Region | Title | System | Version | Edition | Languages | Serial | Status |
| Saltwater Sportfishing | PSX | | Original | | SLUS-01397 | |
| Snowboarding | PSX | | Original | | SLUS-01287 | |
| Street Racquetball | PSX | | Original | | SLUS-01450 | |
| Super Bubble Pop | PSX | | Original | | SLUS-01528 | |
| Super Puzzle Fighter II Turbo | PSX | | Original | | SLUS-00418 | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| Star Wars: Rebel Assault | MCD | | Limited Run Games | | T-60075 | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Slave Zero | DC | 1.001 | Original | | T-15106N | |
| Soul Fighter | DC | 1.000 | Original | | T-41401N | |
| Super Game Converter | DC | 1.000 | Unlicensed | | | |
| S.C.A.R.S. | PC | | Original | | | |
| Samurai Shodown II | PC | | Dual Jewel | | CD-C95-1302-0 | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original, The Magic School Bus: Bonus Pack | | 0396 Part No. 90626, Disc Assy. 451-052-012 | |
| Search & Rescue 3 | PC | 1.0.0.0 | Original | | | |
| Sega Puzzle Pack | PC | | Expert Software | | 682701.101.US | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| Shadow Company: Left for Dead | PC | 1.0 | Original | | 5051802 | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow Force: Razor Unit | PC | | Special Forces Pack | | SFRU-0414 | |
| Shadow Warrior Lo Wang is Shadow Warrior | PC | 1.2 | Special Edition | | 04-12884CD | |
| Shattered Steel | PC | 1.12 | Rerelease | | CD-ICD-732-0 | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original, Rerelease | | | |
| Sid Meier's Civilization II | PC | 2.42a | Infogrames Rerelease | | | |
| Sid Meier's Civilization II | PC | 2.42a | Risk: Gold Edition | | Product # 99227 | |
| Sid Meier's Civilization II | PC | 2.42a | Hasbro Rerelease | | Product # 99227 | |
| Ski Park Manager 2003: Gold Edition Val d'Isère Ski Park Manager 2003: Gold Edition | PC | | | | 71102221 | |
| Small Soldiers: Globaltech Design Lab | PC | | | | Product# 99144 | |
| Snowboard Park Tycoon | PC | | | | 30983.101.US | |
| Snowmobile Racing | PC | | Original | | 04-17527CD | |
| Soldier of Fortune | PC | 1.03 | Bundle Version ASUS OEM | | 1000910.101.US | |
| Soldier of Fortune | PC | 1.03 | Bundle Version ASUS OEM | | | |
| Soldier of Fortune | PC | 1.06 | Gold Edition | | 30173.101.US | |
| Sonic 3D Blast | PC | | Expert Software | | 6822 01 | |
| Sonic 3D Blast | PC | 1.0 | Twin Pack | | 6822 01 | |
| Sonic 3D Blast | PC | 1.0 | Expert Software | | 6822 01 | |
| Sonic CD | PC | 1.0 | Sonic Action 4 Pack | | | |
| Sonic CD | PC | 1.0 | Bundle Version OEM | | P/N 647107-001 | |
| Sonic R | PC | | Expert Software | | 682501.101.US | |
| Sonic R | PC | | Original | | 85076 | |
| Sorry / Boggle / Yahtzee: Triple Pack of Fun | PC | | Original | | Part # 26023CD | |
| Spider-Man | PC | | Original | | 31131.101.US | |
| Spider-Man (Disc 2) | PC | 1.0 | Original | | 32249.102.US | |
| Sports Car GT | PC | 1.52US | CD-ROM Classics | | 1187207 | |
| Spy Fox: "Operation Ozone" | PC | | Original | | | |
| Spy Fox: "Operation Ozone" | PC | | Original | | Part No. 04-22394CD | |
| Star Trek Pinball | PC | 1.00 | Original | | CD-C95-675-0 | |
| Star Trek: Armada | PC | 1.0 | Original | | 1000913.101.US | |
| Star Trek: Armada | PC | 1.1 | Original | | 1000913.101.US | |
| Star Trek: Armada | PC | 1.2 | Rerelease, Star Trek: Action Pack | | 1000913.101.US, 32257.102.US | |
| Star Trek: Armada II | PC | | Star Trek: Action Pack | | 31143.101.US | |
| Star Trek: Bridge Commander | PC | 1.0 | Original | | 31127.101.US | |
| Star Trek: Hidden Evil | PC | | Original | | 1000889.101.US | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disc) | PC | 1.0 | Original | | 0-539-47-102 | |
| Star Wars: Galactic Battlegrounds (Disc 2) (Play) | PC | 1.0 | Original | | 8531831, 8531831R1 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 2) | PC | | Rerelease | | 8531031R, 8531031R1 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 2) | PC | | The Movie Collection | | 1292617, 8531031 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 2) | PC | | Original | | 8531031 | |
| Star Wars: Galactic Battlegrounds: Clone Campaigns | PC | 1.0 | Original | | 7111830 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | LucasArts Archive Series | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | 1.0 | Rerelease | | 9521830R1 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | LucasArts Archive Series | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | 1.0 | Rerelease | | 9521831R1 | |
| Star Wars: Jedi Knight: Mysteries of the Sith Star Wars: Jedi Knight: Dark Forces II: Ambush at Altyr 5 | PC | 1.0 | Demo: Bundle Version OEM | | 647030, CD-C95-990-E | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | 2088130R1 | |
| Star Wars: X-Wing vs. TIE Fighter: Balance of Power | PC | 2.0A | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | 2088131R1 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | | Rerelease | | 2054130 | |
| Starsiege (Disc 1) | PC | 1.0 | Original | | | |
| Starsiege (Disc 2) | PC | 1.0 | Original | | | |
| Starsiege: Tribes | PC | 1.0 | Original | | | |
| Stellar Forces Stellar Forces Expansion Pak: Over 50 Add-On Levels for StarCraft | PC | 2.0 | Original | | | |
| Street Legal | PC | | Original | | 30975.101.US | |
| Sudden Strike | PC | 1.0.0.1 | Original | | 04-22099CD1 | |
| Sudden Strike II | PC | 2.0 | Original | | CDR8000/US2 | |
| Super Huey III | PC | | Cosmi | | CDR 707 D1, SJ 111000 | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |