Region | Title | System | Version | Edition | Languages | Serial | Status |
| Skylanders: Trap Team | PS3 | 01.01 | Starter Pack | | BLUS-31442 | |
| SkyMaze X3D SkyMaze | PC | | X3D | | | |
| SkyTrip America SkyTrip America: An Incredible Ride Through U.S. History! | PC | 1.0 | | | | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Sega CD 32X | | T16204F | |
| Slam Dunk Typing All-Star Typing: Ages 9-12: Slam Dunk Typing | PC | | Original | | WTY744AE-CD | |
| Slam Dunk Typing All-Star Typing: Ages 9-12: Slam Dunk Typing | PC | 1.01 | Rerelease | | TYN744BE-CD | |
| Slater & Charlie Go Camping | PC | 1.000 | SierraOriginals | | | |
| Sled Shred featuring the Jamaican Bobsled Team | WII | | Original | | RVL-R9YE-USA-B0 | |
| Sled Storm | PS2 | 1.00 | Original | | SLUS-20363 | |
| Slingo Mystery: Who's Gold | PC | | Big Fish Games Backup CD | | | |
| Slipstream 5000 | PC | | Original | | CN000500028 | |
| Slot City Jackpot Games (120 Slot Machines) | PC | | Jackpot Games | | CD-4700 | |
| Slots Adventure: War for Olympus | PC | 1.0 | Original | | | |
| Slots Dual Pack Best of Slots from Bally Gaming / Best of Slots II | PC | | Original | | | |
| Slots Featuring WMS Gaming | PC | 1.0.3 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.1 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.2 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Sly 3: Honor Among Thieves | PS2 | 1.00 | Demo | | SCUS 97484 | |
| Small Soldiers | PSX | | Preview | | | |
| Small Soldiers: Globaltech Design Lab | PC | | | | Product# 99144 | |
| Small Soldiers: Squad Commander | PC | | | | Product# 99264 | |
| Smart Games: Challenge 1 | PC | | Rerelease | | 99168 | |
| Smart Games: Challenge 1 | PC | | Rerelease | | 99168 | |
| Smart Games: Challenge 1 | PC | | Original | | P/N:DSGC1CD0001 | |
| Smart Series Presents: Jaja's Adventure | WII | | Original | | RVL-R67E-USA-B0 | |
| Smart Steps: Kindergarten | PC | | Rerelease | | P/N: LDSMASTKIJ | |
| Smart Steps: Kindergarten | PC | 1.0 | Original | | | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |
| Smash Cars | PS2 | 1.03 | Original | | SLUS 20620 | |
| Smash Court Tennis 3 | PSP | 1.00 | Original | | ULUS-10269 | |
| Smash Court Tennis: Pro Tournament | PS2 | 1.00 | Original | | SLUS-20286 | |
| Smashing Drive | XBOX | | Original | | NM-001 | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| SMBX + Tak 2 Art | PC | | Press Kit | | | |
| The Smelly Mystery | PC | 1.0 | Original | | 04-12328CD | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDE-USA-B0 | |
| Smilingüido em: Desafio na Floresta | PC | | Original | | | |
| Smoking Guns Smoking Guns: Shooting Gallery! | PC | 1.0 | Cosmi | | 02-2503-10 | |
| Smuggler's Run: Warzones | GC | | Original | | DL-DOL-GSRE-USA | |
| The Smurfs 2 | XBOX360 | | Original | | US-2237 | |
| The Smurfs 2 | WII | | Original | | RVL-S2XE-USA-B0 | |
| The Smurfs: Dance Party | WII | | Toys R Us | | RVL-SDUX-USA-B0 | |
| Sneakers | XBOX | | Original | | MS-035 | |
| Sniper Elite | XBOX | | Original | | MI-013 | |
| Sniper Elite III: Ultimate Edition | PS3 | 01.00 | Original | | BLUS-31532 | |
| SNK NeoGeo USA Consumer Corporation: E3 2004 Games | PC | | Press Kit | | | |
| SNK Playmore E3 2006 Games | PC | | Press Kit | | | |
| SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | T-40207N | |
| Snoopy's Campfire Stories | PC | | Original | | | |
| Snow Storm | PC | | Original | | 9099 | |
| Soccer America: International Cup | PS2 | 1.00 | Original | | SLUS-20196 | |
| Soccer Mania | PS2 | 1.00 | Original | | SLUS-20456 | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.00 | Demo | | SCUS 97368 | |
| SOCOM: U.S. Navy SEALs | PS2 | 1.00 | Demo | | SCUS 97205 | |
| SOCOM: U.S. Navy SEALs | PS2 | 1.00 | Public Beta v1.0 | | SCUS 97859 | |
| SOCOM: U.S. Navy SEALs | PS2 | 2.01 | Original | | SCUS-97134 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo | PSP | 1.00 | Public Beta v1.0 | | UCUS 98637 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 2 | PSP | 1.00 | Best Buy Demo | | UCUS 98692 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 3 | PSP | 1.01 | Original | | UCUS-98716 | |
| Sócrates en la Casa del Terror Sócrates en la Casa Embrujada | PC | | Covermount | | | |
| Software & Document: Master CD for Video Family | PC | 1.20 | Bundle Version Jaton OEM | | | |
| The Software Toolworks CD Game Pack | PC | | Original | | | |
| The Software Toolworks Presents: Maniac Sports | MAC | | Original | | 2200820-590001 / I034100 | |
| Solitaire Antics Ultimate | PC | 1.0.3L | Original | | | |
| Solitaire Games | PC | | GSP | | 92534-A | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| Solitaire Master | PC | | Original | | 20-1280-10 | |
| Solitaire Master 2 | PC | 2.0 | Original | | 11-2806-10 | |
| Solitaire Master 4 | PC | 1.0 | Original | | 02-8156-10 | |
| Solitaire Master 5 | PC | 1.0 | Original | | 02-2153-10 | |
| Solitaire: 50 Complete Games! | PC | 2.0 | Rerelease | | 10-0990-10 | |
| A Sombra do Zorro | PC | | Original | | INFOG 095 | |
| Sonic and the Secret Rings Comic Book DVD from Archie Comics | PC | | | | | |
| Sonic Mega Collection Plus | PS2 | 0.80 | Beta | | | |
| Sonic MegaMix | MCD | | Unlicensed | | | |
| Sonic's Ultimate Genesis Collection | XBOX360 | | Platinum Hits | | SE-2064 | |
| Sony E3 2004: Press Information | PC | | Press Kit | | | |
| Sony PlayStation 2: SCEA Santa Monica Studios: 2004 Press Information: Press Print | PC | | Press Kit | | | |
| Sorority House: An Interactive Game of Hide and Peek | PC | 1.0 | Original | | | |
| Soulcalibur II | XBOX | | Demo | | NM-003 | |
| Sounds Best on Sound Blaster Every Game Sounds Best on Sound Blaster: 24-bit Advanced HD | PC | | | | | |
| Soundtrack1: The Definitive Xbox Compilation (Disc 2) | PC | | Original | | 314 584 098 2 | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | 2.0 | | | SANSARL-01 | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM (PC and Compatibles) Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM (For Macintosh Computers) Don Bluth's Space Ace | MAC | | Original | | | |
| Space Bunnies Must Die! | PC | | Demo | | MSDE-37216 | |
| Space Bunnies Must Die! | PC | | Original | | CD-RC004 | |
| Space Camp | WII | | Original | | RVL-RIYE-USA | |
| Space Chimps | XBOX360 | | Original | | BT-2004 Version: 1. | |
| Space Chimps | WII | | Original | | RVL-RP9E-USA | |
| Space Chimps | PS2 | 1.03 | Original | | SLUS 21783 | |
| Space Invaders Extreme | PSP | 1.00 | Original | | ULUS-10346 | |
| Space Jam | PC | 1.00 | Original | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | | |
| Space Quest IV: Roger Wilco and the Time Rippers Space Quest IV | PC | 1.0 | Original | | CDRM SQU344AE-CD | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | SierraOriginals | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | | |
| Space Shuttle | PC | | Original | | CDRM1109910 | |
| Space Shuttle | MAC | | Original | | CDRM1087300 | |
| Space Station Simulator | PC | 1.1 | Original | | | |
| SpaceChem | PC | 1011 | Original | | | |
| SpaceChem | PC | 1012 | Limited Edition | | | |
| Spaceship Warlock | MAC | | Original | | CDRM 403300 | |
| Spawn: Armageddon | XBOX | | Original | | NM-012 | |
| Spawn: Armageddon | GC | | Original | | DL-DOL-GPWE-USA | |
| Spawn: Armageddon | PS2 | 1.00 | Original | | SLUS-20707 | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-1216N | |
| Spec Ops II: Omega Squad | DC | 1.008 | Original | | T-41704N | |
| Spec Ops: Ranger Team Bravo | PC | | Original | | CD-RC010 | |
| Special Forces: Nemesis Strike (Disc 1) (Game Disc) | PC | 1.0 | Original | | | |
| Special Forces: Nemesis Strike (Disc 2) | PC | 1.0 | Original | | | |
| Special Permit for Cabela's Big Game Hunter | PC | | Original | | | |
| Spectral Souls: Resurrection of the Ethereal Empires | PSP | 1.00 | Original | | ULUS-10076 | |
| Spectre VR Classic | PC | | Original | | MQ 13-004-120 | |
| Speed Busters: American Highways | PC | | Original | | | |
| Spelling Challenges and More! | PSP | 1.00 | Original | | ULUS 10255 | |
| Sphinx and the Cursed Mummy | XBOX | | Original | | TQ-035 | |
| Sphinx and the Cursed Mummy | PS2 | 1.00 | Original | | SLUS-20482 | |
| Spider-Man | PC | | Demo | | | |
| Spider-Man | DC | 1.000 | Original | | T-13008N | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSME-USA | |
| Spider-Man | XBOX | Rev 1 | Platinum Hits | | AV-006 | |
| Spider-Man (Disc 1) | PC | | Original | | 32249.101.US | |
| Spider-Man (Disc 2) | PC | | Original | | 32249.102.US | |
| Spider-Man 2 | PC | | Demo | | | |
| Spider-Man 3 | PC | | Original | | 33121.101.US | |
| Spider-Man 3 | PS3 | 01.00 | Original | | BLUS-30031 | |
| Spider-Man 3 | PS3 | 01.00 | Collector's Edition | | BLUS-30030 | |
| Spider-Man 3 | PS2 | 2.00 | Greatest Hits | | SLUS-21552 | |
| Spider-Man: Friend or Foe | XBOX360 | | Original | | AV-2042 | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOE-USA | |
| Spider-Man: Friend or Foe | PC | | Original | | 33167.101.US | |
| Spider-Man: Friend or Foe | PSP | 1.00 | Original | | ULUS-10318 | |
| Spider-Man: Shattered Dimensions | PC | | Original | | 33355101US | |
| Spider-Man: Web of Shadows | XBOX360 | | Original | | AV-2069 | |
| Spider-Man: Web of Shadows: Amazing Allies Edition | PS2 | 1.01 | Original | | SLUS-21822 | |
| Spine Sense: The Interactive Back Protection Program | CDI | | Original | | | |
| Sport Image: World Cup 1994 | PC | 2.0 | SoftKey | | WCF344AE-CD | |
| Sports Jam | DC | 1.001 | Original | | T-44304N | |
| Sportsman's Paradise II | PC | 1.0 | Original | | P/N 4-19599CDSL | |
| Spring Refresh 2010: 3.21 IDU Update (E-M) | PS3 | | Kiosk Demo | | | |
| Spy Games: Elevator Mission | WII | | Original | | RVL-RECE-USA-B0 | |
| Spy Kids Learning Adventures: The Nightmare Machine | PC | | Original | | 03963 | |
| Spycraft: The Great Game | PC | | Enhanced DVD-ROM Edition | | | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| Spycraft: The Great Game (Disc 1) | PC | | Original | | CDD-3110-101-U3 | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| Spycraft: The Great Game (Disc 3) | PC | | Original | | CDD-3110-103-U3 | |
| SpyHunter 2 | XBOX | | Original | | MW-027 | |
| SpyHunter: Nowhere to Run | XBOX | | Original | | MW-055 | |
| Square Enix E3 2004 Media CD | PC | | Press Kit | | | |
| Square Enix Sampler Disc Volume One: Drakengard Playable Demo | PS2 | 1.00 | | | SLUS 29087 | |
| SquareSoft: E3 2001 Media CD | PC | | Press Kit | | | |
| SRS: Street Racing Syndicate | XBOX | | Original | | NM-019 | |
| SSI Strategy Collection: Critic's Choice Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| Stacked with Daniel Negreanu | XBOX | | Original | | MM-001 | |
| Star Fox Adventures: Game Preview CD | PC | | Promo | | | |
| Star Miner: Battle for Supremacy Asteroid Miner | PC | 1.30 FULL | Pocketware | | #9 | |
| Star Stable: The Autumn Riders | PC | 1.00.0000 | Original | | 61-0803 04 | |
| Star Trek | XBOX360 | | Original | | NM-2139 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Original | | CD-ICD-016-0 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Rerelease | | | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Original | | | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | | | CD-ICD-016-4 | |
| Star Trek: Armada | PC | 1.0 | Original | | | |
| Star Trek: Armada | PC | 1.0 | Original | | 1000913.101.US | |
| Star Trek: Armada | PC | 1.1 | Original | | 1000913.101.US | |
| Star Trek: Armada II | PC | | Star Trek: Action Pack | | 31143.101.US | |
| Star Trek: Deep Space Nine: Dominion Wars | PC | 1.00 | Original | | | |
| Star Trek: Judgment Rites | PC | | Limited CD-ROM Collector's Edition | | | |
| Star Trek: Klingon Academy (Disc 1) | PC | | Original | | CD-C95-856-0 | |
| Star Trek: Klingon Academy (Disc 2) | PC | | Original | | CD-C95-856-1 | |
| Star Trek: Klingon Academy (Disc 3) | PC | | Original | | CD-C95-856-2 | |
| Star Trek: Klingon Academy (Disc 4) | PC | | Original | | CD-C95-856-3 | |
| Star Trek: Klingon Academy (Disc 5) | PC | | Original | | CD-C95-856-4 | |
| Star Trek: Klingon Academy (Disc 6) | PC | | Original | | CD-C95-856-5 | |
| Star Trek: Shattered Universe | XBOX | | Original | | TM-016 | |
| Star Trek: Starfleet Academy | PC | 1.15 | Bundle Version OEM (DVD-ROM) | | CD-DVD-069-GQE | |
| Star Trek: Starfleet Academy (Disc 1) | MAC | 1.1 | Original | | CD-MCR-069-0 | |
| Star Trek: Starfleet Academy: Chekov's Lost Missions | PC | | Original | | | |
| Star Trek: Starfleet Command (Bonus CD) | PC | | Original | | CD-C95-637-1 | |
| Star Trek: Starfleet Command | PC | 1.01.00 | Rerelease | | CD-C95-637-2 | |
| Star Trek: Starfleet Command III | PC | 1.0 | Original | | 32337.101.US | |
| Star Trek: Starfleet Command III | PC | 1.0 | Original | | 32255.101.US | |
| Star Trek: Starfleet Command: Neutral Zone | PC | 1.0.0.2 | Original | | CD-C95-1195-0 | |
| Star Trek: The Next Generation: Interactive Technical Manual | PC | 2.0 | Original | | | |
| Star Wars Galaxies: An Empire Divided (Disc 1) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 1) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 2) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 2) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 3) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 3) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: The Complete Online Adventures (Disc 1) | PC | | Original | | 8131830 | |
| Star Wars Trilogy CD-ROM: Limited Edition Entertainment Utility | PC | | Original | | | |
| Star Wars: Attacktix: Battle Figure Game | PC | | Starter Set CD-ROM Series 2 | | | |
| Star Wars: Attacktix: Battle Figure Game | PC | | Starter Set CD-ROM | | | |
| Star Wars: Behind the Magic: Vehicles Special Edition | PC | 1.0 | Original | | | |
| Star Wars: Demolition | DC | 1.001 | Original | | T-23003N | |
| Star Wars: Empire at War (Bonus Disc) | PC | | Original, Collector's Edition | | 8541832 | |
| Star Wars: Empire at War | MAC | 1.05 | Original | | 11490-1DDA | |
| Star Wars: Empire at War: Forces of Corruption | PC | 1.00.55911 | Original | | 7131930 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.0.5.0 | Rerelease | | DVD284D1, SJ102010 | |
| Star Wars: Episode I: The Phantom Menace: Naboo Missions | PC | 1.0 | Bundle Version OEM | | 3151830, CD-W581950-MLE | |
| Star Wars: Fall Force Gaming Preview | PC | 1.0 | Original | | 8330330 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0 | Rerelease | | 9551830R | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | MAC | 1.0.1 | Original | | 10610-1CDA | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0.1.0 | Cosmi | | CDR285D1 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0.1.0 | Star Wars: Fan Favorites II | | 9982230 V1.01.0.1 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | MAC | 1.0.1 | Original | | 10610-2CDA | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | PC | 1.0.1.0 | Cosmi | | CDR285D2 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | PC | 1.0.1.0 | Star Wars: Fan Favorites II | | 9982231 V1.01.0.1 | |
| Star Wars: Jedi Knight: Mysteries of the Sith Star Wars: Jedi Knight: Mysteries of the Sith: Companion Missions | PC | 1.0 | Demo: Special Limited Edition | | 647230 | |
| Star Wars: Jedi Knight: Mysteries of the Sith Star Wars: Jedi Knight: Mysteries of the Sith: Companion Missions | PC | 1.0 | Star Wars: Jedi Knight: Dark Forces II | | 7101830 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.0 | | | 7101830 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.0 | | | 7101830 | |
| Star Wars: Mac Pack | MAC | | Original | | 12300-1DDA | |
| Star Wars: Millennium Falcon CD-ROM Playset | PC | | Original | | | |
| Star Wars: Rebel Assault | MAC | | Demo | | CDRM1209730 | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630, CDRM1208410 | |
| Star Wars: Rebel Assault | PC | 1.2 | Original | | 632630, CDRM1142600 | |
| Star Wars: Rebel Assault: Super Sampler | PC | 1.4 | | | 636030, CDRM1221330 | |
| Star Wars: Republic Commando | PC | 1.0 | Star Wars: Fan Favorites I | | 9982132R V1.01.1.1 | |
| Star Wars: Republic Commando | PC | 1.0 | Star Wars: Fan Favorites I | | 9982132 V1.01.0.1 | |
| Star Wars: Republic Commando | PC | 1.01 | Cosmi | | DVD287D1, SJ032011 | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Rerelease | | 646130 | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | 3121830 | |
| Star Wars: Shadows of the Empire: Battle of Hoth | PC | | Bundle Version Diamond OEM | | 75000204-100 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition | PS3 | 01.00 | Original | | BLUS-30445 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | MAC | | Original | | 12240-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | MAC | | Original | | 12240-1DDA2 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | MAC | 1.0 | Original | | 2062130 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | 1.0 | Collector Series | | 8051832 | |
| Star Wars: X-Wing Alliance: Imperial Entanglements | PC | 1.0 | Bundle Version OEM | | 2091831, CD-C951918-VOE | |
| Star Wars: X-Wing vs. TIE Fighter: The Academy | PC | 1.00 | Bundle Version Logitech OEM | | 601479-0100 | |
| Star Wars: X-Wing: Collector's CD-ROM | MAC | 1.01 | Original | | 2052130 | |
| Starbright Asthma CD-ROM Game: Quest for the Code | PC | | | | | |
| StarCraft II: Heart of the Swarm | PC | | Original | | | |
| StarLancer (Disc 1) Microsoft StarLancer | PC | | Original | | 0200 Part Number X05-67021 | |
| StarLancer (Disc 2) Microsoft StarLancer | PC | | Original | | 0200 Part Number X05-67023 | |
| Starshine Legacy: Episode 2: Secret of Pine Hill Mansion | PC | | Original | | SLE2, US-61-0603 05 | |
| State of Emergency | XBOX | | Original | | TT-006 | |
| State of Emergency | PC | 1.00.0008 | Original | | | |
| State of Emergency 2 | PS2 | 1.02 | Original | | SLUS 20966 | |
| Steambot Chronicles | PS2 | 1.00 | Trade Demo | | SLUS-28061 | |
| Steambot Chronicles | PS2 | 1.00 | Original | | SLUS-21344 | |
| Steel Panthers II: Modern Battles | PC | 1.0 | Original | | 2209310-590002 | |
| Steel Panthers III: Brigade Command: 1939-1999 | PC | 1.0 | Original | | 2218010-590001 | |
| Steel Panthers III: Campaign Disk | PC | | Original | | 2220210-590001 | |
| Steel Panthers: Campaign Disk | PC | | Original | | 2209310-590001 | |
| A Steven Spielberg Film: Minority Report: Bonus CD-ROM! | PC | | Original | | | |
| Steven Spielberg's Director's Chair (Disc 1) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD100CD | |
| Steven Spielberg's Director's Chair (Disc 2) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD200CD | |
| Steven Spielberg's Director's Chair (Disc 3) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD300CD | |
| Stickybear Family Fun | CDI | | Original | | 310690258-2 | |
| Still Life | XBOX | | Original | | MI-011 | |
| Storm | PC | 1.0 | Original | | 7-20286-92174-4 | |
| Stowaway DK Multimedia: Stephen Biesty's Incredible Cross-Section: Stowaway | PC | | | | | |
| Str.at.e.s. 1: Match-A-Batch | PC | 2.0 | Original | | | |
| Str.at.e.s. 1: Match-A-Batch | PC | 2.0 | Rerelease | | | |
| Strategic Command: European Theater | PC | 1.0 | Original | | | |
| Strategy Games of the World | PC | 1.2 | Bundle Version IBM OEM | | P/N 75H9348 | |
| Strawberry Shortcake: Amazing Cookie Party | PC | | Scholastic | | P/N CDR9663741 | |
| Street Fighter Alpha: Warriors' Dreams | PC | | Original | | | |
| Street Fighter Alpha: Warriors' Dreams | SS | 1.000 | Beta | | | |
| Street Fighter IV | PC | 1.0.0.1 | Original | | SYX26084GM | |
| Street Maps & Vacation Planner | PALM | | Cosmi | | PDA051501, PDA631D1 | |
| Street Sports: Jammit | PC | | Super 16 CD Pak Volume 2 | | MQ 13-004-166 | |
| Street Supremacy | PSP | 1.00 | Original | | ULUS-10069 | |
| Streets of SimCity | PC | | | | | |
| Streets of SimCity | PC | | Ultimate Sim Series | | 10402 | |
| Strike Commander | PC | | CD-ROM Classics | | | |
| Strike Commander | PC | | EA Gold CD-ROM Classics | | | |
| Strong Bad's Cool Game for Attractive People | PC | 1.5.0.0 | Original | | | |
| Su-27 Flanker Mission Disk | PC | | Original | | 2212510-590001 | |
| Sub Command (Disc 1) Sub Command: Akula Seawolf 688(I) | PC | | Naval Combat Pack | | 903366CD3 | |
| Sub Command (Disc 2) Sub Command: Akula Seawolf 688(I) | PC | | Naval Combat Pack | | 903366CD4 | |
| Sudoku Master | PC | | Rerelease | | 03659 | |
| Sudoku Master | PALM | | Original | | 3340R-2006-03-CDA-US | |
| Sudoku Master | PC | 1.0 | Original | | 02-0950-10 | |
| The Suffering | XBOX | | Original | | MW-021 | |
| The Sum of All Fears | GC | | Original | | DL-DOL-G3ME-USA | |
| Summer & Winter Olympic Challenge | PC | | Original | | ROM-53360 | |
| Summer & Winter Olympic Challenge | PC | | Original | | ROM-53360 | |
| Summer Athletics: The Ultimate Challenge | XBOX360 | | Original | | CV-2004 | |
| Summer Refresh 2011: 3.65 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Summer Sports 2: Island Sports Party | WII | | Original | | RVL-RI6E-USA-B0 | |
| Summer Sports: Paradise Island | WII | | Original | | RVL-RSUE-USA | |
| Summer Stars 2012 | WII | | Original | | RVL-SSJE-USA-B0 | |
| Summon Night 5 | PSP | 1.01 | Original | | ULUS-10656 | |
| Summoner 2 | PS2 | 1.00 | Demo | | SLUS 29029 | |
| Suncom Technologies Presents: 10 Hit Games by Apogee | PC | | Original | | 63-0647 | |
| Super Arcade Games: Version 5 | PC | | Original | | | |
| Super Bean | PC | | SelectSoft (CD-R) | | MPSI 44459 | |
| Super Game Converter | DC | 1.000 | Unlicensed | | | |
| Super Game Pak | PALM | | Ultimate Game Collection, Cosmi | | PDA102501, PDA634D1 | |
| Super GameHouse Solitaire Collection | PC | | Original | | | |
| Super Huey III: Combat & Rescue / Spy Hunter/Sub Attack | PC | | Original | | CDRS409CD1 | |
| Super Magnetic Neo | DC | 1.001 | Demo | | T-40206ND | |
| Super Magnetic Neo | DC | 1.001 | Original | | T-40206N | |
| Super Mario's Wacky Worlds | CDI | 0.11 | Prototype | | | |
| Super Meat Boy (Installation Disc) | PC | | IndieBox | | | |
| Super Meat Boy: Ultra Edition | PC | | Original | | | |
| Super Monkey Ball Adventure | PSP | 1.02 | Original | | ULUS-10132 | |
| Super Monkey Ball Deluxe | XBOX | | Original | | SE-056 | |
| Super Munchers | PC | | SoftKey | | PSM944BE-CD | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.0 | Original | | MEM744AE-CD | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.01 | Original | | MEM744CE-CD | |
| Super Solvers Reading Ages 9-12 | PC | | Original | | SMR744AE-CD | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.01 | Rerelease | | | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.1 | Rerelease | | | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.11 | Rerelease | | GAG744BE-CD | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.2 | Rerelease | | 381427-CD3 | |
| Super Solvers: Midnight Rescue! | PC | 1.0 | Original | | | |
| Super Solvers: Midnight Rescue! | PC | 1.1 | Rerelease | | CSM744AE-CD | |
| Super Solvers: Midnight Rescue! | PC | 1.12 | Rerelease | | CSM744BE-CD | |
| Super Solvers: OutNumbered! | PC | 1.1 | Rerelease | | CSO744AE-CD | |
| Super Solvers: OutNumbered! | PC | 1.12 | Rerelease | | CSO744BE-CD | |
| Super Stories: Mom is Going to Stop It | CDI | | | | | |
| Super Stories: My Favorite Things | CDI | | | | | |
| Super Street Fighter II Turbo HD Remix (Asset Disc) | PC | | Super Turbo Hyper Champion Special Edition Pack | | | |
| Superbike World Championship | PC | 0.1.0.24 | Ultimate Motorcycle Series | | 799607 | |
| SuperCharged Xpansion Pack SuperCharged Xpansion Pack for Doom, Doom II & Hexen | PC | | Rerelease | | | |
| Superman | PSX | | Prototype | | | |
| Superman Returns | XBOX | | Original | | EA-160 | |
| Superman Returns | XBOX360 | | Original | | EA-2029 | |
| Superman Returns | PS2 | 1.00 | Original | | SLUS-21434 | |
| Superman: Shadow of Apokolips | PS2 | 1.00 | Original | | SLUS-20235 | |
| Superman: The Man of Steel | XBOX | | Original | | IG-022 | |
| Supreme Commander | XBOX360 | | Original | | AY-2001 | |
| Supreme Commander | PC | | Original | | P/N: 120904-B | |
| Supreme Commander (Bonus Disc) | PC | | Original | | | |
| Supreme Commander 2 | PC | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Surface: Mystery of Another World | PC | | Collector's Edition | | 33418010US | |
| Survival: The Ultimate Challenge | PC | 1.0 | Original | | 31209.101.US | |
| Survivor Ultimate | PC | 1.00.28 | Original | | Part # 23411CD | |
| Suzuki Alstare: Extreme Racing | DC | 1.000 | Original | | T-17703N | |
| Suzuki TT Superbikes: Real Road Racing Championship | PS2 | 1.00 | Original | | SLUS-21863 | |
| Swap Magic | PS2 | 1.12 | Unlicensed | | | |
| Swap Magic 3 | PS2 | 3.10 (American) | Unlicensed | | | |
| Swap Magic 3 Plus | PS2 | 1.00 | Unlicensed | | | |
| Swap Magic 3 Plus | PS2 | 1.12 | Unlicensed | | | |
| Swarm Rampage | PC | 1.00 | Original | | | |
| SWAT: Global Strike Team | XBOX | | Original | | VV-037 | |
| Swift Classics Card Games for Windows | PC | | Cosmi | | CDR 720 OD1, SJ 041001 G | |
| SwiftWare | PALM | | Cosmi | | PDA060501, PDAMC1 | |
| Sword of the Stars: Ultimate Collection | PC | 1.6.7 | Original | | | |
| SydMead's TerraForming | PCE | | Original | | TGXCD1040 | |
| Symbiocom | PC | | Original | | | |
| Symbol Set 1: Fantasy Overland | PC | | Original | | | |
| Symbol Set 2: Fantasy Floorplans | PC | | Original | | | |
| Syphon Filter 2 (Disc 2) | PSX | | Preview Version | | PSRM-01710 … | |
| Syphon Filter: The Omega Strain | PS2 | 1.02 | Beta | | SCUS 97397 | |
| System Shock | MAC | | Original | | EA 568407 | |
| Systemax Ultimate Software Collection (Disc 01) (Daria's Inferno / Who Wants to Beat Up a Millionaire) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 02) (I See Sue... the T. Rex / Amazons & Aliens / Cheerios: Playtime) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 03) (How Many Bugs in a Box? / More Bugs in Boxes / Jim Henson's Muppet Babies: Toyland Train / Miss Spider's Tea Party) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 04) (Forbes: Corporate Warrior / Starwebs: Web Shop / Writing Tutor / Complete Idiots Guide: Marketing Materials Maker) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 05) (S&S Encyclopedia / Typing Tutor 12) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 06) (Women's Fitness / Christina Aguilera: Follow Your Dreams) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 08) (Garfield: Mad About Cats / Money Town) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 09) (Darkened Skye: Disc 1 / Zoboomafoo with the Kratt Brothers Animal Kids) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 10) (Deer Avenger / Ski-Doo X-Team Racing) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 11) (Pearl Harbor: Zero Hour / Real War) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 12) (S&S Encyclopedia of Science / Curious George: Reads, Writes and Spells) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 13) (Multimedia Billiards / Astrology Starscopes / Music Match Juke Box Deluxe 6.1 / Extreme Chess / Typing Tutor Jr. / Bumper Wars) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 14) (Darkened Skye: Disc 2) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 18) (M&M's: The Lost Formulas) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 21) (Mob Rule) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 22) (Richard Scarry's: Busy Town) | PC | 2.0 | Original | | | |
| Systemax Ultimate Software Collection (Disc 26) (Sabrina, the Teenage Witch: Brat Attack) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 27) (Star Trek: Deep Space Nine - The Fallen) | PC | | Original | | | |