Region | Title | System | Version | Edition | Languages | Serial | Status |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.2 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Sly 3: Honor Among Thieves | PS2 | 1.00 | Demo | | SCUS 97484 | |
| Small Soldiers | PSX | | Preview | | | |
| Smart Games: Challenge 1 | PC | | Rerelease | | 99168 | |
| Smart Games: Challenge 1 | PC | | Original | | P/N:DSGC1CD0001 | |
| Smart Steps: Kindergarten | PC | | Rerelease | | P/N: LDSMASTKIJ | |
| Smart Steps: Kindergarten | PC | 1.0 | Original | | | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |
| Smashing Drive | XBOX | | Original | | NM-001 | |
| SMBX + Tak 2 Art | PC | | Press Kit | | | |
| The Smelly Mystery | PC | 1.0 | Original | | 04-12328CD | |
| Smilingüido em: Desafio na Floresta | PC | | Original | | | |
| Smoking Guns Smoking Guns: Shooting Gallery! | PC | 1.0 | Cosmi | | 02-2503-10 | |
| The Smurfs 2 | XBOX360 | | Original | | US-2237 | |
| The Smurfs 2 | WII | | Original | | RVL-S2XE-USA-B0 | |
| Snap Dragon | PC | 1.0 | Original | | | |
| Snap! 3D Bowling | PC | | Original | | | |
| Snap! 400 Word Searches | PC | | Original | | CS-296 | |
| Snap! Pinball | PC | | Original | | | |
| Snap! Pool Perfect Pool | PC | 1.1 | Original | | | |
| Snap! Subtraction: Ages 5-8 | PC | | Original | | | |
| Sneakers | XBOX | | Original | | MS-035 | |
| Sniper Elite | XBOX | | Original | | MI-013 | |
| Sniper Elite III | XBOX360 | | Original | | FO-2051 | |
| Sniper Elite V2 | XBOX360 | | Original | | FO-2024 | |
| Sniper: Ghost Warrior | PC | | Original | | L0001US | |
| SNK NeoGeo USA Consumer Corporation: E3 2004 Games | PC | | Press Kit | | | |
| SNK Playmore E3 2006 Games | PC | | Press Kit | | | |
| Snoopy vs. the Red Baron | PC | | Original | | | |
| Snoopy's Campfire Stories | PC | | Original | | | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| Snow Drop | PC | | Original | | P-002 | |
| Snow Sakura | PC | | Original | | GC030 | |
| Snowboard Park Tycoon | PC | | | | 30983.101.US | |
| SnowJob Starring Tracy Scoggins (Disc 2) | 3DO | | Original | | | |
| So Who's Dr. Rabbit? | PC | | Original | | | |
| Soccer America: International Cup | PS2 | 1.00 | Original | | SLUS-20196 | |
| SocketScan | PALM | Release 108K | Original | | P/N 6210-00108 K | |
| SOCOM: U.S. Navy SEALs | PS2 | 1.00 | Public Beta v1.0 | | SCUS 97859 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo | PSP | 1.00 | Public Beta v1.0 | | UCUS 98637 | |
| Sócrates en la Casa del Terror Sócrates en la Casa Embrujada | PC | | Covermount | | | |
| Soft Kill | PC | | Original | | | |
| Software & Document: Master CD for Video Family | PC | 1.20 | Bundle Version Jaton OEM | | | |
| The Software Toolworks CD Deluxe Pack: Version 2 | PC | | Bundle Version Packard Bell OEM | | 2192611-590001 170122 | |
| The Software Toolworks' Star Wars Chess | PC | 1.00 | Bundle Version OEM | | 13-004-060 | |
| Sol-Feace | MCD | RE | Bundled with Sega CD | | 4130 | |
| Soldier of Fortune | PC | 1.03 | Bundle Version ASUS OEM | | 1000910.101.US | |
| Soldier of Fortune | PC | 1.03 | Bundle Version ASUS OEM | | | |
| Soldier of Fortune: Payback | XBOX360 | | Original | | AV-2050 | |
| Soldiers at War | PC | | Preview | | | |
| Soldiers of Anarchy | PC | | Original | | S5280010 | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | PC | | Rerelease | | 517-05-232 | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | PC | | Rerelease | | | |
| Solid State Pinball: Crystal Caliburn | PC | | Rerelease | | 517-05-232 | |
| Solitaire Antics | PC | 1.0 | Original | | | |
| Solitaire Antics Ultimate | PC | 1.0.3L | Original | | | |
| Solitaire Games | PC | | GSP | | 92534-A | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| Solitaire Master 4 | PC | 1.0 | Original | | 02-8156-10 | |
| Solitaire Master 5 | PC | 1.0 | Original | | 02-2153-10 | |
| Sonic & Knuckles Collection | PC | | Expert Software | | 6820 01 | |
| Sonic & Knuckles Collection | PC | | Expert Software | | 6820 01 | |
| Sonic & Sega All-Stars Racing with Banjo-Kazooie | XBOX360 | | Original | | SE-2069 | |
| Sonic 3D Blast | PC | 1.0 | Expert Software | | 6822 01 | |
| Sonic Adventure | DC | 1.000 | Trial Version for E3 | | HDR-0001 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | 51117 | |
| Sonic and the Secret Rings Comic Book DVD from Archie Comics | PC | | | | | |
| Sonic CD | MCD | | Original | | | |
| Sonic CD | MCD | | Original | | 4407 | |
| Sonic CD | PC | | Expert Software | | 6805 01 | |
| Sonic CD | MCD | 1.15 | Beta | | | |
| Sonic Heroes | XBOX | | Platinum Family Hits | | SE-043 | |
| Sonic Mega Collection Plus | PS2 | 0.80 | Beta | | | |
| Sonic MegaMix | MCD | | Unlicensed | | | |
| Sonic Riders | XBOX | | Original | | SE-135 | |
| Sonic Riders (Disc 1) | PC | 1.0 | Scholastic | | P/N CDR5047633 | |
| Sonic Unleashed | XBOX360 | | Original, Platinum Hits | | SE-2066 | |
| Sonic's Ultimate Genesis Collection | XBOX360 | | Platinum Hits | | SE-2064 | |
| Sonny's Race for Chocolatey Taste | PC | | General Mills | | A38341 | |
| Sony E3 2004: Press Information | PC | | Press Kit | | | |
| Sony PlayStation 2: SCEA Santa Monica Studios: 2004 Press Information: Press Print | PC | | Press Kit | | | |
| Sorting Adventures: Interactive Activities | PC | | Original | | AAP899, PP463 | |
| Soulbringer (Disc 1) | PC | 1.0.0.1 | Original | | | |
| Soulbringer (Disc 2) | PC | 1.0.0.1 | Original | | | |
| Soulbringer (Disc 1) | PC | | Original | | CD-C95-1077-0 | |
| Soulcalibur II | XBOX | | Demo | | NM-003 | |
| Soulcalibur II | PS2 | 1.00 | Demo | | SLUS 29058 | |
| Soultrap | PC | | Original | | | |
| Sounds Best on Sound Blaster Every Game Sounds Best on Sound Blaster: 24-bit Advanced HD | PC | | | | | |
| Soundtrack1: The Definitive Xbox Compilation (Disc 2) | PC | | Original | | 314 584 098 2 | |
| South Park: The Fractured But Whole (Disc 1) | PC | | Gold Edition | | UBP60802045-DISC1 | |
| South Park: The Fractured But Whole (Disc 2) | PC | | Gold Edition | | UBP60802045-DISC2 | |
| South Park: The Fractured But Whole (Disc 3) | PC | | Gold Edition | | UBP60802045-DISC3 | |
| Soviet Strike | PSX | Rev 1 | Greatest Hits | | SLUS-00061 | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | 2.0 | | | SANSARL-01 | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM (PC and Compatibles) Don Bluth's Space Ace | PC | | Original | | | |
| The Space Bar (Disc 1) | PC | 1.0 | Original | | 115-7G | |
| The Space Bar (Disc 1) | MAC | 1.0 | Original | | 115-7H | |
| The Space Bar (Disc 2) | PC | 1.0 | Original | | 115-7I | |
| The Space Bar (Disc 3) | PC | 1.0 | Original | | 115-7J | |
| Space Chimps | XBOX360 | | Original | | BT-2004 Version: 1. | |
| Space Colony | PC | | Original | | | |
| Space Dudes | PC | | Original | | | |
| Space Hulk: Vengeance of the Blood Angels | SS | 1.000 | Original | | T-5007H | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | Beta 8 | Beta (CD-R) | | | |
| Space Invaders | PSX | | Review | | | |
| Space Jam | PC | 1.00 | Original | | | |
| Space Quest: Collector's Edition Space Quest: 15th Anniversary Collector's Edition | PC | | Original | | | |
| Space Ranger | CDI | | Unlicensed | | OGCDI-1180 | |
| Space Rangers | PC | 1.7.2 | Cinemaware Marquee | | 02-1506-12 | |
| Space Shuttle | PC | | Original | | CDRM1109910 | |
| Space Shuttle | MAC | | Original | | CDRM1087300 | |
| Space Shuttle The Software Toolworks Presents... Space Shuttle | PC | Rev A | Bundle Version OEM | | RVL 13-004-073 | |
| Space Sirens | PC | | Original | | SKU: UN017 | |
| Space Station Tycoon | WII | | Prototype | | | |
| SpaceChem | PC | 1011 | Original | | | |
| SpaceChem | PC | 1012 | Limited Edition | | | |
| Spaceship Warlock | PC | 1.1.3 | Original | | | |
| Spartan: Total Warrior | XBOX | | Original | | SE-139 | |
| Spartan: Total Warrior | XBOX | | Review | | | |
| Spawn: Armageddon | XBOX | | Original | | NM-012 | |
| Spec Ops: Rangers Lead the Way | PC | | Demo | | CD-RC008 | |
| Spec Ops: The Line | PC | | Premium Edition | | 41152-1 | |
| Spectral Force 3 | XBOX360 | | Original | | AT-2003 | |
| Spectre VR CD | MAC | | Original | | | |
| Spectre VR Classic | PC | | Original | | MQ 13-004-120 | |
| Speed Busters | PC | 1.02 | Demo | | | |
| Speed Freaks (Misc Artwork: PC-CD 2nd July '99) | PC | | Press Kit | | | |
| Speed Kings | XBOX | | Original | | AC-011 | |
| Speed Thief X3D Speed Thief | PC | | X3D | | | |
| Speedboat Attack | PC | 1.0.3.1 | Original | | | |
| Speedy Eggbert II | PC | 1.0 | Original | | | |
| SpellForce: Universe (Disc 1) | PC | 1.52 | Original | | DVD564CD | |
| SpellForce: Universe (Disc 2) | PC | 2.00 | Original | | DVD563CD | |
| Spelunky | PC | | Fangamer (Collector's Edition) | | | |
| Sphinx and the Cursed Mummy | XBOX | | Original | | TQ-035 | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSME-USA | |
| Spider-Man | XBOX | Rev 1 | Platinum Hits | | AV-006 | |
| Spider-Man 2 | PC | | Demo | | | |
| Spider-Man 3 | PS2 | 2.00 | Greatest Hits | | SLUS-21552 | |
| Spider-Man: Friend or Foe | XBOX360 | | Original | | AV-2042 | |
| Spider-Man: Web of Shadows | XBOX360 | | Original | | AV-2069 | |
| The Spiderwick Chronicles | XBOX360 | | Bundled with Audiobook | | VU-2022 | |
| The Spiderwick Chronicles | WII | | Original | | RVL-R48E-USA | |
| Spikeout: Battle Street | XBOX | | Original | | SE-041 | |
| Spirit of Speed 1937 | DC | 1.001 | Original | | T-8118N | |
| Splashdown | XBOX | | Original | | IG-027 | |
| Splatt! | PC | | Original | | | |
| Spooky Castle | PC | 1.0 | Original | | 11-2057-10 SPC | |
| Sport Image: World Cup 1994 | PC | 2.0 | SoftKey | | WCF344AE-CD | |
| Sports Illustrated Kids: Baseball | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Skateboarding | PC | | Wendy's Kids' Meal | | | |
| Sports: Football | CD32 | | | | | |
| SportzFreakz | PC | 1.0 | Original | | | |
| SPRay | WII | | Beta | | | |
| Spring 2012 Refresh Standard: PS3 IDU 4.11 | PS3 | | Kiosk Demo | | | |
| Spring 2013: Standard IDU 4.31 | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2010: 3.21 IDU Update (E-M) | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2011 3.60 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Spy Fox in "Cheese Chase" | PC | | Original | | | |
| Spy Fox in "Dry Cereal" | PC | | Rerelease | | Part # 0001407 | |
| Spy Fox in "Dry Cereal" | PC | | Demo | | | |
| Spy Fox: "Operation Ozone" | PC | | Original | | | |
| Spy Fox: "Operation Ozone" | PC | | Rerelease | | pvaol008spyo | |
| Spy Kids Learning Adventures: The Candy Conspiracy | PC | | Original | | 03962 | |
| Spy Kids Learning Adventures: The Nightmare Machine | PC | | Original | | 03963 | |
| Spy vs. Spy | XBOX | | Original | | TT-124 | |
| Spyborgs | WII | | Beta | | | |
| Spycraft: The Great Game | PC | | Enhanced DVD-ROM Edition | | | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| SpyHunter 2 | XBOX | | Original | | MW-027 | |
| SpyHunter: Nowhere to Run | XBOX | | Original | | MW-055 | |
| SpyHunter: Nowhere to Run | PS2 | 1.00 | Preview | | | |
| Spyro the Dragon | PSX | | SCEE Preview | | | |
| Spyro the Dragon | PSX | | SCEA Preview | | | |
| Square Enix E3 2004 Media CD | PC | | Press Kit | | | |
| SquareSoft: E3 2001 Media CD | PC | | Press Kit | | | |
| Squeeballs Party | WII | | Original | | RVL-R6YE-USA-B0 | |
| SRS: Street Racing Syndicate | XBOX | | Original | | NM-019 | |
| SSI Strategy Collection: Critic's Choice Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| SSN-21 Seawolf Sea Wolf | PC | | Bundle Version Creative Labs OEM | | | |
| SSN-21 Seawolf | PC | | CD-ROM Classics: Gold Edition | | 5735 | |
| SSX 3 | XBOX | | Original | | EA-060 | |
| SSX Blur | WII | | Beta | | | |
| SSX on Tour | XBOX | | Original | | EA-130 | |
| SSX Tricky | XBOX | | Platinum Hits | | EA-004 | |
| Stacked with Daniel Negreanu | XBOX | | Original | | MM-001 | |
| The Stanley Parable (Installation Disc) | PC | | IndieBox | | | |
| Stanley's Sticker Stories | PC | 1.04 | Original | | 381428-CD4/I083ha | |
| Star Fighter | SS | 1.001 | Original | | T-8135H | |
| Star Fox Adventures: Game Preview CD | PC | | Promo | | | |
| Star Miner: Battle for Supremacy Asteroid Miner | PC | 1.30 FULL | Pocketware | | #9 | |
| Star Trek | XBOX360 | | Original | | NM-2139 | |
| Star Trek Pinball | PC | | Bundle Version OEM | | CD-C95-675-UNU | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Rerelease | | | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Original | | | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | | | CD-ICD-016-4 | |
| Star Trek: Armada | PC | 1.0 | Original | | | |
| Star Trek: Deep Space Nine: Dominion Wars | PC | 1.00 | Original | | | |
| Star Trek: Deep Space Nine: The Fallen | PC | 11-2000-a | Demo | | | |
| Star Trek: Judgment Rites | PC | | Limited CD-ROM Collector's Edition | | | |
| Star Trek: New Worlds (Explore New Worlds) | PC | | Limited Edition | | CD-C95-1097-DS | |
| Star Trek: Shattered Universe | XBOX | | Original | | TM-016 | |
| Star Trek: Starfleet Academy | PC | 1.15 | Bundle Version OEM (DVD-ROM) | | CD-DVD-069-GQE | |
| Star Trek: Starfleet Academy: Chekov's Lost Missions | PC | | Original | | | |
| Star Trek: Starship Creator Deluxe | PC | | Original | | 0-671-31776-8 | |
| Star Trek: Starship Creator Warp II | PC | 1.0 | Rerelease | | | |
| Star Trek: Starship Creator Warp II | PC | 1.0 | Original | | | |
| Star Trek: The Next Generation: Interactive Technical Manual | PC | 2.0 | Original | | | |
| Star Trek: Voyager: Elite Force | PC | 0.28 | Bundle Version Linksys OEM | | 1000912.101.US | |
| Star Warped | PC | | Original | | PAL-CD-10050A | |
| Star Wars Galaxies: 10-Day Trial | PC | | Original | | 8330530 | |
| Star Wars Galaxies: An Empire Divided (Disc 1) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 2) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 3) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: The Complete Online Adventures (Disc 1) | PC | | Original | | 8131830 | |
| Star Wars Trilogy CD-ROM: Limited Edition Entertainment Utility | PC | | Original | | | |
| Star Wars: Anakin's Speedway | PC | | Original | | #3518030 | |
| Star Wars: Battlefront II | PS2 | 1.01 | Beta | | SLUS-29164 | |
| Star Wars: Battlefront II | PS2 | 1.01 | Beta | | SLUS-21240 | |
| Star Wars: Battlefront II | PS2 | 2.00 | Greatest Hits | | SLUS 21240 … | |
| Star Wars: Behind the Magic: Vehicles Special Edition | PC | 1.0 | Original | | | |
| Star Wars: Dark Forces | PC | 1.0 Build 1 | Rerelease | | 3064130 | |
| Star Wars: Dark Forces | PC | 1.0L Build 1 | Star Wars Masterpieces | | 8031831 | |
| Star Wars: Demolition | DC | 1.001 | Original | | T-23003N | |
| Star Wars: Episode I: Cover Disk 4 | PC | | Press Kit | | | |
| Star Wars: Episode I: Disc #3: Covers | PC | | Press Kit | | | |
| Star Wars: Episode I: Jedi Power Battles | DC | 1.004 | Original | | T-23002N | |
| Star Wars: Episode I: Racer | PC | 1.0 | Limited Run Games | | | |
| Star Wars: Episode I: The Gungan Frontier | PC | | Demo | | #3519030 | |
| Star Wars: Fall Force Gaming Preview | PC | 1.0 | Original | | 8330330 | |
| Star Wars: Jedi Knight: Dark Forces II | PC | 1.0 | Star Wars Masterpieces | | 9991130 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Original | | 9521830 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Rerelease | | 9521830 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | Rerelease | | 9521831 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0 | Rerelease | | 9551830R | |
| Star Wars: Jedi Knight: Mysteries of the Sith Star Wars: Jedi Knight: Mysteries of the Sith: Companion Missions | PC | 1.0 | Star Wars: Jedi Knight: Dark Forces II | | 7101830 | |
| Star Wars: Jedi Starfighter | XBOX | | Original | | LA-005 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 1) (Play Disc) | PC | 2.00.424 | Original | | 3261830R1 v2.1.0.0 | |
| Star Wars: Rebel Assault | MAC | | Demo | | CDRM1209730 | |
| Star Wars: Rebel Strike Spike | SS | 1.000 | Prototype | | | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Rerelease | | 646130 | |
| Star Wars: Shadows of the Empire: Battle of Hoth | PC | | Bundle Version Diamond OEM | | 75000204-100 | |
| Star Wars: The Clone Wars | XBOX | | Original | | LA-004 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition | PS3 | 01.00 | Original | | BLUS-30445 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | 1.0 | Collector Series | | 8051832 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | 2088130 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | 1.00 | Original | | 2081831 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | 2088130R1 | |
| Star Wars: X-Wing vs. TIE Fighter: Balance of Power | PC | 2.0A | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | 2088131 | |
| Star Wars: X-Wing vs. TIE Fighter: Flight School | PC | 1.00 | Original | | 2085830 | |
| Star Wars: Yoda's Challenge | PC | | Original | | 3520030 | |
| Star Wars: Yoda's Challenge Activity Center | PC | | Demo | | #3529030 | |
| Starball | PC | 1.20 | Original | | | |
| StarCraft | PC | | BestSeller Series | | 334854216691 /1 | |
| StarCraft (PDF Manual) | PC | | BestSeller Series | | 334854216691 /3 | |
| StarCraft II: Heart of the Swarm | PC | | Original | | | |
| StarCraft: Brood War (Expansion Set) | PC | | BestSeller Series | | 334854216691 /2 | |
| Starfighter Assets CD | PC | | Press Kit | | | |
| Starship Troopers | PC | 0.3.2.69 | Original | | P/N 21121-5 | |
| Starsiege | PC | 1.02 | Original | | | |
| State of Emergency | XBOX | | Original | | TT-006 | |
| Stay Tooned! | PC | 1.0 | Original | | | |
| Steel Panthers | PC | 1.0 | Original | | | |
| Steel Panthers II: Modern Battles | PC | 1.0 | Original | | 2209310-590002 | |
| Steel Panthers III: Brigade Command: 1939-1999 | PC | 1.0 | Original | | 2218010-590001 | |
| Steel Panthers III: Campaign Disk | PC | | Original | | 2220210-590001 | |
| Steel Soldiers | PC | | Original | | | |
| Stella Gets a New Brain! | PC | | Original | | AR-4601 | |
| Stella Gets a New Brain! | PC | 2.0 | Original | | AR-4602 | |
| Stellaluna | MAC | | Original | | 2069-1-01 | |
| Stellar 7 | PC | | | | | |
| Steven Spielberg's Director's Chair (Disc 1) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD100CD | |
| Steven Spielberg's Director's Chair (Disc 2) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD200CD | |
| Steven Spielberg's Director's Chair (Disc 3) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD300CD | |
| Stickybear Preschool | CDI | | Pre-Release Demonstration Disc | | 310-690-257-2 | |
| Still Life | XBOX | | Original | | MI-011 | |
| Stoked | XBOX360 | | Original | | DE-2003 | |
| Stoked: Big Air Edition | XBOX360 | | Original | | DE-2005 | |
| Stonekeep | PC | 1.1 | Interactive Preview | | | |
| Storybook Weaver Deluxe | PC | 1.0 | Original | | | |
| Storybook Weaver Deluxe | PC | 1.1 | Original | | Product #HCD642 | |
| Storybook Weaver Deluxe | PC | 1.2 | Rerelease | | HCD642-CD | |
| Storybook Weaver Deluxe | PC | 2.0 | Rerelease | | 10049 | |
| Storybook Weaver Deluxe | PC | 2.0 | Rerelease | | SBW744DE-CD | |
| Storybook Weaver Deluxe | PC | 2.0 | Rerelease | | #SBW744BE-CD | |
| Storybook Weaver Deluxe 2004 | PC | 3.0 | Original | | 483050-CD | |
| Stowaway DK Multimedia: Stephen Biesty's Incredible Cross-Section: Stowaway | PC | | | | | |
| Strategic Command: European Theater | PC | 1.0 | Original | | | |
| Strategy Games of the World | PC | 1.2 | Bundle Version IBM OEM | | P/N 75H9348 | |
| Strawberry Shortcake: Amazing Cookie Party | PC | | Scholastic | | P/N CDR9663741 | |
| Streak Hoverboard Racing | PSX | | Review | | SLUS-00629 | |
| Streak Hoverboard Racing | PSX | | Beta | | | |
| Street Fighter Alpha: Warriors' Dreams | SS | 1.000 | Beta | | | |
| Street Fighter Anniversary Collection | XBOX | | Original | | CC-015 | |
| Street Fighter IV | PC | 1.0.0.1 | Original | | SYX26084GM | |
| Street Fighter IV: The Ties That Bind (Bonus Disc) | XBOX360 | | Xbox 360 Game Bundle | | CC-2033 | |
| Street Hoops | XBOX | | Original | | AV-003 | |
| Street Maps & Vacation Planner | PALM | | Cosmi | | PDA051501, PDA631D1 | |
| Strike Commander | PC | | EA Gold CD-ROM Classics | | | |
| Strike Force Bowling | XBOX | | Original | | CV-008 | |
| Strike It Rich! $trike It Rich! | PALM | 1.00 Build 0524c | Original | | | |
| Strong Bad's Cool Game for Attractive People | PC | 1.5.0.0 | Original | | | |
| Stronghold | PC | 1.1 | Original | | | |
| Stronghold (Bonus Castle: The Tower of London) | PC | | Pre-Order Bonus | | | |
| Stronghold | PC | 1.00 | Slash Corporation | | | |
| Stronghold | PC | 1.00 | Dungeons & Dragons Ultimate Fantasy | | | |
| Stronghold | PC | 1.00 | Dungeons & Dragons Ultimate Fantasy | | | |
| Stronghold FireFly Studios' Stronghold | PC | 1.3 | Interactive Demo | | | |
| Stronghold 3 | PC | | Original | | 50070-LBL | |
| Stronghold 3 Gold Stronghold 3: Gold | PC | | Original | | 50080-LBL | |
| Stronghold Crusader | PC | | Interactive Demo | | | |
| Stuart Little 2 | PSX | | Beta | | SCUS-94669 | |
| Stupid Invaders (Disc 2) | DC | 1.001 | Original | | T-17708N | |
| Su-27 Flanker | PC | 1.1 | Rerelease | | | |
| Sub Command (Disc 1) Sub Command: Akula Seawolf 688(I) | PC | | Naval Combat Pack | | 903366CD3 | |
| Sub Command (Disc 2) Sub Command: Akula Seawolf 688(I) | PC | | Naval Combat Pack | | 903366CD4 | |
| Sub Culture | PC | | Covermount | | 981009 | |
| Sub Culture | PC | | Original | | | |
| The Sudoku Challenge! Collection | PC | | Original | | | |
| Sudoku Deluxe Sudoku Pack | PALM | 2.1 | Original | | P/N: 750-3009-CD-B | |
| Sudoku Master | PALM | | Original | | 3340R-2006-03-CDA-US | |
| Sudoku Master | PC | 1.0 | Original | | 02-0950-10 | |
| The Suffering | XBOX | | Original | | MW-021 | |
| The Suffering (Bonus) | PC | 1.0 | Original | | 28424 CD3 v1.0 | |
| The Suffering (Disc 1) | PC | 1.0 | Original | | 28424 CD1 v1.0 | |
| The Suffering (Disc 2) | PC | 1.0 | Original | | 28424 CD2 v1.0 | |
| Summer Athletics: The Ultimate Challenge | XBOX360 | | Original | | CV-2004 | |
| Summer Refresh 2011: 3.65 IDU FW Update | PS3 | | Kiosk Demo | | | |
| SunAge | PC | 1.07.0 | Original | | PC00770CD | |
| Suncom Technologies Presents: 10 Hit Games by Apogee | PC | | Original | | 63-0647 | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |
| Super Air Zonk: Rockabilly-Paradise | PCE | | Original | | TGXCD1042 | |
| Super Bean | PC | | SelectSoft (CD-R) | | MPSI 44459 | |
| Super Bender Boot Disc | PS2 | 2.00 | | | | |
| Super Breakout | PC | | Pocketware | | P/N: LTATPSUBRP | |
| Super Bubble Pop | XBOX | | Original | | JA-004 | |
| Super Bubble Pop | PC | 1.0 | Original | | 14-9009-10 | |
| Super Collapse! 3 | PC | | Original | | | |
| Super Fruit Fall | WII | | Original | | RVL-RF4E-USA | |
| Super Game Converter | DC | 1.000 | Unlicensed | | | |
| Super Game Pak | PALM | | Ultimate Game Collection, Cosmi | | PDA102501, PDA634D1 | |
| Super GameHouse Solitaire Collection | PC | | Original | | | |
| Super Huey III: Combat & Rescue / Spy Hunter/Sub Attack | PC | | Original | | CDRS409CD1 | |
| Super Mario's Wacky Worlds | CDI | 0.11 | Prototype | | | |
| Super Meat Boy (Installation Disc) | PC | | IndieBox | | | |
| Super Monkey Ball Deluxe | XBOX | | Original | | SE-056 | |
| Super Munchers | PC | | SoftKey | | PSM944BE-CD | |
| Super Runabout: San Francisco Edition | DC | 1.005 | Original | | T-12511N | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.0 | Original | | MEM744AE-CD | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.01 | Original | | MEM744CE-CD | |
| Super Solvers Reading Ages 9-12 | PC | | Original | | SMR744AE-CD | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.01 | Rerelease | | | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.1 | Rerelease | | | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.11 | Rerelease | | GAG744BE-CD | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.2 | Rerelease | | 381427-CD3 | |
| Super Solvers: Midnight Rescue! | PC | 1.0 | Original | | | |
| Super Solvers: Midnight Rescue! | PC | 1.1 | Rerelease | | CSM744AE-CD | |
| Super Solvers: Midnight Rescue! | PC | 1.12 | Rerelease | | CSM744BE-CD | |
| Super Solvers: OutNumbered! | PC | 1.1 | Rerelease | | CSO744AE-CD | |
| Super Solvers: OutNumbered! | PC | 1.12 | Rerelease | | CSO744BE-CD | |
| Super Solvers: Spellbound! | PC | 1.0 | Encore | | 10175-CD2 | |
| Super Solvers: Spellbound! | PC | 1.1 | Rerelease | | SBO744AE-CD | |
| Super Solvers: Spellbound! | PC | 1.11 | Rerelease | | SBO744BE-CD | |
| Super Stories: Mom is Going to Stop It | CDI | | | | | |
| Super Stories: My Favorite Things | CDI | | | | | |
| Super Street Fighter II Turbo HD Remix (Asset Disc) | PC | | Super Turbo Hyper Champion Special Edition Pack | | | |
| Super Strike Trilogy | MCD | | Unlicensed | | | |
| Super Why! The Power to Read | PC | | Original | | 23899-00 | |
| Superbike 2000 EA Sports: Superbike 2000 | PC | | CD-ROM Classics | | 1215007 | |
| Superbike Challenge | PC | | Covermount | | | |
| Superbike World Championship | PC | 0.1.0.24 | Ultimate Motorcycle Series | | 799607 | |
| Supercar Street Challenge | PS2 | 1.00 | Original | | SLUS-20012 | |
| SuperCharged Xpansion Pack SuperCharged Xpansion Pack for Doom, Doom II & Hexen | PC | | Rerelease | | | |
| Superman | PSX | | Prototype | | | |
| Superman Returns | XBOX | | Original | | EA-160 | |
| Superman Returns | XBOX360 | | Original | | EA-2029 | |
| Superman: The Man of Steel | XBOX | | Original | | IG-022 | |
| SuperPower | PC | 1.0 | | | PC35320JC | |
| Supreme Commander | XBOX360 | | Original | | AY-2001 | |
| Supreme Commander | PC | | Original | | P/N: 120904-B | |
| Supreme Commander (Bonus Disc) | PC | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Surf's Up | XBOX360 | | Original | | US-2041 | |
| Surgical Strike | MCD | | Sega CD 32X (Disc 2) | | 4435, 157036 | |
| A Survey of Western Art: The Electronic Library of Art | VIS | | Original | | 25-6153 | |
| Survival: The Ultimate Challenge | PC | 1.0 | Original | | 31209.101.US | |
| Swap Magic | PS2 | 1.12 | Unlicensed | | | |
| Swap Magic 3 | PS2 | 3.10 (American) | Unlicensed | | | |
| Swap Magic 3 Plus | PS2 | 1.00 | Unlicensed | | | |
| Swap Magic 3 Plus | PS2 | 1.12 | Unlicensed | | | |
| SWAT 4 | PC | | Demo | | | |
| SWAT 4 (Disc 1) | PC | 31973 | Original | | | |
| SWAT 4 (Disc 2) | PC | 31973 | Original | | | |
| SWAT: Global Strike Team | XBOX | | Original | | VV-037 | |
| SwiftWare | PALM | | Cosmi | | PDA060501, PDAMC1 | |
| Switchball | PC | 1.0 | Demo | | V536 15G091171100 | |
| Sword of the New World: Granado Espada | PC | 2.1.18 | | | | |
| Sword of the Stars: Ultimate Collection | PC | 1.6.7 | Original | | | |
| SX Superstar | XBOX | | Original | | AC-016 | |
| SX Superstar | PS2 | 1.00 | Preview | | SLUS-20600 | |
| Syberia (Disc 1) | PC | 1.0.0.8 | Press Review Copy | | | |
| Syberia (Disc 2) | PC | 1.0.0.8 | Press Review Copy | | | |
| SydMead's TerraForming | PCE | | Original | | TGXCD1040 | |
| Symbiocom | PC | | Original | | | |
| Symbol Set 1: Fantasy Overland | PC | | Original | | | |
| Symbol Set 2: Fantasy Floorplans | PC | | Original | | | |
| Syndicate | MAC | | Original | | 7558 | |
| Syndicate Plus | PC | | Bundle Version OEM | | | |
| Syphon Filter 2 (Disc 2) | PSX | | Preview Version | | PSRM-01710 … | |
| Syphon Filter: Logan's Shadow | PSP | 0.10 | Test Sample | | UCUS-98606 | |
| Syphon Filter: The Omega Strain | PS2 | 1.02 | Beta | | SCUS 97397 | |
| Systemax Ultimate Software Collection (Disc 01) (Daria's Inferno / Who Wants to Beat Up a Millionaire) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 02) (I See Sue... the T. Rex / Amazons & Aliens / Cheerios: Playtime) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 03) (How Many Bugs in a Box? / More Bugs in Boxes / Jim Henson's Muppet Babies: Toyland Train / Miss Spider's Tea Party) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 04) (Forbes: Corporate Warrior / Starwebs: Web Shop / Writing Tutor / Complete Idiots Guide: Marketing Materials Maker) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 05) (S&S Encyclopedia / Typing Tutor 12) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 06) (Women's Fitness / Christina Aguilera: Follow Your Dreams) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 08) (Garfield: Mad About Cats / Money Town) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 09) (Darkened Skye: Disc 1 / Zoboomafoo with the Kratt Brothers Animal Kids) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 10) (Deer Avenger / Ski-Doo X-Team Racing) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 11) (Pearl Harbor: Zero Hour / Real War) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 12) (S&S Encyclopedia of Science / Curious George: Reads, Writes and Spells) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 13) (Multimedia Billiards / Astrology Starscopes / Music Match Juke Box Deluxe 6.1 / Extreme Chess / Typing Tutor Jr. / Bumper Wars) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 14) (Darkened Skye: Disc 2) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 18) (M&M's: The Lost Formulas) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 21) (Mob Rule) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 22) (Richard Scarry's: Busy Town) | PC | 2.0 | Original | | | |
| Systemax Ultimate Software Collection (Disc 26) (Sabrina, the Teenage Witch: Brat Attack) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 27) (Star Trek: Deep Space Nine - The Fallen) | PC | | Original | | | |