Region | Title | System | Version | Edition | Languages | Serial | Status |
| S.C.A.R.S. | PC | 1.1 | Original | | | |
| S.W.I.N.E. (Install Disk) | PC | 1.2 | Original | | | |
| S.W.I.N.E. (Play Disk) | PC | 1.2 | Original | | | |
| Sabre Team | CD32 | | Original | | | |
| Sacrifice | PC | | Bundle Version ASUS OEM | | CD-C951041-AS2E | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Scorched Planet | PC | | Original | | | |
| Screamer | PC | | Original, White Label | | | |
| Seek and Destroy Seek & Destroy | CD32 | | Original | | | |
| Semper Fi | PC | | Original | | | |
| Sensible Golf | PC | | Original | | | |
| Sensible Soccer '98 | PC | | Original | | | |
| Sensible Soccer: European Champions | CD32 | | Original | | SSI 1 | |
| Settlers II, The: Veni, Vidi, Vici | PC | | Budget | | MMICDR 5803 | |
| Shadow Man | PC | | Original | | CD194141.00-EUR | |
| Sheep | PC | 1.0.0.1 | Xplosiv | | EI-1381 | |
| Sid Meier's Alpha Centauri | PC | 1.0I | EA Classics | | SKU ORE08903235D2 | |
| Sid Meier's Alpha Centauri (Documentation CD) | PC | 1.0I | EA Classics | | SKU ORE08903235D | |
| Sid Meier's Classic Collection | PC | | Original | | | |
| Sid Meier's Railroad Tycoon Deluxe | PC | 2.0 | Totally Sold Out Software | | | |
| Siege | PC | 1.2 | Action Sixteen | | | |
| Sierra Pro Pilot (Disc 1) | PC | | | | S0012160 | |
| Sierra Pro Pilot (Disc 2) | PC | | | | S0012161 | |
| Sign of the Sun | PC | | | | | |
| SimAnt | PC | | Dice | | DCG 007220, DMM 007633 | |
| SimCity | CDTV | | Original | | 91133 | |
| SimCity 2000 Special Edition | PC | | Dice | | DCG 006681 | |
| SimCopter | PC | | Dice | | DCG 007268 | |
| SimEarth SimEarth: The Living Planet | PC | | Dice | | DCG 007305 | |
| SimIsle: Missions in the Rainforest | PC | | Dice | | DCG 007084 | |
| SimPark | PC | | Original | | 01127-054-0601 | |
| SimSafari | PC | | Dice | | DCG 008685 | |
| SimTower: The Vertical Empire | PC | 1.0 | Dice | | DCG 007343 | |
| SimTown | PC | | Dice | | DCG 008661 | |
| Sink or Swim | PC | | Original | | | |
| Skeleton Krew | CD32 | | Original | | | |
| Snoopy: The Case of the Missing Blanket | CDTV | | Original | | | |
| Soldier of Fortune | PC | 1.03 | Bundle Version ASUS OEM | | | |
| Space Ace | CDI | | Original, For Demonstration Only | | 810 0073, 818 0017 | |
| Space Station Simulator | PC | 1.01 | Original | | | |
| Spaghetti Western Shooter | WII | | Original, Bundled with Wii Gun | | RVL-SPHP-EUR-B0 | |
| Speed 2 | WII | | Bundled with Wii Wheel | | RVL-SQPP-EUR-B0 | |
| Speed Busters | PC | | Original | | | |
| Speed Haste | PC | | Budget | | MMICDR 5078, MMICDR 5114 | |
| Speedboat Attack | PC | 0.9.9.0 | Best Buys | | BB 004 | |
| Speedlink Competition Pro USB: Sports Tournament Edition | PC | | Bundle Version Speedlink OEM | | SL-6603-SPORTS-EU | |
| Spherical Worlds | ACD | | Original | | | |
| Sports Car GT | PC | 1.52m | Rerelease | | WWE08801952D | |
| Star Command Revolution | PC | | Budget | | MMICDR 5082 | |
| Star Control | PC | | Telstar Fun & Games | | TFGD 2177/1 | |
| Star Control 2 | PC | | Telstar Fun & Games | | TFGD 2179/2 | |
| Star Trek: New Worlds | PC | | Bundle Version ASUS OEM | | CD-C951097-ASE | |
| Star Trek: Starfleet Command | PC | | | | | |
| Star Trek: The Next Generation: A Final Unity | PC | 1.0 | Original, Award Winners No. 1 | | EI-1041 | |
| Star Wars: Episode I: Jedi Power Battles | PSX | | Original | | SLES-02607 | |
| Star Wars: Rebel Assault | PC | 1.4 | Original | | | |
| Star Wars: Rebellion | PC | 1.0 | Original | | | |
| Star Wars: Rogue Squadron 3D | PC | 1.0 | Bundle Version OEM | | | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter: The Academy | PC | 1.00 | Bundle Version Logitech OEM | | 601479-0100 | |
| Star Wars: X-Wing: Collector's CD-ROM Star Wars: X-Wing: CD-ROM Edition | PC | | Original, Collezione CD-Rom by C.T.O. | | | |
| Stellar 7 | PC | | | | | |
| Street Racer | PC | | | | | |
| Strip Pot | PC | | Original | | | |
| Su-27 Flanker: Squadron Commander's Edition | PC | 1.0 | SoftKey | | D01028 | |
| Subwar 2050 | PC | | Original | | | |
| Summer Olympix | CD32 | | Original | | | |
| Super Methane Bros. | CD32 | | Original | | | |
| Super Skidmarks | CD32 | 2.2 | Original | | | |
| Super Street Fighter II Turbo | PC | 1.5 | | | | |
| Super Taxi Driver | PC | 1.0 | Budget | | MMICDR 5543 | |
| Super-VGA Harrier | PC | | 10 Pack CD-ROM Series | | | |
| Superbike World Championship | PC | | | | EAX08801929D | |
| Supercars International | PC | | Hit Squad | | HITSQDUK 026 | |
| Supreme Snowboarding | PC | | Bundle Version Sony OEM | | | |
| Surf Ninjas | CD32 | | Original | | | |
| Survival | PC | | Original | | | |
| Syndicate | CD32 | | Original, Bundled with Alfred Chicken | | | |
| Synnergist | PC | | Original | | | |