Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sacred Plus (Disc 1) | PC | 1.8.30 | Original | | | |
| Sacred Plus (Disc 2) | PC | 1.8.30 | Original | | | |
| Sanitarium (Disc 2) | PC | 1.0 | Original | | CS090737 | |
| Screamer | PC | | Screamer Injection | | | |
| Screamer | PC | | Original, White Label | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer Rally | PC | | Original, Screamer Injection | | | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | | White Label: Doubles | | | |
| Sega Rally 2 (Disc 1) (Install Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-1 | |
| Sega Rally 2 (Disc 2) (Play Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-2 | |
| Sega Rally Championship PC | PC | 1.0 | Original | | MK 85048-50 | |
| Sega Rally Championship PC | PC | 2.11 | Fair Game, Grabit | | FG-1282, GDL016 | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.02 | Original | | | |
| Shadow Man | PSX | | Original, Acclaimed Range | | SLES-00947 … | |
| Shift 2: Unleashed | PC | | Original, Limited Edition | | EAX07707774D | |
| Shogun: Total War (Disc 1) | PC | 1.0 | Original | | EAE08801965D1 | |
| Shogun: Total War (Disc 2) | PC | 1.0 | Original | | EAE08801965D2 | |
| Showcase 2000/01 Codemasters PC Demo: New Titles: November 2000 | PC | | Demo | | CLED 0003, MBETCD2200 | |
| Sid Meier's Alpha Centauri | PC | 1.0I | Original | | ORE08901524D | |
| Sid Meier's Civilization II | PC | 1.02 | Original, Collector's Edition | | MPX91260DO1R | |
| Silent Hill | PSX | | Original, Platinum | | SLES-01514 … | |
| SimCity 2000 Special Edition | PC | 1.0 | Original | | MXE08301447D | |
| SimCity 2000 Special Edition | PC | 1.0 | Original | | MXE08301447D | |
| SimCity 3000 | PC | 1.0.557.0 | Original | | MXX08801496D | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | 1.1.613.0 | Original | | MXX08004179D | |
| SimCity Enhanced CD-ROM | PC | | White Label | | | |
| SimIsle: Missions in the Rainforest | PC | 1.0 | | | 1058-030-0601-0-A | |
| SimTower: The Vertical Empire | PC | 1.0 | Original | | 1051-031-0601-A | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | PC | 1.06 | Original | | | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | PC | 1.06 | Original | | | |
| StarCraft II: Wings of Liberty | PC | 1.0.0.15405 | Original, Collector's Edition | | S2281209, S2286901 | |
| Stonekeep | PC | 1.05 | Original, Covermount | | CD-ICD-045-UK | |
| SWAT 3: Close Quarters Battle | PC | 1.4 | Elite Edition | | S0021400 | |
| SWIV 3D | PC | | Original | | SCI1901UK | |
| Syberia (Disc 1) | PC | 1.0 | Original | | 64702102/1 | |
| Syberia (Disc 2) | PC | 1.0 | Original | | 64702102/2 | |
| Syndicate Wars | PC | | Original | | BFX05100371D | |
| Sacred 2: Fallen Angel (Disc 1) | PC | 2.0.2.0 | Original | | ECD008452M | |
| Sacred 2: Fallen Angel (Disc 2) | PC | 2.0.2.0 | Original | | ECD008452M | |
| Die Siedler II: Gold Edition | PC | 1.51 | Original | | | |
| Star Trek: Armada | PC | 1.0 | Original | | 1000913.101.GM | |
| Star Trek: Armada II | PC | 1.0 | Original | | 31143.101.GM | |
| Schizm: Mysterious Journey (Disc 1) | PC | 1.0.0.744 | Original | | SZM844AB-CD1 | |
| Schizm: Mysterious Journey (Disc 2) | PC | 1.0.0.744 | Original | | SZM844AB-CD2 | |
| Schizm: Mysterious Journey (Disc 3) | PC | 1.0.0.744 | Original | | SZM844AB-CD3 | |
| Schizm: Mysterious Journey (Disc 4) | PC | 1.0.0.744 | Original | | SZM844AB-CD4 | |
| Schizm: Mysterious Journey (Disc 5) | PC | 1.0.0.744 | Original | | SZM844AB-CD5 | |
| SimCity 3000 UK Edition | PC | | Original | | MXE08803369D | |