Region | Title | System | Version | Edition | Languages | Serial | Status |
| The Sims: Superstar (Expansion Pack) (Disc 2) | PC | | | | 1462617 | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | PC | | | | 1462607 | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 2) | PC | | Expansion Collection Volume Two | | 1472017 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 2) | PC | | Original | | 1472017 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 1) | PC | | Expansion Collection Volume Two | | 1472007 | |
| The Sims: House Party (Expansion Pack) | PC | | Double Deluxe, Expansion Collection Volume One, Mega Deluxe | | 1446107 | |
| The Sims: Double Deluxe (Bonus CD) | PC | | Double Deluxe, Mega Deluxe | | 1474107 | |
| The Sims: Bustin' Out | GC | | Original | | DL-DOL-G4ME-USA | |
| The Sims | PC | | Bundle Version Gateway OEM | | 1500827 | |
| The Sims 3: Seasons (Expansion Pack) | PC | | Original, Limited Edition | | 1978303301 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims 3: Monte Vista | PC | | Original, The Sims 3: Worlds Bundle | | 7299103401 | |
| The Sims 3: Hidden Springs | PC | | Original, The Sims 3: Worlds Bundle | | 1979707 | |
| The Sims 3: Dragon Valley | PC | | Original | | 7312803402 | |
| The Sims 2: Sneak Preview CD | PC | | Original | | 1472027 | |
| The Sims 2: H&M Fashion Stuff | PC | | Original | | 1536607 | |
| The Sims 2: Family Fun Stuff | PC | | Original | | 1515807 | |
| The Sims 2: Double Deluxe | PC | | Original | | 1597007 | |
| The Sims 2: Double Deluxe (Bonus DVD) | PC | | Original | | 1597027 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | Original | | 1672917 | |
| The Sims 2: Castaway | WII | | Original | | RVL-R42E-USA | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQE-USA | |
| SimLife SimLife: The Genetic Playground | PC | | Scholastic Clubs and Fairs | | 1111707, P1 | |
| SimFarm SimFarm: SimCity's Country Cousin | PC | | Rerelease, 10 Sims for $20 | | 11116, 1162207 | |
| SimEarth | PC | | Dual Jewel, 10 Sims for $20 | | 1111507 | |
| SimCoaster | PC | | Sim Mania 2, The Kids Collection | | 1242617 | |
| SimClassics: Maxis Collections 2 | PC | | Original | | 0092-000-0601-A | |
| SimClassics: 3 in 1 Pack | PC | | Original | | 0543-000-0601-A | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| SimCity Enhanced CD-ROM | PC | | Original | | CD-ICD-041-0 | |
| SimCity Classic | PC | | CD-ROM Classics, 10 Sims for $20, Sim Mania Pack | | 1162907 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | | Original | | 1474007 | |
| SimCity 3000 Unlimited | PC | | Rerelease | | 1446307, 1641507 | |
| SimCity 3000 (PC Game Sampler) | PC | | Domino's Pizza / Easter Seals | | | |
| SimCity 2000 Special Edition | PC | | Original | | 0126-000-0601-A | |
| SimCity 2000 SimCity 2000: The Ultimate City Simulator | PC | | Bundle Version Creative Labs OEM | | | |
| SimCity (Preview Disc) | PC | | Target | | 7298103301 | |
| SimAnt SimAnt: The Electronic Ant Colony | PC | | CD-ROM Classics, 10 Sims for $20 | | 1111407 | |
| Silverload | PC | | | | | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| Sid Meier's Civilization Revolution | XBOX360 | | Original | | TT-2021 | |
| Sid Meier's Civilization IV: Colonization | PC | | Original | | 31491-1 | |
| Sid Meier's Civilization IV (Disc 2) (Play) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 2) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.7 | |
| Sid Meier's Civilization IV (Disc 1) (Install) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization III (Bonus CD) | PC | | Game of the Year Edition | | Part # 24356CD2 | |
| Sid Meier's Civilization II: Fantastic Worlds | PC | | Original | | 0-529-47-101 | |
| Shrek 2 | PC | | | | 32585.101.US | |
| Shopmania | PC | | Original | | P/N 61227-CD | |
| Shooting Gallery | PALM | | Original | | | |
| Shogun: Total War (Disc 2) | PC | | Original | | 798717, 1224617 | |
| Shockwave 2: Beyond the Gate (Disc 01) | 3DO | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| The Ship | PC | | Original | | | |
| Shift 2: Unleashed | PC | | Limited Edition | | 1948307 | |
| Sherlock Holmes: Consulting Detective: Vol. I Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | 5 ft. 10 PAK Vol. 2 | | | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Rerelease | | CDRM 835400 | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | PC | | Original | | | |
| Sherlock Holmes and the Hound of the Baskervilles | PC | | Collector's Edition | | 33369101US | |
| Shape Shifter | PC | | Original | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadoan (Disc 2) | PC | | Original | | CD-ICD-228-1 | |
| Shadoan (Disc 1) | PC | | Original | | CD-ICD-228-0 | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| Sesame Street: Let's Make a Word! | PC | | Original, Software for the fun of it | | KES006 | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | PC | | Original | | | |
| Sesame Street Search & Learn Adventures | PC | | Original, Software for the fun of it | | EOA844AE-CD, KES005 | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Serious Sam: The First Encounter | PALM | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Adventures | PC | | Original | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| SeaWorld Adventure Parks Tycoon | PC | | Original | | 31711.101.US | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| The Scroll | PC | | | | | |
| Screamer 2 Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| Scratches | PC | | Original | | | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble Complete | PC | | Original, Monopoly & Scrabble Complete, Scrabble Complete/Jeopardy 2003 | | 11290-CD, Part # 23970CD | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Scholastic, Classic Value Series | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002, 99002● | |
| Score International Baja 1000: The Official Game | PC | | Original | | 35619./101.US | |
| Score 4 | PC | | Original | | | |
| Scooby-Doo! Night of 100 Frights | GC | | Original | | DL-DOL-GIHE-USA | |
| Science Fiction: The Ultimate Collection (Disc 1) | PC | | | | 11014 | |
| Sci-Fi Pinball | PC | | Original | | | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| Sacra Terra: Angelic Night | PC | | Original | | | |