Region | Title | System | Version | Edition | Languages | Serial | Status |
| Scooby-Doo 2: Monsters Unleashed | PC | 3.0 | Original | | | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| Shamrock Spring '97 Shamrock Spring '97 Demo Disk | PC | | | | | |
| Shivers Two: Harvest of Souls | PC | 1.0 | Demo | | | |
| Slots Adventure: War for Olympus | PC | 1.0 | Original | | | |
| Soccer Score Soccer | PC | | Original | | | |
| Speed Busters: American Highways | PC | | Original | | | |
| Spider-Man | PC | | Demo | | | |
| Spirit: Stallion of the Cimarron: Forever Free | PC | | Original | | | |
| Stay Tooned! | PC | 1.0 | Original | | | |
| Stronghold FireFly Studios' Stronghold | PC | | Stronghold Warchest | | | |
| Stronghold FireFly Studios' Stronghold | PC | 1.0 | Original | | | |
| Stronghold Crusader FireFly Studios' Stronghold Crusader | PC | 1.0 | Original | | | |
| Star Wars: Jar Jar's Journey Adventure Book | PC | 1.0 | Original | | #3520530 | |
| SimAnt | PC | 2.0 | Classics, Maxis Collector's Series | | 0014-000-0612-A | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Snowmobile Racing | PC | | Original | | 04-17527CD | |
| SimTheme Park (Bonus Rides and Attractions) Sim Theme Park | PC | | Gold Edition, Sim Mania 2 | | 1229817, 1403347, 1641527 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition | | 1403337 | |
| The Sims 2 (Bonus Disk) | PC | | Special DVD Edition | | 1488317 | |
| SimCity 3000 Unlimited | PC | 2.0.949.0 | Original | | 1500907 | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | 170121 | |
| Sesame Street: Let's Make a Word! | PC | | Bundle Version Creative Labs OEM | | 1713310119-1 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | 2088130 | |
| Star Wars: X-Wing vs. TIE Fighter: Balance of Power | PC | 2.0A | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | 2088131 | |
| Soldier of Fortune | PC | 1.06 | Gold Edition | | 30173.101.US | |
| Singularity | PC | 1.0 | Original | | 33309101US | |
| StarFlyers Alien Space Chase | PC | 1.0 | Original | | 380853A-CD | |
| Stuart Little Learning Adventures: His Adventures in Wordland (Disc 2) | PC | 1.0 | Original | | 381676-CD2 | |
| Scooby-Doo! Case File #1: The Glowing Bug Man | PC | 1.0 | Original, Scholastic | | 381681-CD, 381681-CD SP1 | |
| Star Stable: The Autumn Riders | PC | 1.00.0000 | Original | | 61-0803 04 | |
| Star Wars: Rebel Assault | PC | 1.02 | Original | | 632630, CDRM1132180 | |
| Star Wars: Starfighter | PC | 1.0 | Original, Rerelease | | 6551830, 6551830R1 | |
| Star Wars: Episode III: Revenge of the Sith: Activity Center (Disc 1) | PC | 1.0 | Original | | 682967-CD1 | |
| Star Wars: Episode III: Revenge of the Sith: Activity Center (Disc 2) | PC | 1.0 | Original | | 682967-CD2 | |
| Star Wars: Dark Forces | PC | 1.0L Build 1 | Super Sampler Edition: LucasArts Archives Vol. II, The: Star Wars Collection | | 8031831 | |
| Star Wars: Rebel Assault | PC | 1.72 | The LucasArts Archives Vol. II: Star Wars Collection | | 8031833 | |
| Star Wars: Making Magic | PC | QA1.03 | Original, LucasArts Archives Vol. II, The: Star Wars Collection | | 8031835 | |
| Sonic's Schoolhouse | PC | 1.0 | Original | | 85047 | |
| Sega Rally Championship | PC | 1.0 | Original | | 85048 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | 85067 | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Smart Games Puzzle Challenge 3 | PC | 1.0 | Original | | 99254 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.05.48824 | Original | | 9999830 | |
| Sherlock Holmes: The Awakened | PC | 3.0 | Original | | Art. Number PF0903/US2 | |
| Soulbringer (Disc 2) | PC | 1.0.0.1 | Original, Dual Jewel | | CD-C95-1077-1, CD-C95-1306-4 | |
| Soulbringer (Disc 1) | PC | 1.0.0.1 | Dual Jewel, Rerelease | | CD-C95-1306-3 | |
| Super Duper Arcade 2 | PC | | Original | | CS99ARC011, Part No. 04-17836CD | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| Seek and Destroy Seek & Destroy | PC | 1.0 | Original | | J230D | |
| Sesame Street: Let's Make a Word! | PC | | Original, Software for the fun of it | | KES006 | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.0 | Original | | MEM744AE-CD | |
| Super Duper Arcade 1 | PC | | Original | | Part No. 04-17834CD | |
| Sherlock Holmes: Nemesis (Disc 1) | PC | 1.00.0777 | Original | | PCO589CD1, SNY 1.0 | |
| Sherlock Holmes: Nemesis (Disc 2) | PC | 1.00.0777 | Original | | PCO589CD2, SNY 1.0 | |
| Stardate 2410.2: Crusade in Space: The Zardula Incursion | PC | 1.16 | Original | | ROW-10602 | |
| Sesame Street Toddler: Elmo's Art Workshop (Disc 2) | PC | 3.0 | Rerelease | | STL744AE-CD2 | |