Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sherlock Holmes: Consulting Detective: Vol. I Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | 5 ft. 10 PAK Vol. 2 | | | |
| Shrak Shrak for Quake | PC | 1.0 | Original | | | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Linux | | | |
| Sitting Ducks | PC | 1.0 | Rerelease | | | |
| The Software Toolworks CD Game Pack | PC | | Original | | | |
| Sonic CD | MCD | | Original | | | |
| Sonic Riders (Disc 1) | PC | 1.0 | Original | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | | |
| Spectre VR CD | MAC | | Original | | | |
| Spy Fox in "Dry Cereal" | PC | | Demo | | | |
| Spycraft: The Great Game | PC | | Enhanced DVD-ROM Edition | | | |
| State of Decay: Year-One Survival Edition | PC | | Original | | | |
| Stellar 7 | PC | | 5 Ft 10 Pak In A Box Volume One | | | |
| Stories: The Path of Destinies (Installation Disc) | PC | 0.0.18092 | Collector's Edition, GameTrust Collection | | | |
| Street Fighter IV | PC | 1.00.3013 | Original, Limited Edition | | | |
| Stronghold (Bonus Castle: The Tower of London) | PC | | Pre-Order Bonus | | | |
| Super Games for Windows: Volume II | PC | | Original | | | |
| Super Lucky's Tale (Disc 1) | PC | | Original | | | |
| Super Lucky's Tale (Disc 2) | PC | | Original | | | |
| SuperCharged Xpansion Pack SuperCharged Xpansion Pack for Doom, Doom II & Hexen | PC | | Rerelease | | | |
| Strike Commander / Syndicate Plus / Ultima VIII: Pagan / Wing Commander II | PC | | Bundle Version Creative Labs OEM | | 1213330161 | |
| The Sims Strategy Guide and SimFan Pack | PC | | Pre-Order Bonus | | 1414407 | |
| The Sims 3: World Adventures (Expansion Pack) | PC | 0.2.0.56 | Original, The Sims 3 Expansion Bundle | | 1539307 | |
| Sonic CD | PC | 1.01 | Bundle Version Packard Bell OEM | | 170882, P/N 647107-002 | |
| The Sims 3: Generations (Expansion Pack) | PC | 1.0.0.1 | Original, The Sims 3 Expansion Bundle | | 1957307 | |
| The Sims 4: Island Living | PC | | Original, Rerelease | | 3765703401, 3765703402 | |
| The Sims 4: Discover University (Expansion Pack) | PC | | Original | | 3765903401 | |
| SimCity 3000 | PC | | Pre-Order Bonus | | 4083407 | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| Sega Rally Championship | SS | 1.006 | Original, Sega Saturn NetLink Bundle | | 80012, 81207 | |
| Sonic & Knuckles Collection | PC | | Original, Jack in the Box | | 85037 | |
| Slam Tilt Pinball | PC | 1.0 | Expert Software | | 8694 01 | |
| Software JukeBox: Home & Entertainment Edition: Vol. 1 No. 1 | PC | | Original | | CDRM1006830 | |
| Syberia | PC | SSV1.0 | Demo | | DEM379CD | |
| Super Street Fighter II Turbo | 3DO | RE1 | Original | | FZ-SC3851, FZ-SM3851 | |
| Sonic Riders (Disc 2) | PC | 1.0 | Original, Scholastic | | P/N CDR5047633 | |
| Sonic Riders (Disc 3) | PC | 1.0 | Original, Scholastic | | P/N CDR5047633 | |
| The Shield: The Game | PS2 | 1.01 | Original | | SLUS 21040 | |
| Samurai Champloo: Sidetracked | PS2 | 1.00 | Original | | SLUS 21343 | |
| The Sopranos: Road to Respect | PS2 | 1.01 | Original, Limited Edition | | SLUS 21388 … | |
| Samurai Shodown Anthology | PS2 | 1.01 | Original | | SLUS 21629 | |
| Slob Zone 3D H.U.R.L. | PC | 1.0 SE | Special Edition | | SLZ344AE-CD | |
| Stellar-Fire | MCD | | Original | | T-110025 | |
| Spot Goes to Hollywood | SS | 1.000 | Original | | T-7001H | |
| Sport Image: World Cup 1994 | PC | 2.0 | SoftKey | | WCF344AE-CD | |