Region | Title | System | Version | Edition | Languages | Serial | Status |
| Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | | |
| Samurai Shodown | MCD | | Original | | T-60175-50 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 | |
| Sensible Soccer | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 5, Demo) | | | |
| Sensible Soccer | MCD | | Original | | T-93185-50 | |
| Sewer Shark | MCD | | Original | | T-93015-50 | |
| Shining Force CD | MCD | | Original | | 4656-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T-162035-50 | |
| The Smurfs | MCD | | Original | | T-151015-50 | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-158025-50 | |
| SoulStar | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 3, Demo) | | T 115035-50 | |
| SoulStar | MCD | | Original | | T-115035-50 | |
| SoulStar / Battlecorps | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 8) | | T 115035-50 / T 115045-50 | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015-50 | |
| Star Wars: Rebel Assault | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 7) | | | |
| Star Wars: Rebel Assault | MCD | | Original | | T-60075-50 | |
| Star Wars: Rebel Assault | MCD | | Bundled with Magazine (Demo) | | | |
| Starblade | MCD | | Original | | 4284-50 | |
| Supreme Warrior (Disc 1) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 1) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 2) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 2) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Surgical Strike | MCD | | Original | | 4435-50, 670-6783-50 | |
| Sega Internet-Selain | SS | 1.012 | Bundled with Net Link Internet Modem | | 80124 | |
| S.C.A.R.S. | PC | 1.0 | | | | |
| S.T.O.R.M. (Disc 1) | PC | | Original | | A541W3GD[1] | |
| S.T.O.R.M. (Disc 2) | PC | | Original, Dice | | A541W3GD[2], DMM 031730 | |
| S.T.O.R.M. (Disc 3) | PC | | Original, Dice | | A541W3GD[3], DMM 031730 | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic II) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic) | PC | | eXtra Klasyka Next | | | |
| Saga The Settlers I-IV (The Settlers I + II) | PC | | eXtra Klasyka XK Gold | | | |
| Saga The Settlers I-IV (The Settlers III: Złota Edycja - Disc 1) | PC | 1.60 | eXtra Klasyka XK Gold | | | |
| Saga The Settlers I-IV (The Settlers III: Złota Edycja - Disc 2) | PC | 1.60 | eXtra Klasyka XK Gold | | | |
| Saga: Gniew Wikingów | PC | 1.0.0.1 | eXtra Klasyka | | | |
| Sam & Max Hit the Road | PC | | White Label: Doubles | | | |
| Sam & Max Hit the Road | PC | 2.0 | LucasArts Classic | | 41117.101.UK | |
| Sam & Max Hit the Road | PC | 1.0 | LucasArts Classic | | 41117.101.GM | |
| Sam & Max Hit the Road | PC | | Collezione CD-Rom by C.T.O. | | | |
| Sam & Max Hit the Road | PC | | LucasArts Classic | | 41117.101.IT | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Scarab S.C.A.R.A.B. | PC | | Original | | EAE08801181D | |
| Schleichfahrt | PC | | Original | | | |
| Schleichfahrt | PC | | | | | |
| Schleichfahrt | PC | | Original, Classics | | | |
| Das Schwarze Auge: Schatten über Riva | PC | 1.00 | Original | | SPI 032 | |
| Screamer | PC | | Screamer Injection | | | |
| Screamer | PC | | Award Winners No. 1 | | EI-1041 | |
| Screamer | PC | | Sold Out Extreme | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer 2 | PC | | Megapak 8 | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer Rally | PC | | Original, Screamer Injection | | | |
| Screaming Skies | PC | | Tewi | | Bestell-Nr. 27669 | |
| SD Qlympics Olympic Challenge | PC | | Grabit | | GDL031 | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | | White Label: Doubles | | | |
| Secret Service CD 55 (Strona A) | PC | | | | | |
| Secret Service CD 55 (Strona B) | PC | | | | | |
| Secret Service CD 56 (Strona A) | PC | | | | | |
| Sega Rally Championship PC | PC | 1.0 | Original | | MK 85048-50 | |
| Sega Rally Championship PC | PC | 2.11 | Fair Game, Grabit | | FG-1282, GDL016 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | MK 85067-50 | |
| Sega Worldwide Soccer PC | PC | | Original | | MK 85056-50 | |
| Sega Worldwide Soccer PC | PC | | 3D Power Pack | | 500-0009-50 | |
| Sensible World of Soccer '96/'97 (Upgrade PC CD-ROM Disc) | PC | | Original | | | |
| Sensible World of Soccer '96/'97 | PC | 2.0 | Original | | | |
| Sensible World of Soccer: European Championship Edition | PC | 1.2 | White Label | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.02 | Original | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | Rerelease | | | |
| The Settlers II: Złota Edycja | PC | 1.51 | eXtra Klasyka | | | |
| The Settlers III (Disc 1) | PC | | Revival | | REV036 | |
| The Settlers III (Disc 2) | PC | | Revival | | REV036 | |
| The Settlers III: Złota Edycja (Disc 1) | PC | | Nowa eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 2) | PC | | Nowa eXtra Klasyka | | | |
| Shadow Warrior Lo Wang is Shadow Warrior | PC | 1.2 | Premier Collection | | MSHADPEN70 | |
| Shadow Warrior Lo Wang is Shadow Warrior | PC | 1.2 | Original | | CDR5002 | |
| Shanghai: Dynasty | PC | 1.0 | Original | | 1000053.101.UK | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-M9 | |
| Shattered Steel | PC | 1.08 | | | CD-ICD-201-M9 | |
| Shellshock | PC | | Original | | | |
| Shellshock | PC | | Kixx | | | |
| Shellshock | PC | | Original | | | |
| Sid Meier's Civilization II | PC | 1.02 | Original, Collector's Edition | | MPX91260DO1R | |
| Sid Meier's Civilization II | PC | | Original | | MP391260DO1R | |
| Sid Meier's Civilization II Civilization II di Sid Meier | PC | | CD-ROM Classic Collection 5 | | MP591260DO1R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 DO1R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Collector's Edition | | | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 D01R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP391 307 DO1R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization Sid Meier Presenta Civilization II: Conflitti in Civilization: Scenari | PC | | CD-ROM Classic Collection 5 | | MP 591 307 DO1R | |
| Sid Meier's Civilization II: Fantastic Worlds | PC | | Original | | MP391 435 DO1R | |
| Sid Meier's CivNet | PC | | Original | | MP191226DOIR | |
| SideLine | PC | | Original | | | |
| Die Siedler II: Gold Edition | PC | 1.51 | Original | | | |
| Siedler II, Die: Veni, Vidi, Vici | PC | 1.0 | Original | | | |
| Siedler II, Die: Veni, Vidi, Vici | PC | 1.0 | Original | | | |
| Die Siedler III (Disc 1) | PC | | Purple Hills | | | |
| Die Siedler III (Disc 2) | PC | | Purple Hills | | | |
| Die Siedler: Platin Editon I • II • III • IV (Disc 1) | PC | | Platin Edition | | | |
| Die Siedler: Platin Editon I • II • III • IV (Disc 3) | PC | | Platin Edition | | | |
| Skull Caps | PC | | Original | | | |
| Slam Tilt | PC | | Original | | | |
| Soccer Kid | PC | | Original, Soft Price | | | |
| Sonic 3D: Flickies' Island | PC | | Original | | MK 85064-50 | |
| Sonic CD | PC | | Original | | MK 85015-50 | |
| Sonic CD | PC | | Original, Family Pack | | MK 85015-50, MK 85086-50 | |
| Sonic R | PC | | Original | | MK 85076-50 | |
| Soul Ride | PC | | Linux (LGP) | | | |
| Space in Motion: Future Trade | PC | 1.01 | Original | | | |
| Speedboat Attack | PC | 0.9.9.0 | Covermount | | | |
| Speedboat Attack | PC | 0.9.9.0 | Best Buys | | BB 004 | |
| Speedster | PC | | Original, Argentum Collection | | | |
| SSN-21 Seawolf | PC | | EA CD-ROM Classics | | E3205CXD | |
| Star General | PC | 1.0 | Original | | CS090339 | |
| Star General | PC | 1.0 | Original | | CS090341 | |
| Star Wars: Jedi Knight (Disc 1) | PC | | Original | | | |
| Star Wars: Jedi Knight (Disc 2) | PC | | Original | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Original | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | Original | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | LucasArts Classic | | 41177.101.UK | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | LucasArts Classic | | 41177.102.UK | |
| Star Wars: Jedi Knight: Dark Forces II (Disco 1) | PC | 1.00 | LucasArts Classic | | 41177.101.IT | |
| Star Wars: Jedi Knight: Dark Forces II (Disco 2) | PC | 1.00 | LucasArts Classic | | 41177.102.IT | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | LucasArts Classic | | 41177.103.UK | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | Original | | 7101830 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | Original | | | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.00 | LucasArts Classic | | 41177.103.IT | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | | |
| Star Wars: X-Wing Alliance (Disc 1) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing Alliance (Disc 2) | PC | 1.0 | Star Wars: Battle Pack | | | |
| Star Wars: X-Wing Alliance (Disc 2) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | 1.0 | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.0 | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter: Balance of Power | PC | 2.0.0 | Original | | | |
| StarFighter 3000 | PC | | Original | | | |
| StarFighter 3000 | PC | 1.08 | Best Buys | | BB 001 | |
| Stars! | PC | 2.7a | Original | | EI-1036 | |
| Stars! | PC | 2.70i | Grabit | | GDL051 | |
| Steel Panthers II: Modern Battles | PC | 1.00 | Original | | CS090345 | |
| Steel Panthers II: Moderne Schlachten | PC | 1.0 | Original, Cash & Carry Collection | | CS090347 | |
| Stonekeep | PC | 1.1 | Original | | CD-ICD-045-GR | |
| Stonekeep | PC | 1.2 | Covermount | | CD-ICD-045-EME | |
| Stratosphere: Conquest of the Skies | PC | 1.00G | Original | | | |
| Street Racer | PC | | Original, Ubisoft Classique | | | |
| Sub Culture | PC | | Original | | | |
| Sub Culture | PC | | Original | | | |
| Sudden Strike | PC | 1.1 | Sudden Strike Anthology | | PF5003/UK2 | |
| Sudden Strike | PC | 1.2 | Rerelease | | CDR8028-SP | |
| Sudden Strike | PC | 1.2 | Gold Edition! (Software Pyramide) | | | |
| Sudden Strike Forever | PC | 1.21 | Sudden Strike Anthology | | PF5003/UK2 | |
| Sudden Strike II | PC | 2.0 | Sudden Strike Anthology | | PF5003/UK2 | |
| Sudoku Master | PC | 1.0 | Microforum | | | |
| Super Bubsy | PC | | Original | | ALE08801309D | |
| Super Stardust 96 | PC | | CD-ROM 5 Mark-Reihe | | Art.-Nr. 2857 | |
| Super Street Fighter II Turbo | PC | 1.0 | Original | | 51100000 | |
| SuperKarts | PC | 1.01 | White Lines: Don't Do It - 3 Game Driving Pack | | | |
| Surface Tension | PC | | Original | | 722DISKE | |
| Świat Przygód z Hugo 5/2004 | PC | | | | | |
| Swing Plus: Total Mindcontrol | PC | | Original | | | |
| SWIV 3D | PC | | Original | | SCI1901UK | |
| SWIV 3D | PC | | Original | | SCI1901GE/IT | |
| SWIV 3D (Playable Demo) | PC | v5.25 | | | | |
| Syndicate Wars | PC | | Original | | BFX05100371D | |
| The Shadow of the Third Moon | ACD | 1.1 | Original | | | |
| Seek and Destroy Seek & Destroy | CD32 | | Original | | | |
| Sensible Soccer: European Champions | CD32 | | Original | | SSI 1 | |
| Shadow Fighter | CD32 | | Original | | | |
| Skeleton Krew | CD32 | | Original | | | |
| Soccer Kid | CD32 | | Original | | | |
| Summer Olympix | CD32 | | Original | | | |
| Super Methane Bros. | CD32 | | Original | | | |
| Secrets of Tatjana | CDI | | Original | | 810 0046 | |