Region | Title | System | Version | Edition | Languages | Serial | Status |
| S!Zone for SimCity 2000 | PC | | Original | | | |
| S.C.A.R.S. | PC | | Original | | | |
| S.C.A.R.S. | PSX | | Original | | SLUS-00692 | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| Saban's Power Rangers Zeo: Full Tilt Battle Pinball | PSX | | Original | | SLUS-00256 | |
| Saban's Power Rangers: Lightspeed Rescue | PSX | | Original | | SLUS-01114 | |
| Saban's Power Rangers: Time Force | PSX | | Original | | SLUS-01351 | |
| Sable Maze: Forbidden Garden & Twelve Fears | PC | | Original | | 33528010US | |
| Sable Maze: Sullivan River / Norwich Caves | PC | | | | 33471010US | |
| Sabrina the Teenage Witch: A Twitch in Time! | PSX | | Original | | SLUS-01208 | |
| Sabrina the Teenage Witch: Brat Attack | PC | | Original | | S02560 | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| Sacred 2 (Disc 2) | PC | | Original | | | |
| Sacred 2: Fallen Angel (Disc 1) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 2) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 3) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| The Sacred Amulet | PC | | Original | | | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| Sacrifice (Editors Press Kit) | PC | | Press Kit | | | |
| Sacrifice (Scapex Tutorial Video) | PC | | Preproduction | | | |
| Sacrifice | PC | | Bundle Version Hewlett Packard OEM | | CD-C951041-PC2E | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Safecracker | PC | | Rerelease | | | |
| SaGa Frontier | PSX | | Original | | SCUS-94230 | |
| SaGa Frontier 2 | PSX | | Original | | SLUS-00933 | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Sailing | CDI | | Original, Demonstration Disc | | 310-690-101-2, 310690101-2 | |
| Saint | WII | | Original | | RVL-RZCE-USA-B0 | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Saints Row 2 | PC | | Original | | | |
| Saints Row: The Third (Disc 1) | PC | | Original | | | |
| Saints Row: The Third (Disc 2) | PC | | Original | | | |
| Saiyuki: Journey West | PSX | | Original | | SLUS-01381 | |
| Sakura Wars: So Long, My Love | WII | | Original | | RVL-SAKE-USA-E0 | |
| Saltwater Sportfishing | PSX | | Original | | SLUS-01397 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | Original | | 634031 | |
| Sam & Max Hit the Road | PC | | Original | | 634430 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | |
| Sam & Max: Beyond Time and Space | PC | | Original | | 27898CD | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Sam & Max: Season One | WII | | Beta | | | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XE-USA | |
| Sam & Max: This Time It's Virtual! | PC | | Limited Run Games | | | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Samba de Amigo | WII | | Original | | RVL-R3BE-USA | |
| Same or Different | PC | | Book Bundle | | 08028 | |
| Sammy Sosa High Heat Baseball 2001 | PSX | | Original | | SLUS-01063 | |
| Sammy Sosa Softball Slam | PSX | | Original | | SLUS-01064 | |
| Sammy Soza Softball Slam | PC | | Original | | PCD-5048-001 | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Shodown II | PC | | Dual Jewel | | CD-C95-1302-0 | |
| Samurai Shodown II | PC | | Original | | CD-C95-1166-0 | |
| Samurai Shodown III: Blades of Blood | PSX | | Original | | SCUS-94206 | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Shodown V | XBOX | | Original | | SN-004 | |
| Samurai Shodown: Warriors Rage | PSX | | Original | | SLUS-01039 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59E-USA-E0 | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5E-USA | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-87015 | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| San Francisco Rush: Extreme Racing | PSX | | Original | | SLUS-00505 | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sanitarium | PC | | Demo | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Original | | | |
| Sargon Chess | CDI | | Original, Original: Longbox | | 310690030-2 | |
| Sargon Chess | CDI | | Beta | | 310-690-030-2 | |
| Satisfashion: Rock the Runway | WII | | Original | | RVL-SS5E-USA-B0 | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Saw | XBOX360 | | Original | | KN-2050 | |
| Saw II: Flesh & Blood | XBOX360 | | Original | | KN-2082 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| Scaler | GC | | Original | | DL-DOL-GKUE-USA | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| SCEA Gamers Day 2002: Press Info | PC | | Press Kit | | | |
| SCEE Software Brochure + Press Information: E3 2003 | PC | | Press Kit | | | |
| Scene It? Bright Lights! Big Screen! | XBOX360 | | Original | | WR-2037 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCE-USA-B0 | |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| Scene It? Twilight | WII | | Original | | RVL-SCNE-USA-B0 | |
| Schizm: Mysterious Journey (Side A) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Side B) | PC | | DVD-ROM Edition | | | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Scholastic's The Magic School Bus Explores the World of Animals | PC | | Original, The Magic School Bus: Bonus Pack | | 0299 Part No. X03-94114, 1001 Part No. X08-51052 | |
| Scholastic's The Magic School Bus Lands on Mars: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0400 Part No. X05-64212 | |
| Scholastic's The Magic School Bus: Volcano Adventure: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0401 Part No. X08-06054 | |
| Scholastic's The Magic School Bus: Whales & Dolphins: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3, The Magic School Bus: Bonus Pack | | 0201 Part No. X06-15571 | |
| School Tycoon | PC | | Scholastic | | P/N: CDR 21661-1R | |
| School Tycoon | PC | | Original | | | |
| School Zone Flash Action Software: Multiplication/Division | PC | | Original | | 08021 | |
| School Zone Math: First & Second Grade | PC | | Original | | 08020 | |
| Schoolhouse Rock! 1st & 2nd Grade (Disc 2) (2nd Grade) | PC | | Original | | 21330CD-2, SGE744AE-CD2 | |
| Schoolhouse Rock! 1st & 2nd Grade Essentials (Disc 1) | PC | | Original | | 21330CD-1 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! America Rock | PC | | Original | | 21080CD | |
| Schoolhouse Rock! Grammar Rock | PC | | SmartSaver | | SGR744AE-CD | |
| Schoolhouse Rock! Grammar Rock | PC | | Original | | 9227 | |
| Schoolhouse Rock! Grammar Rock | MAC | | Original | | 9227 | |
| Schoolhouse Rock! Math Rock | PC | | Original | | 21010CD | |
| Schoolhouse Rock! Math Rock | PC | | Smart Saver | | SHR744AE-CD | |
| Schoolhouse Rock! Thinking Games | PC | | Original | | BBT844AE-CD | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744BE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744AE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 2) (Learning Adventures) | PC | | Original | | SRT744AE-CD2 | |
| SCI Games E3 2005 Press Kit | PC | | Press Kit | | | |
| The Sci-Fi Collection | PC | | Original | | | |
| Sci-Fi Pinball | PC | | Original | | | |
| Science Arcade | PC | | Original | | Part No.: MAR476 | |
| Science Blaster Jr. | PC | | Rerelease | | | |
| Science Blaster Jr. | PC | | Original | | | |
| Science Fiction: The Ultimate Collection (Disc 1) | PC | | | | 11014 | |
| Science Is Elementary 1 | PSX | | Original | | LSP-990161 … | |
| Science Is Elementary 2 | PSX | | Original | | LSP-990162 … | |
| Science Is Elementary 3 | PSX | | Original | | LSP-990163 … | |
| Science Papa | WII | | Original | | RVL-RZEE-USA-B0 | |
| Scissors 'n' Stones | PC | | Original | | | |
| Scooby-Doo and the Cyber Chase | PSX | | Demo | | SLUS-90098 | |
| Scooby-Doo and the Cyber Chase | PSX | | Original, Greatest Hits | | SLUS-01396 … | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Scooby-Doo! and the Spooky Swamp | WII | | Original | | RVL-SJ2E-USA-B0 | |
| Scooby-Doo! First Frights | WII | | Original | | RVL-RQNE-USA-B0 | |
| Scooby-Doo! Jinx at the Sphinx | PC | | Scholastic | | 380849-CD | |
| Scooby-Doo! Mystery Mayhem | GC | | Original | | DL-DOL-GC3E-USA | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Night of 100 Frights | XBOX | | Original | | TQ-031 | |
| Scooby-Doo! Night of 100 Frights | PSX | | Prototype | | | |
| Scooby-Doo! Night of 100 Frights | GC | | Original | | DL-DOL-GIHE-USA | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DE-USA | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Scorched Planet | PC | | Original | | | |
| Scorcher | PC | | Original | | 04-11264CD | |
| Score 4 | PC | | Original | | | |
| Score International Baja 1000: The Official Game | PC | | Original | | 35619./101.US | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| ScottForesman Wide World of Mathematics | PC | | Original | | 45678910 ET 030201009998 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble | PC | | General Mills | | AM0703R72 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Scholastic, Classic Value Series | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble | PSX | | Original | | SLUS-00903 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002, 99002● | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble Complete | PC | | Cosmi | | CDRZ652D1, SJ122005 | |
| Scrabble Complete | PC | | Original, Bundle Version Microgistix OEM | | 11290-CD, Part # 23970CD | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble: Champion Edition | PC | | Original | | 11191A-CD v1.0 S | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Scramble Cobra | 3DO | | Original | | FZ-SM0404 | |
| Scramble Cobra | 3DO | | Beta (CD-R) | | | |
| Scratches | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Rerelease | | | |
| Screamer | PC | | White Label | | | |
| Screamer | PC | | White Label | | | |
| Screamer 2 Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| Scribblenauts Unlimited | PC | | Original | | 5000145356 | |
| The Scroll | PC | | | | | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Sea-Doo Hydro Cross | PSX | | Original | | SLUS-01149 | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Seal of Evil | PC | | Original | | 904066DVD | |
| Seal of the Pharaoh | 3DO | | Original | | FZ-SM1751 | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| SeaWorld Adventure Parks Tycoon | PC | | Original | | 31711.101.US | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | GC | | Original | | DL-DOL-GJZE-USA | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| The Secret of Googol 1a: Reshaping Googol: The Submarine | PSX | | Original | | LSP-020160 … | |
| The Secret of Googol 1b: Reshaping Googol: The Tower | PSX | | Original | | LSP-020150 … | |
| The Secret of Googol 2a: Reshaping Googol: The Castle | PSX | | Original | | LSP-020180 … | |
| The Secret of Googol 2b: Reshaping Googol: Under the Ocean | PSX | | Original | | LSP-020170 … | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PSX | | Original | | LSP-020260 … | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PSX | | Original | | LSP-020280 … | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PSX | | Original | | LSP-020450 … | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PSX | | Original | | LSP-020570 … | |
| The Secret of Googol 7: Eggs All Around: Egg Trek / Balloon Picnic | PSX | | Original | | LSP-020650 … | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PSX | | Original | | LSP-020780 … | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The Secret of Monkey Island | MCD | | Original | | T-60035 | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| The Secret of the Silver Earring (Disc 1) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of the Silver Earring (Disc 2) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| Secret Weapons of the Luftwaffe | PC | | Original | | 2156010-590001/I042, CDRM1003790 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Atlantis (Disc 1) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 2) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 3) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Secrets of the East | PC | | Scholastic | | P/N CDR9909538 | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Section 8 | PC | | Original | | 50027-LBL | |
| Seek & Find Adventures | PC | | Original | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Seek and Destroy Seek & Destroy | PC | | Original | | EPSAD01 | |
| Sega Bass Fishing | WII | | Original | | RVL-RBTE-USA | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Sega E3 Press Kit 2005 2005 E3 Press Kit | PC | | Press Kit | | | |
| Sega Entertainment's Arcade Sampler | PC | | | | | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega GT 2002 | XBOX | | Original | | SE-003 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega GT Online | XBOX | | Original | | SE-033 | |
| Sega Puzzle Pack | PC | | Expert Software | | 682701.101.US | |
| Sega Puzzle Pack | PC | | Rerelease | | 85091 / FS22923 | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Sega Rally 2 (Disc 1) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0919 | |
| Sega Rally 2 (Disc 2) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally Championship Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 | |
| Sega Screenshots 2000 Sega E3 2000 | PC | | Press Kit | | | |
| Sega Smash Pack | PC | | Original | | 85087 | |
| Sega Smash Pack 2 | PC | | Original, Sonic Action 4 Pack | | 30107.101.US | |
| Sega Smash Pack Twin Pack | PC | | Original | | 30884.101.US | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| Sega Soccer Slam | GC | | Original | | DL-DOL-GSSE-USA | |
| Sega Superstars Tennis | WII | | Original | | RVL-RT5E-USA | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| Sengoku Basara: Samurai Heroes | WII | | Original | | RVL-SB3E-USA-B0 | |
| Sensei 2 | PC | | Original | | GC-007 | |
| Sentient | PSX | | Original | | SCUS-94110 | |
| Sentient | PC | | Original | | | |
| Sentinel Returns | PSX | | Original | | SLUS-00604 | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Serious Sam | XBOX | | Original | | TT-004 | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Sesame Street Search & Learn Adventures | PC | | Original, Software for the fun of it | | EOA844AE-CD, KES005 | |
| Sesame Street Sports | PSX | | Original | | SLUS-01180 | |
| Sesame Street: Art Workshop | PC | | Original | | 9369 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS4E-USA-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | PC | | Original | | | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS3E-USA-B0 | |
| Sesame Street: Elmo's Art Workshop | PC | | Original | | EAW844AE-CD | |
| Sesame Street: Elmo's Letter Adventure | PSX | | Original, Twin Pack | | SLUS-00621 … | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Elmo's Number Journey | PSX | | Original, Twin Pack | | SLUS-00622 … | |
| Sesame Street: Elmo's Preschool | PC | | | | 11040CD | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 1) (Reading Basics) | PC | | Original | | EPK-744AE-CD1 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| Sesame Street: Learn, Play and Grow Preschool / Sesame Street: Let's Go to Preschool / Sesame Street: First Steps | PC | | Southwestern Kids' Collection | | 05SS3-R01 | |
| Sesame Street: Let's Make a Word! | PC | | Original, Software for the fun of it | | KES006 | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Sesame Street: Let's Make a Word! | PC | | Bundle Version Creative Labs OEM | | 1713310119-1 | |
| Sesame Street: Letters | PC | | | | 9367A | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: Numbers | MAC | | Original | | 691-0759-A, 743807A | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Numbers | 3DO | | Original | | | |
| Sesame Street: Reading Basics | PC | | Encore | | 10200 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| Seven Games of the Soul (Disc 1) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 2) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 3) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 4) Faust | PC | | Original | | | |
| Seven Kingdoms: The Fryhtan Wars / Shadow Company: Left for Dead | PC | | Demo | | 5051859 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Original | | T-6201 | |
| Sex | 3DO | | Original | | | |
| Shade: Wrath of Angels (Press Disc) | PC | | Press Kit | | | |
| Shadoan | PC | | Interactive Preview | | | |
| Shadoan (Disc 1) | PC | | Original | | CD-ICD-228-0 | |
| Shadoan (Disc 2) | PC | | Original | | CD-ICD-228-1 | |
| Shadow Company: Left for Dead (Digital Press Kit) | PC | | Press Kit | | 5051895 | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow Force: Razor Unit | PC | | Special Forces Pack | | SFRU-0414 | |
| Shadow Madness | PSX | | Demo | | SLUS-90031 | |
| Shadow Madness (Disc 1) | PSX | | Original | | SLUS-00468 | |
| Shadow Madness (Disc 2) | PSX | | Original | | SLUS-00718 | |
| Shadow Man | PC | | Demo | | | |
| Shadow Man | PC | | Original | | | |
| Shadow Man | PSX | | Original | | SLUS-00895 | |
| Shadow Master | PSX | | Original | | SLUS-00545 | |
| Shadow of the Beast | PCE | | Original | | TGXCD1018 | |
| Shadow of the Beast II | MCD | | Original | | T-113045 | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-037 | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Gold Medal 12 CD Pack | | MQ 13-004-116 | |
| Shadow the Hedgehog | XBOX | | Original | | SE-134 | |
| Shadow the Hedgehog | GC | | Original | | DL-DOL-GUPE-USA | |
| Shadow Tower | PSX | | Original | | SLUS-00863 | |
| Shadow Wolf Mysteries: Curse of the Full Moon / Bane of the Family | PC | | | | 33425010US | |
| SHADOW: War of Succession | 3DO | | Original | | | |
| Shadowbane: The Rise of Chaos | PC | | Original | | 651727-CD | |
| ShadowCaster | PC | | CD-ROM Classics, Electronic Arts Presents | | 5393 | |
| ShadowCaster | PC | | Top Ten Pak II | | 5454 | |
| Shadowlands | PC | | Megapak 2 | | | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| Shadowrun Returns (Game Disc) | PC | | Original | | | |
| Shadows of Cairn | PC | | Rerelease | | | |
| Shakii the Wolf | PC | | Original | | | |
| Shamrock Spring '97 Shamrock Spring '97 Demo Disk | PC | | | | | |
| Shamrock's Fall '96 Demo CD | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shanghai Double Pack | PC | | Original | | | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shanghai: Triple-Threat | 3DO | | Original | | | |
| Shanghai: Triple-Threat | 3DO | | 3DO Action Pak | | | |
| Shanghai: True Valor | PSX | | Original | | SLUS-00795 | |
| Shaolin | PSX | | Preview | | | |
| Shape Shifter | PCE | | Original | | TGXCD1021 | |
| Shape Shifter | PC | | Original | | | |
| Shari Lewis Lamb Chop's Play-Along! Action Songs | CDI | | Original | | 310690289-2 | |
| Shark Alert | CDI | | Original, Demonstration Disc | | 310-690-278-2, 310690278-2 | |
| Sharks! An Interactive Journey An Interactive Journey With... Sharks! | PC | | Original | | | |
| Shattered Steel | PC | | Interactive Preview | | CD-ICD-308-0 | |
| Shattered Union | XBOX | | Original | | TT-131 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shaun White Skateboarding | WII | | Original | | RVL-SHNE-USA-B0 | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Shaun White Snowboarding: Road Trip | WII | | Target Limited Edition | | RVL-RW7E-USA | |
| Shaun White Snowboarding: Road Trip | WII | | Original | | RVL-RDFE-USA | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NE-USA-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| Sheep | PSX | | Original | | SLUS-01298 | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| Shellshock | PSX | | Original | | SLUS-00031 | |
| Shenmue II | XBOX | | Original | | MS-050 | |
| Shenmue III | PC | | Backer Exclusive Edition | | | |
| Sherlock Holmes and the Hound of the Baskervilles | PC | | Collector's Edition | | 33369101US | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | PC | | Original | | | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | XBOX360 | | Original | | JW-2003 | |
| Sherlock Holmes: Consulting Detective | PCE | | Original | | TGXCD1011 | |
| Sherlock Holmes: Consulting Detective | MCD | | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | T-4501 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Rerelease | | CDRM 835400 | |
| Sherlock Holmes: Consulting Detective: Vol. I Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | 5 ft. 10 PAK Vol. 2 | | | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. II | PCE | | Original | | TGXCD1039 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 1) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 2) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Crimes & Punishments | XBOX360 | | Original | | FE-2015 | |
| Shift 2: Unleashed | PC | | Limited Edition | | 1948307 | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shining Force CD | MCD | | Original | | 4656 | |
| Shining Force CD | MCD | | Original | | 4656 | |
| Shining Soul II + Shining Force Assets Shining Soul 2 + Shining Force Assets | PC | | Press Kit | | | |
| The Ship | PC | | Original | | | |
| Shipwreckers! | PSX | | Original | | SLUS-00558 | |
| Shipwreckers! | PSX | | Demo | | SLUS-90013 | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shiren the Wanderer | WII | | Original | | RVL-RFSE-USA-B0 | |
| Shivers | PC | | Demo | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | 831744330/S174150 | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shockwave Assault (Disc 1) (Shockwave: Invasion Earth) | PSX | | Original | | SLUS-00028 | |
| Shockwave Assault (Disc 2) (Shockwave: Operation Jumpgate) | PSX | | Original | | SLUS-00137 | |
| Shogun: Total War (Disc 1) | PC | | Rerelease | | 798727 | |
| Shogun: Total War (Disc 2) | PC | | Original | | 798717, 1224617 | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shonen Jump's One Piece: Grand Battle | GC | | Original | | DL-DOL-GOPE-USA | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shopmania | PC | | Original | | P/N 61227-CD | |
| Shorelines | CDI | | | | | |
| Showdown: Legends of Wrestling | XBOX | | Original | | AC-029 | |
| Showtime Championship Boxing | WII | | Original | | RVL-RSYE-USA | |
| Shrek | XBOX | | Original | | TM-001 | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| Shrek 2 | PC | | Original | | 32585.101.US | |
| Shrek 2 (Final Press Kit) | PC | | Press Kit | | | |
| Shrek 2 | PC | | | | 32585.101.US | |
| Shrek 2 | GC | | Original, Player's Choice | | DL-DOL-G3RE-USA, DL-DOL-G3RE-USA-02 | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9E-USA | |
| Shrek Game Land Activity Center | PC | | Original | | 32053.101.US | |
| Shrek Super Party | XBOX | | Original | | TM-004 | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYE-USA | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093140(US) | |
| Shrek Treasure Hunt | PSX | | Original | | SLUS-01463 | |
| Shrine Circus Tycoon | PC | | | | 31933.101.US | |
| Sid Meier's Alien Crossfire | PC | | Original | | 1405807 | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Linux | | | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Sid Meier's Civilization Chronicles (Disc 1) | PC | | Original | | 31074-1.1 | |
| Sid Meier's Civilization Chronicles (Disc 2) | PC | | Original | | 31074-1.2 | |
| Sid Meier's Civilization II: Fantastic Worlds | PC | | Original | | 0-529-47-101 | |
| Sid Meier's Civilization III (Bonus CD) | PC | | Game of the Year Edition | | Part # 24356CD2 | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Rerelease, Sid Meier's Civilization Chronicles | | 31074-1.3 | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Original | | 25766CD1 | |
| Sid Meier's Civilization III Complete (Disc 2) (Play the World) | PC | | Original | | 25766CD2 | |
| Sid Meier's Civilization III Complete (Disc 3) (Conquests) | PC | | Original | | 25766CD3 | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization IV (Disc 1) (Install) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 2) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.7 | |
| Sid Meier's Civilization IV (Disc 2) (Play) | PC | | Original | | | |
| Sid Meier's Civilization IV: Beyond the Sword | MAC | | Original | | 12090-1DDA | |
| Sid Meier's Civilization IV: Colonization | PC | | Original | | 31491-1 | |
| Sid Meier's Civilization Revolution | XBOX360 | | Original | | TT-2021 | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| Sid Meier's Civilization VI | PC | | Original | | 41829-1 | |
| Sid Meier's Gettysburg! | PC | | CD-ROM Classics | | 1187707 | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDE-USA-B0 | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Sid Meier's SimGolf | PC | | Rerelease | | 1641547 | |
| Sierra Holiday Software Sampler | PC | | | | | |
| Sierra Press Kit | PC | | Press Kit | | | |
| Sierra Products Demo America Online featuring Sierra Online | PC | | | | R00482 | |
| Sierra Super Sampler Sierra On-Line Demos | PC | | | | | |
| Sierra's School House: English (Disc 1) | PC | | Original | | | |
| Sierra's School House: English (Disc 2) | PC | | | | | |
| Sierra's School House: Math (Disc 1) | PC | | Original | | | |
| Sierra's School House: Math (Disc 2) | PC | | Original | | | |
| Sierra's School House: Science (Disc 1) | PC | | Original | | 831614230/S161155 | |
| Sierra's School House: Science (Disc 2) | PC | | Original | | 831614230/S161155 | |
| Sierra's Sneak Peeks 2 | PC | | Demo | | | |
| Silent Bomber | PSX | | Original | | SLUS-00902 | |
| Silent Hill | PSX | | Trade Demo | | SLUS-80707 | |
| Silent Hill | PSX | | Demo | | SLUS-90050 | |
| Silent Hill | PSX | | Original, Greatest Hits | | SLUS-00707 … | |
| Silent Hill 2: Restless Dreams | XBOX | | Platinum Hits | | KN-004 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-R5WE-USA-B0 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| Silhouette Mirage | PSX | | Original | | SLUS-00728 … | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| Silpheed | MCD | | Original | | 4423 | |
| Silverload | PSX | | Original | | SLUS-00050 | |
| Silverload | PC | | | | | |
| SimAnimals | WII | | Original | | RVL-R4AE-USA | |
| SimAnimals: Africa | WII | | Original | | RVL-R7AE-USA-B0 | |
| SimAnt SimAnt: The Electronic Ant Colony | PC | | CD-ROM Classics, 10 Sims for $20 | | 1111407 | |
| SimAnt | PC | | Scholastic | | 5710346C SP2 | |