Region | Title | System | Version | Edition | Languages | Serial | Status |
| S.C.A.R.S. | PC | | Original | | | |
| S.L.A.I.: Steel Lancer Arena International | PS2 | 1.02 | Original | | SLUS-20969 | |
| S.T.A.L.K.E.R.: Clear Sky | PC | 1.0 | Original | | ECD950001D | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | 28015-CD1 | |
| S²: Silent Storm (Disc 2) | PC | 1.2 | Original | | 28015-CD2 | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| Sable Maze: Forbidden Garden & Twelve Fears | PC | | Original | | 33528010US | |
| Sable Maze: Sullivan River / Norwich Caves | PC | | | | 33471010US | |
| Sabre Ace | PC | 1.0 | Covermount | | | |
| Sabre Ace: Conflict over Korea | PC | 1.0 | Original | | D83115 | |
| Sabrina the Teenage Witch: Brat Attack | PC | | Original | | S02560 | |
| Sabrina the Teenage Witch: Spellbound | PC | 1.0c | Original | | S03836 | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sacred (Disc 1) | PC | 1.8 | Rerelease | | 10153-CD1 | |
| Sacred (Disc 2) | PC | 1.8 | Rerelease | | 10153-CD2 | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| Sacred 2 (Disc 2) | PC | | Original | | | |
| The Sacred Amulet | PC | | Original | | | |
| Sacred Gold (Disc 1) | PC | 2.24 | Original | | 10130-CD1 | |
| Sacred Gold (Disc 2) | PC | 1.0 | Original | | 10130-CD2 | |
| Sacred Gold (Disc 3) | PC | 1.0 | Original | | 10130-CD3 | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| The Sacred Rings (Disc 1) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 2) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 3) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 4) | PC | 1.0 | Original | | PCO466CD | |
| Sacrifice | PC | | Bundle Version Hewlett Packard OEM | | CD-C951041-PC2E | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Safecracker | PC | | Rerelease | | | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.0 | Original | | PCO519CD | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.01 | Original | | PCO519CD | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| Sail 2000 | PC | 1.04 | Original | | | |
| Saint | WII | | Original | | RVL-RZCE-USA-B0 | |
| Saints of Virtue | PC | 1.1 | Original | | | |
| Saints Row 2 | PC | | Original | | | |
| Saints Row: The Third (Disc 1) | PC | | Original | | | |
| Saints Row: The Third (Disc 2) | PC | | Original | | | |
| Saints Row: The Third: The Full Package | PS3 | 01.00 | Original | | BLUS-31062 | |
| Salt Lake 2002 | PS2 | 1.01 | Original | | SLUS-20378 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | Original | | 634031 | |
| Sam & Max Hit the Road | PC | | Original | | 634430 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Sam & Max: Beyond Time and Space | PC | | Original | | 27898CD | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XE-USA | |
| Sam & Max: This Time It's Virtual! | PC | | Limited Run Games | | | |
| Sammy Soza Softball Slam | PC | | Original | | PCD-5048-001 | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Jack: The Shadow of Aku | PS2 | 1.03 | Original | | SLUS-20899 | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Shodown II | PC | | Dual Jewel | | CD-C95-1302-0 | |
| Samurai Shodown II | PC | | Original | | CD-C95-1166-0 | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Shodown V | XBOX | | Original | | SN-004 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors 2 | PS2 | 1.01 | Original | | SLUS-21462 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Samurai Warriors 2: Empires | PS2 | 1.00 | Original | | SLUS 21585 | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59E-USA-E0 | |
| Samurai Warriors: State of War | PSP | 1.01 | Original | | ULUS-10089 | |
| Samurai Warriors: Xtreme Legends | PS2 | 1.00 | Original | | SLUS-21080 | |
| San Francisco Rush 2049 | DC | 1.001 | Original | | T-9707N | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sanitarium (Disc 1) | PC | 1.00 RC15 / Build 836 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 2) | PC | 1.0 | Original | | | |
| SAS: Secure Tomorrow | PC | 1.0 | Original | | | |
| Satisfashion: Rock the Runway | WII | | Original | | RVL-SS5E-USA-B0 | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Savage Warriors | PC | 1.0 | Original | | 2205110-S90001/1055SA | |
| Savage Warriors | PC | 1.0 | Original | | | |
| Savage: The Battle for Newerth | PC | 1.0 | Original | | | |
| Saw | XBOX360 | | Original | | KN-2050 | |
| Saw II: Flesh & Blood | XBOX360 | | Original | | KN-2082 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| SBK: Superbike World Championship | PSP | 1.01 | Original | | ULUS-10395 | |
| Scaler | GC | | Original | | DL-DOL-GKUE-USA | |
| Scaler | PS2 | 1.00 | Original | | SLUS-20957 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Scarface: The World Is Yours | PC | 1.00.1 | Original | | | |
| Scene It? Bright Lights! Big Screen! | XBOX360 | | Original | | WR-2038 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCX-CAN-B0 | |
| Scene It? Bright Lights! Big Screen! | PS3 | 01.02 | Original | | BLUS-30448 … | |
| Scene It? Bright Lights! Big Screen! | XBOX360 | | Original | | WR-2037 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCE-USA-B0 | |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| Schizm: Mysterious Journey (Side A) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Side B) | PC | | DVD-ROM Edition | | | |
| School Tycoon | PC | | Scholastic | | P/N: CDR 21661-1R | |
| School Tycoon | PC | | Original | | | |
| Schoolhouse Rock! America Rock | PC | | Original | | 21080CD | |
| Schoolhouse Rock! Grammar Rock | PC | | Original | | 9227 | |
| The Sci-Fi Collection | PC | | Original | | | |
| Science Fiction: The Ultimate Collection (Disc 1) | PC | | | | 11014 | |
| Science Papa | WII | | Original | | RVL-RZEE-USA-B0 | |
| Scissors 'n' Stones | PC | | Original | | | |
| Scooby-Doo! | IXL | 1.0.0 | Original | | R9709 | |
| Scooby-Doo! and the Spooky Swamp | WII | | Original | | RVL-SJ2E-USA-B0 | |
| Scooby-Doo! First Frights | PS2 | 1.00 | Original | | SLUS-21900 | |
| Scooby-Doo! Jinx at the Sphinx | PC | | Scholastic | | 380849-CD | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.01 | Original | | 380849A-CD | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.02 | | | 380849B-CD | |
| Scooby-Doo! Mystery Mayhem | PS2 | 1.00 | Original | | SLUS-20701 | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Night of 100 Frights | XBOX | | Original | | TQ-031 | |
| Scooby-Doo! Night of 100 Frights | GC | Rev 1 | Original | | DL-DOL-GIHE-USA | |
| Scooby-Doo! Phantom of the Knight | PC | 1.0 | Original | | 380325-CD | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DE-USA | |
| Scooby-Doo! Unmasked | PS2 | 1.01 | Original | | SLUS-21091 | |
| Scooby-Doo! Who's Watching Who? | PSP | 1.01 | Original | | ULUS-10168 | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Scorched Planet | PC | | Bundle Version Matrox OEM | | /MYST-CD/GA1/01 | |
| Scorched Planet | PC | | Original | | | |
| Scorcher | SS | 1.008 | Original | | 81214 | |
| Score 4 | PC | | Original | | | |
| Score International Baja 1000: The Official Game | PC | | Original | | 35619./101.US | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Score International Baja 1000: The Official Game | PS2 | 1.00 | Original | | SLUS 21850 | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| The Scorpion King: Rise of the Akkadian | PS2 | 1.03 | Original | | SLUS-20424 | |
| Scrabble | PC | | General Mills | | | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble | PSP | 1.00 | Original | | ULUS-10412 | |
| Scrabble Complete | PC | | Cosmi | | CDRZ652D1, SJ122005 | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble: Champion Edition | PC | | Original | | 11191A-CD v1.0 S | |
| Scrabble: Champion Edition | PC | 1.0S | Rerelease | | 11191B-CD | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Scrabble: Crossword Game | MAC | 1.0.0.52 | Original | | P/N 10328-5 | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Rerelease | | | |
| Screamer | PC | | White Label | | | |
| Scribblenauts Unlimited | PC | | Original | | 5000145356 | |
| The Scroll | PC | | | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.0 | Original | | | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Sea Monsters: A Prehistoric Adventure | PS2 | 1.01 | Original | | SLUS-21741 | |
| Sea-Doo Hydro Cross | PSX | | Original | | SLUS-01149 | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Seal of Evil | PC | | Original | | 904066DVD | |
| Search & Rescue 3 | PC | 1.0.0.0 | Original | | | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Season Ticket Baseball 2003 | PC | 1.0 | Original | | 04-23416CDSL | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| Secret Agent Barbie | PC | 1.0c | Original | | S7127810 | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The Secret of Monkey Island | MCD | | Original | | T-60035 | |
| The Secret of Monkey Island | PC | 2.3 | Original | | 2147010-590001 / I 042 | |
| The Secret of the Silver Earring (Disc 1) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of the Silver Earring (Disc 2) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| The Secret Saturdays: Beasts of the 5th Sun | PSP | 1.00 | Original | | ULUS-10443 | |
| The Secret Saturdays: Beasts of the 5th Sun | PS2 | 1.01 | Original | | SLUS-21896 | |
| Secret Service: Security Breach | PC | 1.1 | Original | | 31035.101.US | |
| Secret Weapons of the Luftwaffe | PC | | Original | | 2156010-590001/I042, CDRM1003790 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Secret Weapons over Normandy (Disc 1) | PC | 1.0 | Original | | 2101830 | |
| Secret Weapons over Normandy (Disc 2) | PC | 1.0 | Original | | 2101831 | |
| Secret Weapons over Normandy (Disc 3) | PC | 1.0 | Original | | 2101832 | |
| Secret Weapons over Normandy (Disc 4) (Play Disc) | PC | 1.0 | Original | | 2101833 | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Atlantis (Disc 1) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 2) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 3) | PC | | Original | | PC0549CD SNY 2.0 | |
| Secrets of Great Art | PC | 1.1 | Original | | P/N 61218-CD | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Secrets of the Ark: A Broken Sword Game (Disc 1) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 2) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 3) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the East | PC | | Scholastic | | P/N CDR9909538 | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Section 8 | PC | | Original | | 50027-LBL | |
| Section Z Capcom Classics: Section Z | PC | 1.0 | PDA | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Sega Ages Volume 1 | SS | 1.001 | Original | | T-12707H | |
| Sega Bass Fishing 2 | DC | 1.080 | Original | | 51166 | |
| Sega Classics Arcade Collection | MCD | 1.01 | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | 4126 | |
| Sega Genesis Classic Collection: Gold Edition | PC | 1.0.019 | Original | | | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega GT 2002 | XBOX | | Original | | SE-003 | |
| Sega GT Online | XBOX | | Original | | SE-033 | |
| Sega Marine Fishing | DC | 1.001 | Original | | 51096 | |
| Sega Puzzle Pack | PC | | Expert Software | | 682701.101.US | |
| Sega Puzzle Pack | PC | | Rerelease | | 85091 / FS22923 | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Sega Rally 2 (Disc 1) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0919 | |
| Sega Rally 2 (Disc 2) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally Championship | PC | 1.0 | Original | | 85048 | |
| Sega Rally Championship Plus Netlink Edition | SS | 1.001 | Net Link Game Pack | | 81215, 81608 | |
| Sega Rally Revo | PSP | 1.00 | Original | | ULUS-10311 | |
| Sega Smash Pack | PC | | Original | | 85087 | |
| Sega Smash Pack | PC | 1.0 | Expert Software | | 682601.101.US | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| Sega Soccer Slam | PS2 | 1.00 | Original | | SLUS-20509 | |
| Sega Superstars | PS2 | 1.00 | Original | | SLUS 20999 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | 85067 | |
| Sega Worldwide Soccer '97 | SS | 1.001 | Original | | 81112 | |
| Sengoku Rance 戦国ランス | PC | 1.07 | Limited Edition | | MG-AS-RE-004 | |
| Sensei 2 | PC | | Original | | GC-007 | |
| Sentient | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Rerelease | | CD-W58-1103-1 | |
| Serious Sam | XBOX | | Original | | TT-004 | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| Serious Sam Gold (Disc 1) | PC | 1.05 | Original | | | |
| Serious Sam Gold (Disc 2) | PC | 1.05 | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| Serious Sam: The First Encounter | PC | | | | | |
| Serious Sam: The First Encounter | PALM | | Original | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| The Settlers: Heritage of Kings | PC | 1.01.0163 | Original | | 682011-DVD | |
| The Settlers: Rise of an Empire | PC | 1.0.4140 | Original | | | |
| The Settlers: Rise of an Empire | PC | 1.0.4140.0 | Scholastic | | P/N DVD5107350 | |
| Seven Games of the Soul (Disc 1) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 2) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 3) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 4) Faust | PC | | Original | | | |
| Seven Kingdoms | PC | 1.1 | Colección 'Juega y Aprende' | | | |
| Seven Kingdoms: Conquest | PC | 1.00 | Original | | DVD580CD | |
| Seven Samurai 20XX | PS2 | 1.00 | Original | | SLUS 20621 | |
| Seventh Cross Evolution | DC | 1.000 | Original | | T-41301N | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Original | | T-6201 | |
| Shadow Company: Left for Dead | PC | 1.0 | Original | | 5051802 | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow Force: Razor Unit | PC | | Special Forces Pack | | SFRU-0414 | |
| Shadow Man | PC | | Original | | | |
| Shadow Man | DC | 1.001 | Original | | T-8106N | |
| Shadow Man | DC | 1.010 | Original | | T-8106N | |
| Shadow Man: 2econd Coming | PS2 | 1.03 | Original | | SLUS-20413 | |
| Shadow of the Beast | PCE | | Original | | TGXCD1018 | |
| Shadow of the Beast II | MCD | | Original | | T-113045 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-037 | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Gold Medal 12 CD Pack | | MQ 13-004-116 | |
| Shadow Wolf Mysteries: Curse of the Full Moon / Bane of the Family | PC | | | | 33425010US | |
| Shadowbane: The Rise of Chaos | PC | | Original | | 651727-CD | |
| ShadowCaster | PC | | Top Ten Pak II | | 5454 | |
| ShadowGate Classic | PPC | 1.0.0.4 | Original | | 5053626 | |
| Shadowgrounds (Disc 1) | PC | 1.01 | Original | | 000046-CD1 | |
| Shadowgrounds (Disc 2) | PC | 1.01 | Original | | 000046-CD2 | |
| Shadowlands | PC | | Megapak 2 | | | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| Shadowrun Returns (Game Disc) | PC | | Original | | | |
| Shadows of Cairn | PC | | Rerelease | | | |
| Shadows of Cairn | PC | 1.0.022 | Rerelease | | ROM-53337 | |
| Shakii the Wolf | PC | | Original | | | |
| Shanghai Double Pack | PC | | Original | | | |
| Shanghai II: Dragon's Eye | PC | 1.05 | 2 for 1 | | CDD-3044-101-U3 | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shanghai: Great Moments | PC | 2.00 | Bundle Version Canon OEM | | | |
| Shannara | PC | 1.0.0 | Original | | | |
| Shannara | PC | 1.0 | Rerelease | | 7-81055-33802-6 | |
| Shape Shifter | PCE | | Original | | TGXCD1021 | |
| Shape Shifter | PC | | Original | | | |
| Shattered Steel | PC | 1.0 | Original | | CD-ICD-201-0 | |
| Shattered Steel | PC | 1.00 | Original | | CD-ICD-201-0 | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-1 | |
| Shattered Steel | PC | 1.12 | Rerelease | | CD-ICD-732-0 | |
| Shattered Union | XBOX | | Original | | TT-131 | |
| Shaun Palmer's Pro Snowboarder | PS2 | 1.00 | Original | | SLUS-20199 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shaun White Skateboarding | WII | | Original | | RVL-SHNE-USA-B0 | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| Shaun White Snowboarding | PS3 | 01.01 | Target Limited Edition | | BLUS-30233 | |
| Shaun White Snowboarding | PS2 | 1.01 | Original | | SLUS 21853 | |
| Shaun White Snowboarding | PSP | 1.01 | Original | | ULUS 10399 | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NE-USA-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| ShellShock 2: Blood Trails | PC | 1.0 | Original | | 5000026211 | |
| ShellShock: Nam '67 | PC | 1.00 | Original | | MSHOCPUS01 | |
| ShellShock: Nam '67 | PS2 | 2.00 | Original | | SLUS-20828 | |
| Shepherd's Crossing | PSP | 1.00 | Original | | ULUS-10499 | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | PC | | Original | | | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | XBOX360 | | Original | | JW-2003 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Rerelease | | CDRM 835400 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 2 | Original | | CDRM 770000 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 5.1 | 5 ft. 10 PAK Vol. 2 | | CD 7012 SPI | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. II | PCE | | Original | | TGXCD1039 | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| Sherlock Holmes: Consulting Detective: Vol. III | PC | 4 | Original | | CDRM1061930 | |
| Sherlock Holmes: Crimes & Punishments | XBOX360 | | Original | | FE-2015 | |
| Sherlock Holmes: Nemesis (Disc 1) | PC | 1.00.0777 | Original | | PCO589CD1, SNY 1.0 | |
| Sherlock Holmes: Nemesis (Disc 2) | PC | 1.00.0777 | Original | | PCO589CD2, SNY 1.0 | |
| The Shield: The Game | PC | 1.0.0.0 | | | 11451-1DDA | |
| Shifters | PS2 | 1.02 | Original | | SLUS 20271 | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shin Megami Tensei: Persona | PSP | 1.00 | Original | | ULUS-10432 | |
| Shining Force EXA | PS2 | 1.00 | Original | | SLUS-21567 | |
| Shinobi Legions | SS | 1.000 | Original | | T-2301H | |
| The Ship | PC | | Original | | | |
| Shiren the Wanderer | WII | | Original | | RVL-RFSE-USA-B0 | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.00 | | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | 831744330/S174150 | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shockwave Assault | SS | 1.000 | Original | | T-5005H | |
| Shogo: Mobile Armor Division 昇剛 | PC | 1.0 | Original | | | |
| Shogo: Mobile Armor Division | PC | 2.2 | Bundle Version Creative Labs OEM | | 1713310341 | |
| Shogun: Total War (Disc 1) | PC | | Rerelease | | 798727 | |
| Shogun: Total War: Gold Edition | PC | 1.00 | Total War: Eras | | SYX26218GM1 | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shonen Jump's One Piece: Pirates' Carnival | PS2 | 1.00 | Original | | SLUS-21364 | |
| Shonen Jump's Shaman King: Power of Spirit | PS2 | 1.00 | Original | | SLUS-20953 | |
| Shooting Gallery | PALM | | Original | | | |
| Short Track Racing: Trading Paint | PS2 | 1.00 | Original | | SLUS 21857 | |
| Showdown: Legends of Wrestling | XBOX | | Original | | AC-029 | |
| Showdown: Legends of Wrestling | PS2 | 1.01 | Original | | SLUS-21017 | |
| Shox | PS2 | 1.00 | Original | | SLUS-20533 | |
| Shrek | XBOX | | Original | | TM-001 | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| Shrek 2 | PC | | Original | | 32585.101.US | |
| Shrek 2 | PC | | | | 32585.101.US | |
| Shrek 2: Team Action | PC | 1.0 | Original | | 32789.101.US | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9E-USA | |
| Shrek Game Land Activity Center | PC | | Original | | 32053.101.US | |
| Shrek Super Party | XBOX | | Original | | TM-004 | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYE-USA | |
| Shrek Super Party | PS2 | 1.00 | Original | | SLUS 20516 | |
| Shrine Circus Tycoon | PC | | | | 31933.101.US | |
| Shutter Island: The Adventure Game | PC | 1.0.0 | Original | | | |
| Sid Meier's Alien Crossfire | PC | | Original | | 1405807 | |
| Sid Meier's Alpha Centauri | MAC | RELEASE 4.0 | Original | | | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Linux | | | |
| Sid Meier's Civil War Collection | PC | 1.00f | | | 1225507 | |
| Sid Meier's Civilization Chronicles (Disc 1) | PC | | Original | | 31074-1.1 | |
| Sid Meier's Civilization Chronicles (Disc 2) | PC | | Original | | 31074-1.2 | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| Sid Meier's Civilization II | PC | 2.42 | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Risk: Gold Edition | | Product # 99227 | |
| Sid Meier's Civilization II | PC | 2.42a | Infogrames Rerelease | | | |
| Sid Meier's Civilization III | PC | 1.29f | Game of the Year Edition (Rerelease) | | | |
| Sid Meier's Civilization III | PC | 1.29f | Scholastic | | P/N CDR9640733 | |
| Sid Meier's Civilization III Complete | MAC | 1.22 | Original | | 11180-1DDA | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Original | | 25766CD1 | |
| Sid Meier's Civilization III Complete (Disc 2) (Play the World) | PC | | Original | | 25766CD2 | |
| Sid Meier's Civilization III Complete (Disc 3) (Conquests) | PC | | Original | | 25766CD3 | |
| Sid Meier's Civilization IV: Beyond the Sword | MAC | | Original | | 12090-1DDA | |
| Sid Meier's Civilization VI | PC | | Original | | 41829-1 | |
| Sid Meier's Civilization: Beyond Earth | PC | | Original | | 41403-1 | |
| Sid Meier's Colonization Sid Meier's Colonization: Create a New Nation | PC | 3.141592 | Rerelease | | P/N 70119 | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDE-USA-B0 | |
| Sid Meier's Pirates! | PSP | 1.02 | Original | | ULUS-10224 | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Sid Meier's Railroad Tycoon | PC | 455.03 | RomZōn! | | 0-447-40-101 | |
| Sid Meier's SimGolf | PC | 1.01 | EA Classics | | CD 796 | |
| Sid Meier's SimGolf | PC | | Rerelease | | 1641547 | |
| Siege | PC | 1.2 | | | | |
| Siege of Avalon Anthology | PC | 1.1.2001.913 | Original | | | |
| Sierra Pro Pilot (Disc 1) | PC | 1.0 | Original | | | |
| Sierra Pro Pilot (Disc 2) | PC | 1.0 | Original | | | |
| Silent Heroes: Elite Troops of WWII | PC | 1.0.29.0 | Original | | | |
| Silent Hill 2: Restless Dreams | XBOX | | Platinum Hits | | KN-004 | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | S2344310 | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | S2344310 | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-R5WE-USA-B0 | |
| Silent Hill: Shattered Memories | PSP | 1.00 | Original | | ULUS-10450 | |
| Silent Hunter | PC | 1.0 | Rerelease | | WWD144AE-CD | |
| Silent Hunter 4: Wolves of the Pacific Silent Hunter 4: Wolves of the Pacific: U-Boat Missions | PC | 1.5 | Gold Edition | | 684589-DVD1 | |
| Silent Hunter: Commander's Edition | PC | 1.31 | Original | | 2211110-590004 | |
| Silent Hunter: Commander's Edition | PC | 1.31 | Ultimate Wargame Collection Volume 2: World War II | | 379280-CD2 | |
| Silent Hunter: Wolves of the Pacific | PC | 1.2.0.0 | Original | | 683438-DVD1 | |
| Silent Line: Armored Core | PS2 | 1.00 | Original | | SLUS-20644 | |
| Silent Scope | DC | 1.000 | Original | | T-9507N | |
| Silent Scope 2: Dark Silhouette | PS2 | 1.00 | Original | | SLUS-20243 | |
| Silent Scope 3 | PS2 | 1.00 | Original | | SLUS-20514 | |
| Silent Steel | PC | 1.82.42.100 | DVD-ROM | | | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.00 | Original | | | |
| Silkolene Honda Motocross GP | PC | 1.0 | Original | | 13030 | |
| Silver | DC | 1.001 | Original | | T-15108N | |
| Silver (Disc 1) | PC | 1.08C | | | | |
| Silver (Disc 2) | PC | 1.08C | | | | |
| The Silver Case | PC | 1.01 | Limited Run Games Limited Edition | | | |
| SimAnimals: Africa | WII | | Original | | RVL-R7AE-USA-B0 | |
| SimAnt | PC | | Scholastic | | 5710346C SP2 | |
| SimCity 2000 Network Edition | PC | 1.0.42.0 | Megapak 8 | | 01130-059-0601 | |
| SimCity 2000 Special Edition | PC | 1.0 | CD-ROM Classics | | 1131107 | |
| SimCity 2000: CD Collection | PC | 1.0 | Original | | | |
| SimCity 2000: CD Collection | PC | 1.2 | Windows | | 0026-000-0601-A | |
| SimCity 2000: CD Collection | PC | 1.2cj | Windows | | 0026-000-0601-A | |
| SimCity 3000 | PC | | Linux | | | |
| SimCity 3000 | PC | | Pre-Order Bonus | | 4083407 | |
| SimCity 3000 | PC | | Scholastic | | 1500107 | |
| SimCity 3000 | MAC | 1.0.557 | Original | | 1500607 | |
| SimCity 3000 | PC | 1.2.673.0 | Rerelease | | 1500117 | |
| SimCity 3000 Unlimited | PC | | Bundle Version Compaq OEM | | 1500907, 239478-001 | |
| SimCity 3000 Unlimited | PC | 2.0.949 | Scholastic | | 1500907 | |
| SimCity 4 (Disc 1) | PC | 1.0 | Original | | MXB08803894CD1 | |
| SimCity 4 (Disc 2) | PC | 1.0 | Original | | MXB08803894CD2 | |
| SimCity 4 (Disc 1) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 4 (Disc 1) | PC | 1.0 | Cosmi | | 1474007, CDR123D1 | |
| SimCity 4 (Disc 2) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 4 (Disc 2) | PC | 1.0 | Cosmi | | 1474017, CDR123D2 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | | Original | | 1474007 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | 1.0 | Scholastic | | CDR5034957 | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | | SimCity Box | | 1907327 | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | 1.0 | Scholastic | | CDR5034957 | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | 1.1.610.0 | SimCity Box | | 1907327 | |
| SimCity Classic | PC | | Collector's Series | | 0002-000-0612-A | |
| SimCity Creator | WII | | Original | | RVL-R4CE-USA | |
| SimCity Enhanced CD-ROM | PC | | Rerelease | | CD-ICD-204-0 | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| SimCity Enhanced CD-ROM | PC | | Original | | CD-ICD-041-0 | |
| SimCity Enhanced CD-ROM | PC | 1.0 | Rerelease | | CD-ICD-508-0 | |
| SimClassics: 3 in 1 Pack | PC | | Original | | 0543-000-0601-A | |
| SimClassics: Maxis Collections 2 | PC | | Original | | 0092-000-0601-A | |
| SimCoaster | PC | | Scholastic | | 14257?7 | |
| SimCoaster | PC | | Rerelease | | 14257?7 | |
| SimEarth: The Living Planet | PCE | | Original | | TGXCD1036 | |
| SimGolf | PC | 1.0 | Original | | 0093-000-0601-A | |
| SimIsle: Missions in the Rainforest | PC | 1.0 | Original | | 0058-030-0901 | |
| SimLife SimLife: The Genetic Playground | PC | | Rerelease | | | |
| Simon the Sorcerer | PC | 1.00 | Original | | | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| The Simpsons Game | PSP | 1.00 | Original | | ULUS-10295 | |
| The Sims 2 | XBOX | | Original | | EA-907 | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| The Sims 2 | PSP | 1.00 | Original | | ULUS-10031 | |
| The Sims 2 (Disc 1) | PC | 1.0 | Original | | 1472607 | |
| The Sims 2 (Disc 1) | PC | 1.0.0.1005 | Rerelease | | 1472647 | |
| The Sims 2 (Disc 2) | PC | 1.0.0.1005 | Rerelease | | 1472657 | |
| The Sims 2 (Disc 3) | PC | 1.0.0.1005 | Rerelease | | 1472667 | |
| The Sims 2 (Disc 3) | PC | 1.0.0.932 | Original | | 1472627 | |
| The Sims 2 (Disc 4) | PC | 1.0 | Original | | 1472637 | |
| The Sims 2 (Disc 4) | PC | 1.0.0.1005 | Rerelease | | 1472677 | |
| The Sims 2: Castaway | PSP | 1.00 | Original | | ULUS 10296 | |
| The Sims 2: Deluxe | PC | 1.0.0.1068 | Original | | 1672907 | |
| The Sims 2: Double Deluxe The Sims 2: Store Edition | PC | 2.0 | Rerelease | | 1597037 | |
| The Sims 2: Holiday Edition (Disc 1) | PC | 1.0.0.1022 | 2006 Edition | | 1527607 | |
| The Sims 2: Holiday Edition (Disc 1) | PC | 1.0.0.1048 | Original | | 1518907 | |
| The Sims 2: Holiday Edition (Disc 2) | PC | 1.0.0.1048 | Original | | 1518917 | |
| The Sims 2: Holiday Edition (Disc 3) | PC | 1.0.0.1048 | Original | | 1518927 | |
| The Sims 2: Holiday Edition (Disc 4) | PC | 1.0.0.1048 | Original | | 1518937 | |
| The Sims 2: Pets | PSP | 1.00 | Original | | ULUS 10130 | |
| The Sims 3 | PC | | Original | | | |
| The Sims 3: Pets | PS3 | 01.00 | Original | | BLUS-30803 | |
| The Sims Carnival: BumperBlast | PC | 1.0.10 | Original | | 1586907 | |
| The Sims Castaway Stories | PC | 1.0 | Original | | 1575007 | |
| The Sims Online (Disc 1) | PC | 1.0 | Charter Edition | | 1461517 | |
| The Sims Online (Disc 2) | PC | 1.0 | Charter Edition | | 1461527 | |
| The Sims | XBOX | | Original | | EA-047 | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims Mandrake Linux Gaming Edition (The Sims for Linux) | PC | | Linux (Mandrake Linux Gaming Edition) | | | |
| The Sims | MAC | | | | | |
| The Sims | MAC | | | | | |
| The Sims: Complete Collection (Disc 1) | PC | 1.0 | Original | | 1647407 | |
| The Sims: Complete Collection (Disc 2) | PC | 1.0 | Original | | 1647417 | |
| The Sims: Complete Collection (Disc 2) | PC | 1.0 | Original | | 1647417 | |