Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sid Meier's Railroad Tycoon | PC | 455.03 | RomZōn! | | 0-447-40-101 | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Colonization Sid Meier's Colonization: Create a New Nation | PC | 3.141592 | Rerelease | | P/N 70119 | |
| Sid Meier's Civilization III Complete (Disc 3) (Conquests) | PC | | Original | | 25766CD3 | |
| Sid Meier's Civilization III Complete (Disc 2) (Play the World) | PC | | Original | | 25766CD2 | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Original | | 25766CD1 | |
| Sid Meier's Civilization III | PC | 1.29f | Game of the Year Edition (Rerelease) | | | |
| Sid Meier's Civilization III | PC | 1.29f | Scholastic | | P/N CDR9640733 | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | 0-520-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Infogrames Rerelease | | | |
| Sid Meier's Civilization II | PC | 2.42a | Risk: Gold Edition | | Product # 99227 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42 | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization Chronicles (Disc 3) (Sid Meier's Civilization III Complete: Disc 1) | PC | | Original | | 31074-1.3 | |
| Sid Meier's Civilization Chronicles (Disc 2) | PC | | Original | | 31074-1.2 | |
| Sid Meier's Civilization Chronicles (Disc 1) | PC | | Original | | 31074-1.1 | |
| Sid Meier's Civil War Collection | PC | 1.00f | | | 1225507 | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Linux | | | |
| Sid Meier's Alien Crossfire | PC | | Original | | 1405807 | |
| Shutter Island: The Adventure Game | PC | 1.0.0 | Original | | | |
| Shrine Circus Tycoon | PC | | | | 31933.101.US | |
| Shrek Game Land Activity Center | PC | | Original | | 32053.101.US | |
| Shrek 2: Team Action | PC | 1.0 | Original | | 32789.101.US | |
| Shrek 2 | PC | | Original | | 32585.101.US | |
| Shrek 2 (Final Press Kit) | PC | | Press Kit | | | |
| Shrek 2 | PC | | | | 32585.101.US | |
| Shrak Shrak for Quake | PC | 2.0 | Rerelease | | | |
| Shogun: Total War (Disc 1) | PC | | Rerelease | | 798727 | |
| Shogo: Mobile Armor Division | PC | 2.2 | Bundle Version Creative Labs OEM | | 1713310341 | |
| Shogo: Mobile Armor Division 昇剛 | PC | 1.0 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | 831744330/S174150 | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.00 | | | | |
| Shivers Two: Harvest of Souls | PC | 1.0 | Demo | | | |
| Shining Soul II + Shining Force Assets Shining Soul 2 + Shining Force Assets | PC | | Press Kit | | | |
| Sherlock Holmes: Nemesis (Disc 2) | PC | 1.00.0777 | Original | | PCO589CD2, SNY 1.0 | |
| Sherlock Holmes: Nemesis (Disc 1) | PC | 1.00.0777 | Original | | PCO589CD1, SNY 1.0 | |
| Sherlock Holmes: Consulting Detective: Volume One, Version Two | PC | | Original | | CDRM 770000 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 5.1 | 5 ft. 10 PAK Vol. 2 | | CD 7012 SPI | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective Volume Three, Version Four | PC | | Original | | CDRM1061930 | |
| Shattered Steel | PC | 1.12 | Rerelease | | CD-ICD-732-0 | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-1 | |
| Shattered Steel | PC | 1.00 | Original | | CD-ICD-201-0 | |
| Shattered Steel | PC | 1.0 | Original | | CD-ICD-201-0 | |
| Sharks! An Interactive Journey An Interactive Journey With... Sharks! | PC | | Original | | | |
| Shape Shifter | PC | | Original | | | |
| Shannara | PC | 1.0 | Rerelease | | 7-81055-33802-6 | |
| Shannara | PC | 1.0.0 | Original | | | |
| Shanghai: Great Moments | PC | 2.00 | Bundle Version Canon OEM | | | |
| Shanghai II: Dragon's Eye | PC | 1.05 | 2 for 1 | | CDD-3044-101-U3 | |
| Shanghai Double Pack | PC | | Original | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shamrock Spring '97 | PC | | Demo | | | |
| Shadows of Cairn | PC | 1.0.022 | Rerelease | | ROM-53337 | |
| Shadows of Cairn | PC | | Rerelease | | | |
| Shadowlands | PC | | Megapak 2 | | | |
| Shadowgrounds (Disc 2) | PC | 1.01 | Original | | 000046-CD2 | |
| Shadowgrounds (Disc 1) | PC | 1.01 | Original | | 000046-CD1 | |
| ShadowCaster | PC | | CD-ROM Classics | | 5393 | |
| ShadowCaster | PC | | Top Ten Pak II | | 5454 | |
| Shadowbane: The Rise of Chaos | PC | | Original | | 651727-CD | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Gold Medal 12 CD Pack | | MQ 13-004-116 | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadow Man | PC | | Original | | | |
| Shadow Man | PC | | Demo | | | |
| Shadow Force: Razor Unit | PC | | Special Forces Pack | | SFRU-0414 | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow Company: Left for Dead | PC | 1.0 | Original | | 5051802 | |
| Shadow Company: Left for Dead (Digital Press Kit) | PC | | Press Kit | | 5051895 | |
| Shade: Wrath of Angels (Press Disc) | PC | | Press Kit | | | |
| Seven Kingdoms | PC | 1.1 | Colección 'Juega y Aprende' | | | |
| Seven Games of the Soul (Disc 4) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 3) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 2) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 1) Faust | PC | | Original | | | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| Sesame Street: Toddlers Deluxe (Disc 3) (Numbers) | PC | 2.0 | Original | | STO844AE-CD-3 | |
| Sesame Street: Toddlers Deluxe (Disc 2) (Letters) | PC | 2.0 | Original | | STO844AE-CD-2 | |
| Sesame Street: Toddlers Deluxe (Disc 1) (Art Workshop) | PC | 2.0 | Original | | STO844AE-CD-1 | |
| Sesame Street: Reading Basics | PC | | Encore | | 10200 | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: My Baby & Me (Disc 2) (Sesame Street Greatest Hits Sampler) | PC | 1.0 | Original | | SSY744AE-CD2 | |
| Sesame Street: My Baby & Me (Disc 1) (Baby & Me) | PC | 1.0 | Original | | SSY744AE-CD1 | |
| Sesame Street: Letters | PC | | | | 9367A | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: Let's Make a Word! | PC | | Bundle Version Creative Labs OEM | | 1713310119-1 | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 2) (Search & Learn Adventures) | PC | 2.0 | | | SPC844AE-CD-2 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 1) (Elmo's Preschool) | PC | 2.0 | | | SPC844AE-CD-1 | |
| Sesame Street: Elmo's Preschool (Disc 2) (Search & Learn Adventures) | PC | 3.1 | Original | | P/N 379663-CD2 | |
| Sesame Street: Elmo's Preschool (Disc 1) (Elmo's Preschool) | PC | 3.1 | Original | | P/N 379663-CD1 | |
| Sesame Street: Elmo's Preschool | PC | | | | 11040CD | |
| Sesame Street: Elmo's Art Workshop | PC | | Original | | EAW844AE-CD | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Art Workshop | PC | | Original | | 9369 | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Sesame Street Reading is Fun! Toddler (Disc 1) (Grover's Travels) | PC | 2.0 | Original | | SRF844AE-CD-1 | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| Serious Sam: The First Encounter | PC | | | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam Gold (Disc 2) | PC | 1.05 | Original | | | |
| Serious Sam Gold (Disc 1) | PC | 1.05 | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Rerelease | | CD-W58-1103-1 | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sensei 2 | PC | | Original | | GC-007 | |
| Senha N. 1 | PC | | | | | |
| Sega Touring Car Championship | PC | 1.0 | Original | | 85067 | |
| Sega Smash Pack | PC | 1.0 | Expert Software | | 682601.101.US | |
| Sega Smash Pack | PC | | Original | | 85087 | |
| Sega Screenshots 2000 Sega E3 2000 | PC | | Press Kit | | | |
| Sega Rally Championship | PC | 1.0 | Original | | 85048 | |
| Sega Rally 2 (Disc 2) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally 2 (Disc 1) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0919 | |
| Sega Puzzle Pack | PC | | Rerelease | | 85091 / FS22923 | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Sega Puzzle Pack | PC | | Expert Software | | 682701.101.US | |
| Sega Genesis Classic Collection: Gold Edition | PC | 1.0.019 | Original | | | |
| Sega E3 Press Kit 2005 2005 E3 Press Kit | PC | | Press Kit | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Section Z Capcom Classics: Section Z | PC | 1.0 | PDA | | | |
| Secrets of the East | PC | | Scholastic | | P/N CDR9909538 | |
| Secrets of the Ark: A Broken Sword Game (Disc 3) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 2) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 1) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of Great Art | PC | 1.1 | Original | | P/N 61218-CD | |
| The Secrets of Atlantis (Disc 3) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 2) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 1) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| Secret Weapons over Normandy (Disc 4) (Play Disc) | PC | 1.0 | Original | | 2101833 | |
| Secret Weapons over Normandy (Disc 3) | PC | 1.0 | Original | | 2101832 | |
| Secret Weapons over Normandy (Disc 2) | PC | 1.0 | Original | | 2101831 | |
| Secret Weapons over Normandy (Disc 1) | PC | 1.0 | Original | | 2101830 | |
| Secret Weapons of the Luftwaffe | PC | | Original | | 2156010-590001/I042, CDRM1003790 | |
| Secret Service: Security Breach | PC | 1.1 | Original | | 31035.101.US | |
| The Secret of the Silver Earring (Disc 2) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| The Secret of the Silver Earring (Disc 1) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of Monkey Island | PC | 2.3 | Original | | 2147010-590001 / I 042 | |
| The Secret of Monkey Island | PC | 2.3 | Original | | 2147010-590001 / I 042 | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PC | 2.0 | Original | | | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PC | 2.0 | Original | | | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PC | 2.0 | Original | | | |
| The Secret of Googol 2: Reshaping Googol: Castle / Ocean | PC | 2.0 | Original | | | |
| The Secret Island of Dr. Quandary | PC | 1.0 | SoftKey | | PDQ944AE-CD | |
| Secret Agent Barbie | PC | 1.0c | Original | | S7127810 | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| Season Ticket Baseball 2003 | PC | 1.0 | Original | | 04-23416CDSL | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search & Rescue 3 | PC | 1.0.0.0 | Original | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.0 | Original | | | |
| The Scroll | PC | | | | | |
| Screamer | PC | | White Label | | | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scrabble: Champion Edition | PC | 1.0S | Rerelease | | 11191B-CD | |
| Scrabble: Champion Edition | PC | | Original | | 11191A-CD v1.0 S | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble Complete | PC | | Cosmi | | CDRZ652D1, SJ122005 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble | PC | | General Mills | | | |
| ScottForesman Wide World of Mathematics | PC | | Original | | 45678910 ET 030201009998 | |
| Score 4 | PC | | Original | | | |
| Scorched Planet | PC | | Original | | | |
| Scorched Planet | PC | | Bundle Version Matrox OEM | | /MYST-CD/GA1/01 | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Scooby-Doo! Phantom of the Knight | PC | 1.0 | Original | | 380325-CD | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.02 | | | 380849B-CD | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.01 | Original | | 380849A-CD | |
| Scissors 'n' Stones | PC | | Original | | | |
| Science Fiction: The Ultimate Collection (Disc 1) | PC | | | | 11014 | |
| Science Blaster Jr. | PC | | Original | | | |
| Science Blaster Jr. | PC | | Rerelease | | | |
| Science Arcade | PC | | Original | | Part No.: MAR476 | |
| The Sci-Fi Collection | PC | | Original | | | |
| SCI Games E3 2005 Press Kit | PC | | Press Kit | | | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 2) (Learning Adventures) | PC | | Original | | SRT744AE-CD2 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744AE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744BE-CD1 | |
| Schoolhouse Rock! Thinking Games | PC | | Original | | BBT844AE-CD | |
| Schoolhouse Rock! Math Rock | PC | 1.0 | Scholastic | | P/N CDR9835976 | |
| Schoolhouse Rock! Math Rock | PC | | Smart Saver | | SHR744AE-CD | |
| Schoolhouse Rock! Math Rock | PC | | Original | | 21010CD | |
| Schoolhouse Rock! Grammar Rock | PC | 1.0 | Scholastic | | P/N CDR9835984 | |
| Schoolhouse Rock! Grammar Rock | PC | | Original | | 9227 | |
| Schoolhouse Rock! Grammar Rock | PC | | SmartSaver | | SGR744AE-CD | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 1st & 2nd Grade Essentials (Disc 1) | PC | | Original | | 21330CD-1 | |
| School Zone Transition Math: Grades K-1 | PC | .5 | Original | | 08034 | |
| School Zone Phonics: Grades 2-3 | PC | v.5 | Original | | 08064 | |
| School Zone Math: Grade 2 | PC | v.5 | Original | | 08032 | |
| School Zone Math: First & Second Grade | PC | | Original | | 08020 | |
| School Zone Flash Action Software: Multiplication/Division | PC | | Original | | 08021 | |
| School Tycoon | PC | | Original | | | |
| School Tycoon | PC | | Scholastic | | P/N: CDR 21661-1R | |
| Scholastic's The Magic School Bus: Volcano Adventure: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0401 Part No. X08-06054 | |
| Scholastic's The Magic School Bus Lands on Mars: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0400 Part No. X05-64212 | |
| Scholastic's The Magic School Bus in Concert: Activity Center | PC | 1.0.0.2 | Original | | 0400 Part No. X05-64231 | |
| Scholastic's The Magic School Bus Explores the Solar System | PC | 1.00.0010 | Bundle Version OEM | | 0296 Disc Assy. 000-30505 | |
| Scholastic's The Magic School Bus Explores the Solar System | PC | 1.0 | Original | | 0396 Part No. 90618, Disc Assy. 296-052-002 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original | | Disc Assy. 451-052-012 0396 Part No. 90626 | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | 1.0 | Original | | 0894 Part No. 59104, Disc Assy 299-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | 1.0.0.1528 | Handi-Snacks Promotional | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scholastic's The Magic School Bus Discovers Flight: Activity Center | PC | 1.0.0.2 | Original | | 0201 Part No. X06-16068 | |
| Schizm: Mysterious Journey (Playable Demo) | PC | 0.99 | Demo | | | |
| SCEA Gamers Day 2002: Press Info | PC | | Press Kit | | | |
| Save Planet Polluto | PC | 1.0 | Original | | | |
| Savage: The Ultimate Quest for Survival | PC | 1.0 | | | | |
| Savage: The Battle for Newerth | PC | 1.0 | Original | | | |
| Savage Warriors | PC | 1.0 | Original | | | |
| Savage Warriors | PC | 1.0 | Original | | 2205110-S90001/1055SA | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 2) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.00 RC15 / Build 836 | Original | | | |
| Sanitarium | PC | | Demo | | | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | 170121 | |
| Samurai Shodown II | PC | | Dual Jewel | | CD-C95-1302-0 | |
| Samurai Shodown II | PC | | Original | | CD-C95-1166-0 | |
| Sammy's Science House | PC | 3.0 | Southwestern Kids' Collection | | R2522/8612a.7.01 | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Sammy's Science House | PC | 1.0 | Original | | | |
| Sammy Soza Softball Slam | PC | | Original | | PCD-5048-001 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max Hit the Road | PC | | Original | | 634031 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | Original | | 634430 | |
| Saints of Virtue | PC | 1.1 | Original | | | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Sail 2000 | PC | 1.04 | Original | | | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.01 | Original | | PCO519CD | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.0 | Original | | PCO519CD | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Sacrifice (Scapex Tutorial Video) | PC | | Preproduction | | | |
| Sacrifice | PC | | Bundle Version Hewlett Packard OEM | | CD-C951041-PC2E | |
| Sacrifice (Editors Press Kit) | PC | | Press Kit | | | |
| The Sacred Rings (Disc 4) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 3) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 2) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 1) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| Sacred Gold (Disc 3) | PC | 1.0 | Original | | 10130-CD3 | |
| Sacred Gold (Disc 2) | PC | 1.0 | Original | | 10130-CD2 | |
| Sacred Gold (Disc 1) | PC | 2.24 | Original | | 10130-CD1 | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| Sacred (Disc 2) | PC | 1.8 | Rerelease | | 10153-CD2 | |
| Sacred (Disc 1) | PC | 1.8 | Rerelease | | 10153-CD1 | |
| Sabrina the Teenage Witch: Spellbound | PC | 1.0c | Original | | S03836 | |
| Sabrina the Teenage Witch: Brat Attack | PC | | Original | | S02560 | |
| Sabre Ace: Conflict over Korea | PC | 1.0 | Original | | D83115 | |
| Sabre Ace | PC | 1.0 | Covermount | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 2) | PC | 1.0 | Original | | 28015-CD2 | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 1) | PC | 1.0 | Original | | 28015-CD1 | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| S.C.A.R.S. | PC | | Original | | | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8X-LTN-E0 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXX-LTN-E0 | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59E-USA-E0 | |
| Swords | WII | | Original | | RVL-SSZE-USA-B0 | |
| Survivor | WII | | Original | | RVL-RLNE-USA-B0 | |
| Surf's Up | WII | | Original | | RVL-RXUE-USA | |
| Super Swing Golf Season 2 | WII | | Original | | RVL-R2PE-USA | |
| Super Swing Golf | WII | | Original | | RVL-RPYE-USA | |
| Super PickUps | WII | | Original | | RVL-RQUE-USA-B0 | |
| Super Fruit Fall | WII | | Original | | RVL-RF4E-USA | |
| Summer Stars 2012 | WII | | Original | | RVL-SSJE-USA-B0 | |
| Summer Sports: Paradise Island | WII | | Original | | RVL-RSUE-USA | |
| Summer Sports 2: Island Sports Party | WII | | Original | | RVL-RI6E-USA-B0 | |
| Storybook Workshop | WII | | Original | | RVL-R4VE-USA-B0 | |
| Story Hour: Fairy Tales | WII | | Original | | RVL-R4FE-USA | |
| Story Hour: Adventures | WII | | Original | | RVL-R3AE-USA | |
| SSX Blur | WII | | Original | | RVL-RSXE-USA | |
| SSX Blur | WII | | Beta | | | |
| Squeeballs Party | WII | | Original | | RVL-R6YE-USA-B0 | |
| Spyborgs | WII | | Original | | RVL-RSWE-USA-B0 | |
| Spyborgs | WII | | Beta | | | |
| Spy Games: Elevator Mission | WII | | Original | | RVL-RECE-USA-B0 | |
| SPRay | WII | | Original | | RVL-RYIE-USA | |
| SPRay | WII | | Beta | | | |
| The Spiderwick Chronicles | WII | | Original | | RVL-R48E-USA | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOE-USA | |
| Speed Zone | WII | | Original | | RVL-RZSE-USA-B0 | |
| Speed | WII | | Original | | RVL-SPEE-USA-B0 | |
| Space Station Tycoon | WII | | Prototype | | | |
| Space Chimps | WII | | Original | | RVL-RP9E-USA | |
| Space Camp | WII | | Original | | RVL-RIYE-USA | |
| The Smurfs: Dance Party | WII | | Toys R Us | | RVL-SDUX-USA-B0 | |
| The Smurfs 2 | WII | | Original | | RVL-S2XE-USA-B0 | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDE-USA-B0 | |
| Smart Series Presents: Jaja's Adventure | WII | | Original | | RVL-R67E-USA-B0 | |
| Sled Shred featuring the Jamaican Bobsled Team | WII | | Original | | RVL-R9YE-USA-B0 | |
| Skylanders: SuperChargers Racing | WII | | Starter Pack | | RVL-SKNE-USA-B0 | |
| Skylanders: Spyro's Adventure | WII | | Starter Pack | | RVL-SSPY-BRA-B0 | |
| Skylanders: Giants | WII | | Starter Pack | | RVL-SKYY-USA-B0 | |
| Ski-Doo Snowmobile Challenge | WII | | Original | | RVL-R87E-USA-B0 | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Ski and Shoot | WII | | Original | | RVL-RUME-USA | |
| Skate It | WII | | Beta | | | |
| Six Flags Fun Park | WII | | Original | | RVL-R6FE-USA | |
| Sing 4: The Hits Edition | WII | | Original | | RVL-SIHE-USA-B0 | |
| The Sims 3 | WII | | Beta | | | |
| SimCity Creator | WII | | Original | | RVL-R4CE-USA | |
| SimAnimals: Africa | WII | | Original | | RVL-R7AE-USA-B0 | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-R5WE-USA-B0 | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDE-USA-B0 | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shiren the Wanderer | WII | | Original | | RVL-RFSE-USA-B0 | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NE-USA-B0 | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Shaun White Skateboarding | WII | | Original | | RVL-SHNE-USA-B0 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Scooby-Doo! and the Spooky Swamp | WII | | Original | | RVL-SJ2E-USA-B0 | |
| Science Papa | WII | | Original | | RVL-RZEE-USA-B0 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCE-USA-B0 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCX-CAN-B0 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Satisfashion: Rock the Runway | WII | | Original | | RVL-SS5E-USA-B0 | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XE-USA | |
| Sam & Max: Season One | WII | | Beta | | | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Saint | WII | | Original | | RVL-RZCE-USA-B0 | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| SX Superstar | GC | | Original | | DL-DOL-GS3E-USA | |
| Swingerz Golf | GC | | Original | | DL-DOL-GWGE-USA | |
| Surf's Up | GC | | Original | | DL-DOL-GXUE-USA | |
| Super Bubble Pop | GC | | Original | | DL-DOL-GBYE-USA | |
| The Sum of All Fears | GC | | Original | | DL-DOL-G3ME-USA | |
| Strike Force Bowling | GC | | Original | | DL-DOL-G5BE-USA | |
| Street Hoops | GC | | Original | | DL-DOL-GHPE-USA | |
| Starsky & Hutch | GC | | Original | | DL-DOL-GT5E-USA | |
| SSX 3 | GC | | Original | | DL-DOL-GXBE-USA | |
| SRS: Street Racing Syndicate | GC | | Original | | DL-DOL-GCSE-USA | |
| SpyHunter | GC | | Original | | DL-DOL-GSHE-USA | |
| Spirits & Spells | GC | | Original | | DL-DOL-G2PE-USA | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSME-USA | |
| Speed Kings | GC | | Original | | DL-DOL-GDCE-USA | |
| Spawn: Armageddon | GC | | Original | | DL-DOL-GPWE-USA | |
| Spartan: Total Warrior | GC | | Original | | DL-DOL-GWAE-USA | |
| Smuggler's Run: Warzones | GC | | Original | | DL-DOL-GSRE-USA | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYE-USA | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9E-USA | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| Sega Soccer Slam | GC | | Original | | DL-DOL-GSSE-USA | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DE-USA | |
| Scooby-Doo! Night of 100 Frights | GC | Rev 1 | Original | | DL-DOL-GIHE-USA | |
| Scaler | GC | | Original | | DL-DOL-GKUE-USA | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Super Game Converter | DC | 1.000 | Unlicensed | | | |
| Sydney 2000 | DC | 1.000 | Original | | T-36808N | |
| Suzuki Alstare: Extreme Racing | DC | 1.000 | Original | | T-17703N | |
| Surf Rocket Racers | DC | 1.000 | Original | | T-40216N | |
| Super Runabout: San Francisco Edition | DC | 1.005 | Original | | T-12511N | |
| Super Magnetic Neo | DC | 1.001 | Original | | T-40206N | |
| Super Magnetic Neo | DC | 1.001 | Demo | | T-40206ND | |
| Stupid Invaders (Disc 2) | DC | 1.001 | Original | | T-17708N | |
| Stupid Invaders (Disc 1) | DC | 1.001 | Original | | T-17708N | |
| Striker Pro 2000 | DC | 1.002 | Original | | T-15111N | |
| Street Fighter III: 3rd Strike | DC | 1.001 | Original | | T-1213N | |
| Street Fighter Alpha 3 | DC | 1.001 | Original | | T-1203N | |
| StarLancer | DC | 1.002 | Original | | T-40209N | |
| Star Wars: Episode I: Jedi Power Battles | DC | 1.004 | Original | | T-23002N | |
| Star Wars: Demolition | DC | 1.001 | Original | | T-23003N | |
| Sports Jam | DC | 1.001 | Original | | T-44304N | |
| Spirit of Speed 1937 | DC | 1.001 | Original | | T-8118N | |
| Spider-Man | DC | 1.000 | Original | | T-13008N | |
| Speed Devils: Online Racing | DC | 1.002 | Original | | T-17718N | |
| Speed Devils | DC | 1.004 | Original | | T-17702N | |
| Spec Ops II: Omega Squad | DC | 1.008 | Original | | T-41704N | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-1216N | |
| South Park Rally | DC | 1.001 | Original | | T-8116N | |
| Soul Fighter | DC | 1.000 | Original | | T-41401N | |
| Sonic Shuffle | DC | 1.000 | Original | | 51060 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | 51117 | |
| Sonic Adventure | DC | 1.004 | Original | | 51000 | |
| Sonic Adventure | DC | 1.000 | Trial Version for E3 | | HDR-0001 | |
| Soldier of Fortune | DC | 1.001 | Original | | T-40212N | |
| SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | T-40207N | |
| Slave Zero | DC | 1.002 | Original | | T-15106N | |
| Slave Zero | DC | 1.001 | Original | | T-15106N | |
| Skies of Arcadia (Disc 2) | DC | 1.002 | Original | | 51052 | |
| Skies of Arcadia (Disc 1) | DC | 1.002 | Original | | 51052 | |
| Silver | DC | 1.001 | Original | | T-15108N | |
| Silent Scope | DC | 1.000 | Original | | T-9507N | |
| Shenmue (Disc 3) | DC | 1.003 | Original | | 51059 | |
| Shenmue (Disc 2) | DC | 1.003 | Original | | 51059 | |
| Shenmue (Shenmue Passport) | DC | 1.004 | Original | | 51059 | |
| Shadow Man | DC | 1.010 | Original | | T-8106N | |
| Shadow Man | DC | 1.001 | Original | | T-8106N | |
| Seventh Cross Evolution | DC | 1.000 | Original | | T-41301N | |
| Sega Marine Fishing | DC | 1.001 | Original | | 51096 | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega Bass Fishing 2 | DC | 1.080 | Original | | 51166 | |
| San Francisco Rush 2049 | DC | 1.001 | Original | | T-9707N | |
| San Francisco Rush 2049 | DC | 1.000 | Demo | | T-9707ND | |
| Super Puzzle Fighter II Turbo | SS | 1.001 | Original | | T-1215H | |
| Striker 96 | SS | 1.002 | Original | | T-8133H | |
| Street Fighter Alpha: Warriors' Dreams | SS | 1.000 | Beta | | | |
| Star Wars: Rebel Strike Spike | SS | 1.000 | Prototype | | | |
| Star Fighter | SS | 1.001 | Original | | T-8135H | |
| Space Hulk: Vengeance of the Blood Angels | SS | 1.000 | Original | | T-5007H | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H | |
| Sky Target | SS | 1.003 | Original | | 81051 | |
| Skeleton Warriors | SS | 1.001 | Original | | T-13204 H | |
| Shockwave Assault | SS | 1.000 | Original | | T-5005H | |
| Shinobi Legions | SS | 1.000 | Original | | T-2301H | |
| Shining Wisdom | SS | 1.000 | Preview | | | |
| Shining Wisdom | SS | 1.000 | Beta | | | |
| Shining Force III | SS | 1.000 | Beta | | | |
| Shellshock | SS | 1.000 | Original | | T-7901H | |
| Sega Worldwide Soccer '97 | SS | 1.001 | Original | | 81112 | |
| Sega Screams Volume 2 | SS | 2.000 | Not for Resale | | 81077 | |
| Sega Rally Championship Plus Netlink Edition | SS | 1.001 | Net Link Game Pack | | 81215, 81608 | |
| Sega Ages Volume 1 | SS | 1.001 | Original | | T-12707H | |
| Scud: The Disposable Assassin | SS | 1.015 | Original | | 14003 | |
| Scorcher | SS | 2.000 | Original | | 81214 | |
| Scorcher | SS | 1.008 | Original | | 81214 | |
| Surgical Strike | MCD | | Original | | 4435 | |
| Surgical Strike | MCD | | Sega CD 32X (Disc 2) | | 4435, 157036 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Super Strike Trilogy | MCD | | Unlicensed | | | |
| Starblade | MCD | | Original | | T-14025 | |
| Star Wars: Rebel Assault | MCD | | Limited Run Games | | T-60075 | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015 | |
| Space Ace | MCD | | Demo | | | |
| Space Ace | MCD | | Original | | T-121025 | |
| SoulStar | MCD | | Original | | T-115035 | |
| Sonic MegaMix | MCD | | Unlicensed | | | |
| Sonic CD | MCD | 1.15 | Beta | | | |
| Sonic CD | MCD | | Bundled with Sega CD | | 4407 | |
| Sonic CD | MCD | | Original | | 4407 | |
| Sol-Feace | MCD | RE | Bundled with Sega CD | | 4130 | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-87035 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T162035 | |
| Shadow of the Beast II | MCD | | Original | | T-113045 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Original | | T-6201 | |
| Sega Classics Arcade Collection | MCD | 1.01 | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | 4126 | |
| The Secret of Monkey Island | MCD | | Original | | T-60035 | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-87015 | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| Syphon Filter: Logan's Shadow | PSP | 0.10 | Test Sample | | UCUS-98606 | |