| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Saturday Night Live Goes Political | PC | | Original |  | |  |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| School Zone Flash Action Software: Multiplication/Division | PC | | Original | | 08021 | |
| School Zone Math: First & Second Grade | PC | | Original | | 08020 | |
| Schoolhouse Rock! Thinking Games | PC | | Original | | BBT844AE-CD | |
| Science Arcade | PC | | Original | | Part No.: MAR476 | |
| Scribblenauts Unlimited | PC | | Original | | 5000145356 | |
| Secrets of the East | PC | | Scholastic | | P/N CDR9909538 | |
| Sesame Street: Art Workshop | PC | | Original | | 9369 | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Elmo's Preschool | PC | | | | 11040CD | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 1) (Reading Basics) | PC | | Original | | EPK-744AE-CD1 | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: Learn, Play and Grow Preschool / Sesame Street: Let's Go to Preschool / Sesame Street: First Steps | PC | | Southwestern Kids' Collection | | 05SS3-R01 | |
| Sesame Street: Letters | PC | | | | 9367A | |
| Sesame Street: Reading Basics | PC | | Encore | | 10200 | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| Shrek 2 | PC | | Original | | 32585.101.US | |
| Shrek Game Land Activity Center | PC | | Original | | 32053.101.US | |
| Sierra's School House: English (Disc 1) | PC | | Original | | | |
| Sierra's School House: English (Disc 2) | PC | | | | | |
| Sierra's School House: Science (Disc 1) | PC | | Original | | 831614230/S161155 | |
| Sierra's School House: Science (Disc 2) | PC | | Original | | 831614230/S161155 | |
| Smart Steps: Kindergarten | PC | | Rerelease | | P/N: LDSMASTKIJ | |
| Sports Illustrated Kids: Baseball | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Basketball | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Skateboarding | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Soccer | PC | | Wendy's Kids' Meal | | | |
| Spy Fox in "Dry Cereal" | PC | | Rerelease | | Part # 0001407 | |
| Spy Fox: "Operation Ozone" | PC | | Rerelease | | pvaol008spyo | |
| Spy Kids Learning Adventures: The Candy Conspiracy | PC | | Original | | 03962 | |
| Spy Kids Learning Adventures: The Nightmare Machine | PC | | Original | | 03963 | |
| Spy Masters: Training Mission / JumpStart Music | PC | | Great Clips | | W0000946 | |
| Stellaluna | MAC | | Original | | 2069-1-01 | |
| Stellar 7 | PC | | Original | | | |
| Stoked | XBOX360 | | Original | | DE-2003 | |
| Street Legal | PC | | Original | | 30975.101.US | |
| Stuart Little: Big City Adventures
Stuart Little: Big City Adventures CD-ROM Game | PC | | Original | | Product # 99716 | |
 | Super Lucky's Tale (Disc 1) | PC | | Original |                     | | |
| Super Lucky's Tale (Disc 2) | PC | | Original | | | |
| Super Why! The Power to Read | PC | | Original | | 23899-00 | |
| School Zone Transition Math: Grades K-1 | PC | .5 | Original | | 08034 | |
| Sesame Street: My Baby & Me (Disc 1) (Baby & Me) | PC | 1.0 | Original | | SSY744AE-CD1 | |
| Sesame Street: My Baby & Me (Disc 2) (Sesame Street Greatest Hits Sampler) | PC | 1.0 | Original | | SSY744AE-CD2 | |
| Sportsman's Double Play | PC | 1.0.0 | Original | | | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.01 | Original | | MEM744BE-CD | |
| Stanley's Sticker Stories | PC | 1.04 | Original | | 381428-CD4/I083ha | |
| Scrabble: Champion Edition | PC | 1.0S | Rerelease | | 11191B-CD | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Super Solvers: Spellbound! | PC | 1.1 | Rerelease | | SBO744AE-CD | |
| Sweet Tooth To Go
Sweet Tooth Deluxe | PC | 1.1R | Original | | 1586807 | |
| Strategy Games of the World | PC | 1.2 | Bundle Version IBM OEM | | P/N 75H9348 | |
| Sesame Street Reading is Fun! Toddler (Disc 1) (Grover's Travels) | PC | 2.0 | Original | | SRF844AE-CD-1 | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Storybook Weaver Deluxe | PC | 2.0 | Rerelease | | 10049 | |
| Storybook Weaver Deluxe | PC | 2.1 | Rerelease | | SBW744EE-CD | |
| Sammy's Science House | PC | 3.0 | Southwestern Kids' Collection | | R2522/8612a.7.01 | |
| Sesame Street: Elmo's Preschool (Disc 1) (Elmo's Preschool) | PC | 3.1 | Original | | P/N 379663-CD1 | |
| Sesame Street: Elmo's Preschool (Disc 2) (Search & Learn Adventures) | PC | 3.1 | Original | | P/N 379663-CD2 | |
