Region | Title | System | Version | Edition | Languages | Serial | Status |
| Striker 96 | PSX | | Original | | SLES-00023 | |
| Sensible Soccer | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 5, Demo) | | | |
| Sega Rally Championship | SS | 1.000 | Original | | MK81207-50 | |
| Sega Worldwide Soccer '98: Club Edition | SS | 1.002 | Original | | MK81123-50 | |
| Sonic R | SS | 1.000 | Original | | MK81800-50 | |
| Steep Slope Sliders | SS | 1.00 | Original | | MK81128-50 | |
| Salt Lake 2002 | PC | 1.0 | Original | | MSALTPEN81 | |
| Scooby-Doo! Jinx at the Sphinx | PC | | GSP | | 1065A | |
| Scooby-Doo! Showdown in Ghost Town | PC | 1.0 | Original | | SGW844AB-CD | |
| Scooter Pro | PC | | Original | | APWCDR1001 | |
| Scrabble Interactive: 2003 Edition | PC | | Focus Essential | | ESS493 | |
| Screamer | PC | | Screamer Injection | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer 4x4 | PC | | Sold Out Software | | | |
| Screamer Rally | PC | | Original, Screamer Injection | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.06 | Sold Out Software | | | |
| Sega Bass Fishing | PC | | Sega Bass Fishing & Sega Marine Fishing: Xplosiv | | EI-1607 | |
| Sega Bass Fishing | PC | | Original | | EI-1269 | |
| Sega GT (Disc 1) (Installation Disc) | PC | | Original, Xplosiv | | EI-1266-1, EI-1266-1 ENGLISH | |
| Sega GT (Disc 2) (Play Disc) | PC | | Original | | EI-1266-2 | |
| Sega Marine Fishing | PC | | Sega Bass Fishing & Sega Marine Fishing: Xplosiv | | EI-1606 | |
| Sega Mega Drive Classic Collection Volume 1 | PC | | Original | | SEGA-PC118 | |
| Sega Mega Drive Classic Collection Volume 2 | PC | | Original | | SEGA-PC119 | |
| Sega Mega Drive Classic Collection Volume 3 | PC | | Original | | SEGA-PC120 | |
| Sega Mega Drive Classic Collection Volume 4 | PC | | Original | | SEGA-PC121 | |
| Sega Rally 2 (Play Disc) Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sega Rally 2 (Install Disc) Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sega Rally Championship PC | PC | 1.0 | Original | | MK 85048-50 | |
| Sega Rally Championship PC | PC | 1.0 | Expert Software | | XP 202022 01 | |
| Sega Rally Championship PC | PC | 2.11 | Original | | MK 85048MX-50 | |
| Sega Rally Championship PC | PC | 2.11 | Fair Game, Grabit | | FG-1282, GDL016 | |
| Sega Rally Championship PC | PC | | Green Pepper | | | |
| Sega Touring Car Championship | PC | 1.0 | Original | | MK 85067-50 | |
| Sega Touring Car Championship | PC | 1.0 | Xplosiv | | EI-1306 | |
| Sega Worldwide Soccer PC | PC | | Original | | MK 85056-50 | |
| Sega Worldwide Soccer PC | PC | | Fair Game | | FG-1281 | |
| Serious Sam: The First Encounter | PC | 1.00a | Original, TakeAdvantage | | | |
| Serious Sam: The First Encounter | PC | 1.05 | Gold Edition (PC Gamer Presents) | | | |
| Serious Sam: The First Encounter | PC | 1.05 | Gold Edition | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Original, TakeAdvantage | | | |
| Serious Sam: The Second Encounter | PC | 1.07 | Gold Edition (PC Gamer Presents) | | | |
| Serious Sam: The Second Encounter | PC | 1.07 | Gold Edition, Covermount | | | |
| The Settlers IV: Gold Edition (Disc 1) | PC | | Focus Essential | | ESS565 | |
| The Settlers IV: Gold Edition (Disc 2) | PC | | Focus Essential | | ESS565 | |
| The Settlers | PC | | Rerelease | | | |
| Shadow Master | PC | | Original | | | |
| Shogun: Total War (Disc 1) | PC | | Rerelease | | EAE088019651D | |
| Shogun: Total War (Disc 1) | PC | 1.0 | Original | | EAE08801965D1 | |
| Shogun: Total War (Disc 2) | PC | | Rerelease | | EAE088019651D2 | |
| Shogun: Total War (Disc 2) | PC | 1.0 | Original | | EAE08801965D2 | |
| Shogun: Total War: The Mongol Invasion | PC | | Original | | EAE08803486D | |
| Showcase 2000/01 Codemasters PC Demo: New Titles: November 2000 | PC | | Demo | | CLED 0003, MBETCD2200 | |
| Showcase Snooker | PC | | Original | | | |
| Shrek 2 Activity Centre: Twisted Fairy Tale Fun | PC | | Original | | 31917.101.UK | |
| Sid Meier's Civilization III | PC | 1.07f | Original, Best of Atari | | 1012661 | |
| Sid Meier's Civilization III Complete (Disc 1) | PC | | Sold Out Software | | | |
| Sid Meier's Civilization III Complete (Disc 2) | PC | | Sold Out Software | | | |
| Sid Meier's Civilization III Complete (Disc 3) | PC | | Sold Out Software | | | |
| Sid Meier's Civilization III: Conquests | PC | 1.0 | Original | | 1011794 | |
| Sid Meier's Civilization III: Play the World | PC | 1.01f | Original, Gold Edition | | 1007417 | |
| Silly Soccer | PC | 1.0 | Rerelease | | | |
| SimCity 2000 Special Edition | PC | | Dice | | DCG 006681 | |
| SimCity 2000 Special Edition | PC | 1.0 | Original | | MXE08301447D | |
| SimCity 3000 | PC | | Dice | | DCG 013290 | |
| SimCity 3000 UK Edition | PC | | Sold Out Software | | SOC001113 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | 1.1.613.0 | Original | | MXX08004179D | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | 1.1.613.0 | Original | | MXX08004179D2 | |
| SimCopter | PC | | Dice | | DCG 007268 | |
| SimEarth SimEarth: The Living Planet | PC | | Dice | | DCG 007305 | |
| SimFarm | PC | | Dice | | DCG 007329, DMM 007695 | |
| SimGolf | PC | | Dice | | DCG 007107 | |
| SimIsle: Missions in the Rainforest | PC | | Dice | | DCG 007084 | |
| Simon the Sorcerer II: The Lion, the Wizard and the Wardrobe | PC | | Original | | | |
| SimPark | PC | | Dice | | DCG 007091 | |
| The Sims 2: Teen Style Stuff | PC | | Original | | MMX08005156D | |
| The Sims (Documentation) | PC | | Original, The Sims: Collector's Edition | | MXE08903517D | |
| The Sims | PC | 1.0 | Original, The Sims: Collector's Edition | | MXE08902626D | |
| The Sims: Hot Date (Expansion Pack) | PC | 1.4 | Original | | MXX088003645D | |
| The Sims: Livin' It Up (Expansion Pack) | PC | 1.2 | Original, The Sims: Collector's Edition | | MXX08903305D | |
| The Sims: On Holiday (Expansion Pack) The Sims: Op Vakantie (Uitbreidingspakket) | PC | 1.5 | Original | | MXX08803801D | |
| The Sims: Unleashed (Expansion Pack) (Disc 1) | PC | 1.7 | Original | | MXX08803906D | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | 1.7 | Original | | MXX08803906D2 | |
| SimSafari | PC | | Dice | | DCG 008685 | |
| SimTown | PC | | Dice | | DCG 008661 | |
| SiN | PC | | Lock 'N' Load | | | |
| SiN Mission Pack: Wages of SiN | PC | 1.03 | Original | | 1000384.101.UK | |
| Sky Sports Football Quiz | PC | | Original | | | |
| Soldier of Fortune | PC | 1.07f | Platinum Edition (Xplosiv) | | EI-1565 | |
| Soldiers: Heroes of World War II (Disc 1) | PC | 1.05.1 | Original | | MSOLCDEU00 | |
| Soldiers: Heroes of World War II (Disc 2) | PC | 1.05.1 | Original | | MSOLCDEU01 | |
| Sonic & Knuckles Collection | PC | | Original | | MK 85037-50 | |
| Sonic & Knuckles Collection | PC | | Xplosiv | | XP-1859 EUROPEAN, XP-1891, XP-1891 EUROPEAN | |
| Sonic 3D: Flickies' Island | PC | | Xplosiv | | XP-1304 | |
| Sonic 3D: Flickies' Island | PC | | Original | | MK 85064-50 | |
| Sonic Adventure DX: Director's Cut (Disc 1) | PC | | Original | | SEGA-PC002-EU | |
| Sonic Adventure DX: Director's Cut (Disc 2) | PC | | Original | | SEGA-PC002-EU | |
| Sonic CD | PC | | Original, Family Pack | | MK 85015-50, MK 85086-50 | |
| Sonic Heroes (Disc 1) | PC | 1.0 | Original | | SEGA-PC008 | |
| Sonic Heroes (Disc 2) | PC | 1.0 | Original | | SEGA-PC008, SEGA-PC008/2 | |
| Sonic R | PC | | Original | | MK 85076-50 | |
| Space Clash: The Last Frontier | PC | | Sold Out Software | | | |
| Spartan | PC | | Sold Out Software | | | |
| Spartan | PC | | Original | | JFC000784 | |
| Spec Ops II: Operation Bravo | PC | | Lock 'N' Load | | | |
| Spec Ops: Ranger Assault | PC | | Sold Out Software | | | |
| Speed Thief | PC | 1.0 | Original | | | |
| Sphere Racer | PC | | Original | | | |
| Spin Busta | PC | 1.0 | Original | | GS0003 | |
| Sports Car GT | PC | 1.52m | Collector, Dice | | DCG 012729, DMM 012767, WWE08803703D | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | LucasArts Classic | | 3000007.101.UK | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | LucasArts Classic | | 3000007.102.UK | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | LucasArts Classic | | 3000007.103.UK | |
| Star Wars: Rogue Squadron 3D | PC | 1.0 | LucasArts Classic | | 30000.101.UK | |
| Star Wraith 2 | PC | 1.0 | Original | | | |
| StarCraft | PC | 1.0 | Original | | S0012152 | |
| StarCraft: Brood War (Expansion Set) | PC | 1.04 | Original | | S0014249 | |
| State of War | PC | 1.0 | Rerelease | | APWCDR1019 | |
| Stronghold FireFly Studios' Stronghold | PC | 1.0 | Original | | | |
| Su Doku Classic 2 | PC | 2.0 | Original | | | |
| Su Doku Master | PC | 1.0 | Original | | | |
| Submarine Titans | PC | 1.1.0 | Original | | | |
| Subversion: The Official Incoming Expansion Pack | PC | | Original | | | |
| Sudden Strike (Additional Missions) | PC | | Original, Rerelease | | | |
| Sudden Strike | PC | 1.0 | Gold Edition!, Rerelease | | CDR7090/UK2, CDR7777-E | |
| Sudden Strike | PC | 1.1 | Sudden Strike Anthology | | PF5003/UK2 | |
| Sudden Strike Forever | PC | 1.21 | Original, Rerelease | | CDR7999/UK2 | |
| Sudden Strike Forever | PC | 1.21 | Gold Edition! | | CDR7090/UK2 | |
| Sudden Strike II | PC | 2.0 | Original | | CDR8000/UK2 | |
| The Sudoku Challenge! | PC | 10.1 | Sold Out Software | | | |
| Super Bust-A-Move | PC | | Original | | | |
| Super Taxi Driver | PC | | Original, Hemming | | | |
| Superbike World Championship | PC | | Sold Out Software | | | |
| Swarm Assault | PC | 1.04 | Original | | APWCDR1020 | |
| Sacred Gold | PC | 2.0.2.24 | GSP White Label: Reload | | 1579B | |
| Serious Sam II | PC | | Original | | | |
| ShellShock: Nam '67 | PC | 1.0 | MAD | | | |
| Sonic Mega Collection Plus | PC | | GSP | | 1654B | |
| Sonic Riders | PC | 1.0 | Original | | SEGA-PC051 | |
| Space Siege | PC | | Original | | SEGA-PC076 | |
| Stormrise | PC | 1.0 | Original | | SEGA-PC089 | |
| Super-Bikes Riding Challenge | PC | 1.0 | Revival | | REV130 | |