Region | Title | System | Version | Edition | Languages | Serial | Status |
| Reading Blaster: Ages 4-6 | PC | 1.1C | Original | | S7108310 | |
| Reading Blaster: Ages 6-8 | PC | 1.0c | Original | | S7098310 | |
| Reading Blaster: Invasion of the Word Snatchers | PC | | Original | | | |
| Ready 2 Rumble: Revolution | WII | | Original | | RVL-RR5E-USA | |
| Ready, Set, Listen! Game | PC | | Original | | | |
| Reah (Disc 1) | PC | | Original | | 04-17771CD1 | |
| Reah (Disc 2) | PC | | Original | | 04-17771CD2 | |
| Reah (Disc 3) | PC | | Original | | 04-17771CD3 | |
| Reah (Disc 4) | PC | | Original | | 04-17771CD4 | |
| Reah (Disc 5) | PC | | Original | | 04-17771CD5 | |
| Reah (Disc 6) | PC | | Original | | 04-17771CD6 | |
| Real Pinball | 3DO | | Original | | FZ-SC0801 | |
| Realms of Fantasy (Disc 1) | PC | | Original | | | |
| Realms of Fantasy (Disc 2) | PC | | Original | | | |
| Red Faction II | GC | | Original | | DL-DOL-GRFE-USA | |
| Red Orb Entertainment CD Sampler | PC | | Original | | | |
| Red White & Blue | PC | | Original | | | |
| Redneck Rampage | PC | | Original | | CD-ICD-474-0 | |
| Redneck Rampage | PC | | Original | | CD-ICD-474-0 | |
| Redrum | PC | 1.1 | Original | | 02-2907-10 | |
| Redshift 2: Multimedia Astronomy | PC | 1.0 | Original | | 0086-040-0130 | |
| Redshift: Multimedia Astronomy | PC | 1.0 | Original | | | |
| Reel Deal Casino: Championship Edition | PC | 1.0 | Original | | | |
| Reel Deal Casino: Championship Edition | PC | 1.6 | Original | | | |
| Reel Deal Casino: Gold Rush (Disc 1) | PC | 1.1 | Original | | | |
| Reel Deal Casino: Gold Rush (Disc 2) | PC | 1.1 | Original | | | |
| Reel Deal Casino: Imperial Fortune | PC | 1.0 | Original | | | |
| Reel Deal Casino: Millionaire's Club (Disc 1) | PC | 1.0 | Original | | | |
| Reel Deal Casino: Millionaire's Club (Disc 2) | PC | 1.0 | Original | | | |
| Reel Deal Slots & Video Poker | PC | 1.0 | Original | | | |
| Reel Deal Slots & Video Poker | PC | 2.0 | Original | | | |
| Reel Deal Slots: 2nd Vol. | PC | 1.2 | Original | | | |
| Reel Deal Slots: Blackbeard's Revenge (Disc 1) | PC | 1.1 | Original | | | |
| Reel Deal Slots: Blackbeard's Revenge (Disc 1) | PC | 1.3 | Original | | | |
| Reel Deal Slots: Blackbeard's Revenge (Disc 2) | PC | 1.1 | Original | | | |
| Reel Deal Slots: Blackbeard's Revenge (Disc 2) | PC | 1.3 | Original | | | |
| Reel Deal Slots: Bonus Mania! (Disc 1) | PC | 1.0 | Original | | | |
| Reel Deal Slots: Bonus Mania! (Disc 2) | PC | 1.0 | Original | | | |
| Reel Deal Slots: Ghost Town (Disc 1) | PC | 1.0 | Original | | | |
| Reel Deal Slots: Ghost Town (Disc 1) | PC | 1.1 | Original | | | |
| Reel Deal Slots: Ghost Town (Disc 1) | PC | 1.3 | Original | | | |
| Reel Deal Slots: Ghost Town (Disc 2) | PC | 1.0 | Original | | | |
| Reel Deal Slots: Ghost Town (Disc 2) | PC | 1.1 | Original | | | |
| Reel Deal Slots: Ghost Town (Disc 2) | PC | 1.3 | Original | | | |
| Reel Deal Slots: Gods of Olympus | PC | 1.0 | Original | | | |
| Reel Deal Slots: Mystic Forest (Disc 1) | PC | 1.0 | Original | | | |
| Reel Deal Slots: Mystic Forest (Disc 1) | PC | 1.1 | Original | | | |
| Reel Deal Slots: Mystic Forest (Disc 1) | PC | 1.4 | Original | | | |
| Reel Deal Slots: Mystic Forest (Disc 1) | PC | 2.0 | Original | | | |
| Reel Deal Slots: Mystic Forest (Disc 2) | PC | 1.0 | Original | | | |
| Reel Deal Slots: Mystic Forest (Disc 2) | PC | 1.1 | Original | | | |
| Reel Deal Slots: Mystic Forest (Disc 2) | PC | 1.4 | Original | | | |
| Reel Deal Slots: Mystic Forest (Disc 2) | PC | 2.0 | Original | | | |
| Reel Deal Slots: Nickel Alley | PC | 1.0 | Original | | | |
| Reel Deal Slots: Treasures of the Far East | PC | 1.0 | Original | | | |
| Reel Deal: Casino Quest! Reel Deal: Casino Master | PC | 1.0 | Original | | | |
| Reign of Fire | XBOX | | Original | | BM-002 | |
| Reload | WII | | Original | | RVL-STDE-USA-B0 | |
| Remington Super Slam Hunting: Alaska | WII | | Original | | RVL-SRKE-USA-B0 | |
| Republic: The Revolution (Disc 1) | PC | | Original | | MREPUPUS01 | |
| Republic: The Revolution (Disc 2) | PC | | Original | | MREPUPUS02 | |
| Rescue Heroes: Hurricane Havoc | PC | 1.0c | Original | | 378505-CD | |
| Rescue Heroes: Lava Landslide | PC | 1.0c | Original | | S7176410 | |
| Reservoir Dogs | XBOX | | Original | | SC-255 | |
| Resonance | PC | | Original | | | |
| Restaurant Empire | PC | | Original | | | |
| Restaurant Empire | PC | 1.14 | Original | | | |
| Restaurant Empire | PC | 1.21 | Original | | | |
| Return of the Incredible Machine: Contraptions | PC | 1.0 | Original | | | |
| Return of the Phantom / F-117A | PC | | Original | | CDRM1115420 | |
| Return to Zork | PC | 1.2 | Original | | CDD-3034-04-3 | |
| Rhem | PC | | Original | | | |
| Richard Scarry's Best Neighborhood Ever Richard Scarry's Best Neighborhood Disc Ever! | PC | 1.0 | Original | | | |
| Richard Scarry's Busytown: Best Activity Center Ever | PC | 1.0c | Original | | 0-671-31580-3 | |
| Richard Scarry's Busytown: Best Christmas Ever | PC | 1.0 | Original | | 0-671-31510-2 | |
| Richard Scarry's Busytown: Best Reading Program Ever | PC | | Original | | | |
| Richard Scarry's How Things Work in Busytown | PC | 1.0 | Original | | 51962-01 | |
| Rick Ribbit: Adventures in Early Learning | VIS | | Original | | 25-6172 | |
| Rig Racer 2 | WII | | Original | | RVL-RR2E-USA | |
| Ringling Bros. and Barnum & Bailey | WII | | Original | | RVL-R8OE-USA-B0 | |
| Ringworld: Revenge of the Patriarch | PC | 1.00 | Original | | | |
| The Rise & Rule of Ancient Empires | PC | 1.01 | Original | | | |
| Rise of Nations: Gold Edition (Disc 1) | PC | 03.02.03.2905 | Original | | 0604 Part No. X10-66520 | |
| Rise of the Triad: Dark War | PC | 1.3 | Original | | | |
| Rise of the Triad: The HUNT Begins | PC | 1.2 | Original | | | |
| Rise of the Triad: The HUNT Begins | PC | 1.2 | Original | | | |
| Risen | XBOX360 | | Original | | KM-2008 | |
| Risk: The Game of Global Domination | PC | | Original | | 99003 | |
| Riven: The Sequel to Myst (Disc 1) | PC | 1.0 | Original | | 1822114 | |
| Riven: The Sequel to Myst (Disc 1) | PC | 1.0 | Original | | 1822114 | |
| Riven: The Sequel to Myst (Disc 2) | PC | 1.0 | Original | | 1822115 | |
| Riven: The Sequel to Myst (Disc 3) | PC | 1.0 | Original | | 1822116 | |
| Riven: The Sequel to Myst (Disc 3) | PC | 1.0 | Original | | 1822116 | |
| Riven: The Sequel to Myst (Disc 4) | PC | 1.0 | Original | | 1822117 | |
| Riverboat Casino | PC | | Original | | | |
| RLH: Run Like Hell | XBOX | | Original | | IP-006 | |
| Road to India: Between Hell and Nirvana (Disc 1) | PC | | Original | | 67202202 | |
| Road to India: Between Hell and Nirvana (Disc 2) | PC | | Original | | 67202302 | |
| Road Trip: The Arcade Edition | GC | | Original | | DL-DOL-GROE-USA | |
| RoadKill | GC | | Original | | DL-DOL-GOCE-USA | |
| Roberta Williams' Laura Bow: The Dagger of Amon Ra The Dagger of Amon Ra | PC | 1.1 | Original | | | |
| Robin Hood: Defender of the Crown | XBOX | | Original | | CC-012 | |
| The Robot Club | PC | | Original | | | |
| Robots | GC | | Original | | DL-DOL-GZQE-USA | |
| Rock 'N Roll Your Own: A Music-Making CD-ROM Experience | PC | | Original | | CDRM1291270 | |
| Rock Band Track Pack: Classic Rock | XBOX360 | | Original | | EA-2224 | |
| Rock Band Track Pack: Classic Rock | WII | | Original | | RVL-R3ZE-USA | |
| Rock Band Track Pack: Classic Rock | PS3 | 01.01 | Original | | BLUS-30327 | |
| Rock Band: Country Track Pack | XBOX360 | | Original | | EA-2250 | |
| Rock Band: Country Track Pack | PS3 | 01.00 | Original | | BLUS-30351 | |
| Rock Band: Country Track Pack 2 | PS3 | 01.01 | Original | | BLUS-30623 | |
| Rock Band: Metal Track Pack | XBOX360 | | Original | | EA-2253 | |
| Rock Band: Track Pack Volume 1 | WII | | Original | | RVL-RREE-USA | |
| Rock Revolution | XBOX360 | | Original | | KN-2016 | |
| Rockett's Camp Adventures | PC | | Original | | 25614-0919 | |
| Rockett's New School | PC | | Original | | 100-10-2000 | |
| Rockett's Secret Invitation | PC | | Original | | 107-10-2000 | |
| Rocky | GC | | Original | | DL-DOL-GRKE-USA | |
| Rocky Mountain Trophy Hunter: Alaskan Expedition | PC | | Original | | P/N 04-17440CDSL | |
| Rodney's Funscreen | VIS | | Original | | 25-6152 | |
| Rogue Ops | GC | | Original | | DL-DOL-GP9E-USA | |
| Rudolph the Red-Nosed Reindeer | WII | | Original | | RVL-SRUE-USA-B0 | |
| Rugby 2005 | XBOX | | Original | | EA-097 | |
| Rules of the Game | PC | | Original | | 04-22266CD | |
| Rune: Halls of Valhalla | MAC | 1.0.7 | Original | | | |
| Sable Maze: Forbidden Garden & Twelve Fears | PC | | Original | | 33528010US | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Sail 2000 | PC | 1.04 | Original | | | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Sammy's Science House | PC | 1.0 | Original | | | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | 170121 | |
| San Francisco Rush 2049 | DC | 1.001 | Original | | T-9707N | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 2) | PC | 1.0 | Original | | | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Savage Warriors | PC | 1.0 | Original | | 2205110-S90001/1055SA | |
| Savage Warriors | PC | 1.0 | Original | | | |
| Save Planet Polluto | PC | 1.0 | Original | | | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| Scaler | GC | | Original | | DL-DOL-GKUE-USA | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scene It? Bright Lights! Big Screen! | PS3 | 01.02 | Original | | BLUS-30448 … | |
| Scene It? Bright Lights! Big Screen! | XBOX360 | | Original | | WR-2037 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCE-USA-B0 | |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| Scholastic's The Magic School Bus Discovers Flight: Activity Center | PC | 1.0.0.2 | Original | | 0201 Part No. X06-16068 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | 1.0 | Original | | 0894 Part No. 59104, Disc Assy 299-052-002 | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original | | Disc Assy. 451-052-012 0396 Part No. 90626 | |
| Scholastic's The Magic School Bus in Concert: Activity Center | PC | 1.0.0.2 | Original | | 0400 Part No. X05-64231 | |
| School Zone Flash Action Software: Multiplication/Division | PC | | Original | | 08021 | |
| School Zone Math: First & Second Grade | PC | | Original | | 08020 | |
| Schoolhouse Rock! 1st & 2nd Grade Essentials (Disc 1) | PC | | Original | | 21330CD-1 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! America Rock | PC | | Original | | 21080CD | |
| Schoolhouse Rock! Grammar Rock | PC | | Original | | 9227 | |
| Schoolhouse Rock! Grammar Rock | MAC | | Original | | 9227 | |
| Schoolhouse Rock! Thinking Games | PC | | Original | | BBT844AE-CD | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744AE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 2) (Learning Adventures) | PC | | Original | | SRT744AE-CD2 | |
| Science Is Elementary 1 | PSX | | Original | | LSP-990161 … | |
| Science Is Elementary 2 | PSX | | Original | | LSP-990162 … | |
| Science Is Elementary 3 | PSX | | Original | | LSP-990163 … | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.01 | Original | | 380849A-CD | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Phantom of the Knight | PC | 1.0 | Original | | 380325-CD | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DE-USA | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Scorcher | SS | 1.008 | Original | | 81214 | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island | PC | 2.3 | Original | | 2147010-590001 / I 042 | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| Secrets of Great Art | PC | 1.1 | Original | | P/N 61218-CD | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega Rally Revo | PSP | 1.00 | Original | | ULUS-10311 | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| Sega Worldwide Soccer '97 | SS | 1.001 | Original | | 81112 | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Sentient | PC | | Original | | | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Sesame Street Reading is Fun! Toddler (Disc 1) (Grover's Travels) | PC | 2.0 | Original | | SRF844AE-CD-1 | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Sesame Street: Art Workshop | PC | | Original | | 9369 | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Elmo's Art Workshop | PC | | Original | | EAW844AE-CD | |
| Sesame Street: Elmo's Preschool (Disc 1) (Elmo's Preschool) | PC | 3.1 | Original | | P/N 379663-CD1 | |
| Sesame Street: Elmo's Preschool (Disc 2) (Search & Learn Adventures) | PC | 3.1 | Original | | P/N 379663-CD2 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: My Baby & Me (Disc 1) (Baby & Me) | PC | 1.0 | Original | | SSY744AE-CD1 | |
| Sesame Street: My Baby & Me (Disc 2) (Sesame Street Greatest Hits Sampler) | PC | 1.0 | Original | | SSY744AE-CD2 | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Sesame Street: Toddlers Deluxe (Disc 1) (Art Workshop) | PC | 2.0 | Original | | STO844AE-CD-1 | |
| Sesame Street: Toddlers Deluxe (Disc 2) (Letters) | PC | 2.0 | Original | | STO844AE-CD-2 | |
| Sesame Street: Toddlers Deluxe (Disc 3) (Numbers) | PC | 2.0 | Original | | STO844AE-CD-3 | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| The Settlers: Rise of an Empire | PC | 1.0.4140 | Original | | | |
| Shadow Company: Left for Dead | PC | 1.0 | Original | | 5051802 | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| Shadowrun Returns (Game Disc) | PC | | Original | | | |
| Shanghai Double Pack | PC | | Original | | | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shape Shifter | PC | | Original | | | |
| Sharks! An Interactive Journey An Interactive Journey With... Sharks! | PC | | Original | | | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NE-USA-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| Shepherd's Crossing | PSP | 1.00 | Original | | ULUS-10499 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 2 | Original | | CDRM 770000 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. III | PC | 4 | Original | | CDRM1061930 | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shin Megami Tensei: Persona | PSP | 1.00 | Original | | ULUS-10432 | |
| The Ship | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | 831744330/S174150 | |
| Shogo: Mobile Armor Division 昇剛 | PC | 1.0 | Original | | | |
| Shogun: Total War: The Mongol Invasion Shōgun: Total War: The Mongol Invasion | PC | 1.00 | Original | | 1430907 | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shrek 2 | PC | | Original | | 32585.101.US | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9E-USA | |
| Shrek Game Land Activity Center | PC | | Original | | 32053.101.US | |
| Shrek Super Party | XBOX | | Original | | TM-004 | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYE-USA | |
| Sid Meier's Alien Crossfire | PC | | Original | | 1405807 | |
| Sid Meier's Alpha Centauri | MAC | RELEASE 4.0 | Original | | | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | 0-520-47-101 | |
| Siege of Avalon Anthology | PC | 1.1.2001.913 | Original | | | |
| Sierra's School House: English (Disc 1) | PC | | Original | | | |
| Sierra's School House: Math (Disc 1) | PC | | Original | | | |
| Sierra's School House: Math (Disc 2) | PC | | Original | | | |
| Sierra's School House: Science (Disc 1) | PC | | Original | | 831614230/S161155 | |
| Sierra's School House: Science (Disc 2) | PC | | Original | | 831614230/S161155 | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| Silent Hill: Shattered Memories | PSP | 1.00 | Original | | ULUS-10450 | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.00 | Original | | | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| SimCity 3000 | MAC | 1.0.557 | Original | | 1500607 | |
| SimCity 4 (Disc 1) | PC | 1.0 | Original | | MXB08803894CD1 | |
| SimCity 4 (Disc 2) | PC | 1.0 | Original | | MXB08803894CD2 | |
| SimGolf | PC | 1.0 | Original | | 0093-000-0601-A | |
| SimIsle: Missions in the Rainforest | PC | 1.0 | Original | | 0058-030-0901 | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| The Simpsons Game | PSP | 1.00 | Original | | ULUS-10295 | |
| The Sims 2 | PSP | 1.00 | Original | | ULUS-10031 | |
| The Sims 2 (Disc 1) | PC | 1.0 | Original | | 1472607 | |
| The Sims 2 (Disc 3) | PC | 1.0.0.932 | Original | | 1472627 | |
| The Sims 2 (Disc 4) | PC | 1.0 | Original | | 1472637 | |
| The Sims 2: Insider Preview CD | PC | | Original | | 1625207 | |
| The Sims 2: Pets | PSP | 1.00 | Original | | ULUS 10130 | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.230 | Original | | 1491707 | |
| SimTower SimTower: The Vertical Empire | PC | 1.0 | Original | | 0051-040-0601-B | |
| SimTown | PC | 1.0 | Original | | 0037-000-0601-A | |
| SimTunes | PC | | Original | | 0135-000-0601-A | |
| Sin SiN | PC | 1.01 | Original | | 1000076.101.US | |
| Sing 4: The Hits Edition | WII | | Original | | RVL-SIHE-USA-B0 | |
| Sing-Along Kids | PC | 1.1 | Original | | | |
| Sinkha | MAC | | Original | | | |
| Sinkha | PC | | Original | | | |
| Ski and Shoot | WII | | Original | | RVL-RUME-USA | |
| Ski-Doo Snowmobile Challenge | XBOX360 | | Original | | VG-2001 | |
| Skin Style | CDI | | Original | | | |
| The Skins Game at Bighorn | PC | | Original | | CD-MPC-126-0 | |
| Skylanders: Imaginators | XBOX360 | | Original | | AV-2352 | |
| Skylanders: SuperChargers | XBOX360 | | Original | | AV-2335 | |
| Skylanders: Swap Force | XBOX360 | | Original | | AV-2281 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | PC | | Original | | | |
| Slam Dunk Typing All-Star Typing: Ages 9-12: Slam Dunk Typing | PC | | Original | | WTY744AE-CD | |
| Slave Zero | DC | 1.001 | Original | | T-15106N | |
| Slingo | PC | | Original | | 99310 | |
| Slingo 2-Pack | PC | | Original | | | |
| Slingo Quest | PC | 0.0.0.104 | Original | | | |
| Slingo: 15th Anniversary Edition | PC | | Original | | | |
| Slots Adventure: War for Olympus | PC | 1.0 | Original | | | |
| Slots Dual Pack Best of Slots from Bally Gaming / Best of Slots II | PC | | Original | | | |
| Slots Featuring WMS Gaming | PC | 1.0.3 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.1 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.2 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Smart Games: Challenge 1 | PC | | Original | | P/N:DSGC1CD0001 | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDE-USA-B0 | |
| Smuggler's Run: Warzones | GC | | Original | | DL-DOL-GSRE-USA | |
| Snap Dragon | PC | 1.0 | Original | | | |
| Sniper Elite III | XBOX360 | | Original | | FO-2051 | |
| Snoopy's Campfire Stories | PC | | Original | | | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| Snow Storm | PC | | Original | | 9099 | |
| So Who's Dr. Rabbit? | PC | | Original | | | |
| So You Wanna Be a Redneck | PC | | Original | | | |
| Soccer Score Soccer | PC | | Original | | | |
| Socket Low Power SDIO WLAN | PPC | Release 142 D | Original | | P/N 6210-00142 D | |
| SocketScan | PALM | Release 108K | Original | | P/N 6210-00108 K | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 3 | PSP | 1.01 | Original | | UCUS-98716 | |
| Soft Kill | PC | | Original | | | |
| The Software Toolworks CD Game Pack | PC | | Original | | | |
| The Software Toolworks Presents: Maniac Sports | MAC | | Original | | 2200820-590001 / I034100 | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | MAC | | Original | | | |
| Solitaire Antics Ultimate | PC | 1.0.3L | Original | | | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| Solitaire Master | PC | | Original | | 20-1280-10 | |
| Solitaire Master 4 | PC | 1.0 | Original | | 02-8156-10 | |
| Solitaire Master 5 | PC | 1.0 | Original | | 02-2153-10 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | 51117 | |
| Sonic Shuffle | DC | 1.000 | Original | | 51060 | |
| Sorry / Boggle / Yahtzee: Triple Pack of Fun | PC | | Original | | Part # 26023CD | |
| Sorry! | PC | | Original | | 99040 | |
| Soulbringer (Disc 1) | PC | 1.0.0.1 | Original | | | |
| Soulbringer (Disc 2) | PC | 1.0.0.1 | Original | | | |
| South Park: The Stick of Truth | PC | | Original | | 689058-DVD | |
| Space Ace | PC | | Original | | | |
| Space Arcade Collection | PC | 1.0 | Original | | 11-4150-10 | |
| The Space Bar (Disc 1) | PC | | Original | | 115-7A | |
| The Space Bar (Disc 1) | MAC | | Original | | 115-7D | |
| The Space Bar (Disc 2) | PC | | Original | | 115-7B | |
| The Space Bar (Disc 2) | MAC | | Original | | 115-7E | |
| The Space Bar (Disc 3) | PC | | Original | | 115-7C | |
| The Space Bar (Disc 3) | MAC | | Original | | 115-7F | |
| Space Bucks | PC | | Original | | | |
| Space Dudes | PC | | Original | | | |
| Space Quest IV: Roger Wilco and the Time Rippers Space Quest IV | PC | 1.0 | Original | | CDRM SQU344AE-CD | |
| Space Quest: Collector's Edition Space Quest: 15th Anniversary Collector's Edition | PC | | Original | | | |
| Space Shuttle | MAC | | Original | | CDRM1087300 | |
| Space Station Simulator | PC | 1.1 | Original | | | |
| SpaceChem | PC | 1011 | Original | | | |
| Spartan: Total Warrior | GC | | Original | | DL-DOL-GWAE-USA | |
| Special Permit for Cabela's Big Game Hunter | PC | | Original | | | |
| Spectral Force 3 | XBOX360 | | Original | | AT-2003 | |
| Spectral Souls: Resurrection of the Ethereal Empires | PSP | 1.00 | Original | | ULUS-10076 | |
| Spectre VR CD | MAC | | Original | | | |
| Spectre VR Classic | PC | | Original | | MQ 13-004-120 | |
| Speed | WII | | Original | | RVL-SPEE-USA-B0 | |
| Speed Kings | GC | | Original | | DL-DOL-GDCE-USA | |
| Sphera: The Inner Journey | PC | 1.0 | Original | | 27791-CD | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOE-USA | |
| The Spiderwick Chronicles | PC | 1.0 | Original | | S7270810 | |
| Spine Sense: The Interactive Back Protection Program | CDI | | Original | | | |
| Spirit of Speed 1937 | DC | 1.001 | Original | | T-8118N | |
| Splashdown | XBOX | | Original | | IG-027 | |
| Split/Second | PSP | 1.00 | Original | | ULUS-10513 | |
| Spooky Castle | PC | 1.0 | Original | | 11-2057-10 SPC | |
| Sportsman's Paradise II | PC | 1.0 | Original | | P/N 4-19599CDSL | |
| SportzFreakz | PC | 1.0 | Original | | | |
| SPRay | WII | | Original | | RVL-RYIE-USA | |
| Spy Fox in "Cheese Chase" | PC | | Original | | | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| Spycraft: The Great Game (Disc 1) | PC | | Original | | CDD-3110-101-U3 | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| Spycraft: The Great Game (Disc 3) | PC | | Original | | CDD-3110-103-U3 | |
| SpyHunter | GC | | Original | | DL-DOL-GSHE-USA | |
| Squad Assault: Second Wave | PC | 1.80 | Original | | | |
| SRS: Street Racing Syndicate | XBOX | | Original | | NM-019 | |
| SRS: Street Racing Syndicate | GC | | Original | | DL-DOL-GCSE-USA | |
| SSI Strategy Collection: Critic's Choice Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| SSX 3 | GC | | Original | | DL-DOL-GXBE-USA | |
| SSX Blur | WII | | Original | | RVL-RSXE-USA | |
| SSX on Tour | XBOX | | Original | | EA-130 | |
| Stacked with Daniel Negreanu | XBOX | | Original | | MM-001 | |
| Stanley's Sticker Stories | PC | 1.04 | Original | | 381428-CD4/I083ha | |
| Star Defender III | PC | | Original | | CD001697 | |
| Star Rangers | PC | | Original | | | |
| Star Stable: The Autumn Riders | PC | 1.00.0000 | Original | | 61-0803 04 | |
| Star Trek Pinball | PC | 1.00 | Original | | CD-C95-675-0 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Original | | CD-ICD-016-0 | |
| Star Trek: Elite Force II (Disc 1) | PC | 1.0 | Original | | 32373.101.US | |
| Star Trek: Elite Force II (Disc 2) | PC | 1.0 | Original | | 32373.102.US | |
| Star Trek: Starfleet Academy: Chekov's Lost Missions | PC | | Original | | | |
| Star Trek: Starfleet Command (Bonus CD) | PC | | Original | | CD-C95-637-1 | |
| Star Trek: Starfleet Command III | PC | 1.0 | Original | | 32337.101.US | |
| Star Trek: Starfleet Command III | PC | 1.0 | Original | | 32255.101.US | |
| Star Trek: The Next Generation: A Final Unity | PC | 1.0 | Original | | | |
| Star Trek: The Next Generation: Birth of the Federation | PC | | Original | | | |
| Star Trek: The Next Generation: Interactive Technical Manual | PC | 2.0 | Original | | | |
| Star Trek: Voyager: Elite Force | MAC | | Original | | | |
| Star Wars Galaxies: 10-Day Trial | PC | | Original | | 8330530 | |
| Star Wars Trilogy CD-ROM: Limited Edition Entertainment Utility | PC | | Original | | | |
| Star Wars: Anakin's Speedway | PC | | Original | | #3518030 | |
| Star Wars: Battlefront II | PC | 1.0 | Original | | 3281930 | |
| Star Wars: Behind the Magic: Vehicles Special Edition | PC | 1.0 | Original | | | |
| Star Wars: Empire at War: Forces of Corruption | PC | 1.00.55911 | Original | | 7131930 | |
| Star Wars: Episode III: Revenge of the Sith: Activity Center (Disc 2) | PC | 1.0 | Original | | 682967-CD2 | |
| Star Wars: Galactic Battlegrounds (Disc 1) (Install) | PC | 1.0 | Original | | 8531830 | |
| Star Wars: Galactic Battlegrounds (Disc 2) (Play) | PC | 1.0 | Original | | 8531831 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Original | | 0762.05.0 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | Original | | 0762.05.0 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | MAC | 1.0.1 | Original | | 10610-1CDA | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | MAC | 1.0.1 | Original | | 10610-2CDA | |
| Star Wars: Millennium Falcon CD-ROM Playset | PC | | Original | | | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630, CDRM1208410 | |
| Star Wars: Rebel Assault | PC | 1.2 | Original | | 632630, CDRM1142600 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | MAC | 1.0 | Original | | 2062130 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter: Balance of Power | PC | 1.10 | Original | | | |
| Star Wars: Yoda's Challenge | PC | | Original | | 3520030 | |
| Starball | PC | 1.20 | Original | | | |
| StarLancer (Disc 1) Microsoft StarLancer | PC | | Original | | 0200 Part Number X05-67021 | |
| StarLancer (Disc 2) Microsoft StarLancer | PC | | Original | | 0200 Part Number X05-67023 | |
| Starshine Legacy: Episode 2: Secret of Pine Hill Mansion | PC | | Original | | SLE2, US-61-0603 05 | |
| Starshine Legacy: Episode 4: The Riddle of the Dark Core | PC | | Original | | US: 61-0612 04 | |
| Starship Troopers | PC | 0.3.2.69 | Original | | P/N 21121-5 | |
| Starship Tycoon | PC | Build 2.24 | Original | | | |
| Starsiege | PC | 1.02 | Original | | | |
| Starsky & Hutch | GC | | Original | | DL-DOL-GT5E-USA | |
| State of Emergency | XBOX | | Original | | TT-006 | |
| Steel Panthers III: Brigade Command: 1939-1999 | PC | 1.0 | Original | | 2218010-590001 | |
| Steel Soldiers | PC | | Original | | | |
| Steel Tide | PC | 1.0.0.1 | Original | | | |
| Stella Gets a New Brain! | PC | | Original | | AR-4601 | |
| Stella Gets a New Brain! | PC | 2.0 | Original | | AR-4602 | |
| Stellar 7 | PC | | Original | | | |
| A Steven Spielberg Film: Minority Report: Bonus CD-ROM! | PC | | Original | | | |
| Stoked | XBOX360 | | Original | | DE-2003 | |
| Stonekeep | PC | 1.05 | Original | | CD-ICD-045-0 | |
| Story Lane Theater 1 | PSX | | Original | | LSP-990141 … | |
| Story Lane Theater 2 | PSX | | Original | | LSP-990142 … | |
| Story Lane Theater 3 | PSX | | Original | | LSP-990143 … | |
| Story Lane Theater 4 | PSX | | Original | | LSP-990144 … | |
| Story Lane Theater 5 | PSX | | Original | | LSP-990145 … | |
| Storybook Weaver Deluxe | PC | 1.0 | Original | | | |
| Storybook Weaver Deluxe | PC | 1.1 | Original | | Product #HCD642 | |
| Storybook Weaver Deluxe 2004 | PC | 3.0 | Original | | 483050-CD | |
| Storybook Workshop | WII | | Original | | RVL-R4VE-USA-B0 | |
| Strategic Command: European Theater | PC | 1.0 | Original | | | |
| Stray Souls: Dollhouse Story | PC | | Original | | | |
| Street Fighter Alpha 2 | PC | | Original | | | |
| Street Fighter II | PC | | Original | | 9108 | |
| Street Fighter Series | PC | | Original | | | |
| Street Fighter Series | PC | | Original | | | |
| Street Hoops | XBOX | | Original | | AV-003 | |
| Street Hoops | GC | | Original | | DL-DOL-GHPE-USA | |
| Street Legal | PC | | Original | | 30975.101.US | |
| Street Supremacy | PSP | 1.00 | Original | | ULUS-10069 | |
| Strife | PC | 1.2 | Original | | | |
| Strike Fighters: Project 1 | PC | 1.0.0.1 | Original | | 24147CD | |
| Strike Force Bowling | GC | | Original | | DL-DOL-G5BE-USA | |
| Stronghold | PC | 1.1 | Original | | | |
| Su-27 Flanker Mission Disk | PC | | Original | | 2212510-590001 | |
| Sub Culture | PC | | Original | | | |
| The Sudoku Challenge! Collection | PC | | Original | | | |
| The Suffering | XBOX | | Original | | MW-021 | |