Region | Title | System | Version | Edition | Languages | Serial | Status |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Dice | | DMM 011143 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Dice | | DMM 011143 | |
| Sonic R | PC | | Sonic R & Sonic 3D (PC Best Buy) | | 177501A | |
| Spider-Man 2: The Game | PC | | Original | | 32581.101.UK | |
| Stranger | PC | | Original | | EI-2237 ML02 | |
| Skate 2 | PS3 | 01.00 | Original | | BLES-00461 | |
| Soulcalibur V | PS3 | 01.00 | Original, Promo | | BLES-01250 | |
| Sly Cooper: Thieves in Time | PS3 | 01.02 | Original | | BCES-01284 … | |
| The Simpsons: Hit & Run (Disc 1) | PC | 1.0 | BestSeller Series | | S1001615 | |
| The Simpsons: Hit & Run (Disc 3) | PC | 1.0 | BestSeller Series | | S1001617 | |
| SimTower: The Vertical Empire | PC | 1.0 | Dice | | DCG 007343 | |
| Stormrise | PC | 1.0 | Original | | SEGA-PC089 | |
| Sonic 3D: Flickies' Island | PC | 1.0.0.1 | Sonic R & Sonic 3D (PC Best Buy) | | 177501B | |
| Sonic Heroes (Disc 1) | PC | 1.0.0.1 | PC Best Buy | | 181038-1 | |
| Sonic Heroes (Disc 2) | PC | 1.0.0.1 | PC Best Buy | | 181038-2 | |
| SunAge | PC | 1.0.0.1 | Original | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | PC Best Buy | | | |
| Syvänmerenseikkailu | PC | 1.6 | Original | | | |
| The Sims: Complete Collection (Disc 1) | PC | 1.91 | Original | | MXX08004951D | |
| The Sims: Complete Collection (Disc 2) | PC | 1.91 | Original | | MXX08004951D2 | |
| The Sims: Complete Collection (Disc 3) | PC | 1.91 | Original | | MXX08004951D3 | |
| The Sims: Complete Collection (Disc 4) | PC | 1.91 | Original | | MXX08004951D4 | |