Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sable Maze: Forbidden Garden & Twelve Fears | PC | | Original | | 33528010US | |
| Sable Maze: Sullivan River / Norwich Caves | PC | | | | 33471010US | |
| Sacrifice (Editors Press Kit) | PC | | Press Kit | | | |
| Sam & Max: Season One | WII | | Beta | | | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | Beta | | | | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original | | Disc Assy. 451-052-012 0396 Part No. 90626 | |
| Schoolhouse Rock! 1st & 2nd Grade Essentials (Disc 1) | PC | | Original | | 21330CD-1 | |
| Science Fiction: The Ultimate Collection (Disc 1) | PC | | | | 11014 | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.01 | Original | | 380849A-CD | |
| Scorcher | SS | 1.008 | Original | | 81214 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| The Second AMUC CD | ACD | | | | CDRM1251610 | |
| Sega Entertainment's Arcade Sampler | PC | | | | | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Self Selling Disc | CDI | 3.1 | | | 310-690-049-2 | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Rerelease | | CD-W58-1103-1 | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| Seven Kingdoms: The Fryhtan Wars / Shadow Company: Left for Dead | PC | | Demo | | 5051859 | |
| Shade: Wrath of Angels (Press Disc) | PC | | Press Kit | | | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow Man | PC | | Demo | | | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shadow Wolf Mysteries: Curse of the Full Moon / Bane of the Family | PC | | | | 33425010US | |
| Shamrock's Fall '96 Demo CD | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| Shining Soul II + Shining Force Assets Shining Soul 2 + Shining Force Assets | PC | | Press Kit | | | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shivers | PC | | Demo | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shorelines | CDI | | | | | |
| Shrek Super Party | XBOX | | Original | | TM-004 | |
| Shrine Circus Tycoon | PC | | | | 31933.101.US | |
| Sid Meier's Alien Crossfire | PC | | Original | | 1405807 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's SimGolf | PC | | Rerelease | | 1641547 | |
| Sierra Holiday Software Sampler | PC | | | | | |
| Sierra Products Demo America Online featuring Sierra Online | PC | | | | R00482 | |
| Sierra's School House: Math (Disc 1) | PC | | Original | | | |
| Sierra's School House: Math (Disc 2) | PC | | Original | | | |
| Sierra's Sneak Peeks 2 | PC | | Demo | | | |
| Silent Hill: Downpour | PS3 | 01.01 | Review | | | |
| SimGolf | PC | 1.0 | Original | | 0093-000-0601-A | |
| The Sims 2 | PC | | Press Kit | | | |
| The Sims 3 | WII | | Beta | | | |
| SimTunes | PC | | Original | | 0135-000-0601-A | |
| Sin SiN | PC | | Demo | | DMO-1000076.101.US | |
| Sin SiN | PC | 1.01 | Rerelease | | 6236-01 | |
| Singularity | PC | | Press Kit | | | |
| Sinkha | MAC | | Original | | | |
| Skate It | WII | | Beta | | | |
| Ski Park Manager 2003: Gold Edition Val d'Isère Ski Park Manager 2003: Gold Edition | PC | | | | 71102221 | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Skin Style | CDI | | Original | | | |
| SkyGunner | PS2 | 1.00 | Trade Demo | | SLUS-28008 | |
| Skylanders: Imaginators | XBOX360 | | Original | | AV-2352 | |
| Skylanders: Spyro's Adventure | PC | | Press Kit | | | |
| Skylanders: SuperChargers | XBOX360 | | Original | | AV-2335 | |
| Skylanders: Swap Force | XBOX360 | | Starter Pack | | AV-2281 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | PC | | Original | | | |
| Sleeping Dogs | PS3 | 00.00 | Preview | | | |
| Slingo Mystery: Who's Gold | PC | | Big Fish Games Backup CD | | | |
| Small Soldiers: Globaltech Design Lab | PC | | | | Product# 99144 | |
| Small Soldiers: Squad Commander | PC | | | | Product# 99264 | |
| SMBX + Tak 2 Art | PC | | Press Kit | | | |
| Smoking Guns Smoking Guns: Shooting Gallery! | PC | 1.0 | Cosmi | | 02-2503-10 | |
| SNK NeoGeo USA Consumer Corporation: E3 2004 Games | PC | | Press Kit | | | |
| SNK Playmore E3 2006 Games | PC | | Press Kit | | | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| Soft Kill | PC | | Original | | | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | MAC | | Original | | | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| Sonic Mega Collection Plus | PS2 | 0.80 | Beta | | | |
| Sony E3 2004: Press Information | PC | | Press Kit | | | |
| Sony PlayStation 2: SCEA Santa Monica Studios: 2004 Press Information: Press Print | PC | | Press Kit | | | |
| Soulcalibur II | XBOX | | Demo | | NM-003 | |
| Soulcalibur II | PS2 | 1.00 | Demo | | SLUS 29058 | |
| Sounds Best on Sound Blaster Every Game Sounds Best on Sound Blaster: 24-bit Advanced HD | PC | | | | | |
| SouthPeak Interactive E3 2000 Electronic Press Kit | PC | | Press Kit | | | |
| Space Bunnies Must Die! | PC | | Demo | | MSDE-37216 | |
| Space Ranger | CDI | | Unlicensed | | OGCDI-1180 | |
| Space Station Tycoon | WII | | Prototype | | | |
| Special Permit for Cabela's Big Game Hunter | PC | | Original | | | |
| Speed Freaks (Misc Artwork: PC-CD 2nd July '99) | PC | | Press Kit | | | |
| Spine Sense: The Interactive Back Protection Program | CDI | | Original | | | |
| Splashdown | XBOX | | Original | | IG-027 | |
| SPRay | WII | | Beta | | | |
| Spring 2012 Refresh Standard: PS3 IDU 4.11 | PS3 | | Kiosk Demo | | | |
| Spring 2013: Standard IDU 4.31 | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2010: 3.21 IDU Update (E-M) | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2011 3.60 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Spyborgs | WII | | Beta | | | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| Square Enix E3 2004 Media CD | PC | | Press Kit | | | |
| SquareSoft: E3 2001 Media CD | PC | | Press Kit | | | |
| SRS: Street Racing Syndicate | XBOX | | Original | | NM-019 | |
| SSI Strategy Collection: Critic's Choice Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| SSX Blur | WII | | Beta | | | |
| Star Defender III | PC | | Original | | CD001697 | |
| Star Trek Pinball | PC | | Bundle Version OEM | | CD-C95-675-UNU | |
| Star Trek Pinball | PC | 1.00 | Original | | CD-C95-675-0 | |
| Star Trek: Secret of Vulcan Fury (Non-Interactive Preview) | PC | | | | CD-C95-647-N1 | |
| Star Trek: Secret of Vulcan Fury (Non-Interactive Trailer) | PC | | | | CD-C95-647-N2 | |
| Star Trek: Starfleet Academy | PC | 1.15 | Bundle Version OEM (DVD-ROM) | | CD-DVD-069-GQE | |
| Star Wars Galaxies: 10-Day Trial | PC | | Original | | 8330530 | |
| Star Wars: Anakin's Speedway | PC | | Original | | #3518030 | |
| Star Wars: Attacktix: Battle Figure Game | PC | | Starter Set CD-ROM Series 2 | | | |
| Star Wars: Episode I: Cover Disk 4 | PC | | Press Kit | | | |
| Star Wars: Episode I: Disc #3: Covers | PC | | Press Kit | | | |
| Star Wars: Rebel Assault | MAC | | Demo | | CDRM1209730 | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630, CDRM1208410 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | MAC | 1.0 | Original | | 2062130 | |
| Star Wars: Yoda's Challenge Activity Center | PC | | Demo | | #3529030 | |
| Starfighter Assets CD | PC | | Press Kit | | | |
| Steven Spielberg's Director's Chair (Disc 1) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD100CD | |
| Steven Spielberg's Director's Chair (Disc 2) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD200CD | |
| Steven Spielberg's Director's Chair (Disc 3) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD300CD | |
| Storybook Weaver Deluxe 2004 | PC | 3.0 | Original | | 483050-CD | |
| Stowaway DK Multimedia: Stephen Biesty's Incredible Cross-Section: Stowaway | PC | | | | | |
| Stratosphere: Conquest of the Skies | PC | | Demo | | | |
| Street Hoops | XBOX | | Original | | AV-003 | |
| The Sudoku Challenge! Collection | PC | | Original | | | |
| Summer Refresh 2011: 3.65 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |
| Super Bender Boot Disc | PS2 | 2.00 | | | | |
| Super Magnetic Neo | DC | 1.001 | Demo | | T-40206ND | |
| Super Stories: Mom is Going to Stop It | CDI | | | | | |
| Super Stories: My Favorite Things | CDI | | | | | |
| Supreme Commander | XBOX360 | | Original | | AY-2001 | |
| SWAT 4 | PC | | Demo | | | |
| Sword of the New World: Granado Espada | PC | 2.1.18 | | | | |
| SX Superstar | PS2 | 1.00 | Preview | | SLUS-20600 | |
| Systemax Ultimate Software Collection (Disc 01) (Daria's Inferno / Who Wants to Beat Up a Millionaire) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 02) (I See Sue... the T. Rex / Amazons & Aliens / Cheerios: Playtime) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 03) (How Many Bugs in a Box? / More Bugs in Boxes / Jim Henson's Muppet Babies: Toyland Train / Miss Spider's Tea Party) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 04) (Forbes: Corporate Warrior / Starwebs: Web Shop / Writing Tutor / Complete Idiots Guide: Marketing Materials Maker) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 05) (S&S Encyclopedia / Typing Tutor 12) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 06) (Women's Fitness / Christina Aguilera: Follow Your Dreams) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 08) (Garfield: Mad About Cats / Money Town) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 09) (Darkened Skye: Disc 1 / Zoboomafoo with the Kratt Brothers Animal Kids) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 10) (Deer Avenger / Ski-Doo X-Team Racing) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 11) (Pearl Harbor: Zero Hour / Real War) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 12) (S&S Encyclopedia of Science / Curious George: Reads, Writes and Spells) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 13) (Multimedia Billiards / Astrology Starscopes / Music Match Juke Box Deluxe 6.1 / Extreme Chess / Typing Tutor Jr. / Bumper Wars) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 14) (Darkened Skye: Disc 2) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 18) (M&M's: The Lost Formulas) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 22) (Richard Scarry's: Busy Town) | PC | 2.0 | Original | | | |
| Systemax Ultimate Software Collection (Disc 26) (Sabrina, the Teenage Witch: Brat Attack) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 27) (Star Trek: Deep Space Nine - The Fallen) | PC | | Original | | | |
| Swap Magic 3 | PS2 | 3.10 (American) | Unlicensed | | | |
| Star Stable: The Autumn Riders | PC | 1.00.0000 | Original | | 61-0803 04 | |
| Starshine Legacy: Episode 2: Secret of Pine Hill Mansion | PC | | Original | | SLE2, US-61-0603 05 | |
| Starshine Legacy: Episode 4: The Riddle of the Dark Core | PC | | Original | | US: 61-0612 04 | |
| SimCity 4 (Disc 1) | PC | 1.0 | Original | | MXB08803894CD1 | |
| SimCity 4 (Disc 2) | PC | 1.0 | Original | | MXB08803894CD2 | |
| San Francisco Rush 2049 | DC | 1.000 | Demo | | T-9707ND | |
| San Francisco Rush 2049 | DC | 1.001 | Original | | T-9707N | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sacred (Disc 1) | PC | 1.8 | Rerelease | | 10153-CD1 | |
| Sacred (Disc 2) | PC | 1.8 | Rerelease | | 10153-CD2 | |
| Sacred 2: Fallen Angel (Disc 1) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 2) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 3) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| Sacrifice (Scapex Tutorial Video) | PC | | Preproduction | | | |
| Sacrifice | PC | | Bundle Version Hewlett Packard OEM | | CD-C951041-PC2E | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Sam & Max: This Time It's Virtual! | PC | | Limited Run Games | | | |
| Sammy's Science House | PC | 1.0 | Original | | | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Sammy's Science House | PC | 3.0 | Southwestern Kids' Collection | | R2522/8612a.7.01 | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Western | PS2 | 1.00 | Trade Demo | | SLUS-28051 | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | 170121 | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sanitarium | PC | | Demo | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 2) | PC | 1.0 | Original | | | |
| Sargon Chess | CDI | | Beta | | 310-690-030-2 | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Savage: The Ultimate Quest for Survival | PC | 1.0 | | | | |
| Save Planet Polluto | PC | 1.0 | Original | | | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| SCEA Gamers Day 2002: Press Info | PC | | Press Kit | | | |
| SCEE Software Brochure + Press Information: E3 2003 | PC | | Press Kit | | | |
| Scene It? Bright Lights! Big Screen! | XBOX360 | | Original | | WR-2037 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCE-USA-B0 | |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| Schizm: Mysterious Journey (Side A) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Side B) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey | PC | 0.99 | Playable Demo | | | |
| Scholastic's The Magic School Bus Discovers Flight: Activity Center | PC | 1.0.0.2 | Original | | 0201 Part No. X06-16068 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | 1.0.0.1528 | Handi-Snacks Promotional | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | 1.0 | Original | | 0894 Part No. 59104, Disc Assy 299-052-002 | |
| Scholastic's The Magic School Bus Explores the Solar System | PC | 1.00.0010 | Bundle Version OEM | | 0296 Disc Assy. 000-30505 | |
| Scholastic's The Magic School Bus in Concert: Activity Center | PC | 1.0.0.2 | Original | | 0400 Part No. X05-64231 | |
| Scholastic's The Magic School Bus Lands on Mars: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0400 Part No. X05-64212 | |
| Scholastic's The Magic School Bus: Volcano Adventure: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0401 Part No. X08-06054 | |
| School Zone Flash Action Software: Multiplication/Division | PC | | Original | | 08021 | |
| School Zone Math: First & Second Grade | PC | | Original | | 08020 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! America Rock | PC | | Original | | 21080CD | |
| Schoolhouse Rock! Grammar Rock | PC | | Original | | 9227 | |
| Schoolhouse Rock! Grammar Rock | MAC | | Original | | 9227 | |
| Schoolhouse Rock! Thinking Games | PC | | Original | | BBT844AE-CD | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744AE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 2) (Learning Adventures) | PC | | Original | | SRT744AE-CD2 | |
| SCI Games E3 2005 Press Kit | PC | | Press Kit | | | |
| Science Is Elementary 1 | PSX | | Original | | LSP-990161 … | |
| Science Is Elementary 2 | PSX | | Original | | LSP-990162 … | |
| Science Is Elementary 3 | PSX | | Original | | LSP-990163 … | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.02 | | | 380849B-CD | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Night of 100 Frights | PSX | | Prototype | | | |
| Scooby-Doo! Night of 100 Frights | PS2 | 0.00 | Beta | | | |
| Scooby-Doo! Night of 100 Frights | PS2 | 0.00 | Beta | | | |
| Scooby-Doo! Phantom of the Knight | PC | 1.0 | Original | | 380325-CD | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| Scrabble | PC | | General Mills | | | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Scramble Cobra | 3DO | | Beta (CD-R) | | | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| The Scroll | PC | | | | | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| Secret Weapons over Normandy | PS2 | 1.00 | Review Build | | SLUS-20762 | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| Secrets of Great Art | PC | 1.1 | Original | | P/N 61218-CD | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Sega Classics Arcade Collection | MCD | 1.01 | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | 4126 | |
| Sega E3 Press Kit 2005 2005 E3 Press Kit | PC | | Press Kit | | | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega Puzzle Pack | PC | | Rerelease | | 85091 / FS22923 | |
| Sega Rally Championship Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 | |
| Sega Rally Revo | PSP | 1.00 | Original | | ULUS-10311 | |
| Sega Screams Volume 2 | SS | 2.000 | Not for Resale | | 81077 | |
| Sega Screenshots 2000 Sega E3 2000 | PC | | Press Kit | | | |
| Sega Worldwide Soccer '97 | SS | 1.001 | Original | | 81112 | |
| Senha N. 1 | PC | | | | | |
| Sentient | PC | | Original | | | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| Serious Sam: The First Encounter | PC | | | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| Sesame Street Reading is Fun! Toddler (Disc 1) (Grover's Travels) | PC | 2.0 | Original | | SRF844AE-CD-1 | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Sesame Street: Art Workshop | PC | | Original | | 9369 | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Elmo's Art Workshop | PC | | Original | | EAW844AE-CD | |
| Sesame Street: Elmo's Preschool | PC | | | | 11040CD | |
| Sesame Street: Elmo's Preschool (Disc 1) (Elmo's Preschool) | PC | 3.1 | Original | | P/N 379663-CD1 | |
| Sesame Street: Elmo's Preschool (Disc 2) (Search & Learn Adventures) | PC | 3.1 | Original | | P/N 379663-CD2 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 1) (Elmo's Preschool) | PC | 2.0 | | | SPC844AE-CD-1 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 2) (Search & Learn Adventures) | PC | 2.0 | | | SPC844AE-CD-2 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| Sesame Street: Learn, Play and Grow Preschool / Sesame Street: Let's Go to Preschool / Sesame Street: First Steps | PC | | Southwestern Kids' Collection | | 05SS3-R01 | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Sesame Street: Let's Make a Word! | PC | | Bundle Version Creative Labs OEM | | 1713310119-1 | |
| Sesame Street: Letters | PC | | | | 9367A | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: My Baby & Me (Disc 1) (Baby & Me) | PC | 1.0 | Original | | SSY744AE-CD1 | |
| Sesame Street: My Baby & Me (Disc 2) (Sesame Street Greatest Hits Sampler) | PC | 1.0 | Original | | SSY744AE-CD2 | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Reading Basics | PC | | Encore | | 10200 | |
| Sesame Street: Toddlers Deluxe (Disc 1) (Art Workshop) | PC | 2.0 | Original | | STO844AE-CD-1 | |
| Sesame Street: Toddlers Deluxe (Disc 2) (Letters) | PC | 2.0 | Original | | STO844AE-CD-2 | |
| Sesame Street: Toddlers Deluxe (Disc 3) (Numbers) | PC | 2.0 | Original | | STO844AE-CD-3 | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Shadow Company: Left for Dead (Digital Press Kit) | PC | | Press Kit | | 5051895 | |
| Shadow Company: Left for Dead | PC | 1.0 | Original | | 5051802 | |
| Shadow of Rome | PS2 | 1.00 | Demo | | SLUS 29139 | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| ShadowCaster | PC | | Top Ten Pak II | | 5454 | |
| Shadows of Cairn | PC | | Rerelease | | | |
| Shanghai Double Pack | PC | | Original | | | |
| Shanghai: Great Moments | PC | 2.00 | Bundle Version Canon OEM | | | |
| Shannara | PC | 1.0 | Rerelease | | 7-81055-33802-6 | |
| Shaolin | PSX | | Preview | | | |
| Shape Shifter | PC | | Original | | | |
| SharkPort: Code and Save Transfer Kit | PS2 | 1.23 | Unlicensed | | | |
| Sharks! An Interactive Journey An Interactive Journey With... Sharks! | PC | | Original | | | |
| Shattered Steel | PC | 1.12 | Rerelease | | CD-ICD-732-0 | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| Shepherd's Crossing | PSP | 1.00 | Original | | ULUS-10499 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Rerelease | | CDRM 835400 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 2 | Original | | CDRM 770000 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 5.1 | 5 ft. 10 PAK Vol. 2 | | CD 7012 SPI | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. III | PC | 4 | Original | | CDRM1061930 | |
| The Shield: The Game | PC | 1.0.0.0 | | | 11451-1DDA | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shin Megami Tensei: Devil Summoner: Raidou Kuzunoha vs. the Soulless Army | PS2 | 1.00 | Trade Demo | | SLUS-28064 | |
| Shin Megami Tensei: Digital Devil Saga | PS2 | 1.00 | Trade Demo | | SLUS-28049 | |
| Shin Megami Tensei: Digital Devil Saga 2 | PS2 | 1.00 | Trade Demo | | SLUS-28052 | |
| Shin Megami Tensei: Nocturne | PS2 | 1.00 | Trade Demo | | SLUS-28045 | |
| Shin Megami Tensei: Persona | PSP | 1.00 | Original | | ULUS-10432 | |
| Shin Megami Tensei: Persona 3 | PS2 | 1.00 | Trade Demo | | SLUS-28067 | |
| Shin Megami Tensei: Persona 3 FES | PS2 | 1.00 | Trade Demo | | SLUS-28068 | |
| Shin Megami Tensei: Persona 3 Portable | PSP | 1.00 | Trade Demo | | ULUS-80022 | |
| Shin Megami Tensei: Persona 4 | PS2 | 1.00 | Trade Demo | | SLUS-28069 | |
| Shining Force III | SS | 1.000 | Beta | | | |
| Shining Wisdom | SS | 1.000 | Beta | | | |
| Shining Wisdom | SS | 1.000 | Preview | | | |
| Shinobi | PS2 | 1.00 | Trade Demo | | SLUS-28016 | |
| The Ship | PC | | Original | | | |
| Shivers Two: Harvest of Souls | PC | 1.0 | Demo | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.00 | | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | 831744330/S174150 | |
| Shogo: Mobile Armor Division 昇剛 | PC | 1.0 | Original | | | |
| Shogo: Mobile Armor Division | PC | 2.2 | Bundle Version Creative Labs OEM | | 1713310341 | |
| Shogun: Total War: The Mongol Invasion Shōgun: Total War: The Mongol Invasion | PC | 1.00 | Original | | 1430907 | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shonen Jump's One Piece: Grand Battle | PS2 | 1.00 | Demo | | SLUS 29159 | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| ShowMaster | CDI | 1.0 | Demo | | | |
| Shrak Shrak for Quake | PC | 2.0 | Rerelease | | | |
| Shrek 2 | PC | | Original | | 32585.101.US | |
| Shrek 2 (Final Press Kit) | PC | | Press Kit | | | |
| Shrek 2 | PC | | | | 32585.101.US | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9E-USA | |
| Shrek Game Land Activity Center | PC | | Original | | 32053.101.US | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYE-USA | |
| Sid Meier's Alpha Centauri | MAC | RELEASE 4.0 | Original | | | |
| Sid Meier's Civil War Collection | PC | 1.00f | | | 1225507 | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | 0-520-47-101 | |
| Sid Meier's Colonization Sid Meier's Colonization: Create a New Nation | PC | 3.141592 | Rerelease | | P/N 70119 | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Siege of Avalon Anthology | PC | 1.1.2001.913 | Original | | | |
| Sierra Press Kit | PC | | Press Kit | | | |
| Sierra's School House: English (Disc 1) | PC | | Original | | | |
| Sierra's School House: English (Disc 2) | PC | | | | | |
| Sierra's School House: Science (Disc 1) | PC | | Original | | 831614230/S161155 | |
| Sierra's School House: Science (Disc 2) | PC | | Original | | 831614230/S161155 | |
| Silent Hill: Shattered Memories | PSP | 1.00 | Original | | ULUS-10450 | |
| Silent Hunter | PC | 1.0 | Rerelease | | WWD144AE-CD | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.00 | Original | | | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| Silver (Disc 1) | PC | 1.08C | | | | |
| Silver (Disc 2) | PC | 1.08C | | | | |
| SimAnt | PC | | Scholastic | | 5710346C SP2 | |
| SimCity 2000 Special Edition | PC | 1.0 | CD-ROM Classics | | 1131107 | |
| SimCity 2000: CD Collection | PC | 1.2 | Windows | | 0026-000-0601-A | |
| SimCity 2000: CD Collection | PC | 1.2cj | Windows | | 0026-000-0601-A | |
| SimCity 3000 | PC | | Domino's Pizza / Easter Seals | | | |
| SimCity 3000 | PC | | Scholastic | | 1500107 | |
| SimCity 3000 | MAC | 1.0.557 | Original | | 1500607 | |
| SimCity 3000 Unlimited | PC | | Bundle Version Compaq OEM | | 1500907, 239478-001 | |
| SimCity Enhanced CD-ROM | PC | | Rerelease | | CD-ICD-204-0 | |
| SimIsle: Missions in the Rainforest | PC | 1.0 | Original | | 0058-030-0901 | |
| SimLife SimLife: The Genetic Playground | PC | | Rerelease | | | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| The Simpsons Game | PSP | 1.00 | Original | | ULUS-10295 | |
| The Simpsons: Road Rage | PS2 | 1.00 | Beta | | SLUS-20305 | |
| The Sims 2 | PSP | 1.00 | Original | | ULUS-10031 | |
| The Sims 2 | PS2 | 1.00 | Beta | | SLUS-21066 | |
| The Sims 2 | PS2 | 1.00 | Beta | | SLUS-21265 | |
| The Sims 2: Insider Preview CD | PC | | Original | | 1625207 | |
| The Sims 2: Pets | PSP | 1.00 | Original | | ULUS 10130 | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.230 | | | 1491707 | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.230 | Original | | 1491707 | |
| The Sims Online (Disc 1) | PC | 1.0 | Charter Edition | | 1461517 | |
| The Sims Online (Disc 2) | PC | 1.0 | Charter Edition | | 1461527 | |
| The Sims Strategy Guide and SimFan Pack | PC | | Pre-Order Bonus | | 1414407 | |
| The Sims | MAC | | | | | |
| SimTheme Park Sim Theme Park | PC | | Scholastic | | 1403307 | |
| SimTower SimTower: The Vertical Empire | PC | 1.0 | Original | | 0051-040-0601-B | |
| SimTown | PC | 1.0 | Original | | 0037-000-0601-A | |
| Sin SiN | PC | 1.01 | Original | | 1000076.101.US | |
| Sing-Along Kids | PC | 1.1 | Original | | | |
| Sing-Along Kids: Vol. 2 | PC | | | | | |
| Sins of a Solar Empire | PC | | Rerelease | | | |
| Sins of a Solar Empire: Trinity | PC | | | | | |
| The Skins Game at Bighorn | PC | | Original | | CD-MPC-126-0 | |
| SkyGunner | PS2 | 1.00 | Demo | | SLUS 29020 | |
| SkyTrip America SkyTrip America: An Incredible Ride Through U.S. History! | PC | 1.0 | | | | |
| Slam 'n Jam '95 | 3DO | | Beta (CD-R) | | | |
| Slam Dunk Typing All-Star Typing: Ages 9-12: Slam Dunk Typing | PC | | Original | | WTY744AE-CD | |
| Slam Dunk Typing All-Star Typing: Ages 9-12: Slam Dunk Typing | PC | 1.01 | Rerelease | | TYN744BE-CD | |
| Slater & Charlie Go Camping | PC | 1.000 | SierraOriginals | | | |
| Slave Zero | DC | 1.001 | Original | | T-15106N | |
| Slingo | PC | | Oregon Lottery | | | |
| Slingo | PC | | Original | | 99310 | |
| Slingo 2-Pack | PC | | Original | | | |
| Slingo Quest | PC | 0.0.0.104 | Original | | | |
| Slingo: 15th Anniversary Edition | PC | | Original | | | |
| Slingo: Wild 7's | PC | | Oregon Lottery | | | |
| Slot City Jackpot Games (120 Slot Machines) | PC | | Jackpot Games | | CD-4700 | |
| Slots Adventure: War for Olympus | PC | 1.0 | Original | | | |
| Slots Dual Pack Best of Slots from Bally Gaming / Best of Slots II | PC | | Original | | | |
| Slots Featuring WMS Gaming | PC | 1.0.3 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.1 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.2 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Small Soldiers | PSX | | Preview | | | |
| Smart Games: Challenge 1 | PC | | Rerelease | | 99168 | |
| Smart Games: Challenge 1 | PC | | Rerelease | | 99168 | |
| Smart Games: Challenge 1 | PC | | Original | | P/N:DSGC1CD0001 | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| Smuggler's Run: Warzones | GC | | Original | | DL-DOL-GSRE-USA | |
| Snap Dragon | PC | 1.0 | Original | | | |
| Snoopy's Campfire Stories | PC | | Original | | | |
| Snow Storm | PC | | Original | | 9099 | |
| Snowboard Park Tycoon | PC | | | | 30983.101.US | |
| So Who's Dr. Rabbit? | PC | | Original | | | |
| So You Wanna Be a Redneck | PC | | Original | | | |
| Socket Low Power SDIO WLAN | PPC | Release 142 D | Original | | P/N 6210-00142 D | |
| SocketScan | PALM | Release 108K | Original | | P/N 6210-00108 K | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.00 | Demo | | SCUS 97368 | |
| SOCOM: U.S. Navy SEALs | PS2 | 1.00 | Demo | | SCUS 97205 | |
| SOCOM: U.S. Navy SEALs | PS2 | 1.00 | Public Beta v1.0 | | SCUS 97859 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo | PSP | 1.00 | Public Beta v1.0 | | UCUS 98637 | |
| Software & Document: Master CD for Video Family | PC | 1.20 | Bundle Version Jaton OEM | | | |
| The Software Toolworks CD Deluxe Pack: Version 2 | PC | | Bundle Version Packard Bell OEM | | 2192611-590001 170122 | |
| The Software Toolworks CD Game Pack | PC | | Original | | | |
| The Software Toolworks Presents: Maniac Sports | MAC | | Original | | 2200820-590001 / I034100 | |
| The Software Toolworks' Star Wars Chess | PC | 1.00 | Bundle Version OEM | | 13-004-060 | |
| Sol-Feace | MCD | RE | Bundled with Sega CD | | 4130 | |
| Soldier of Fortune | PC | 1.03 | Bundle Version ASUS OEM | | 1000910.101.US | |
| Soldier of Fortune | PC | 1.03 | Bundle Version ASUS OEM | | | |
| Soldiers at War | PC | | Preview | | | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | PC | | Rerelease | | | |
| Solitaire Antics Ultimate | PC | 1.0.3L | Original | | | |
| Solitaire Master | PC | | Original | | 20-1280-10 | |
| Solitaire Master 4 | PC | 1.0 | Original | | 02-8156-10 | |
| Solitaire Master 5 | PC | 1.0 | Original | | 02-2153-10 | |
| Solitaire: 50 Complete Games! | PC | 2.0 | Rerelease | | 10-0990-10 | |
| Sonic 3D Blast | PC | 1.0 | Twin Pack | | 6822 01 | |
| Sonic Adventure | DC | 1.000 | Trial Version for E3 | | HDR-0001 | |
| Sonic CD | MCD | 1.15 | Beta | | | |
| Sonic MegaMix | MCD | | Unlicensed | | | |
| Sonic Shuffle | DC | 1.000 | Original | | 51060 | |