Region | Title | System | Version | Edition | Languages | Serial | Status |
| S!Zone for SimCity 2000 | PC | | Original | | | |
| S.C.A.R.S. | PC | | Original | | | |
| S.T.A.L.K.E.R.: Call of Pripyat | PC | 1.6.02 | Collector's Edition | | | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| The Saboteur | PC | 1.0 | Original | | | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| Sacred 2 (Disc 2) | PC | | Original | | | |
| Sacred 2: Fallen Angel (Disc 1) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 2) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 3) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| The Sacred Amulet | PC | | Original | | | |
| Sacrifice (Editors Press Kit) | PC | | Press Kit | | | |
| Sacrifice (Scapex Tutorial Video) | PC | | Preproduction | | | |
| Safecracker | PC | | Rerelease | | | |
| Sail 2000 | PC | 1.04 | Original | | | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Saints of Virtue | PC | 1.1 | Original | | | |
| Saints Row 2 | PC | | Original | | | |
| Saints Row: The Third (Disc 1) | PC | | Original | | | |
| Saints Row: The Third (Disc 2) | PC | | Original | | | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max: Season One | WII | | Beta | | | |
| Sam & Max: Season One | PC | 1.0 | Original | | | |
| Sam & Max: Season Two | PC | 1.5.0.0 | Original | | | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| Sam & Max: This Time It's Virtual! | PC | | Limited Run Games | | | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Sammy's Science House | PC | 1.0 | Original | | | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sanitarium | PC | | Demo | | | |
| Sanitarium (Disc 1) | PC | 1.00 RC15 / Build 836 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitarium (Disc 3) | PC | 1.00.000 | Rerelease | | | |
| Sanity: Aiken's Artifact | PC | 1.0 | Original, Best Buy | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 2) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Original | | | |
| SAS: Secure Tomorrow | PC | 1.0 | Original | | | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Savage Warriors | PC | 1.0 | Original | | | |
| Savage: The Battle for Newerth | PC | 1.0 | Original | | | |
| Savage: The Ultimate Quest for Survival | PC | 1.0 | | | | |
| Save Planet Polluto | PC | 1.0 | Original | | | |
| Scarface: The World Is Yours | PC | 1.00.1 | Original | | | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| SCEA Gamers Day 2002: Press Info | PC | | Press Kit | | | |
| SCEE Software Brochure + Press Information: E3 2003 | PC | | Press Kit | | | |
| Schizm: Mysterious Journey (Side A) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Side B) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey | PC | 0.99 | Playable Demo | | | |
| Schizm: Mysterious Journey (Disc 1) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 2) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 3) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 4) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 5) | PC | 1.0.0.744 | Original | | | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | Beta | | | | |
| School Tycoon | PC | | Original | | | |
| School Tycoon | PC | v1 | Original | | | |
| SCI Games E3 2005 Press Kit | PC | | Press Kit | | | |
| The Sci-Fi Collection | PC | | Original | | | |
| Sci-Fi Pinball | PC | | Original | | | |
| Science Blaster Jr. | PC | | Rerelease | | | |
| Science Blaster Jr. | PC | | Original | | | |
| Scissors 'n' Stones | PC | | Original | | | |
| Scooby-Doo 2: Monsters Unleashed | PC | 3.0 | Original | | | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Night of 100 Frights | PSX | | Prototype | | | |
| Scooby-Doo! Night of 100 Frights | PS2 | 0.00 | Beta | | | |
| Scooby-Doo! Night of 100 Frights | PS2 | 0.00 | Beta | | | |
| Scorched Planet | PC | | Original | | | |
| Score 4 | PC | | Original | | | |
| Scramble Cobra | 3DO | | Beta (CD-R) | | | |
| Scratches | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Rerelease | | | |
| Screamer | PC | | White Label | | | |
| Screamer | PC | | White Label | | | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| The Scroll | PC | | | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.0 | Original | | | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| Secret Files: Tunguska (Disc 1) (Play Disc) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 2) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 3) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 4) | PC | 1.0 | Original | | | |
| The Secret of Googol 1: Reshaping Googol: Submarine / Tower | PC | 2.0 | Original | | | |
| The Secret of Googol 2: Reshaping Googol: Castle / Ocean | PC | 2.0 | Original | | | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PC | 2.0 | Original | | | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PC | 2.0 | Original | | | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 7: Eggs All Around: Egg Trek / Balloon Picnic | PC | 2.0 | Original | | | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PC | 2.0 | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Section Z Capcom Classics: Section Z | PC | 1.0 | PDA | | | |
| Seek & Find Adventures | PC | | Original | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Sega E3 Press Kit 2005 2005 E3 Press Kit | PC | | Press Kit | | | |
| Sega Entertainment's Arcade Sampler | PC | | | | | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega Genesis Classic Collection: Gold Edition | PC | 1.0.019 | Original | | | |
| Sega Screenshots 2000 Sega E3 2000 | PC | | Press Kit | | | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Sentient | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Serious Sam: The First Encounter | PC | 1.00 | Original | | | |
| Serious Sam: The First Encounter | PC | 1.02 | Bundle Version Gainward OEM | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Original | | | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | PC | | Original | | | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Numbers | 3DO | | Original | | | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| The Settlers: Rise of an Empire | PC | 1.0.4140 | Original | | | |
| Seven Games of the Soul (Disc 1) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 2) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 3) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 4) Faust | PC | | Original | | | |
| Sex | 3DO | | Original | | | |
| Shade: Wrath of Angels (Press Disc) | PC | | Press Kit | | | |
| Shadoan | PC | | Interactive Preview | | | |
| Shadow Man | PC | | Demo | | | |
| Shadow Man | PC | | Original | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadow Watch | PC | 1.0 | Original | | | |
| SHADOW: War of Succession | 3DO | | Original | | | |
| Shadowlands | PC | | Megapak 2 | | | |
| Shadowrun Returns (Game Disc) | PC | | Original | | | |
| Shadows of Cairn | PC | | Rerelease | | | |
| Shakii the Wolf | PC | | Original | | | |
| Shamrock Spring '97 Shamrock Spring '97 Demo Disk | PC | | | | | |
| Shamrock's Fall '96 Demo CD | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shanghai Double Pack | PC | | Original | | | |
| Shanghai: Great Moments | PC | 2.00 | Bundle Version Canon OEM | | | |
| Shanghai: Triple-Threat | 3DO | | Original | | | |
| Shanghai: Triple-Threat | 3DO | | 3DO Action Pak | | | |
| Shannara | PC | 1.0 | Original | | | |
| Shaolin | PSX | | Preview | | | |
| Shape Shifter | PC | | Original | | | |
| SharkPort: Code and Save Transfer Kit | PC | 1.04 | Original | | | |
| SharkPort: Code and Save Transfer Kit | PC | 1.10 | Original | | | |
| SharkPort: Code and Save Transfer Kit | PS2 | 1.2 | Unlicensed | | | |
| SharkPort: Code and Save Transfer Kit | PS2 | 1.23 | Unlicensed | | | |
| SharkPort: Code and Save Transfer Kit | PS2 | 2.21 | Unlicensed | | | |
| Sharks! An Interactive Journey An Interactive Journey With... Sharks! | PC | | Original | | | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Sheep | PC | 1.00.000 | Original | | | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| Shenmue III | PC | | Backer Exclusive Edition | | | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | PC | | Original | | | |
| Sherlock Holmes: Consulting Detective: Vol. I Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | 5 ft. 10 PAK Vol. 2 | | | |
| Shining Force III | SS | 1.000 | Beta | | | |
| Shining Soul II + Shining Force Assets Shining Soul 2 + Shining Force Assets | PC | | Press Kit | | | |
| Shining Wisdom | SS | 1.000 | Beta | | | |
| Shining Wisdom | SS | 1.000 | Preview | | | |
| The Ship | PC | | Original | | | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shivers | PC | | Demo | | | |
| Shivers | PC | 1.02 | Rerelease | | | |
| Shivers | PC | 1.02 | Original | | | |
| Shivers Two: Harvest of Souls | PC | 1.0 | Demo | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.0.0.2 | Rerelease | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.00 | | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original, Rerelease | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shock Wave | 3DO | RE2 | Original, Not for Resale | | | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shogo: Mobile Armor Division 昇剛 | PC | 1.0 | Original | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shorelines | CDI | | | | | |
| ShowMaster | CDI | 1.0 | Demo | | | |
| Shrak Shrak for Quake | PC | 1.0 | Original | | | |
| Shrak Shrak for Quake | PC | 2.0 | Rerelease | | | |
| Shrek 2 (Final Press Kit) | PC | | Press Kit | | | |
| Shutter Island: The Adventure Game | PC | 1.0.0 | Original | | | |
| Sid Meier's Alpha Centauri | PC | 1.0I | CD-ROM Classics | | | |
| Sid Meier's Alpha Centauri | MAC | RELEASE 4.0 | Original | | | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Linux | | | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | 3.0 | Original | | | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Sid Meier's Civilization II | PC | 2.42a | Infogrames Rerelease | | | |
| Sid Meier's Civilization III | PC | 1.29f | Game of the Year Edition (Rerelease) | | | |
| Sid Meier's Civilization IV (Disc 1) (Install) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 2) (Play) | PC | | Original | | | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Siege | PC | 1.2 | | | | |
| Sierra Holiday Software Sampler | PC | | | | | |
| Sierra Press Kit | PC | | Press Kit | | | |
| Sierra Pro Pilot (Disc 1) | PC | 1.0 | Original | | | |
| Sierra Pro Pilot (Disc 2) | PC | 1.0 | Original | | | |
| Sierra Pro Pilot 98 | PC | 1.0 | Original | | | |
| Sierra Super Sampler Sierra On-Line Demos | PC | | | | | |
| Sierra's School House: English (Disc 1) | PC | | Original | | | |
| Sierra's School House: English (Disc 2) | PC | | | | | |
| Sierra's School House: Math (Disc 1) | PC | | Original | | | |
| Sierra's School House: Math (Disc 2) | PC | | Original | | | |
| Sierra's Sneak Peeks 2 | PC | | Demo | | | |
| Silent Heroes: Elite Troops of WWII | PC | 1.0.29.0 | Original | | | |
| Silent Hill 2 | PS2 | 1.20 | Beta | | | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | | |
| Silent Hill 4: The Room | PC | 1.0 | Original | | | |
| Silent Hill: Downpour | PS3 | 01.01 | Review | | | |
| Silent Hunter | PC | 1.0.324 | Original | | | |
| Silent Hunter III | PC | 1.4 | Encore | | | |
| Silent Steel | PC | 1.82.42.100 | DVD-ROM | | | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.00 | Original | | | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.01 | Rerelease | | | |
| Silver (Disc 1) | PC | 1.08C | | | | |
| Silver (Disc 2) | PC | 1.08C | | | | |
| The Silver Case | PC | 1.01 | Limited Run Games Limited Edition | | | |
| Silverload | PC | | | | | |
| SimCity 2000 SimCity 2000: The Ultimate City Simulator | PC | | Bundle Version Creative Labs OEM | | | |
| SimCity 2000 for Pocket PC | PPC | 1.0 | Original | | | |
| SimCity 2000: CD Collection | PC | 1.0 | Original | | | |
| SimCity 3000 | PC | | Domino's Pizza / Easter Seals | | | |
| SimCity 3000 | PC | | Linux | | | |
| SimLife SimLife: The Genetic Playground | PC | | Rerelease | | | |
| Simon the Sorcerer | PC | 1.00 | Original | | | |
| The Sims 2 | PC | | Press Kit | | | |
| The Sims 3 | WII | | Beta | | | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims Mandrake Linux Gaming Edition (The Sims for Linux) | PC | | Linux (Mandrake Linux Gaming Edition) | | | |
| The Sims | MAC | | | | | |
| The Sims | MAC | | | | | |
| The Sims: Livin' Large (Expansion Pack) | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims: Vacation (Expansion Pack) | MAC | | Original | | | |
| SiN | PC | | Linux | | | |
| Sin Gold SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| SiN Gold | MAC | | MacPlay | | | |
| SiN Gold | MAC | 1.1.1 | Original | | | |
| Sing-Along Kids | PC | 1.1 | Original | | | |
| Sing-Along Kids: Vol. 2 | PC | | | | | |
| Singularity | PC | | Press Kit | | | |
| Sinistar: Unleashed | PC | | Original | | | |
| Sinkha | MAC | | Original | | | |
| Sinkha | PC | | Original | | | |
| Sins of a Solar Empire | PC | | Rerelease | | | |
| Sins of a Solar Empire | PC | 1.00 | Original | | | |
| Sins of a Solar Empire | PC | 1.165 | Game of the Year Edition | | | |
| Sins of a Solar Empire: Trinity | PC | | | | | |
| Sins of a Solar Empire: Trinity | PC | | Rerelease | | | |
| Sitting Ducks | PC | 1.0 | Rerelease | | | |
| Sitting Ducks | PC | 1.0 | | | | |
| Skate It | WII | | Beta | | | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Skin Style | CDI | | Original | | | |
| Skunny Kart Combo | PC | | Original | | | |
| Skylanders: Spyro's Adventure | PC | | Press Kit | | | |
| SkyMaze X3D SkyMaze | PC | | X3D | | | |
| SkyTrip America SkyTrip America: An Incredible Ride Through U.S. History! | PC | 1.0 | | | | |
| Slam 'n Jam '95 | 3DO | | Beta (CD-R) | | | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | PC | | Original | | | |
| Slater & Charlie Go Camping | PC | 1.000 | SierraOriginals | | | |
| Slayer | 3DO | | Original | | | |
| Slayer | 3DO | | 3DO Action Pak | | | |
| Sleeping Dogs | PS3 | 00.00 | Preview | | | |
| Slingo | PC | | Oregon Lottery | | | |
| Slingo 2-Pack | PC | | Original | | | |
| Slingo Deluxe Slingo Deluxe Bundle | PC | | Original | | | |
| Slingo Mystery: Who's Gold | PC | | Big Fish Games Backup CD | | | |
| Slingo Quest | PC | 0.0.0.104 | Original | | | |
| Slingo: 15th Anniversary Edition | PC | | Original | | | |
| Slingo: Wild 7's | PC | | Oregon Lottery | | | |
| Slopestyle: An Interactive Learning Cube | 3DO | | Original | | | |
| Slots Adventure: War for Olympus | PC | 1.0 | Original | | | |
| Slots Dual Pack Best of Slots from Bally Gaming / Best of Slots II | PC | | Original | | | |
| Slots Featuring WMS Gaming | PC | 1.0.3 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.1 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.2 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Small Soldiers | PSX | | Preview | | | |
| Smart Steps: Kindergarten | PC | 1.0 | Original | | | |
| SMBX + Tak 2 Art | PC | | Press Kit | | | |
| Snap Dragon | PC | 1.0 | Original | | | |
| Snap! 3D Bowling | PC | | Original | | | |
| Snap! Pinball | PC | | Original | | | |
| Snap! Pool Perfect Pool | PC | 1.1 | Original | | | |
| Snap! Subtraction: Ages 5-8 | PC | | Original | | | |
| Sniper: Art of Victory | PC | | Original | | | |
| Sniper: Path of Vengeance | PC | | Original | | | |
| SNK NeoGeo USA Consumer Corporation: E3 2004 Games | PC | | Press Kit | | | |
| SNK Playmore E3 2006 Games | PC | | Press Kit | | | |
| Snoopy vs. the Red Baron | PC | | Original | | | |
| Snoopy's Campfire Stories | PC | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 1) | 3DO | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 2) | 3DO | | Original | | | |
| So Who's Dr. Rabbit? | PC | | Original | | | |
| So You Wanna Be a Redneck | PC | | Original | | | |
| Soccer Kid | 3DO | | Original, 3DO Action Pak, Demo Disc (3DO Demo Disc Program) | | | |
| Soccer Score Soccer | PC | | Original | | | |
| SODA Off-Road Racing | PC | | All American Sports Series | | | |
| Soft Kill | PC | | Original | | | |
| Software & Document: Master CD for Video Family | PC | 1.20 | Bundle Version Jaton OEM | | | |
| The Software Toolworks CD Game Pack | PC | | Original | | | |
| Soldier of Fortune | PC | 1.03 | Bundle Version ASUS OEM | | | |
| Soldier of Fortune | PC | 1.04 | Linux | | | |
| Soldiers at War | PC | | Preview | | | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | MAC | | Original | | | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | PC | | Rerelease | | | |
| Solitaire Antics | PC | 1.0 | Original | | | |
| Solitaire Antics Ultimate | PC | 1.0.3L | Original | | | |
| Sonic and the Secret Rings Comic Book DVD from Archie Comics | PC | | | | | |
| Sonic CD | MCD | | Original | | | |
| Sonic CD | PC | 1.0 | Sonic Action 4 Pack | | | |
| Sonic CD | MCD | 1.15 | Beta | | | |
| Sonic Heroes (Disc 1) | PC | 1.0 | Original | | | |
| Sonic Heroes (Disc 2) | PC | 1.0 | Original | | | |
| Sonic Mega Collection Plus | PS2 | 0.80 | Beta | | | |
| Sonic MegaMix | MCD | | Unlicensed | | | |
| Sonic Riders (Disc 1) | PC | 1.0 | Original | | | |
| Sony E3 2004: Press Information | PC | | Press Kit | | | |
| Sony PlayStation 2: SCEA Santa Monica Studios: 2004 Press Information: Press Print | PC | | Press Kit | | | |
| Sorority House: An Interactive Game of Hide and Peek | PC | 1.0 | Original | | | |
| Sounds Best on Sound Blaster Every Game Sounds Best on Sound Blaster: 24-bit Advanced HD | PC | | | | | |
| South Park | PC | | Original | | | |
| SouthPeak Interactive E3 2000 Electronic Press Kit | PC | | Press Kit | | | |
| Space Ace | PC | | Original | | | |
| Space Ace | MCD | | Demo | | | |
| Space Ace | AJCD | | Original | | | |
| Space Ace | 3DO | | Original | | | |
| Space Ace | 3DO | RE-1 | Original | | | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Bucks | PC | | Original | | | |
| Space Colony | PC | | Original | | | |
| Space Colony | PC | | Interactive Demo | | | |
| Space Dudes | PC | | Original | | | |
| Space Engineers | PC | | Limited Edition | | | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | Beta 8 | Beta (CD-R) | | | |
| Space Invaders | PSX | | Review | | | |
| Space Jam | PC | 1.00 | Original | | | |
| Space Quest 6: Roger Wilco: The Spinal Frontier Space Quest 6: Roger Wilco in The Spinal Frontier | PC | 1.11 | | | | |
| Space Quest 6: Roger Wilco: The Spinal Frontier Space Quest 6: Roger Wilco in The Spinal Frontier | PC | 1.11 | Original | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | SierraOriginals | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | | |
| Space Quest: Collection Series (Disc 1) | PC | | Original | | | |
| Space Quest: Collection Series (Disc 2) | PC | | Original | | | |
| Space Quest: Collector's Edition Space Quest: 15th Anniversary Collector's Edition | PC | | Original | | | |
| Space Shuttle The Software Toolworks Presents... Space Shuttle | 3DO | | Original | | | |
| Space Siege | PC | 1.0 | Original | | | |
| Space Station Simulator | PC | 1.1 | Original | | | |
| Space Station Tycoon | WII | | Prototype | | | |
| Spacebound Space Bound | PC | | Original | | | |
| SpaceChem | PC | 1011 | Original | | | |
| SpaceChem | PC | 1012 | Limited Edition | | | |
| Spaceship Warlock | PC | 1.1.3 | Original | | | |
| Spaceship Warlock | PC | 1.1.3 "MPC" | Ultimate Game Collection | | | |
| SpaceStationSim | PC | 2.0.1.1 | Original | | | |
| Spartan: Total Warrior | XBOX | | Review | | | |
| Spear of Destiny | PC | | Ultimate Game Collection | | | |
| Spear of Destiny | PC | 1.4 | Original | | | |
| Spear of Destiny: Super CD Pack | PC | | Super CD Pack | | | |
| Spec Ops: Platinum Collection (Disc 2) | PC | 1.0 | Original | | | |
| Special Forces: Nemesis Strike (Disc 1) (Game Disc) | PC | 1.0 | Original | | | |
| Special Forces: Nemesis Strike (Disc 2) | PC | 1.0 | Original | | | |
| Special Forces: Nemesis Strike (Disc 3) | PC | 1.0 | Original | | | |
| Special Permit for Cabela's Big Game Hunter | PC | | Original | | | |
| Spectre VR | PC | | Megapak 2 | | | |
| Spectre VR | PC | 1.07wp | Ultimate Game Collection | | | |
| Spectre VR CD | MAC | | Original | | | |
| Speed Busters | PC | 1.02 | Demo | | | |
| Speed Busters: American Highways | PC | | Original | | | |
| Speed Freaks (Misc Artwork: PC-CD 2nd July '99) | PC | | Press Kit | | | |
| Speed Thief X3D Speed Thief | PC | | X3D | | | |
| Spell It Deluxe | PC | | Original | | | |
| Spellcasting: Party Pak | PC | 1.0 | Original | | | |
| Spelunky | PC | | Fangamer (Collector's Edition) | | | |
| Spider-Man | PC | | Demo | | | |
| Spider-Man 2 | PC | | Demo | | | |
| Spider-Man: Web of Shadows (Final Press Kit) | PC | | Press Kit | | | |
| Spine Sense: The Interactive Back Protection Program | CDI | | Original | | | |
| Spintires Spintires: Offroad Truck Simulator | PC | | Original | | | |
| Spirit: Stallion of the Cimarron: Forever Free | PC | | Original | | | |
| Splatt! | PC | | Original | | | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | | |
| Sports Illustrated Kids: Baseball | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Basketball | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Skateboarding | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Soccer | PC | | Wendy's Kids' Meal | | | |
| Sports: Football | CD32 | | | | | |
| Sportsman's Double Play | PC | 1.0.0 | Original | | | |
| SportzFreakz | PC | 1.0 | Original | | | |
| SPRay | WII | | Beta | | | |
| Spring 2012 Refresh Standard: PS3 IDU 4.11 | PS3 | | Kiosk Demo | | | |
| Spring 2013: Standard IDU 4.31 | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2010: 3.21 IDU Update (E-M) | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2011 3.60 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Spy Fox in "Cheese Chase" | PC | | Original | | | |
| Spy Fox in "Dry Cereal" | PC | | Demo | | | |
| Spy Fox: "Operation Ozone" | PC | | Original | | | |
| Spyborgs | WII | | Beta | | | |
| Spycraft: The Great Game | PC | | Enhanced DVD-ROM Edition | | | |
| SpyHunter: Nowhere to Run | PS2 | 1.00 | Preview | | | |
| Spyro the Dragon | PSX | | SCEE Preview | | | |
| Spyro the Dragon | PSX | | SCEA Preview | | | |
| Squad Assault: Second Wave | PC | 1.80 | Original | | | |
| Square Enix E3 2004 Media CD | PC | | Press Kit | | | |
| Square Enix E3 2005 Media CD | PC | | Press Kit | | | |
| Square Enix: Final Fantasy VII Advent Children Trailer | PC | | Press Kit | | | |
| SquareSoft: E3 2001 Media CD | PC | | Press Kit | | | |
| SSI Strategy Collection: Critic's Choice Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| SSN-21 Seawolf Sea Wolf | PC | | Bundle Version Creative Labs OEM | | | |
| SSX Blur | WII | | Beta | | | |
| The Stanley Parable (Installation Disc) | PC | | IndieBox | | | |
| Star Control 3 | PC | | Total War | | | |
| Star Control II | 3DO | | Original, Not for Resale | | | |
| Star Crusader | PC | | Original | | | |
| Star Fox Adventures: Game Preview CD | PC | | Promo | | | |
| Star Rangers | PC | | Original | | | |
| Star Strike | MCD | | Unlicensed | | | |
| Star Trek Omnipedia | PC | | Original | | | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Rerelease | | | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Original | | | |
| Star Trek: Deep Space Nine: Dominion Wars | PC | 1.00 | Original | | | |
| Star Trek: Deep Space Nine: The Fallen | PC | 11-2000-a | Demo | | | |
| Star Trek: Judgment Rites | PC | | Limited CD-ROM Collector's Edition | | | |
| Star Trek: Klingon (Disc 1) (Installation) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Star Trek: Klingon (Disc 2) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Star Trek: Legacy | PC | 1.0 | Original | | | |
| Star Trek: New Worlds | PC | 1.0 | Original | | | |
| Star Trek: Starfleet Academy: Chekov's Lost Missions | PC | | Original | | | |
| Star Trek: Starship Creator Warp II | PC | 1.0 | Rerelease | | | |
| Star Trek: Starship Creator Warp II | PC | 1.0 | Original | | | |
| Star Trek: The Next Generation: A Final Unity | PC | 1.0 | Original | | | |
| Star Trek: The Next Generation: Birth of the Federation | PC | | Original | | | |
| Star Trek: The Next Generation: Interactive Technical Manual | PC | 2.0 | Original | | | |
| Star Trek: Voyager: Elite Force | MAC | | Original | | | |
| Star Wars Galaxies: An Empire Divided (Disc 1) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 1) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 2) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 2) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 3) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 3) | PC | Beta 3 | Beta | | | |
| Star Wars Trilogy CD-ROM: Limited Edition Entertainment Utility | PC | | Original | | | |
| Star Wars: Attacktix: Battle Figure Game | PC | | Starter Set CD-ROM Series 2 | | | |
| Star Wars: Attacktix: Battle Figure Game | PC | | Starter Set CD-ROM | | | |
| Star Wars: Behind the Magic: Vehicles Special Edition | PC | 1.0 | Original | | | |
| Star Wars: DroidWorks | PC | 1.0 | Original | | | |
| Star Wars: Episode I: Cover Disk 4 | PC | | Press Kit | | | |
| Star Wars: Episode I: Disc #3: Covers | PC | | Press Kit | | | |
| Star Wars: Episode I: Racer | PC | 1.0 | Limited Run Games | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | LucasArts Archive Series | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | LucasArts Archive Series | | | |