Region | Title | System | Version | Edition | Languages | Serial | Status |
| The Sky Crawlers: Innocent Aces | WII | | Original | | RVL-RQRE-USA-B0 | |
| Skunny Kart Combo | PC | | Original | | | |
| Skullmonkeys | PSX | | Original | | SLUS-00601 | |
| The Skins Game at Bighorn | PC | | Original | | CD-MPC-126-0 | |
| Skin Style | CDI | | Original | | | |
| Skies of Arcadia: Legends | GC | | Original | | DL-DOL-GEAE-USA | |
| Ski-Doo Snowmobile Challenge | WII | | Original | | RVL-R87E-USA-B0 | |
| Ski-Doo Snowmobile Challenge | XBOX360 | | Original | | VG-2001 | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Ski Park Manager 2003: Gold Edition Val d'Isère Ski Park Manager 2003: Gold Edition | PC | | | | 71102221 | |
| Ski and Shoot | WII | | Original | | RVL-RUME-USA | |
| Skeleton Warriors | PSX | | Original | | SLUS-00209 | |
| Skate. | XBOX360 | | Original | | EA-2067 | |
| Skate It | WII | | Original | | RVL-RVSE-USA | |
| Skate It | WII | | Beta | | | |
| Skate City Heroes | WII | | Original | | RVL-RHUE-USA | |
| Skate 2 | XBOX360 | | Original | | EA-2175 | |
| Six Flags Fun Park | WII | | Original | | RVL-R6FE-USA | |
| Sins of a Solar Empire: Trinity | PC | | | | | |
| Sins of a Solar Empire: Trinity | PC | | Rerelease | | | |
| Sins of a Solar Empire | PC | | Rerelease | | | |
| Sinkha | PC | | Original | | | |
| Sinkha | MAC | | Original | | | |
| Sinistar: Unleashed | PC | | Original | | | |
| Singularity | PC | | Press Kit | | | |
| Sing-Along Kids: Vol. 2 | PC | | | | | |
| Sing 4: The Hits Edition | WII | | Original | | RVL-SIHE-USA-B0 | |
| SiN Gold | MAC | | MacPlay | | | |
| SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| SiN Episodes: Emergence | PC | | Original | | 984707 | |
| Sin & Punishment: Star Successor | WII | | Original | | RVL-R2VE-USA-B0 | |
| SiN | PC | | Linux | | | |
| SimTunes | PC | | Original | | 0135-000-0601-A | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| SimTown | PC | | The Kids Collection | | 1258607 | |
| SimTheme Park Sim Theme Park | PSX | | Original | | SLUS-01069 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition, Scholastic | | 1403357 | |
| SimTheme Park Sim Theme Park | PC | | Scholastic | | 1403307 | |
| SimTheme Park Sim Theme Park | PC | | Original | | 1403307 | |
| SimTheme Park Sim Theme Park | PC | | Sim Mania 2, The Kids Collection | | 1229827, 1641517 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition | | 1403337 | |
| SimTheme Park (Bonus Rides and Attractions) Sim Theme Park | PC | | Gold Edition, Sim Mania 2 | | 1229817, 1403347, 1641527 | |
| The Sims: Vacation (Expansion Pack) | PC | | Original | | 1448807 | |
| The Sims: Vacation (Expansion Pack) | MAC | | Original | | | |
| The Sims: Vacation (Expansion Pack) | PC | | Expansion Collection Volume Three | | 1448807 | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | | Original | | 1640617 | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | PC | | | | 1462617 | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | MAC | | Original | | 10430-2CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | PC | | | | 1462607 | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | MAC | | Original | | 10430-1CDA | |
| The Sims: Pet Stories | PC | | Original | | 1536507 | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 2) | PC | | Expansion Collection Volume Two | | 1472017 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 2) | PC | | Original | | 1472017 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 1) | PC | | Expansion Collection Volume Two | | 1472007 | |
| The Sims: Livin' Large (Expansion Pack) | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims: House Party (Expansion Pack) | PC | | Double Deluxe, Expansion Collection Volume One, Mega Deluxe | | 1446107 | |
| The Sims: Hot Date (Expansion Pack) | MAC | | Original | | 10150-1CDA | |
| The Sims: Double Deluxe (Bonus CD) | PC | | Double Deluxe, Mega Deluxe | | 1474107 | |
| The Sims: Bustin' Out | XBOX | | Original | | EA-067 | |
| The Sims: Bustin' Out | GC | | Original | | DL-DOL-G4ME-USA | |
| The Sims | PC | | Bundle Version Gateway OEM | | 1500827 | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| The Sims Mandrake Linux Gaming Edition (The Sims for Linux) | PC | | Linux (Mandrake Linux Gaming Edition) | | | |
| The Sims | MAC | | | | | |
| The Sims | GC | | Original, Player's Choice | | DL-DOL-GCIE-USA-01 | |
| The Sims | MAC | | | | | |
| The Sims | XBOX | | Original | | EA-047 | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims Strategy Guide and SimFan Pack | PC | | Pre-Order Bonus | | 1414407 | |
| The Sims Online: Sampler Disc | PC | | Original | | 4025407 | |
| The Sims 4: Island Living | PC | | Original, Rerelease | | 3765703401, 3765703402 | |
| The Sims 4: Discover University (Expansion Pack) | PC | | Original | | 3765903401 | |
| The Sims 3: Town Life Stuff | PC | | Original | | 1957907 | |
| The Sims 3: Seasons (Expansion Pack) | PC | | Original, Limited Edition | | 1978303301 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims 3: Monte Vista | PC | | Original, The Sims 3: Worlds Bundle | | 7299103401 | |
| The Sims 3: Katy Perry Sweet Treats | PC | | Original | | 1979807 | |
| The Sims 3: Hidden Springs | PC | | Original, The Sims 3: Worlds Bundle | | 1979707 | |
| The Sims 3: Dragon Valley | PC | | Original | | 7312803402 | |
| The Sims 3 | WII | | Original | | RVL-S3ME-USA-B0 | |
| The Sims 3 | WII | | Beta | | | |
| The Sims 2: University (Expansion Pack) | MAC | | Original | | 11110-1DDA | |
| The Sims 2: Sneak Preview CD | PC | | Original | | 1472027 | |
| The Sims 2: Sneak Preview CD | PC | | Original | | 1472027 | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| The Sims 2: Pets | GC | | Original | | DL-DOL-G4OE-USA | |
| The Sims 2: Pets | WII | | Original | | RVL-R4PE-USA | |
| The Sims 2: Open For Business (Expansion Pack) | MAC | | Original | | 11390-1DDA | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 2) | PC | | | | 1497037 | |
| The Sims 2: Nightlife (Expansion Pack) | MAC | | Original | | 11330-1DDA | |
| The Sims 2: Kitchen & Bath Interior Design Stuff | PC | | Original | | 1578007 | |
| The Sims 2: Insider Preview CD | PC | | Original | | 1625207 | |
| The Sims 2: Happy Holiday Stuff | PC | | Original | | 1527707 | |
| The Sims 2: H&M Fashion Stuff | PC | | Original | | 1536607 | |
| The Sims 2: Family Fun Stuff | PC | | Original | | 1515807 | |
| The Sims 2: Double Deluxe | PC | | Original | | 1597007 | |
| The Sims 2: Double Deluxe (Bonus DVD) | PC | | Original | | 1597027 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | The Sims 2: Double Deluxe | | 1597017 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | Original | | 1672917 | |
| The Sims 2: Castaway | WII | | Original | | RVL-R42E-USA | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| The Sims 2 (Bonus Disk) | PC | | Special DVD Edition | | 1488317 | |
| The Sims 2 | GC | | Original | | DL-DOL-G4ZE-USA | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| The Sims 2 | XBOX | | Original | | EA-907 | |
| The Sims 2 | PC | | Press Kit | | | |
| The Simpsons: Road Rage | XBOX | | Platinum Hits | | EA-019 | |
| The Simpsons: Road Rage | GC | | Original | | DL-DOL-GSPE-USA | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQE-USA | |
| The Simpsons Wrestling | PSX | | Original | | SLUS-01227 | |
| The Simpsons Game | WII | | Original | | RVL-RSNE-USA | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| SimLife SimLife: The Genetic Playground | PC | | Rerelease | | | |
| SimLife SimLife: The Genetic Playground | PC | | Scholastic | | 1111707, 7845126C SP1 | |
| SimLife SimLife: The Genetic Playground | PC | | Scholastic Clubs and Fairs | | 1111707, P1 | |
| SimFarm SimFarm: SimCity's Country Cousin | PC | | Rerelease, 10 Sims for $20 | | 11116, 1162207 | |
| SimFarm SimFarm: SimCity's Country Cousin | PC | | Original, Maxis Collector's Series | | 0003-000-0612-A | |
| SimEarth: The Living Planet | PCE | | Original | | TGXCD1036 | |
| SimEarth | PC | | Scholastic | | 5675434C, DP19 | |
| SimEarth | PC | | Dual Jewel, 10 Sims for $20 | | 1111507 | |
| SimCoaster: Bonus Disk SimCoaster Extra Value Pack | PC | | | | 4002307 | |
| SimCoaster | PC | | Original | | 1425707 | |
| SimCoaster | PC | | Scholastic | | 14257?7 | |
| SimCoaster | PC | | Sim Mania 2, The Kids Collection, Rerelease | | 1242617, 1246307 | |
| SimCoaster | PC | | Rerelease | | 14257?7 | |
| SimClassics: Maxis Collections 2 | PC | | Original | | 0092-000-0601-A | |
| SimClassics: 3 in 1 Pack | PC | | Original | | 0543-000-0601-A | |
| SimCity Enhanced CD-ROM | PC | | Rerelease | | CD-ICD-204-0 | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| SimCity Enhanced CD-ROM | PC | | Original | | CD-ICD-041-0 | |
| SimCity Creator | WII | | Original | | RVL-R4CE-USA | |
| SimCity Classic | PC | | Collector's Series | | 0002-000-0612-A | |
| SimCity Classic | PC | | CD-ROM Classics, 10 Sims for $20, Sim Mania Pack | | 1162907 | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | | SimCity Box | | 1907327 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | | Original | | 1474007 | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| SimCity 3000 Unlimited | PC | | Bundle Version Compaq OEM | | 1500907, 239478-001 | |
| SimCity 3000 Unlimited | PC | | Rerelease | | 1446307, 1641507 | |
| SimCity 3000 | PC | | Domino's Pizza / Easter Seals | | | |
| SimCity 3000 | PC | | Linux | | | |
| SimCity 3000 | PC | | Pre-Order Bonus | | 4083407 | |
| SimCity 3000 | PC | | Scholastic | | 1500107 | |
| SimCity 2000 Special Edition | PC | | CD-ROM Classics, Scholastic | | 10365, 1131107, 5710243CSP1, DP10 | |
| SimCity 2000 Special Edition | PC | | Original | | 0126-000-0601-A | |
| SimCity 2000 SimCity 2000: The Ultimate City Simulator | PC | | Bundle Version Creative Labs OEM | | | |
| SimCity 2000 | PSX | | Original, Greatest Hits | | SLUS-00113 … | |
| SimCity (Preview Disc) | PC | | Target | | 7298103301 | |
| SimAnt SimAnt: The Electronic Ant Colony | PC | | CD-ROM Classics, 10 Sims for $20 | | 1111407 | |
| SimAnt | PC | | Scholastic | | 5710346C SP2 | |
| SimAnimals: Africa | WII | | Original | | RVL-R7AE-USA-B0 | |
| SimAnimals | WII | | Original | | RVL-R4AE-USA | |
| Silverload | PSX | | Original | | SLUS-00050 | |
| Silverload | PC | | | | | |
| Silpheed | MCD | | Original | | 4423 | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| Silhouette Mirage | PSX | | Original | | SLUS-00728 … | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-R5WE-USA-B0 | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Silent Hill 2: Restless Dreams | XBOX | | Platinum Hits | | KN-004 | |
| Silent Hill | PSX | | Trade Demo | | SLUS-80707 | |
| Silent Hill | PSX | | Demo | | SLUS-90050 | |
| Silent Hill | PSX | | Original, Greatest Hits | | SLUS-00707 … | |
| Silent Bomber | PSX | | Original | | SLUS-00902 | |
| Sierra's Sneak Peeks 2 | PC | | Demo | | | |
| Sierra's School House: Science (Disc 2) | PC | | Original | | 831614230/S161155 | |
| Sierra's School House: Science (Disc 1) | PC | | Original | | 831614230/S161155 | |
| Sierra's School House: Math (Disc 2) | PC | | Original | | | |
| Sierra's School House: Math (Disc 1) | PC | | Original | | | |
| Sierra's School House: English (Disc 2) | PC | | | | | |
| Sierra's School House: English (Disc 1) | PC | | Original | | | |
| Sierra Super Sampler Sierra On-Line Demos | PC | | | | | |
| Sierra Products Demo America Online featuring Sierra Online | PC | | | | R00482 | |
| Sierra Press Kit | PC | | Press Kit | | | |
| Sierra Holiday Software Sampler | PC | | | | | |
| Sid Meier's SimGolf | PC | | Rerelease | | 1641547 | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDE-USA-B0 | |
| Sid Meier's Gettysburg! | PC | | CD-ROM Classics | | 1187707 | |
| Sid Meier's Civilization VI | PC | | Original | | 41829-1 | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| Sid Meier's Civilization Revolution | XBOX360 | | Original | | TT-2021 | |
| Sid Meier's Civilization IV: Colonization | PC | | Original | | 31491-1 | |
| Sid Meier's Civilization IV: Beyond the Sword | MAC | | Original | | 12090-1DDA | |
| Sid Meier's Civilization IV (Disc 2) (Play) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 2) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.7 | |
| Sid Meier's Civilization IV (Disc 1) (Install) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization III Complete (Disc 3) (Conquests) | PC | | Original | | 25766CD3 | |
| Sid Meier's Civilization III Complete (Disc 2) (Play the World) | PC | | Original | | 25766CD2 | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Rerelease, Sid Meier's Civilization Chronicles | | 31074-1.3 | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Original | | 25766CD1 | |
| Sid Meier's Civilization III (Bonus CD) | PC | | Game of the Year Edition | | Part # 24356CD2 | |
| Sid Meier's Civilization II: Fantastic Worlds | PC | | Original | | 0-529-47-101 | |
| Sid Meier's Civilization Chronicles (Disc 2) | PC | | Original | | 31074-1.2 | |
| Sid Meier's Civilization Chronicles (Disc 1) | PC | | Original | | 31074-1.1 | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Linux | | | |
| Sid Meier's Alien Crossfire | PC | | Original | | 1405807 | |
| Shrine Circus Tycoon | PC | | | | 31933.101.US | |
| Shrek Treasure Hunt | PSX | | Original | | SLUS-01463 | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093140(US) | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYE-USA | |
| Shrek Super Party | XBOX | | Original | | TM-004 | |
| Shrek Game Land Activity Center | PC | | Original | | 32053.101.US | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9E-USA | |
| Shrek 2 | PC | | Original | | 32585.101.US | |
| Shrek 2 (Final Press Kit) | PC | | Press Kit | | | |
| Shrek 2 | PC | | | | 32585.101.US | |
| Shrek 2 | GC | | Original, Player's Choice | | DL-DOL-G3RE-USA, DL-DOL-G3RE-USA-02 | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| Shrek | XBOX | | Original | | TM-001 | |
| Showtime Championship Boxing | WII | | Original | | RVL-RSYE-USA | |
| Showdown: Legends of Wrestling | XBOX | | Original | | AC-029 | |
| Shorelines | CDI | | | | | |
| Shopmania | PC | | Original | | P/N 61227-CD | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shonen Jump's One Piece: Grand Battle | GC | | Original | | DL-DOL-GOPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shogun: Total War (Disc 2) | PC | | Original | | 798717, 1224617 | |
| Shogun: Total War (Disc 1) | PC | | Rerelease | | 798727 | |
| Shockwave Assault (Disc 2) (Shockwave: Operation Jumpgate) | PSX | | Original | | SLUS-00137 | |
| Shockwave Assault (Disc 1) (Shockwave: Invasion Earth) | PSX | | Original | | SLUS-00028 | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | 831744330/S174150 | |
| Shivers | PC | | Demo | | | |
| Shiren the Wanderer | WII | | Original | | RVL-RFSE-USA-B0 | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shipwreckers! | PSX | | Original | | SLUS-00558 | |
| Shipwreckers! | PSX | | Demo | | SLUS-90013 | |
| The Ship | PC | | Original | | | |
| Shining Soul II + Shining Force Assets Shining Soul 2 + Shining Force Assets | PC | | Press Kit | | | |
| Shining Force CD | MCD | | Original | | 4656 | |
| Shining Force CD | MCD | | Original | | 4656 | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shift 2: Unleashed | PC | | Limited Edition | | 1948307 | |
| Sherlock Holmes: Crimes & Punishments | XBOX360 | | Original | | FE-2015 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 2) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 1) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. II | PCE | | Original | | TGXCD1039 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Rerelease | | CDRM 835400 | |
| Sherlock Holmes: Consulting Detective: Vol. I Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | 5 ft. 10 PAK Vol. 2 | | | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective | PCE | | Original | | TGXCD1011 | |
| Sherlock Holmes: Consulting Detective | MCD | | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | T-4501 | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | XBOX360 | | Original | | JW-2003 | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | PC | | Original | | | |
| Sherlock Holmes and the Hound of the Baskervilles | PC | | Collector's Edition | | 33369101US | |
| Shenmue III | PC | | Backer Exclusive Edition | | | |
| Shenmue II | XBOX | | Original | | MS-050 | |
| Shellshock | PSX | | Original | | SLUS-00031 | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| Sheep | PSX | | Original | | SLUS-01298 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NE-USA-B0 | |
| Shaun White Snowboarding: Road Trip | WII | | Target Limited Edition | | RVL-RW7E-USA | |
| Shaun White Snowboarding: Road Trip | WII | | Original | | RVL-RDFE-USA | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| Shaun White Skateboarding | WII | | Original | | RVL-SHNE-USA-B0 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shattered Union | XBOX | | Original | | TT-131 | |
| Sharks! An Interactive Journey An Interactive Journey With... Sharks! | PC | | Original | | | |
| Shark Alert | CDI | | Original, Demonstration Disc | | 310-690-278-2, 310690278-2 | |
| Shari Lewis Lamb Chop's Play-Along! Action Songs | CDI | | Original | | 310690289-2 | |
| Shape Shifter | PC | | Original | | | |
| Shape Shifter | PCE | | Original | | TGXCD1021 | |
| Shaolin | PSX | | Preview | | | |
| Shanghai: True Valor | PSX | | Original | | SLUS-00795 | |
| Shanghai: Triple-Threat | 3DO | | Original | | | |
| Shanghai: Triple-Threat | 3DO | | 3DO Action Pak | | | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shanghai Double Pack | PC | | Original | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shamrock's Fall '96 Demo CD | PC | | | | | |
| Shamrock Spring '97 Shamrock Spring '97 Demo Disk | PC | | | | | |
| Shakii the Wolf | PC | | Original | | | |
| Shadows of Cairn | PC | | Rerelease | | | |
| Shadowrun Returns (Game Disc) | PC | | Original | | | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| Shadowlands | PC | | Megapak 2 | | | |
| ShadowCaster | PC | | CD-ROM Classics, Electronic Arts Presents | | 5393 | |
| ShadowCaster | PC | | Top Ten Pak II | | 5454 | |
| Shadowbane: The Rise of Chaos | PC | | Original | | 651727-CD | |
| SHADOW: War of Succession | 3DO | | Original | | | |
| Shadow Wolf Mysteries: Curse of the Full Moon / Bane of the Family | PC | | | | 33425010US | |
| Shadow Tower | PSX | | Original | | SLUS-00863 | |
| Shadow the Hedgehog | XBOX | | Original | | SE-134 | |
| Shadow the Hedgehog | GC | | Original | | DL-DOL-GUPE-USA | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Gold Medal 12 CD Pack | | MQ 13-004-116 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-037 | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shadow of the Beast II | MCD | | Original | | T-113045 | |
| Shadow of the Beast | PCE | | Original | | TGXCD1018 | |
| Shadow Master | PSX | | Original | | SLUS-00545 | |
| Shadow Man | PC | | Original | | | |
| Shadow Man | PSX | | Original | | SLUS-00895 | |
| Shadow Man | PC | | Demo | | | |
| Shadow Madness (Disc 2) | PSX | | Original | | SLUS-00718 | |
| Shadow Madness (Disc 1) | PSX | | Original | | SLUS-00468 | |
| Shadow Madness | PSX | | Demo | | SLUS-90031 | |
| Shadow Force: Razor Unit | PC | | Special Forces Pack | | SFRU-0414 | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow Company: Left for Dead (Digital Press Kit) | PC | | Press Kit | | 5051895 | |
| Shadoan (Disc 2) | PC | | Original | | CD-ICD-228-1 | |
| Shadoan (Disc 1) | PC | | Original | | CD-ICD-228-0 | |
| Shadoan | PC | | Interactive Preview | | | |
| Shade: Wrath of Angels (Press Disc) | PC | | Press Kit | | | |
| Sex | 3DO | | Original | | | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Original | | T-6201 | |
| Seven Kingdoms: The Fryhtan Wars / Shadow Company: Left for Dead | PC | | Demo | | 5051859 | |
| Seven Games of the Soul (Disc 4) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 3) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 2) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 1) Faust | PC | | Original | | | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Sesame Street: Reading Basics | PC | | Encore | | 10200 | |
| Sesame Street: Numbers | MAC | | Original | | 691-0759-A, 743807A | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Numbers | 3DO | | Original | | | |
| Sesame Street: Letters | PC | | | | 9367A | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: Let's Make a Word! | PC | | Original, Software for the fun of it | | KES006 | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Sesame Street: Let's Make a Word! | PC | | Bundle Version Creative Labs OEM | | 1713310119-1 | |
| Sesame Street: Learn, Play and Grow Preschool / Sesame Street: Let's Go to Preschool / Sesame Street: First Steps | PC | | Southwestern Kids' Collection | | 05SS3-R01 | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 1) (Reading Basics) | PC | | Original | | EPK-744AE-CD1 | |
| Sesame Street: Elmo's Preschool | PC | | | | 11040CD | |
| Sesame Street: Elmo's Number Journey | PSX | | Original, Twin Pack | | SLUS-00622 … | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Elmo's Letter Adventure | PSX | | Original, Twin Pack | | SLUS-00621 … | |
| Sesame Street: Elmo's Art Workshop | PC | | Original | | EAW844AE-CD | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS3E-USA-B0 | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS4E-USA-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | PC | | Original | | | |
| Sesame Street: Art Workshop | PC | | Original | | 9369 | |
| Sesame Street Sports | PSX | | Original | | SLUS-01180 | |
| Sesame Street Search & Learn Adventures | PC | | Original, Software for the fun of it | | EOA844AE-CD, KES005 | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| Serious Sam | XBOX | | Original | | TT-004 | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel Returns | PSX | | Original | | SLUS-00604 | |
| Sentient | PSX | | Original | | SCUS-94110 | |
| Sentient | PC | | Original | | | |
| Sensei 2 | PC | | Original | | GC-007 | |
| Sengoku Basara: Samurai Heroes | WII | | Original | | RVL-SB3E-USA-B0 | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| Sega Superstars Tennis | WII | | Original | | RVL-RT5E-USA | |
| Sega Soccer Slam | GC | | Original | | DL-DOL-GSSE-USA | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| Sega Smash Pack Twin Pack | PC | | Original | | 30884.101.US | |
| Sega Smash Pack 2 | PC | | Original, Sonic Action 4 Pack | | 30107.101.US | |
| Sega Smash Pack | PC | | Original | | 85087 | |
| Sega Screenshots 2000 Sega E3 2000 | PC | | Press Kit | | | |
| Sega Rally Championship Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 | |
| Sega Rally 2 (Disc 2) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally 2 (Disc 1) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0919 | |
| Sega Puzzle Pack | PC | | Expert Software | | 682701.101.US | |
| Sega Puzzle Pack | PC | | Rerelease | | 85091 / FS22923 | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Sega GT Online | XBOX | | Original | | SE-033 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega GT 2002 | XBOX | | Original | | SE-003 | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega E3 Press Kit 2005 2005 E3 Press Kit | PC | | Press Kit | | | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Sega Bass Fishing | WII | | Original | | RVL-RBTE-USA | |
| Seek and Destroy Seek & Destroy | PC | | Original | | EPSAD01 | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Adventures | PC | | Original | | | |
| Section 8 | PC | | Original | | 50027-LBL | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the East | PC | | Scholastic | | P/N CDR9909538 | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| The Secrets of Atlantis (Disc 3) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 2) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 1) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Secret Weapons of the Luftwaffe | PC | | Original | | 2156010-590001/I042, CDRM1003790 | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| The Secret of the Silver Earring (Disc 2) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| The Secret of the Silver Earring (Disc 1) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The Secret of Monkey Island | MCD | | Original | | T-60035 | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PSX | | Original | | LSP-020780 … | |
| The Secret of Googol 7: Eggs All Around: Egg Trek / Balloon Picnic | PSX | | Original | | LSP-020650 … | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PSX | | Original | | LSP-020570 … | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PSX | | Original | | LSP-020450 … | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PSX | | Original | | LSP-020280 … | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PSX | | Original | | LSP-020260 … | |
| The Secret of Googol 2b: Reshaping Googol: Under the Ocean | PSX | | Original | | LSP-020170 … | |
| The Secret of Googol 2a: Reshaping Googol: The Castle | PSX | | Original | | LSP-020180 … | |
| The Secret of Googol 1b: Reshaping Googol: The Tower | PSX | | Original | | LSP-020150 … | |
| The Secret of Googol 1a: Reshaping Googol: The Submarine | PSX | | Original | | LSP-020160 … | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | GC | | Original | | DL-DOL-GJZE-USA | |
| SeaWorld Adventure Parks Tycoon | PC | | Original | | 31711.101.US | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Seal of the Pharaoh | 3DO | | Original | | FZ-SM1751 | |
| Seal of Evil | PC | | Original | | 904066DVD | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Sea-Doo Hydro Cross | PSX | | Original | | SLUS-01149 | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| The Scroll | PC | | | | | |
| Scribblenauts Unlimited | PC | | Original | | 5000145356 | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Screamer 2 Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| Screamer | PC | | White Label | | | |
| Screamer | PC | | White Label | | | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Rerelease | | | |
| Scratches | PC | | Original | | | |
| Scramble Cobra | 3DO | | Original | | FZ-SM0404 | |
| Scramble Cobra | 3DO | | Beta (CD-R) | | | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble: Champion Edition | PC | | Original | | 11191A-CD v1.0 S | |
| Scrabble Complete | PC | | Cosmi | | CDRZ652D1, SJ122005 | |
| Scrabble Complete | PC | | Original, Bundle Version Microgistix OEM | | 11290-CD, Part # 23970CD | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Scholastic, Classic Value Series | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble | PSX | | Original | | SLUS-00903 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002, 99002● | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble | PC | | General Mills | | AM0703R72 | |
| ScottForesman Wide World of Mathematics | PC | | Original | | 45678910 ET 030201009998 | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| Score International Baja 1000: The Official Game | PC | | Original | | 35619./101.US | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Score 4 | PC | | Original | | | |
| Scorcher | PC | | Original | | 04-11264CD | |
| Scorched Planet | PC | | Original | | | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DE-USA | |
| Scooby-Doo! Night of 100 Frights | PSX | | Prototype | | | |
| Scooby-Doo! Night of 100 Frights | GC | | Original | | DL-DOL-GIHE-USA | |
| Scooby-Doo! Night of 100 Frights | XBOX | | Original | | TQ-031 | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Mystery Mayhem | GC | | Original | | DL-DOL-GC3E-USA | |
| Scooby-Doo! Jinx at the Sphinx | PC | | Scholastic | | 380849-CD | |
| Scooby-Doo! First Frights | WII | | Original | | RVL-RQNE-USA-B0 | |
| Scooby-Doo! and the Spooky Swamp | WII | | Original | | RVL-SJ2E-USA-B0 | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Scooby-Doo and the Cyber Chase | PSX | | Demo | | SLUS-90098 | |
| Scooby-Doo and the Cyber Chase | PSX | | Original, Greatest Hits | | SLUS-01396 … | |
| Scissors 'n' Stones | PC | | Original | | | |
| Science Papa | WII | | Original | | RVL-RZEE-USA-B0 | |
| Science Is Elementary 3 | PSX | | Original | | LSP-990163 … | |