Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sensible Soccer | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 5, Demo) | | | |
| SoulStar | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 3, Demo) | | T 115035-50 | |
| SoulStar / Battlecorps | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 8) | | T 115035-50 / T 115045-50 | |
| Star Wars: Rebel Assault | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 7) | | | |
| Star Wars: Rebel Assault | MCD | | Bundled with Magazine (Demo) | | | |
| S.T.O.R.M. (Disc 1) | PC | | Original | | A541W3GD[1] | |
| S.T.O.R.M. (Disc 2) | PC | | Original, Dice | | A541W3GD[2], DMM 031730 | |
| S.T.O.R.M. (Disc 3) | PC | | Original, Dice | | A541W3GD[3], DMM 031730 | |
| Saga The Settlers I-IV (The Settlers I + II) | PC | | eXtra Klasyka XK Gold | | | |
| Saga The Settlers I-IV (The Settlers III: Złota Edycja - Disc 2) | PC | 1.60 | eXtra Klasyka XK Gold | | | |
| Saga The Settlers I-IV (The Settlers III: Złota Edycja - Disc 1) | PC | 1.60 | eXtra Klasyka XK Gold | | | |
| Sam & Max Hit the Road | PC | 2.0 | LucasArts Classic | | 41117.101.UK | |
| Sam & Max Hit the Road | PC | | LucasArts Classic | | 41117.101.IT | |
| Sam & Max Hit the Road | PC | | Collezione CD-Rom by C.T.O. | | | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Schleichfahrt | PC | | Original, Classics | | | |
| Das Schwarze Auge: Schatten über Riva | PC | 1.00 | Original | | SPI 032 | |
| Screamer | PC | | Screamer Injection | | | |
| Screamer 2 | PC | | Megapak 8 | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer Rally | PC | | Original, Screamer Injection | | | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | | White Label: Doubles | | | |
| Secret Service CD 55 (Strona A) | PC | | | | | |
| Secret Service CD 55 (Strona B) | PC | | | | | |
| Secret Service CD 56 (Strona A) | PC | | | | | |
| Sega Rally Championship PC | PC | 1.0 | Original | | MK 85048-50 | |
| Sega Rally Championship PC | PC | 2.11 | Fair Game, Grabit | | FG-1282, GDL016 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | MK 85067-50 | |
| Sega Worldwide Soccer PC | PC | | Original | | MK 85056-50 | |
| Sensible World of Soccer '96/'97 | PC | 2.0 | Original | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.02 | Original | | | |
| Sid Meier's Civilization II | PC | 1.02 | Original, Collector's Edition | | MPX91260DO1R | |
| Sid Meier's Civilization II | PC | | Original | | MP391260DO1R | |
| Die Siedler II: Gold Edition | PC | 1.51 | Original | | | |
| Die Siedler III (Disc 1) | PC | | Purple Hills | | | |
| Die Siedler III (Disc 2) | PC | | Purple Hills | | | |
| Die Siedler: Platin Editon I • II • III • IV (Disc 1) | PC | | Platin Edition | | | |
| Die Siedler: Platin Editon I • II • III • IV (Disc 3) | PC | | Platin Edition | | | |
| Slam Tilt | PC | | Original | | | |
| Sonic 3D: Flickies' Island | PC | | Original | | MK 85064-50 | |
| Sonic CD | PC | | Original, Family Pack | | MK 85015-50, MK 85086-50 | |
| Sonic R | PC | | Original | | MK 85076-50 | |
| Speedboat Attack | PC | 0.9.9.0 | Best Buys | | BB 004 | |
| Star General | PC | 1.0 | Original | | CS090339 | |
| Star General | PC | 1.0 | Original | | CS090341 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | Original | | 7101830 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | 1.00 | Original | | | |
| Steel Panthers II: Modern Battles | PC | 1.00 | Original | | CS090345 | |
| Steel Panthers II: Moderne Schlachten | PC | 1.0 | Original, Cash & Carry Collection | | CS090347 | |
| Stonekeep | PC | 1.1 | Original | | CD-ICD-045-GR | |
| Stonekeep | PC | 1.2 | Covermount | | CD-ICD-045-EME | |
| Stratosphere: Conquest of the Skies | PC | 1.00G | Original | | | |
| Street Racer | PC | | Original, Ubisoft Classique | | | |
| Sudden Strike | PC | 1.1 | Sudden Strike Anthology | | PF5003/UK2 | |
| Sudden Strike | PC | 1.2 | Gold Edition! (Software Pyramide) | | | |
| Sudden Strike Forever | PC | 1.21 | Sudden Strike Anthology | | PF5003/UK2 | |
| Sudden Strike II | PC | 2.0 | Sudden Strike Anthology | | PF5003/UK2 | |
| Super Bubsy | PC | | Original | | ALE08801309D | |
| Super Street Fighter II Turbo | PC | 1.0 | Original | | 51100000 | |
| Świat Przygód z Hugo 5/2004 | PC | | | | | |
| SWIV 3D | PC | | Original | | SCI1901UK | |
| Syndicate Wars | PC | | Original | | BFX05100371D | |
| Sensible Soccer: European Champions | CD32 | | Original | | SSI 1 | |
| Shadow Fighter | CD32 | | Original | | | |
| Skeleton Krew | CD32 | | Original | | | |
| Summer Olympix | CD32 | | Original | | | |
| Secrets of Tatjana | CDI | | Original | | 810 0046 | |