlay | | | |
| SiN Gold | MAC | 1.1.1 | Original | | | |
| Sinistar: Unleashed | PC | | Original | | | |
| Sinkha | PC | | Original | | | |
| Sins of a Solar Empire | PC | | Rerelease | | | |
| Sins of a Solar Empire | PC | 1.00 | Original | | | |
| Sins of a Solar Empire | PC | 1.165 | Game of the Year Edition | | | |
| Sins of a Solar Empire: Trinity | PC | | | | | |
| Sins of a Solar Empire: Trinity | PC | | Rerelease | | | |
| Sitting Ducks | PC | 1.0 | Rerelease | | | |
| Sitting Ducks | PC | 1.0 | | | | |
| Skunny Kart Combo | PC | | Original | | | |
| SkyMaze X3D SkyMaze | PC | | X3D | | | |
| Slater & Charlie Go Camping | PC | 1.000 | SierraOriginals | | | |
| Slayer | 3DO | | Original | | | |
| Slayer | 3DO | | 3DO Action Pak | | | |
| Slingo | PC | | Oregon Lottery | | | |
| Slingo 2-Pack | PC | | Original | | | |
| Slingo Deluxe Slingo Deluxe Bundle | PC | | Original | | | |
| Slingo Mystery: Who's Gold | PC | | Big Fish Games Backup CD | | | |
| Slingo Quest | PC | 0.0.0.104 | Original | | | |
| Slingo: 15th Anniversary Edition | PC | | Original | | | |
| Slingo: Wild 7's | PC | | Oregon Lottery | | | |
| Slots Adventure: War for Olympus | PC | 1.0 | Original | | | |
| Slots Dual Pack Best of Slots from Bally Gaming / Best of Slots II | PC | | Original | | | |
| Slots Featuring WMS Gaming | PC | 1.0.3 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.1 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.2 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Smilingüido em: Desafio na Floresta | PC | | Original | | | |
| Snap! 3D Bowling | PC | | Original | | | |
| Snap! Pinball | PC | | Original | | | |
| Snap! Pool Perfect Pool | PC | 1.1 | Original | | | |
| Sniper: Art of Victory | PC | | Original | | | |
| Sniper: Path of Vengeance | PC | | Original | | | |
| Snoopy vs. the Red Baron | PC | | Original | | | |
| Snoopy's Campfire Stories | PC | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 1) | 3DO | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 2) | 3DO | | Original | | | |
| Soccer Kid | 3DO | | Original, 3DO Action Pak, Demo Disc (3DO Demo Disc Program) | | | |
| Soft Kill | PC | | Original | | | |
| The Software Toolworks CD Game Pack | PC | | Original | | | |
| Soldier of Fortune | PC | 1.03 | Bundle Version ASUS OEM | | | |
| Soldier of Fortune | PC | 1.04 | Linux | | | |
| Solitaire Antics | PC | 1.0 | Original | | | |
| Solitaire Antics Ultimate | PC | 1.0.3L | Original | | | |
| Sonic CD | PC | 1.0 | Sonic Action 4 Pack | | | |
| Sonic Heroes (Disc 1) | PC | 1.0 | Original | | | |
| Sonic Heroes (Disc 2) | PC | 1.0 | Original | | | |
| Sonic MegaMix | MCD | | Unlicensed | | | |
| Sonic Riders (Disc 1) | PC | 1.0 | Original | | | |
| Sorority House: An Interactive Game of Hide and Peek | PC | 1.0 | Original | | | |
| Soulbringer (Disc 1) | PC | 1.0.0.1 | Original | | | |
| Soulbringer (Disc 2) | PC | 1.0.0.1 | Original | | | |
| Soultrap | PC | | Original | | | |
| South Park | PC | | Original | | | |
| Space Ace | PC | | Original | | | |
| Space Ace | AJCD | | Original | | | |
| Space Ace | 3DO | | Original | | | |
| Space Ace | 3DO | RE-1 | Original | | | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM (PC and Compatibles) Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM (For Macintosh Computers) Don Bluth's Space Ace | MAC | | Original | | | |
| Space Bucks | PC | | Original | | | |
| Space Colony | PC | | Original | | | |
| Space Engineers | PC | | Limited Edition | | | |
| Space Invaders: Amenaza Espacial | PC | | Covermount | | | |
| Space Jam | PC | 1.00 | Original | | | |
| Space Quest 6: Roger Wilco: The Spinal Frontier Space Quest 6: Roger Wilco in The Spinal Frontier | PC | 1.11 | | | | |
| Space Quest 6: Roger Wilco: The Spinal Frontier Space Quest 6: Roger Wilco in The Spinal Frontier | PC | 1.11 | Original | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | SierraOriginals | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | | |
| Space Quest: Collection Series (Disc 1) | PC | | Original | | | |
| Space Quest: Collection Series (Disc 2) | PC | | Original | | | |
| Space Quest: Collector's Edition Space Quest: 15th Anniversary Collector's Edition | PC | | Original | | | |
| Space Siege | PC | 1.0 | Original | | | |
| Space Station Simulator | PC | 1.1 | Original | | | |
| Spacebound Space Bound | PC | | Original | | | |
| SpaceChem | PC | 1011 | Original | | | |
| SpaceChem | PC | 1012 | Limited Edition | | | |
| Spaceship Warlock | PC | 1.1.3 | Original | | | |
| Spaceship Warlock | PC | 1.1.3 "MPC" | Ultimate Game Collection | | | |
| SpaceStationSim | PC | 2.0.1.1 | Original | | | |
| Spaguetti Party: La Familia Pomodoro | PC | | Covermount | | | |
| Spear of Destiny | PC | | Ultimate Game Collection | | | |
| Spear of Destiny | PC | 1.4 | Original | | | |
| Spear of Destiny: Super CD Pack | PC | | Super CD Pack | | | |
| Spec Ops: Platinum Collection (Disc 2) | PC | 1.0 | Original | | | |
| Special Forces: Nemesis Strike (Disc 1) (Game Disc) | PC | 1.0 | Original | | | |
| Special Forces: Nemesis Strike (Disc 2) | PC | 1.0 | Original | | | |
| Special Forces: Nemesis Strike (Disc 3) | PC | 1.0 | Original | | | |
| Spectre VR | PC | | Megapak 2 | | | |
| Spectre VR | PC | 1.07wp | Ultimate Game Collection | | | |
| Speed Busters: American Highways | PC | | Original | | | |
| Speed Thief X3D Speed Thief | PC | | X3D | | | |
| Speedboat Attack | PC | 1.0.3.1 | Original | | | |
| Speedy Eggbert II | PC | 1.0 | Original | | | |
| Spellcasting: Party Pak | PC | 1.0 | Original | | | |
| Spelunky | PC | | Fangamer (Collector's Edition) | | | |
| Spintires Spintires: Offroad Truck Simulator | PC | | Original | | | |
| Spirit: Stallion of the Cimarron: Forever Free | PC | | Original | | | |
| Splatt! | PC | | Original | | | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | | |
| Sports Illustrated Kids: Baseball | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Basketball | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Skateboarding | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Soccer | PC | | Wendy's Kids' Meal | | | |
| Sports: Football | CD32 | | | | | |
| Sportsman's Double Play | PC | 1.0.0 | Original | | | |
| SportzFreakz | PC | 1.0 | Original | | | |
| Spy Fox in "Cheese Chase" | PC | | Original | | | |
| Spy Fox: "Operation Ozone" | PC | | Original | | | |
| Spycraft: The Great Game | PC | | Enhanced DVD-ROM Edition | | | |
| Squad Assault: Second Wave | PC | 1.80 | Original | | | |
| SSI Strategy Collection: Critic's Choice Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| SSN-21 Seawolf Sea Wolf | PC | | Bundle Version Creative Labs OEM | | | |
| The Stanley Parable (Installation Disc) | PC | | IndieBox | | | |
| Star Control 3 | PC | | Total War | | | |
| Star Control II | 3DO | | Original, Not for Resale | | | |
| Star Crusader | PC | | Original | | | |
| Star Rangers | PC | | Original | | | |
| Star Strike | MCD | | Unlicensed | | | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Rerelease | | | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Original | | | |
| Star Trek: Armada | PC | 1.0 | Original | | | |
| Star Trek: Deep Space Nine: Dominion Wars | PC | 1.00 | Original | | | |
| Star Trek: Judgment Rites | PC | | Limited CD-ROM Collector's Edition | | | |
| Star Trek: Klingon (Disc 1) (Installation) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Star Trek: Klingon (Disc 2) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Star Trek: Legacy | PC | 1.0 | Original | | | |
| Star Trek: New Worlds | PC | 1.0 | Original | | | |
| Star Trek: Starship Creator Warp II | PC | 1.0 | Rerelease | | | |
| Star Trek: Starship Creator Warp II | PC | 1.0 | Original | | | |
| Star Trek: The Next Generation: A Final Unity | PC | 1.0 | Original | | | |
| Star Trek: The Next Generation: Birth of the Federation | PC | | Original | | | |
| Star Trek: Voyager: Elite Force | MAC | | Original | | | |
| Star Wars: Attacktix: Battle Figure Game | PC | | Starter Set CD-ROM Series 2 | | | |
| Star Wars: Attacktix: Battle Figure Game | PC | | Starter Set CD-ROM | | | |
| Star Wars: DroidWorks | PC | 1.0 | Original | | | |
| Star Wars: Episode I: Racer | PC | 1.0 | Limited Run Games | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | LucasArts Archive Series | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | LucasArts Archive Series | | | |
| Star Wars: Knights of the Old Republic Collection | PC | 1.0.3.0 | Original | | | |
| Star Wars: Millennium Falcon CD-ROM Playset | PC | | Original | | | |
| Starball | PC | 1.20 | Original | | | |
| Starbright Asthma CD-ROM Game: Quest for the Code | PC | | | | | |
| StarCraft | PC | 1.0 | Original | | | |
| StarCraft | PC | 1.15.2 | StarCraft Battle Chest | | | |
| StarCraft II: Legacy of the Void (Disc 1) | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 2) | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original, Collector's Edition | | | |
| Stardew Valley | PC | 1.4.5 | Fangamer | | | |
| Starship Titanic (Disc 1) Douglas Adams: Starship Titanic | PC | 1.00.42b | Rerelease | | | |
| Starship Tycoon | PC | Build 2.24 | Original | | | |
| Starsiege | PC | 1.02 | Rerelease | | | |
| Starsiege (Disc 1) | PC | 1.0 | Original | | | |
| Starsiege (Disc 2) | PC | 1.0 | Original | | | |
| Starsiege: Tribes | PC | 1.0 | Original | | | |
| State of Decay: Year-One Survival Edition | PC | | Original | | | |
| State of Emergency | PC | 1.00.0008 | Original | | | |
| State of War | PC | 1.0 | Original | | | |
| Stay Tooned! | PC | 1.0 | Original | | | |
| Steel Panthers | PC | 1.0 | Original | | | |
| Steel Panthers | PC | 1.1 | Awesome 4 Pak | | | |
| Steel Soldiers | PC | | Original | | | |
| Steel Tide | PC | 1.0.0.1 | Original | | | |
| Steins;Gate | PC | System 1.20 / Script 1.11 | Best Edition | | | |
| Steins;Gate | PC | System 1.20 / Script 1.11 | Limited Edition | | | |
| Stellar 7 | PC | | Original | | | |
| Stellar 7 | PC | | | | | |
| Stellar 7 | PC | | 5 Ft 10 Pak In A Box Volume One | | | |
| Stellar 7 | PC | 7.3 | 5 ft. 10 Pak Vol. I | | | |
| Stellar 7: Draxon's Revenge | 3DO | | Original | | | |
| Stephen King's F13 Stephen King's F13: Ctrl,Alt, ...Shiver | PC | | Original | | | |
| Stolen (Disc 1) (Game Disc) Stolen: Infiltrate · Steal · Vanish | PC | | Original | | | |
| Stolen (Disc 2) Stolen: Infiltrate · Steal · Vanish | PC | | Original | | | |
| Stories: The Path of Destinies (Installation Disc) | PC | 0.0.18092 | Collector's Edition, GameTrust Collection | | | |
| Strange Adventures in Infinite Space | PC | | Cheapass Games | | | |
| Strategic Command: European Theater | PC | 1.0 | Original | | | |
| Stray Souls: Dollhouse Story | PC | | Original | | | |
| Street Fighter Alpha 2 | PC | | Original | | | |
| Street Fighter Alpha: Warriors' Dreams | PC | | Original | | | |
| Street Fighter IV | PC | 1.00.3013 | Original, Limited Edition | | | |
| Street Fighter Series | PC | | Original | | | |
| Street Fighter Series | PC | | Original | | | |
| Streets of SimCity | PC | | | | | |
| Strife | PC | 1.1 | Original | | | |
| Strife | PC | 1.2 | Original | | | |
| Strike Commander | PC | | CD-ROM Classics | | | |
| Strike Commander | PC | | EA Gold CD-ROM Classics | | | |
| Strike It Rich! $trike It Rich! | PALM | 1.00 Build 0524c | Original | | | |
| Strong Bad's Cool Game for Attractive People | PC | 1.5.0.0 | Original | | | |
| Stronghold | PC | 1.1 | Original | | | |
| Stronghold FireFly Studios' Stronghold | PC | | Stronghold Warchest | | | |
| Stronghold FireFly Studios' Stronghold | PC | 1.0 | Original | | | |
| Stronghold | PC | 1.00 | Slash Corporation | | | |
| Stronghold | PC | 1.00 | Dungeons & Dragons Ultimate Fantasy | | | |
| Stronghold | PC | 1.00 | Dungeons & Dragons Ultimate Fantasy | | | |
| Stronghold FireFly Studios' Stronghold | PC | 1.1 | Original | | | |
| Stronghold FireFly Studios' Stronghold | PC | 1.2 | Original, Maximum Strategy | | | |
| Stronghold 2 (Disc 1) (Install) Firefly Studios' Stronghold 2 | PC | | Original | | | |
| Stronghold 2 (Disc 2) (Play) Firefly Studios' Stronghold 2 | PC | | Original | | | |
| Stronghold Crusader FireFly Studios' Stronghold Crusader | PC | 1.0 | Original | | | |
| Stupid Invaders (Disc 1) | PC | 1.0 | Original | | | |
| Stupid Invaders (Disc 2) | PC | 1.0 | Original | | | |
| Stupid Invaders (Disc 3) | PC | 1.0 | Original | | | |
| Stupid Invaders (Disc 4) | PC | 1.0 | Original | | | |
| Su-27 Flanker | PC | 1.0 | Original, Awesome 4 Pak | | | |
| Su-27 Flanker | PC | 1.1 | Rerelease | | | |
| Sub Culture | PC | | Original | | | |
| Sudoku Ball: Detective | PC | 1.1 | Original | | | |
| The Suffering: Ties That Bind (Disc 1) | PC | | Original | | | |
| The Suffering: Ties That Bind (Disc 2) | PC | | Original | | | |
| The Suffering: Ties That Bind (Disc 3) | PC | | Original | | | |
| Summoner (Disc 1) | PC | 1.00 | Original | | | |
| Summoner (Disc 2) | PC | 1.00 | Original | | | |
| Super 3D Noah's Ark | PC | | Original | | | |
| Super Arcade Games: Version 5 | PC | | Original | | | |
| Super City Create City | PC | 1.0 | Original, Covermount | | | |
| Super Collapse! 3 | PC | | Original | | | |
| Super Collapse! II | PC | 1.33 | Original | | | |
| Super GameHouse Collection Super Collapse! / Super Glinx! / Super Nisqually | PC | | MacPlay | | | |
| Super GameHouse Solitaire Collection | PC | | Original | | | |
| Super Games for Windows: Volume II | PC | | Original | | | |
| Super League Pro Rugby Super League Rugby | PC | | Serie Plus | | | |
| Super Lucky's Tale (Disc 1) | PC | | Original | | | |
| Super Lucky's Tale (Disc 2) | PC | | Original | | | |
| Super Meat Boy (Installation Disc) | PC | | IndieBox | | | |
| Super Meat Boy: Ultra Edition | PC | | Original | | | |
| Super Puzzle Fighter II Turbo | PC | | Original | | | |
| Super Scattergories | PC | | Scholastic | | | |
| Super Street Fighter II | PC | 1.0 | Bonus Pack | | | |
| Super Street Fighter II | PC | 1.0 | Original, Bonus Pack | | | |
| Super Street Fighter II Turbo | PC | 1.0 | Bundle Version OEM | | | |
| Super Street Fighter II Turbo | PC | 1.0 | Original | | | |
| Super Strike Trilogy | MCD | | Unlicensed | | | |
| Super Trailer City Trailer Park Tycoon | PC | 1.0.0.1 | Covermount | | | |
| Super Wing Commander | 3DO | | Original, Demo Disc (3DO Demo Disc Program) | | | |
| SuperBikes Racing SuperMoto Racing | PC | | Original, Covermount | | | |
| Superhero League of Hoboken | PC | 1.1 | Original | | | |
| SuperPower | PC | 1.1 | Original | | | |
| Supreme Commander 2 | PC | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | 3DO | | Original | | | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | 3DO | | Original | | | |
| Swarm Rampage | PC | 1.00 | Original | | | |
| SWAT 3: Close Quarters Battle | PC | 1.0 | Original | | | |
| SWAT 3: Close Quarters Battle | PC | 1.4 | Elite Edition | | | |
| SWAT 3: Close Quarters Battle (Play CD) | PC | 2.0 | Tactical Game of the Year Edition | | | |
| SWAT 3: Close Quarters Battle (Tactics CD) | PC | 2.0 | Tactical Game of the Year Edition | | | |
| SWAT 3: Close Quarters Battle (Disc 1) (Play Disc) | PC | 2.0 | Tactical Game of the Year Edition: SWAT 4 | | | |
| SWAT 3: Close Quarters Battle (Disc 2) (Tactics Disc) | PC | 2.0 | Tactical Game of the Year Edition: SWAT 4 | | | |
| SWAT 4 (Disc 1) | PC | 1.0 | Original | | | |
| SWAT 4 (Disc 1) | PC | 31973 | Original | | | |
| SWAT 4 (Disc 2) | PC | 31973 | Original | | | |
| SWAT: Career Pack (Disc 4) (Police Quest: SWAT) | PC | | Original | | | |
| Sword of the New World: Granado Espada | PC | 2.1.18 | | | | |
| Sword of the Stars: Ultimate Collection | PC | 1.6.7 | Original | | | |
| Syberia (Disc 1) | PC | 1.0 | Original | | | |
| Syberia (Disc 2) | PC | 1.0 | Original | | | |
| Syberia II (Disc 1) | PC | 1.0 | Viva Media Adventure Anthology | | | |
| Symbiocom | PC | | Original | | | |
| Syndicate | 3DO | | Original | | | |
| Syndicate Plus | PC | | Original | | | |
| Syndicate Plus | PC | | Bundle Version OEM | | | |
| System Shock | PC | F1.6C / F1.6S | Original | | | |
| Systemax Ultimate Software Collection (Disc 01) (Daria's Inferno / Who Wants to Beat Up a Millionaire) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 10) (Deer Avenger / Ski-Doo X-Team Racing) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 11) (Pearl Harbor: Zero Hour / Real War) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 14) (Darkened Skye: Disc 2) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 18) (M&M's: The Lost Formulas) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 21) (Mob Rule) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 26) (Sabrina, the Teenage Witch: Brat Attack) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 27) (Star Trek: Deep Space Nine - The Fallen) | PC | | Original | | | |
| Scorched Planet | PC | | Bundle Version Matrox OEM | | /MYST-CD/GA1/01 | |
| Smashing Reversi Reversi | PC | | Pocketware | | #11 | |
| Star Wars: Episode I: The Gungan Frontier | PC | 1.0 | Original | | #3512030 | |
| Star Wars: Anakin's Speedway | PC | | Original | | #3518030 | |
| Space Tripper Space Defender | PC | 1.4 | Pocketware | | #8 | |
| Star Miner: Battle for Supremacy Asteroid Miner | PC | 1.30 FULL | Pocketware | | #9 | |
| Sid Meier's Railroad Tycoon | PC | 455.03 | RomZōn! | | 0-447-40-101 | |
| Sid Meier's Civilization II | PC | 1.0 | Original | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42 | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Star Trek: Generations (Disc 1) | PC | 1.0 | Original | | 0-521-47-101 | |
| Star Trek: Generations (Disc 2) | PC | 1.0 | Original | | 0-521-47-102 | |
| Star Trek: The Next Generation: Klingon Honor Guard (Install Disc) | PC | 1.0 | Original | | 0-539-47-101 | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disc) | PC | 1.0 | Original | | 0-539-47-102 | |
| Star Trek: Starship Creator Deluxe | PC | | Original | | 0-671-31776-8 | |
| Star Trek: Deep Space Nine: The Fallen | PC | 1.0 | Original | | 0-671-57663-1 | |
| Shadowgrounds (Disc 1) | PC | 1.01 | Original | | 000046-CD1 | |
| Shadowgrounds (Disc 2) | PC | 1.01 | Original | | 000046-CD2 | |
| Shadowgrounds Survivor | PC | 1.0 | Original | | 000152 DVD | |
| SimCity Classic | PC | 2.0 | Deluxe Edition | | 0002-000-0601B | |
| SimCity Classic | PC | | Collector's Series | | 0002-000-0612-A | |
| SimCity Classic | PC | 1.1 (Windows), 1.4 (Mac) | Scholastic | | 0002-000-0612-A | |
| SimFarm SimFarm: SimCity's Country Cousin | PC | | Original, Maxis Collector's Series | | 0003-000-0612-A | |
| SimAnt | PC | 2.0 | Classics, Maxis Collector's Series | | 0014-000-0612-A | |
| SimCity 2000: CD Collection | MAC | 1.0 | Original | | 0026-000-0601-A | |
| SimCity 2000: CD Collection | PC | 1.00 | Windows 95 | | 0026-000-0601-A | |
| SimCity 2000: CD Collection | PC | 1.2 | Windows | | 0026-000-0601-A | |
| SimCity 2000: CD Collection | PC | 1.2cj | Windows | | 0026-000-0601-A | |
| SimTown | PC | 1.0 | Original | | 0037-000-0601-A | |