Region | Title | System | Version | Edition | Languages | Serial | Status |
| S.C.A.R.S. | PC | | Original | | | |
| S.L.A.I.: Steel Lancer Arena International S.L.A.I.: Phantom Crash | PS2 | 0.11 | Beta | | SLUS 29132 | |
| Sable Maze: Forbidden Garden & Twelve Fears | PC | | Original | | 33528010US | |
| Sable Maze: Sullivan River / Norwich Caves | PC | | | | 33471010US | |
| Sacrifice (Editors Press Kit) | PC | | Press Kit | | | |
| Saints Row: The Third (Disc 1) | PC | | Original | | | |
| Saints Row: The Third (Disc 2) | PC | | Original | | | |
| Sam & Max: Season One | WII | | Beta | | | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Samurai Warriors 2: Empires | PS2 | 1.00 | Original | | SLUS 21585 | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| Sargon Chess | CDI | | Original, Original: Longbox | | 310690030-2 | |
| Saturday Night Speedway | PS2 | 1.00 | Original | | SLUS 20640 | |
| Saw | XBOX360 | | Original | | KN-2050 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | Beta | | | | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original | | Disc Assy. 451-052-012 0396 Part No. 90626 | |
| Schoolhouse Rock! 1st & 2nd Grade (Disc 2) (2nd Grade) | PC | | Original | | 21330CD-2, SGE744AE-CD2 | |
| Schoolhouse Rock! 1st & 2nd Grade Essentials (Disc 1) | PC | | Original | | 21330CD-1 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! Grammar Rock | PC | | SmartSaver | | SGR744AE-CD | |
| Science Fiction: The Ultimate Collection (Disc 1) | PC | | | | 11014 | |
| Scooby-Doo! | IXL | 1.0.0 | Original | | R9709 | |
| Scooby-Doo! | IXL | 2.0.0 | Original | | R9709 | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.01 | Original | | 380849A-CD | |
| Scooby-Doo! Night of 100 Frights | XBOX | | Original | | TQ-031 | |
| Scorcher | SS | 1.008 | Original | | 81214 | |
| Score International Baja 1000: The Official Game | PS2 | 1.00 | Original | | SLUS 21850 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble | PC | | General Mills | | AM0703R72 | |
| Scrabble | PSP | 1.00 | Original | | ULUS-10412 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| SD Gundam Force: Showdown! | PS2 | 1.01 | Original | | SLUS 20698 | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | PS2 | 1.00 | Original | | SLUS 21289 | |
| The Secret of Googol 1: Reshaping Googol: Submarine / Tower | PC | 2.0 | Original | | | |
| The Secret of Googol 2: Reshaping Googol: Castle / Ocean | PC | 2.0 | Original | | | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PC | 2.0 | Original | | | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PC | 2.0 | Original | | | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PC | 2.0 | Original | | | |
| The Secret Saturdays: Beasts of the 5th Sun | PSP | 1.00 | Original | | ULUS-10443 | |
| Secret Service | PS2 | 1.01 | Original | | SLUS 21836 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Secret Weapons over Normandy | PS2 | 1.01 | Original | | SLUS 20762 | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Sega Entertainment's Arcade Sampler | PC | | | | | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| Sega Sports Tennis | PS2 | 1.01 | Original | | SLUS 20480 | |
| Sega Superstars | PS2 | 1.00 | Original | | SLUS 20999 | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Self Selling Disc | CDI | 3.1 | | | 310-690-049-2 | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Rerelease | | CD-W58-1103-1 | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Serious Sam: The First Encounter | PC | 1.02 | Bundle Version Gainward OEM | | | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| The Settlers: Heritage of Kings | PC | 1.01.0163 | Original | | 682011-DVD | |
| Seven Kingdoms: The Fryhtan Wars / Shadow Company: Left for Dead | PC | | Demo | | 5051859 | |
| Seven Samurai 20XX | PS2 | 1.00 | Original | | SLUS 20621 | |
| Sex | 3DO | | Original | | | |
| Shade: Wrath of Angels (Press Disc) | PC | | Press Kit | | | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow Man | PC | | Demo | | | |
| Shadow Man | DC | 1.001 | Original | | T-8106N | |
| Shadow Man: 2econd Coming | PS2 | 1.03 | Original | | SLUS-20413 | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shadow Wolf Mysteries: Curse of the Full Moon / Bane of the Family | PC | | | | 33425010US | |
| Shamrock's Fall '96 Demo CD | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shape Shifter | PCE | | Original | | TGXCD1021 | |
| Shari Lewis Lamb Chop's Play-Along! Action Songs | CDI | | Original | | 310690289-2 | |
| SharkPort: Code and Save Transfer Kit | PC | 1.04 | Original | | | |
| SharkPort: Code and Save Transfer Kit | PS2 | 2.21 | Unlicensed | | | |
| Shattered Union | XBOX | | Original | | TT-131 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Shepherd's Crossing | PS2 | 1.00 | Original | | SLUS 21798 | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| Sherlock Holmes: Crimes & Punishments | XBOX360 | | Original | | FE-2015 | |
| Shifters | PS2 | 1.02 | Original | | SLUS 20271 | |
| Shining Soul II + Shining Force Assets Shining Soul 2 + Shining Force Assets | PC | | Press Kit | | | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shivers | PC | | Demo | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shorelines | CDI | | | | | |
| Short Track Racing: Trading Paint | PS2 | 1.00 | Original | | SLUS 21857 | |
| Showdown: Legends of Wrestling | XBOX | | Original | | AC-029 | |
| Shrek | XBOX | | Original | | TM-001 | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| Shrek Super Party | XBOX | | Original | | TM-004 | |
| Shrek Super Party | PS2 | 1.00 | Original | | SLUS 20516 | |
| Shrine Circus Tycoon | PC | | | | 31933.101.US | |
| Sid Meier's Alien Crossfire | PC | | Original | | 1405807 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization IV (Disc 2) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.7 | |
| Sid Meier's SimGolf | PC | | Rerelease | | 1641547 | |
| Sierra Holiday Software Sampler | PC | | | | | |
| Sierra Products Demo America Online featuring Sierra Online | PC | | | | R00482 | |
| Sierra Super Sampler Sierra On-Line Demos | PC | | | | | |
| Sierra's School House: Math (Disc 1) | PC | | Original | | | |
| Sierra's School House: Math (Disc 2) | PC | | Original | | | |
| Sierra's Sneak Peeks 2 | PC | | Demo | | | |
| Silent Hill: Downpour | PS3 | 01.01 | Review | | | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| SimCity 2000 | SS | 1.401 | Original | | T-12601H | |
| SimCity 2000 Special Edition | PC | | Original | | 0126-000-0601-A | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| SimCoaster: Bonus Disk SimCoaster Extra Value Pack | PC | | | | 4002307 | |
| SimEarth | PC | | Dual Jewel, 10 Sims for $20 | | 1111507 | |
| SimEarth: The Living Planet | PCE | | Original | | TGXCD1036 | |
| SimGolf | PC | 1.0 | Original | | 0093-000-0601-A | |
| SimLife SimLife: The Genetic Playground | PC | | Scholastic Clubs and Fairs | | 1111707, P1 | |
| The Simpsons Skateboarding | PS2 | 1.01 | Original | | SLUS-20114 | |
| The Sims 2 | XBOX | | Original | | EA-907 | |
| The Sims 2 | PC | | Press Kit | | | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 2) | PC | | | | 1497037 | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| The Sims 3 | WII | | Beta | | | |
| The Sims 3: Diesel Stuff The Sims 3: Diesel for Successful Living Stuff | PC | 14.0.48.017001 | Original | | 1968807 | |
| The Sims 3: Fast Lane Stuff | PC | 5.0.44.008001 | Original | | 1950207 | |
| The Sims 3: Katy Perry Sweet Treats | PC | | Original | | 1979807 | |
| The Sims 3: Master Suite Stuff | PC | 11.0.84.014001 | Original | | 1962307 | |
| The Sims 3: Outdoor Living Stuff | PC | 7.0.55.010001 | Original | | 1950307 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims 3: Seasons (Expansion Pack) | PC | | Original, Limited Edition | | 1978303301 | |
| The Sims | XBOX | | Original | | EA-047 | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims: Hot Date (Expansion Pack) | MAC | | Original | | 10150-1CDA | |
| The Sims: Livin' Large (Expansion Pack) | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | MAC | | Original | | 10430-1CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | MAC | | Original | | 10430-2CDA | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | | Original | | 1640617 | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| SimTunes | PC | | Original | | 0135-000-0601-A | |
| SiN | PC | | Demo | | DMO-1000076.101.US | |
| SiN | PC | 1.01 | Rerelease | | 6236-01 | |
| Sin Gold SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| SingStar '80s | PS2 | 1.00 | Original | | SCUS 97622 | |
| SingStar '90s | PS2 | 1.00 | Original | | SCUS 97626 | |
| SingStar ABBA | PS2 | 1.00 | Original | | SCUS-97642 | |
| SingStar Country | PS2 | 1.00 | Original, Bundled with Microphone | | SCUS 97650 … | |
| SingStar Legends | PS2 | 1.00 | Original | | SCUS 97640 | |
| SingStar Pop Vol. 2 | PS2 | 1.00 | Original | | SCUS 97649 | |
| Singularity | PC | | Press Kit | | | |
| Sinkha | MAC | | Original | | | |
| Sitting Ducks | PS2 | 1.00 | Original | | SLUS 20886 | |
| Skate 2 | XBOX360 | | Original | | EA-2175 | |
| Skate It | WII | | Beta | | | |
| Skate. | XBOX360 | | Original | | EA-2067 | |
| Ski Park Manager 2003: Gold Edition Val d'Isère Ski Park Manager 2003: Gold Edition | PC | | | | 71102221 | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Skin Style | CDI | | Original | | | |
| SkyGunner | PS2 | 1.00 | Trade Demo | | SLUS-28008 | |
| Skylanders: Imaginators | XBOX360 | | Original | | AV-2352 | |
| Skylanders: Spyro's Adventure | PC | | Press Kit | | | |
| Skylanders: SuperChargers | XBOX360 | | Original | | AV-2335 | |
| Skylanders: Swap Force | XBOX360 | | Starter Pack | | AV-2281 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | PC | | Original | | | |
| Sleeping Dogs | PS3 | 00.00 | Preview | | | |
| Slingo Deluxe Slingo Deluxe Bundle | PC | | Original | | | |
| Slingo Mystery: Who's Gold | PC | | Big Fish Games Backup CD | | | |
| Sly 2: Band of Thieves | PS2 | 1.00 | Demo | | SCUS 97415 | |
| Small Soldiers: Globaltech Design Lab | PC | | | | Product# 99144 | |
| Small Soldiers: Squad Commander | PC | | | | Product# 99264 | |
| Smash Cars | PS2 | 1.03 | Original | | SLUS 20620 | |
| Smash Court Tennis: Pro Tournament 2 | PS2 | 1.00 | Original | | SLUS 20933 | |
| Smashing Drive | XBOX | | Original | | NM-001 | |
| SMBX + Tak 2 Art | PC | | Press Kit | | | |
| The Smithsonian Presents the Riches of Coins | CDI | | Original, Demonstration Disc | | 310-690-088-2, 310690088-2 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| Smoking Guns Smoking Guns: Shooting Gallery! | PC | 1.0 | Cosmi | | 02-2503-10 | |
| The Smurfs 2 | XBOX360 | | Original | | US-2237 | |
| Sneakers | XBOX | | Original | | MS-035 | |
| Sniper Elite | XBOX | | Original | | MI-013 | |
| Sniper: Ghost Warrior 3 (Disc 1) | PC | | Season Pass Edition | | TCIU01221UND | |
| Sniper: Ghost Warrior 3 (Disc 2) | PC | | Season Pass Edition | | TCIU01221UND2 | |
| Sniper: Ghost Warrior 3 (Disc 3) | PC | | Season Pass Edition | | TCIU01221UND3 | |
| Sniper: Ghost Warrior 3 (Disc 4) | PC | | Season Pass Edition | | TCIU01221UND4 | |
| Sniper: Path of Vengeance | PC | | Original | | | |
| SNK NeoGeo USA Consumer Corporation: E3 2004 Games | PC | | Press Kit | | | |
| SNK Playmore E3 2006 Games | PC | | Press Kit | | | |
| SnoCross 2 featuring Blair Morgan | PS2 | 1.04 | Original | | SLUS 21130 | |
| Snoopy vs. the Red Baron | PS2 | 1.01 | Original | | SLUS 21380 | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.00 | Beta | | SCUS 97366 | |
| Soft Kill | PC | | Original | | | |
| Soldier of Fortune: Payback | XBOX360 | | Original | | AV-2050 | |
| Soldiers of Anarchy | PC | | Original | | S5280010 | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | PC | | Rerelease | | 517-05-232 | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | MAC | | Original | | | |
| Solitaire Antics | PC | 1.0 | Original | | | |
| Solitaire Games | PC | | GSP | | 92534-A | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| Sonic 3D Blast | PC | | Expert Software | | 6822 01 | |
| Sonic Adventure | DC | 1.004 | Original | | 51000 | |
| Sonic Mega Collection Plus | PS2 | 0.80 | Beta | | | |
| Sonic's Ultimate Genesis Collection | XBOX360 | | Platinum Hits | | SE-2064 | |
| Sony E3 2004: Press Information | PC | | Press Kit | | | |
| Sony PlayStation 2: SCEA Santa Monica Studios: 2004 Press Information: Press Print | PC | | Press Kit | | | |
| Soulcalibur II | XBOX | | Demo | | NM-003 | |
| Soulcalibur II | PS2 | 1.00 | Demo | | SLUS 29058 | |
| Sounds Best on Sound Blaster Every Game Sounds Best on Sound Blaster: 24-bit Advanced HD | PC | | | | | |
| SouthPeak Interactive E3 2000 Electronic Press Kit | PC | | Press Kit | | | |
| Space Ace | CDI | | Original, Demonstration Disc | | 310-690-059-2, 310690059-2 | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Bunnies Must Die! | PC | | Demo | | MSDE-37216 | |
| Space Chimps | XBOX360 | | Original | | BT-2004 Version: 1. | |
| Space Chimps | PS2 | 1.03 | Original | | SLUS 21783 | |
| Space Ranger | CDI | | Unlicensed | | OGCDI-1180 | |
| Space Station Tycoon | WII | | Prototype | | | |
| Spaceship Warlock | MAC | | Original | | CDRM 403300 | |
| Spartan: Total Warrior | XBOX | | Original | | SE-139 | |
| Spawn: Armageddon | XBOX | | Original | | NM-012 | |
| Special Permit for Cabela's Big Game Hunter | PC | | Original | | | |
| Speed Freaks (Misc Artwork: PC-CD 2nd July '99) | PC | | Press Kit | | | |
| Speed Kings | XBOX | | Original | | AC-011 | |
| Spelling Challenges and More! | PSP | 1.00 | Original | | ULUS 10255 | |
| Spider-Man: Friend or Foe | XBOX360 | | Original | | AV-2042 | |
| Spider-Man: Web of Shadows (Final Press Kit) | PC | | Press Kit | | | |
| The Spiderwick Chronicles | XBOX360 | | Bundled with Audiobook | | VU-2022 | |
| Spine Sense: The Interactive Back Protection Program | CDI | | Original | | | |
| Splashdown | XBOX | | Original | | IG-027 | |
| Splashdown | PS2 | 1.00 | Original | | SLUS 20223 | |
| SPRay | WII | | Beta | | | |
| Spring 2012 Refresh Standard: PS3 IDU 4.11 | PS3 | | Kiosk Demo | | | |
| Spring 2013: Standard IDU 4.31 | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2010: 3.21 IDU Update (E-M) | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2011 3.60 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Sprint Cars: Road to Knoxville | PS2 | 1.02 | Original | | SLUS 21418 | |
| Spy vs. Spy | XBOX | | Original | | TT-124 | |
| Spyborgs | WII | | Beta | | | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| Square Enix E3 2004 Media CD | PC | | Press Kit | | | |
| SquareSoft: E3 2001 Media CD | PC | | Press Kit | | | |
| SRS: Street Racing Syndicate | XBOX | | Original | | NM-019 | |
| SRS: Street Racing Syndicate | PS2 | 2.00 | Original | | SLUS 20582 | |
| SSI Strategy Collection: Critic's Choice Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| SSX 3 | XBOX | | Original | | EA-060 | |
| SSX Blur | WII | | Beta | | | |
| SSX Tricky | XBOX | | Platinum Hits | | EA-004 | |
| Star Defender III | PC | | Original | | CD001697 | |
| Star Trek Pinball | PC | | Bundle Version OEM | | CD-C95-675-UNU | |
| Star Trek Pinball | PC | 1.00 | Original | | CD-C95-675-0 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 310690304-2 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 310690304-2 | |
| Star Trek: Deep Space Nine: Dominion Wars | PC | 1.00 | Original | | | |
| Star Trek: Elite Force II (Disc 1) | MAC | | Original | | 10440-1CDA | |
| Star Trek: Elite Force II (Disc 2) | MAC | | Original | | 10440-2CDA | |
| Star Trek: Secret of Vulcan Fury (Non-Interactive Preview) | PC | | | | CD-C95-647-N1 | |
| Star Trek: Secret of Vulcan Fury (Non-Interactive Trailer) | PC | | | | CD-C95-647-N2 | |
| Star Trek: Starfleet Academy | PC | 1.15 | Bundle Version OEM (DVD-ROM) | | CD-DVD-069-GQE | |
| Star Trek: Starfleet Academy (Disc 1) | MAC | 1.1 | Original | | CD-MCR-069-0 | |
| Star Trek: Starship Creator Deluxe | PC | | Original | | 0-671-31776-8 | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disk) | MAC | | Original | | P/N 04-17512CD1 | |
| Star Trek: The Next Generation: Klingon Honor Guard (Install Disk) | MAC | | Original | | P/N 04-17512CD2 | |
| Star Wars Galaxies: 10-Day Trial | PC | | Original | | 8330530 | |
| Star Wars: Anakin's Speedway | PC | | Original | | #3518030 | |
| Star Wars: Attacktix: Battle Figure Game | PC | | Starter Set CD-ROM Series 2 | | | |
| Star Wars: Battlefront | MAC | 1.2 | Original | | 10900-1DDA | |
| Star Wars: Dark Forces | MAC | 1.1 | Original | | 3062130 | |
| Star Wars: Empire at War | MAC | 1.05 | Original | | 11490-1DDA | |
| Star Wars: Episode I: Cover Disk 4 | PC | | Press Kit | | | |
| Star Wars: Episode I: Disc #3: Covers | PC | | Press Kit | | | |
| Star Wars: Jedi Knight Gold Pack | MAC | | Original | | 12280-1DDA | |
| Star Wars: Jedi Knight II: Jedi Outcast | MAC | 1.03 | Original | | 10200-1CDA | |
| Star Wars: Jedi Knight: Dark Forces II: Pathways to the Force | PC | | Bundle Version Diamond OEM | | 646230, 75000202-100, CD-C95-829-DIA | |
| Star Wars: Knights of the Old Republic | MAC | 1.03 | Original | | 10660-1DDA | |
| Star Wars: Mac Pack | MAC | | Original | | 12300-1DDA | |
| Star Wars: Rebel Assault | MAC | | Demo | | CDRM1209730 | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630, CDRM1208410 | |
| Star Wars: Rebel Assault | MAC | 1.01 | Original | | 634630 | |
| Star Wars: Rebel Assault | MAC | 1.06 | LucasArts Macintosh Archives Vol. I, The | | 8022132 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | 1.0 | Original | | 3092130 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | 1.0 | Original | | 3092131 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | MAC | | Original | | 12240-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | MAC | | Original | | 12240-1DDA2 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | MAC | 1.0 | Original | | 2062130 | |
| Star Wars: X-Wing vs. TIE Fighter: The Academy | PC | 2.0 | Bundle Version Diamond OEM | | 75000203-100 | |
| Star Wars: X-Wing: Collector's CD-ROM | MAC | 1.01 | Original | | 2052130 | |
| Star Wars: Yoda's Challenge Activity Center | PC | | Demo | | #3529030 | |
| StarCraft II: Heart of the Swarm | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 1) | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 2) | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original, Collector's Edition | | | |
| Starfighter Assets CD | PC | | Press Kit | | | |
| State of Emergency 2 | PS2 | 1.02 | Original | | SLUS 20966 | |
| Steel Battalion | XBOX | | Original | | CC-002 | |
| Steven Spielberg's Director's Chair (Disc 1) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD100CD | |
| Steven Spielberg's Director's Chair (Disc 2) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD200CD | |
| Steven Spielberg's Director's Chair (Disc 3) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD300CD | |
| Stoked: Big Air Edition | XBOX360 | | Original | | DE-2005 | |
| Stolen (Disc 1) (Game Disc) Stolen: Infiltrate · Steal · Vanish | PC | | Original | | | |
| Stolen (Disc 2) Stolen: Infiltrate · Steal · Vanish | PC | | Original | | | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| The Story of Jonah | CDI | 2.04 | Original, FPD | | 310-690-067-2, 310690067-2 | |
| The Story of Samson | CDI | | Original, Demonstration Disc | | 310-690-190-2, 310690190-2 | |
| Storybook Weaver Deluxe 2004 | PC | 3.0 | Original | | 483050-CD | |
| Stowaway DK Multimedia: Stephen Biesty's Incredible Cross-Section: Stowaway | PC | | | | | |
| Str.at.e.s. 1: Match-A-Batch | PC | 2.0 | Original | | | |
| Stratosphere: Conquest of the Skies | PC | | Demo | | | |
| Street Hoops | XBOX | | Original | | AV-003 | |
| Strike Commander | PC | | Original | | RVL 13-004-0046 | |
| Strike Force Bowling | XBOX | | Original | | CV-008 | |
| Striker Pro | CDI | | Original, Demonstration Disc | | 310-690-143-2, 310690143-2 | |
| Stronghold 2 (Disc 1) (Install) Firefly Studios' Stronghold 2 | PC | | Original | | | |
| Stronghold 2 (Disc 2) (Play) Firefly Studios' Stronghold 2 | PC | | Original | | | |
| Stronghold 3 | PC | | Original | | 50070-LBL | |
| Stronghold Crusader | PC | | Interactive Demo | | | |
| Stuart Little 3: Big Photo Adventure | PS2 | 1.01 | Original | | SLUS 21341 | |
| The Sudoku Challenge! Collection | PC | | Original | | | |
| Sudoku Crunch for Kids! | PC | | Original | | P/N 61081-CD | |
| Sudoku Deluxe Sudoku Pack | PALM | 2.1 | Original | | P/N: 750-3009-CD-B | |
| The Suffering | PS2 | 1.01 | Original | | SLUS 20636 | |
| The Suffering: Ties That Bind | PS2 | 1.01 | Original | | SLUS 21189 | |
| Summer Athletics: The Ultimate Challenge | XBOX360 | | Original | | CV-2004 | |
| Summer Athletics: The Ultimate Challenge | PS2 | 1.00 | Original | | SLUS 21786 | |
| Summer Heat Beach Volleyball | PS2 | 1.00 | Original | | SLUS 20634 | |
| Summer Refresh 2011: 3.65 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |
| Super Air Zonk: Rockabilly-Paradise | PCE | | Original | | TGXCD1042 | |
| Super Bender Boot Disc | PS2 | 2.00 | | | | |
| Super Bubble Pop | XBOX | | Original | | JA-004 | |
| Super Collapse! 3 | PC | | Original | | | |
| Super GameHouse Solitaire Collection | PC | | Original | | | |
| Super Magnetic Neo | DC | 1.001 | Demo | | T-40206ND | |
| Super Meat Boy (Installation Disc) | PC | | IndieBox | | | |
| Super PickUps | PS2 | 1.00 | Original | | SLUS 21450 | |
| Super Stories: Mom is Going to Stop It | CDI | | | | | |
| Super Stories: My Favorite Things | CDI | | | | | |
| Superbike 2000 EA Sports: Superbike 2000 | PC | | CD-ROM Classics | | 1215007 | |
| Supreme Commander | XBOX360 | | Original | | AY-2001 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | MCD | | Original | | T162045 | |
| Surf City | CDI | | Original, Demonstration Disc | | 310-690-131-2, 310690131-2 | |
| Surf's Up | XBOX360 | | Original | | US-2041 | |
| Suzuki TT Superbikes: Real Road Racing Championship | PS2 | 1.00 | Original | | SLUS-21863 | |
| SWAT 3: Close Quarters Battle | PC | 1.4 | Elite Edition | | | |
| SWAT 4 | PC | | Demo | | | |
| SWAT: Global Strike Team | XBOX | | Original | | VV-037 | |
| SWAT: Global Strike Team | PS2 | 1.00 | Original | | SLUS 20433 | |
| Sword of the New World: Granado Espada | PC | 2.1.18 | | | | |
| SX Superstar | PS2 | 1.00 | Preview | | SLUS-20600 | |
| Syndicate Plus | PC | | CD-ROM Classics: Gold Edition | | 5737 | |
| Systemax Ultimate Software Collection (Disc 01) (Daria's Inferno / Who Wants to Beat Up a Millionaire) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 02) (I See Sue... the T. Rex / Amazons & Aliens / Cheerios: Playtime) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 03) (How Many Bugs in a Box? / More Bugs in Boxes / Jim Henson's Muppet Babies: Toyland Train / Miss Spider's Tea Party) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 04) (Forbes: Corporate Warrior / Starwebs: Web Shop / Writing Tutor / Complete Idiots Guide: Marketing Materials Maker) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 05) (S&S Encyclopedia / Typing Tutor 12) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 06) (Women's Fitness / Christina Aguilera: Follow Your Dreams) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 08) (Garfield: Mad About Cats / Money Town) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 09) (Darkened Skye: Disc 1 / Zoboomafoo with the Kratt Brothers Animal Kids) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 10) (Deer Avenger / Ski-Doo X-Team Racing) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 11) (Pearl Harbor: Zero Hour / Real War) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 12) (S&S Encyclopedia of Science / Curious George: Reads, Writes and Spells) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 13) (Multimedia Billiards / Astrology Starscopes / Music Match Juke Box Deluxe 6.1 / Extreme Chess / Typing Tutor Jr. / Bumper Wars) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 14) (Darkened Skye: Disc 2) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 18) (M&M's: The Lost Formulas) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 22) (Richard Scarry's: Busy Town) | PC | 2.0 | Original | | | |
| Systemax Ultimate Software Collection (Disc 26) (Sabrina, the Teenage Witch: Brat Attack) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 27) (Star Trek: Deep Space Nine - The Fallen) | PC | | Original | | | |
| Space Engineers | PC | | Limited Edition | | | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| SimCity | PC | 1.0 | Original, Limited Edition | | 1971403401 | |
| The Sims 4 (Disc 1) | PC | 1.0 | Limited Edition | | 7303703301, 7303703303 | |
| The Sims 4 (Disc 2) | PC | 1.0 | Limited Edition | | 7303703302, 7303703401 | |
| The Sims 4: Discover University (Expansion Pack) | PC | | Original | | 3765903401 | |
| The Sims 3 | PC | 1.42.130.019037 | The Sims 3 Starter Pack | | 1539003301 | |
| Spy Kids 3-D: Game Over | PC | | Original | | I6100 | |
| SimCity 4 (Disc 1) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 4 (Disc 2) | MAC | 1.0 | Original | | 10350-1CDA | |
| The Sims: Livin' Large (Expansion Pack) | PC | 1.0 | Original | | 1422707 | |
| Stardew Valley | PC | 1.4.5 | Fangamer | | | |
| Sid Meier's Civilization VI | PC | | Original | | 41829-1 | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | S2344310 | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | S2344310 | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | | |
| Silent Hill 3 (Disc 2) | PC | 1.0.0.1 | Original | | S2344320 | |
| Silent Hill 3 (Disc 3) | PC | 1.0.0.1 | Original | | S2344330 | |
| Silent Hill 3 (Disc 4) | PC | 1.0.0.1 | Original | | S2344340 | |
| Silent Hill 3 (Disc 5) | PC | 1.0.0.1 | Original | | S2344350 | |
| Swap Magic 3 | PS2 | 3.10 (American) | Unlicensed | | | |
| Swap Magic 3 Plus | PS2 | 1.00 | Unlicensed | | | |
| Swap Magic 3 Plus | PS2 | 1.12 | Unlicensed | | | |
| Spintires Spintires: Offroad Truck Simulator | PC | | Original | | | |
| SimCity Societies Destinations | PC | 1.0 | SimCity Box | | 1907307 | |
| Spore | PC | 1.0 | Galactic Edition | | 1908007 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | The Sims 2: Double Deluxe | | 1597017 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | Original | | 1672917 | |
| Spore: Creepy & Cute Parts Pack | PC | | Original | | 1907607 | |
| Spore: Galactic Adventures | PC | 1.0 | Original | | 1535407 | |
| Star Stable: The Autumn Riders | PC | 1.00.0000 | Original | | 61-0803 04 | |
| Starshine Legacy: Episode 1: Mystery of the Soulriders | PC | | Original | | US-61-0603 04 | |
| Starshine Legacy: Episode 2: Secret of Pine Hill Mansion | PC | | Original | | SLE2, US-61-0603 05 | |
| Starshine Legacy: Episode 3: The Legend of Pandoria | PC | | Original | | US-61-0609-04 | |
| Starshine Legacy: Episode 4: The Riddle of the Dark Core | PC | | Original | | US: 61-0612 04 | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Bundled with Bluetooth Headset | | BCUS-98152 | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Original | | BCUS-98183 | |
| SingStar Dance | PS3 | 01.00 | Original | | BCUS-98266 | |
| SingStar Queen | PS3 | 01.00 | Original | | BCUS-98206 | |
| SingStar | PS3 | 01.01 | Original | | BCUS-98151 … | |
| SingStar ABBA | PS3 | 01.00 | Original | | BCUS-98192 | |
| SingStar Vol. 2 | PS3 | 01.00 | Original | | BCUS-98186 | |
| Skylanders: Spyro's Adventure | PC | 1.0 | Starter Pack | | 33366010US | |
| Saints Row 2 | PC | | Original | | | |
| Steel Beasts: Gold Edition | PC | 1.2.2.6 | Original | | 23952CD | |
| Saints Row: The Third: The Full Package | PS3 | 01.00 | Original | | BLUS-31062 | |
| The Sims 3 | PS3 | 01.00 | Original, Greatest Hits | | BLUS-30609 … | |
| The Sims 3: Pets | PS3 | 01.00 | Original | | BLUS-30803 | |
| The Sims Medieval | PC | 1.0.286.00001 | Limited Edition | | 1945407 | |
| The Sims Medieval: Pirates & Nobles | PC | 2.0.109.00001 | Original | | 1962507 | |
| The Sims 2: Castaway | PSP | 1.00 | Original | | ULUS 10296 | |
| San Francisco Rush 2049 | DC | 1.000 | Demo | | T-9707ND | |
| San Francisco Rush 2049 | DC | 1.001 | Original | | T-9707N | |
| The Smurfs 2 | PS3 | 01.00 | Original | | BLUS-31151 | |
| Sudoku Ball: Detective | PC | 1.1 | Original | | | |
| Stratego | PC | | Original | | 99032 | |
| S!Zone for SimCity 2000 | PC | | Original | | | |
| S.C.A.R.S. | PSX | | Original | | SLUS-00692 | |
| S.L.A.I.: Steel Lancer Arena International | PS2 | 1.02 | Original | | SLUS-20969 | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | 28015-CD1 | |
| S²: Silent Storm (Disc 2) | PC | 1.2 | Original | | 28015-CD2 | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| Saban's Power Rangers Zeo: Full Tilt Battle Pinball | PSX | | Original | | SLUS-00256 | |
| Saban's Power Rangers: Lightspeed Rescue | PSX | | Original | | SLUS-01114 | |
| Saban's Power Rangers: Time Force | PSX | | Original | | SLUS-01351 | |
| Sabre Ace: Conflict over Korea | PC | 1.0 | Original | | D83115 | |
| Sabrina the Teenage Witch: A Twitch in Time! | PSX | | Original | | SLUS-01208 | |
| Sabrina the Teenage Witch: Brat Attack | PC | | Original | | S02560 | |
| Sabrina the Teenage Witch: Spellbound | PC | 1.0c | Original | | S03836 | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sacred (Disc 1) | PC | 1.2.0.10 | Original | | 28302-CD1 v1.0 | |
| Sacred (Disc 1) | PC | 1.8 | Rerelease | | 10153-CD1 | |
| Sacred (Disc 2) | PC | 1.2.0.10 | Original | | 28302-CD2 v1.0 | |
| Sacred (Disc 2) | PC | 1.8 | Rerelease | | 10153-CD2 | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| Sacred 2 (Disc 2) | PC | | Original | | | |
| Sacred 2: Fallen Angel (Disc 1) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 2) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 3) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| The Sacred Amulet | PC | | Original | | | |
| Sacred Gold (Disc 1) | PC | 2.24 | Original | | 10130-CD1 | |
| Sacred Gold (Disc 2) | PC | 1.0 | Original | | 10130-CD2 | |
| Sacred Gold (Disc 3) | PC | 1.0 | Original | | 10130-CD3 | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| Sacrifice (Scapex Tutorial Video) | PC | | Preproduction | | | |
| Sacrifice | PC | | Bundle Version Hewlett Packard OEM | | CD-C951041-PC2E | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Safecracker | PC | | Rerelease | | | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.0 | Original | | PCO519CD | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.01 | Original | | PCO519CD | |
| SaGa Frontier | PSX | | Original | | SCUS-94230 | |
| SaGa Frontier 2 | PSX | | Original | | SLUS-00933 | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Sailing | CDI | | Original, Demonstration Disc | | 310-690-101-2, 310690101-2 | |
| Saint | WII | | Original | | RVL-RZCE-USA-B0 | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Saints of Virtue | PC | 1.1 | Original | | | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Saiyuki: Journey West | PSX | | Original | | SLUS-01381 | |
| Sakura Wars: So Long, My Love | WII | | Original | | RVL-SAKE-USA-E0 | |
| Sakura Wars: So Long, My Love (Disc 1) (English Voice Over) | PS2 | 1.00 | Original | | SLUS 21927 | |
| Sakura Wars: So Long, My Love (Disc 2) (Japanese Voice Over) | PS2 | 1.00 | Original | | SLUS 21930 | |
| Salt Lake 2002 | PS2 | 1.01 | Original | | SLUS-20378 | |
| Saltwater Sportfishing | PSX | | Original | | SLUS-01397 | |