Region | Title | System | Version | Edition | Languages | Serial | Status |
| Saru! Get You! 2: Ukki Ukki Disc サルゲッチュ2 ウッキーウッキーディスク | PS2 | 1.01 | Hibaihin | | PAPX 90330 | |
| Satsui no Shoumei: In the 1st Degree: Making CD-ROM 殺意の証明 イン ザ ファースト ディグリー メイキングCD-ROM | PC | | Hibaihin | | IP-081M | |
| Secre Demo Disk | FMT | | Hibaihin | | HME-921 | |
| SegaColle Sega Bible Mogitate SegaSaturn Soukan-gou セガコレセガバイブルモギタテセガサターン。 創刊号 1997.11 | SS | 1.000 | Hibaihin | | 610-6805-01 | |
| Sentimental Graffiti 2: Third Window センチメンタルグラフティ2 サードウィンドウ | DC | 3.000 | Hibaihin | | 610-7749 | |
| Shadow Hearts: Special Disc SHADOW HEARTS スペシャルディスク | PC | | Hibaihin | | | |
| Shin Sangoku Musou 3: Fan Disc 「真・三國無双3」ファンディスク | PC | | Hibaihin | | GCITY-65248 | |
| Shining Force III Premium Disc シャイニング・フォースⅢ プレミアム・ディスク | SS | 1.000 | Hibaihin | | 610-6979 | |
| Sony Music Entertainment: PlayStation Title Digest Sony Music Entertainment: PlayStation Tittle Digest | PSX | | Hibaihin | | SLPM 80148 | |
| Special Disc with SegaSaturn Internet 2 SPECIAL DISC with SEGASATURN インターネット2 | SS | 1.020 | Hibaihin | | T-31303G | |
| SpeSaru Disc 2003 スペサルディスク2003 | PS2 | 1.01 | Hibaihin | | SCPM 85303 | |
| Steep Slope Sliders スティープ・スロープ・スライダーズ | SS | 0.500 | Hibaihin | | 610-6716 | |
| Summer Days サマーデイズ | PC | 2.00 | Hibaihin | | | |
| Super Nova: Battery Navi バッテリー・ナビ | 3DO | | Hibaihin | | V1-9507 | |
| System Catalog: Kigyou-muke System no Goannai System Catalog 企業向けシステムのご案内 | 3DO | | Hibaihin | | HOU-013DO01 | |
| Shutokou Battle R 首都高バトルR | PSX | | Highlight-ban | | SLPM 80088 | |
| SegaSaturn: Movie Tools: Cinepak for Sega Saturn | SS | | Hybrid Version | | L17-1000 | |
| Star Wars: La Forza nella Matematica: La Galassia dei Giochi di Jabba | PC | 1.0 | I CD-ROM di Donna Moderna | | | |
| Star Wars: Prime Scoperte: Activity Center | PC | 1.0 | I CD-ROM di Donna Moderna | | | |
| Sid Meier's Civilization II | PC | 2.42a | Infogrames Rerelease | | | |
| Star Trek: Klingon Academy | PC | 1.0 | Interactive Demo | | CD-C95-856-D1 | |
| Stronghold FireFly Studios' Stronghold | PC | 1.3 | Interactive Demo | | | |
| Slot City Jackpot Games (120 Slot Machines) | PC | | Jackpot Games | | CD-4700 | |
| Space Ace | PC | | Jackson Libri | | | |
| SSX Tricky | GC | | Jitsuen-you Sample | | DL-DOL-DSTJ-DIS | |
| Star Wars: Rogue Squadron II スター・ウォーズ ローグ スコードロン Ⅱ | GC | | Jitsuen-you Sample | | DL-DOL-DSWJ-DIS | |
| Sheep, Dog 'n' Wolf | PC | | Kellogg's | | | |
| Super Bubble Pop | PC | 1.0 | Kellogg's Frosties | | | |
| SimTunes | PC | 1.2nre | Kids Classics | | 1128707 | |
| Silver (Disc 1) | PC | | King Edition | | | |
| Silver (Disc 2) | PC | | King Edition | | | |
| Spring 2012 Refresh Standard: PS3 IDU 4.11 | PS3 | | Kiosk Demo | | | |
| Spring 2013: Standard IDU 4.31 | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2010: 3.21 IDU Update (E-M) | PS3 | | Kiosk Demo | | | |
| Spring Refresh 2011 3.60 IDU FW Update | PS3 | | Kiosk Demo | | | |
| Summer Refresh 2011: 3.65 IDU FW Update | PS3 | | Kiosk Demo | | | |
| SlamTilt Resurrection (Disc 1) (Demon) | PC | | Klasyka Gier Komputerowych | | | |
| SlamTilt Resurrection (Disc 2) (Pirat) | PC | | Klasyka Gier Komputerowych | | | |
| SD Gundam: GGeneration-F (Disc 1) SDガンダム ジージェネレーション・エフ | PSX | | Koudansha 8-shi Rengou Kikaku Tokubetsu-ban | | SLPM 84004 | |
| SD Gundam: GGeneration-F (Disc 2) SDガンダム ジージェネレーション・エフ | PSX | | Koudansha 8-shi Rengou Kikaku Tokubetsu-ban | | SLPM 84005 | |
| SD Gundam: GGeneration-F (Disc 3) SDガンダム ジージェネレーション・エフ | PSX | | Koudansha 8-shi Rengou Kikaku Tokubetsu-ban | | SLPM 84006 | |
| SD Gundam: GGeneration-F (Disc 4) (Premium Disc) SDガンダム ジージェネレーション・エフ | PSX | | Koudansha 8-shi Rengou Kikaku Tokubetsu-ban | | SLPM 84007 | |
| Star Trek: Judgment Rites | PC | | Limited CD-ROM Collector's Edition | | | |
| Sangoku-hime: Sangoku Ransei: Haten no Saihai 三極姫~三国乱世・覇天の采配~ | PSP | 1.00 | Limited Edition | | ULJS 00434 | |
| Söldner-X: Himmelsstürmer | PC | | Limited Edition | | EAS-0002 | |
| SpaceChem | PC | 1012 | Limited Edition | | | |
| Star Trek: New Worlds (Explore New Worlds) | PC | | Limited Edition | | CD-C95-1097-DS | |
| Sam & Max: This Time It's Virtual! | PC | | Limited Run Games | | | |
| The Silver Case | PC | 1.01 | Limited Run Games Limited Edition | | | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 7.000 | Lindbergh Red EX | | DVP-0049F | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 8.003 | Lindbergh Red EX | | DVP-0049G | |
| Sega Network Taisen Mahjong MJ4 Evolution セガネットワーク対戦麻雀MJ4 Evolution | LINDBERGH | 1.001 | Lindbergh Red EX | | DVP-0081 | |
| StarHorse 2: Final Destination | LINDBERGH | 5.000 | Lindbergh StarHorse 2 | | DVP-0086D | |
| Sega-Race TV セガ-レースTV | LINDBERGH | 1.002 | Lindbergh Yellow | | DVP-0044 | |
| Star Wars: Episode I: Racer | PC | | M6 Multimedia | | M6MMC3 | |
| Sverigejakten | PC | | McDonald's Happy Meal | | SV 9 | |
| Savage Warriors | PC | 1.0 | Megapak 4 | | 2205110-590001/1055SA | |
| Screamer 2 | PC | | Megapak 8 | | | |
| Shakii il Lupo Shakii the Wolf | PC | | Microforum | | | |
| Syyrah: The Warp Hunter Una pioggia di asteroidi minaccia la terra in questo nuovo divertentissimo puzzle-game "tetraedrico". | PC | | Microforum | | | |
| Super Bubsy スーパーバブジー | PC | | MicroMouse Holiday Pack | | | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Mihon-hin | | 670-10314 | |
| Sega Rally Championship セガラリー・チャンピオンシップ | SS | 1.000 | Mihonban | | SGS-9047 | |
| Shining Wisdom シャイニング・ウィズダム | SS | 1.000 | Mihonban | | SGS-9057 | |
| Sengoku Blade: Sengoku Ace Episode II 戦国ブレード | SS | 1.002 | Mihonhin | | ST-14410G | |
| Scandal スキャンダル | PS2 | 1.00 | Movie Disc | | PCPX 96304 | |
| Starsky & Hutch | PC | | Nestlé | | | |
| Sea Rescue | PC | | Nestlé Corn Flakes | | | |
| Sega Saturn Bootleg II: On the Road Sega Screams Volume 1 | SS | 1.002 | Not for Resale | | 81068, 81075 | |
| Sega Screams Volume 2 | SS | 2.000 | Not for Resale | | 81077 | |
| Sports Champions / Medieval Moves: Deadmund's Quest Combo Disc | PS3 | 01.00 | Not for Resale | | BCUS-90490 | |
| Scramble Cobra: Premium Version スクランブル・コブラ プレミアム・バージョン | 3DO | | Not for Sale | | FZ-JJ9PSC-5H | |
| SimCity 3000: Original Data CD-ROM: T-ZONE Gentei Version シムシティ3000 オリジナルデータCD-ROM T-ZONE限定バージョン | PC | | Not for Sale | | | |
| Space Channel 5 Theme Music: Mexican Flyer スペース・チャンネル5 | DC | 1.080 | Not for Sale | | | |
| Slingo | PC | | Oregon Lottery | | | |
| Slingo: Wild 7's | PC | | Oregon Lottery | | | |
| S.T.O.R.M. (Disc 1) | PC | | Original | | A541W3GD[1] | |
| SAAR + AMOK PD CD-ROM Überarbeitete Version 12/93 | ACD | | Original | | | |
| Saban's Power Rangers Zeo Versus the Machine Empire | PC | | Original | | | |
| Saban's Power Rangers: Time Force | PC | | Original | | | |
| Sable Maze: Forbidden Garden & Twelve Fears | PC | | Original | | 33528010US | |
| The Saboteur | XBOX360 | | Original | | EA-2191 | |
| The Saboteur | PS3 | 01.00 | Original | | BLUS-30407 | |
| Sabre Team | CD32 | | Original | | | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sacred 3 | PS3 | 01.02 | Original | | BLUS-30876 | |
| Sacrifice (Disc 1) | PC | 0521.12.14 | Original | | | |
| Sacrifice (Disc 2) | PC | 0521.12.14 | Original | | | |
| Sacrifice (Disc 3) (Poradnik do Edytora Scapex) | PC | | Original | | | |
| Sacrifice | PC | 0492.10.25 | Original | | CD-C95-1041-0, CD-C95-1041-E | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Safar'Wii | WII | | Original | | RVL-RD6P-EUR-B0 | |
| Safari Kongo | PC | 1.2 | Original | | | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| SaGa Frontier 2 | PSX | | Original | | SLES-02118 | |
| Sail 2000 | PC | 1.04 | Original | | | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Saints Row: Gat out of Hell | PS3 | 01.00 | Original | | BLUS-31496 | |
| Saints Row: Gat out of Hell | XBOX360 | | Original | | KM-2048 | |
| Saints Row: The Third: The Full Package (Disc 1) (DLC Installer) | XBOX360 | | Original | | TQ-2213 | |
| Saka Tsuku Tokudai-gou: J.League Pro Soccer Club o Tsukurou! サカつく特大号 J.LEAGUE プロサッカークラブをつくろう! | DC | 1.003 | Original | | HDR-0126 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen Dream Passport 3 サクラ大戦 ドリームパスポート 3 | DC | 1.007 | Original | | 610-7996 | |
| Sakura Taisen Online: Teito no Nagai Hibi サクラ大戦オンライン ~帝都の長い日々~ | DC | 1.007 | Original | | HDR-0184 | |
| Sakura Taisen: Hanagumi Taisen Columns 2 サクラ大戦 ~花組対戦コラムス2~ | DC | 1.000 | Original | | HDR-0046 | |
| Sakura Wars: So Long, My Love | WII | | Original | | RVL-SAKP-UKV-E0 | |
| Salaryman Champ: Tatakau Salaryman サラリーマンチャンプ たたかうサラリーマン | KS573 | | Original | | A18 JA A02 | |
| Salvat Enciclopedia Interactiva | CDI | | Original | | B-44677-96 | |
| Salvat Enciclopedia Interactiva: Nueva Versión '98 | CDI | L.01.01 | Original | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YP-EUR-B0 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Samanta Svift. Tajna Atlantidy' Саманта Свифт. Тайна Атлантиды | PC | 1.3 | Original | | | |
| Samanta Svift. Tajna Zolotogo Prikosnoveniya Саманта Свифт. Тайна Золотого Прикосновения | PC | 1.2 | Original | | | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Samba de Amigo サンバDEアミーゴ | DC | 1.000 | Original | | HDR-0063 | |
| Samba World Cup | ACD | | Original | | | |
| Samgukji II 2000 Plus 三國志Ⅱ 2000 PLUS | PC | | Original | | | |
| Samidare 五月雨 | PC | 1.05 | Original | | PNB-001 | |
| Samidare 五月雨 | PC | 1.051 | Original | | PNB-001 | |
| Sammy's Science House | PC | 1.0 | Original | | | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Shodown III | PSX | | Original | | SCES-00563 | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors | PS2 | 1.00 | Original | | SLES-52552 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5P-EUR | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5E-USA | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | 170121 | |
| San Francisco Rush 2049 | DC | 1.001 | Original | | T-9707N | |
| Sanae-chan wa Torawarete Shimatta! (Disc 1) さなえチャンは囚われてしまった! | PC | | Original | | | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sango 2 制霸三國貳 | PC | 1.0 | Original | | | |
| Sangokushi III 三國志Ⅲ | PCE | | Original | | KOCD3003 | |
| Sangokushi Koumeiden 三國志孔明傳 | PC | | Original | | | |
| Sangokushi Tai Sen: Dairyuusei 三国志戴閃-大流星- | PC | 1.01 | Original | | | |
| Sangokushi VII 三國志Ⅶ | PSP | 1.03 | Original | | ULJM 05083 | |
| Sanguo Qunyingzhuan III (Disc 1) (Anzhuangpan) 三国群英传Ⅲ | PC | 1.06C | Original | | | |
| Sanguo Qunyingzhuan III (Disc 2) (Youxipan) 三国群英传Ⅲ | PC | 1.06C | Original | | | |
| Sanguo Yanyi 2 三國演義 2 | PC | 1.00 | Original | | RYA-032 | |
| Sanguo Yinghao 三國英豪 | PC | | Original | | | |
| Sanguo Zhi Xinghai Fengyun (Disc 1) 三國之星海風雲 | PC | | Original | | | |
| Sanguo Zhi Xinghai Fengyun (Disc 2) 三國之星海風雲 | PC | | Original | | | |
| Sanguozhi Fengyun Zaiqi 三國志·風雲再起 | PC | 1.2 | Original | | | |
| Sanguozhi IV 三國志Ⅳ | PSX | | Original | | SCPS 45003 | |
| Sanguozhi IV 三國志Ⅳ | PC | | Original | | | |
| Sanguozhi Shu-Han Yingxiongzhuan 三國志 蜀漢英雄傳 | PC | 1.3 | Original | | | |
| Sanitarium (Disc 1) Шизариум | PC | 1.01 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Sansuu Senshi Blaster: Anzan Power de Spot-kun o Sukue! 算数戦士ブラスター 暗算パワーでスポット君を救え! | PC | | Original | | | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Santa Claus Saves the Earth | PSX | | Original | | SLES-04023 | |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 2) | PC | 1.0 | Original | | | |
| Sargon V: World Class Chess サルゴンⅤ | FMT | | Original | | HMD-191 | |
| Sąsiedzi z Piekła Rodem 1 + 2 | PC | | Original | | | |
| SAT.1 Swing | PC | | Original | | | |
| Satsui no Shoumei: In the 1st Degree (Disc 1) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078A | |
| Satsui no Shoumei: In the 1st Degree (Disc 2) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078B | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Savage 2: A Tortured Soul | PC | 01.00.00 | Original | | | |
| Savage Warriors | PC | 1.0 | Original | | 2205110-S90001/1055SA | |
| Savage Warriors | PC | 1.0 | Original | | | |
| Save Planet Polluto | PC | 1.0 | Original | | | |
| Saw | PS3 | 01.00 | Original | | BLUS-30358 | |
| Say What You Want | CDI | | Original | | | |
| SBFR the Best 2: Black | PC | | Original | | SSEB-0042 | |
| SBFR the Best 2: White | PC | | Original | | SSEB-0041 | |
| SBFR the Best 3: Kirby First History | PC | | Original | | SSEB-0054 | |
| SBFR the Best 4: PKMN First History | PC | | Original | | SSEB-0055 | |
| SBK 08: Superbike World Championship | XBOX360 | | Original | | LS-2001 | |
| SBK 09: Superbike World Championship | XBOX360 | | Original | | LS-2004 | |
| SBK 09: Superbike World Championship | PSP | 1.02 | Original | | ULES-01247 | |
| SBK Generations | XBOX360 | | Original | | LS-2033 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| SBK X: Superbike World Championship | PS3 | 01.01 | Original | | BLES-00774 … | |
| SBK X: Superbike World Championship | PS3 | 01.00 | Original | | BLUS-30683 | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| Scaler | GC | | Original | | DL-DOL-GKUE-USA | |
| Scan & Teach: Fragenkatalog Die neue CD-i: Fragenkatalog | CDI | 1.0 | Original | | 66010 | |
| Scan & Teach: Thema 1-6: Klasse 3 | CDI | | Original | | | |
| Scan & Teach: Thema 7-12: Klasse 3 | CDI | | Original | | | |
| Scarface: The World Is Yours | PC | 1.00.1 | Original | | S1004053 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| The Scene Archive: 1988-1998 | ACD | | Original | | | |
| Scene It? Box Office Smash! | XBOX360 | | Original | | MS-2144 | |
| Scene It? Box Office Smash! Scene It? Campione d'Incassi: Nuovissimi filmati e quiz sul cinema | XBOX360 | | Original | | MS-2144 | |
| Scene It? Box Office Smash! | XBOX360 | | Original | | MS-2144 | |
| Scene It? Bright Lights! Big Screen! | PS3 | 01.02 | Original | | BLUS-30448 … | |
| Scene It? Bright Lights! Big Screen! | XBOX360 | | Original | | WR-2037 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCE-USA-B0 | |
| Scene It? Ganz großes Kino! | XBOX360 | | Original | | WR-2040 | |
| Scene It? Ganz großes Kino! | WII | | Original | | RVL-SSCD-NOE-B0 | |
| Scene It? Grandes Éxitos de Taquilla | XBOX360 | | Original | | MS-2144 | |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| A Scene It? Lights, Cameraction! A Scene It? Luci, Camerazione! Il gioco a quiz sul cinema | XBOX360 | | Original | | MS-2098 | |
| Scene Xplorer '97 Scene Explorer: From the Beginning into the Future | ACD | | Original | | | |
| Schiff-Simulator 2008 Ship Simulator 2008 | PC | | Original | | | |
| Schleichfahrt | PC | | Original | | | |
| Schmidt Interaktivspass: Kartenspiele | PC | 1.0.0.0 | Original | | S0022612 | |
| Scholastic's The Magic School Bus Discovers Flight: Activity Center | PC | 1.0.0.2 | Original | | 0201 Part No. X06-16068 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | 1.0 | Original | | 0894 Part No. 59104, Disc Assy 299-052-002 | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | 1.1.0.2 | Original | | 0396 Part No. 90612, Disc Assy. 299-056-002 | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original | | Disc Assy. 451-052-012 0396 Part No. 90626 | |
| Scholastic's The Magic School Bus Explores the Solar System | PC | 1.00.0000 | Original | | 0396 Part No. 90618, 1001 Part No. X08-51174, Disc Assy. 296-052-002 | |
| Scholastic's The Magic School Bus in Concert: Activity Center | PC | 1.0.0.2 | Original | | 0400 Part No. X05-64231 | |
| Die Schönsten Hotels der Welt | PHOTO-CD | | Original | | 813 0060 | |
| School Zone Flash Action Software: Multiplication/Division | PC | | Original | | 08021 | |
| School Zone Math: First & Second Grade | PC | | Original | | 08020 | |
| Schoolhouse Rock! 1st & 2nd Grade (Disc 2) (2nd Grade) | PC | | Original | | 21330CD-2, SGE744AE-CD2 | |
| Schoolhouse Rock! 1st & 2nd Grade Essentials (Disc 1) | PC | | Original | | 21330CD-1 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! America Rock | PC | | Original | | 21080CD | |
| Schoolhouse Rock! Grammar Rock | PC | | Original | | 9227 | |
| Schoolhouse Rock! Grammar Rock | MAC | | Original | | 9227 | |
| Schoolhouse Rock! Math Rock | PC | | Original | | 21010CD | |
| Schoolhouse Rock! Thinking Games | PC | | Original | | BBT844AE-CD | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744AE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 2) (Learning Adventures) | PC | | Original | | SRT744AE-CD2 | |
| Science & Nature: Elements Science 1: Elements | ARCH | 1.00 | Original | | | |
| Science & Nature: Materials Science Series II: Materials | ARCH | 1.00 | Original | | | |
| Science Is Elementary 1 | PSX | | Original | | LSP-990161 … | |
| Science Is Elementary 2 | PSX | | Original | | LSP-990162 … | |
| Science Is Elementary 3 | PSX | | Original | | LSP-990163 … | |
| Science: Electricity and Magnetism: Secondary Edition Science 3: Electricity and Magnetism | ARCH | 1.0 | Original | | | |
| Scooby-Doo 2: Monsters Unleashed | PC | 3.0 | Original | | | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | Rev 1 | Original | | 093080(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093083(UK) | |
| Scooby-Doo! Fluch der Folianten | GC | | Original | | DL-DOL-GC3D-NOE | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.01 | Original | | 380849A-CD | |
| Scooby-Doo! La Nuit des 100 Frissons | PS2 | 1.00 | Original | | SLES-51018 | |
| Scooby-Doo! Les Civilisations Perdues | VFLASH | | Original | | 093085(FR) | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Phantom of the Knight | PC | 1.0 | Original | | 380325-CD | |
| Scooby-Doo! Piramidalna Zagadka | PC | 1.0 | Original | | SCA844AB-CD | |
| Scooby-Doo! Showdown in Ghost Town | PC | 1.0 | Original | | SGW844AB-CD | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DE-USA | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Scorcher | SS | 1.008 | Original | | 81214 | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Score International Baja 1000: World Championship Off Road Racing Score International Baja 1000: The Official Game | XBOX360 | | Original | | AV-2083 | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble CD-ROM | PC | | Original | | 23713-0726 Rev a | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Screamer 2 | PC | | Original | | | |
| ScreamRide | XBOX360 | | Original | | MS-2726 | |
| Screen Fighter Screen Saver スクリーンファイター スクリーンセーバー | PC | | Original | | SRC-00001 | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| The Scroll Daughter of Serpents | PC | | Original | | | |
| SDevTC: Version 2 | PC | 2 | Original | | | |
| SDevTC: Version 2.4 | PC | 2.4 | Original | | DTL-S2200 | |
| Sea Dogs: Piraci | PC | 1.06 | Original | | | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7P-EUR | |
| SeaBass Fishing シーバス・フィッシング | SS | 1.001 | Original | | T-6005G | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| Seasons Greetings from Philips Media | CDI | | Original | | | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | GC | | Original | | DL-DOL-GJZP-EUR | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| Secret Agent Clank | PSP | 1.01 | Original | | UCAS-40218 | |
| Secret Agent Clank 시크릿 에이전트 클랭크 | PSP | 1.00 | Original | | UCKS 45096 | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island | PC | 2.3 | Original | | 2147010-590001 / I 042 | |
| Secret of Video Architecture X68000画面表示仕様の秘密 | X68K | | Original | | | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Secrets of Great Art | PC | 1.1 | Original | | P/N 61218-CD | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Section 8 | XBOX360 | | Original | | GP-2004 | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Sega Classics Arcade Collection: Limited Edition | MCD | | Original | | 4127 | |
| Sega Classics Arcade Collection: Limited Edition | MCD | | Original | | 4127 | |
| Sega Game Honpo: Puyo Puyo セガゲーム本舗 ぷよぷよ | PC | | Original | | | |
| Sega Game Honpo: Wonder Boy V, Monster World III セガゲーム本舗 ワンダーボーイⅤ モンスターワールドⅢ | PC | | Original | | SGH-013 | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega Net Mahjong MJ Arcade セガNET麻雀MJ Arcade | SRE | | Original | | DVR-5055D | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 4.000 | Original | | GDX-0006C | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 5.000 | Original | | GDX-0006D | |
| Sega Network Taisen Mahjong MJ3 セガ・ネットワーク対戦麻雀MJ3 | CHIHIRO | 5.000 | Original | | GDX-0017D | |
| Sega Network Taisen Mahjong MJ3 Evolution セガ・ネットワーク対戦麻雀MJ3 EVOLUTION | CHIHIRO | 2.000 | Original | | GDX-0021A | |
| Sega Network Taisen Mahjong MJ3 Evolution-you Firmware Koushin Program セガ・ネットワーク対戦麻雀MJ3 EVOLUTION用ファームウェア更新プログラム | CHIHIRO | 1.000 | Original | | GDX-0023 | |
| Sega Network Taisen Mahjong MJ5 セガネットワーク対戦麻雀MJ5 | SRE | | Original | | DVR-0027 | |
| Sega Network Taisen Mahjong MJ5 Evolution セガネットワーク対戦麻雀MJ5 EVOLUTION | SRE | | Original | | DVR-0071 | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083 | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083D | |
| Sega Rally 2 (Install Disc) Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sega Rally 2 (Play Disc) Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.000 | Original | | MK-51019-50 | |
| Sega Rally Championship 세가 랠리 | SS | 1.000 | Original | | GS-9506J | |
| Sega Rally Revo | PS3 | 01.00 | Original | | BLUS-30068 | |
| Sega Rally Revo | PSP | 1.00 | Original | | ULUS-10311 | |
| Sega Saturn Development Tool Kit | PC | | Original | | 610-5750 | |
| Sega Soccer Slam セガ サッカースラム | GC | | Original | | DL-DOL-GSSJ-JPN | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| Sega Worldwide Soccer '97 | SS | 1.001 | Original | | 81112 | |
| SegaSaturn: Graphic & Sound Tools for Macintosh | SS | | Original | | N16-1000 | |
| SegaSaturn: SGL Tool Kit: Sega 3D Game Library | SS | 1.000 | Original | | L15-1000 | |
| Le Seigneur des Anneaux: Le Retour du Roi | GC | | Original | | DL-DOL-GKLF-FRA | |
| Le Seigneur des Anneaux: Le Tiers Age | PS2 | 1.00 | Original | | SLES-52802 | |
| Seitai Heiki Expendable 生体兵器 エクスペンダブル | DC | 1.001 | Original | | T-15003M | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Sell It to Me! Part One: Preparing The Way | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Handling Telephone Sales Enquiries and Making Appraisals Pay | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Paperwork, Bloody Paperwork and Selling to Women | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Selling You to You and Taking Personal Control | CDI | | Original | | | |
| Sengoku Efuda Yuugi: Hototogisu Tairan 戦国絵札遊戯 不如帰 大乱 | PSP | 1.02 | Original | | ULJS 00326 | |
| Senkaku Mondai o Yatchimasu 2 尖閣問題を殺っちます2 | PC | | Original | | | |
| Senko no Ronde 旋光の輪舞 | NAOMI | 1.001 | Original | | GDL-0030 | |
| Sensible World of Soccer | PC | 1.0 | Original | | | |
| Sentient | PC | 1.4.0.124 | Original | | | |
| Sentient | PC | | Original | | | |
| Sento Monogatari Sono I 「占都物語」そのⅠ | SS | 1.000 | Original | | T-6801G | |
| Sento Monogatari: Sono I 「占都物語」 そのI | PC | | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Original | | | |
| Sequence Palladium Mania Kit: Desktop Accessory シークエンス・パラディウム マニアキット デスクトップアクセサリ | PC | | Original | | WIC-6346 | |
| The Serious Sam Collection | XBOX360 | | Original | | MK-2010 | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serum-Werk Bernburg AG: Veterinärpharmaka: Vol. 1 | CDI | | Original | | | |
| Sesame Street Reading is Fun! Toddler (Disc 1) (Grover's Travels) | PC | 2.0 | Original | | SRF844AE-CD-1 | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Sesame Street Sports | PSX | | Original | | SLES-03180 | |
| Sesame Street: Art Workshop | PC | | Original | | 9369 | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Elmo's Art Workshop | PC | | Original | | EAW844AE-CD | |
| Sesame Street: Elmo's Preschool (Disc 1) (Elmo's Preschool) | PC | 3.1 | Original | | P/N 379663-CD1 | |
| Sesame Street: Elmo's Preschool (Disc 2) (Search & Learn Adventures) | PC | 3.1 | Original | | P/N 379663-CD2 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 1) (Reading Basics) | PC | | Original | | EPK-744AE-CD1 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: My Baby & Me (Disc 1) (Baby & Me) | PC | 1.0 | Original | | SSY744AE-CD1 | |
| Sesame Street: My Baby & Me (Disc 2) (Sesame Street Greatest Hits Sampler) | PC | 1.0 | Original | | SSY744AE-CD2 | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Numbers | MAC | | Original | | 691-0759-A, 743807A | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Ready, Set, Grover! The Videogame | WII | | Original | | RVL-SESU-AUS-B0 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Sesame Street: Toddlers Deluxe (Disc 1) (Art Workshop) | PC | 2.0 | Original | | STO844AE-CD-1 | |
| Sesame Street: Toddlers Deluxe (Disc 2) (Letters) | PC | 2.0 | Original | | STO844AE-CD-2 | |
| Sesame Street: Toddlers Deluxe (Disc 3) (Numbers) | PC | 2.0 | Original | | STO844AE-CD-3 | |
| Session Power Up Kit for DrumMania 2nd Mix / PercussionFreaks 2nd Mix | KS573 | | Original | | 912 *Z A01 | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| The Settlers III (Disc 1) 工人物語III | PC | 1.23 | Original | | | |
| The Settlers III (Disc 2) | PC | 0.0.0.123 | Original | | | |
| The Settlers III: Misja Amazonek | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Nowe Misje (Disc 2) | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| The Settlers IV: Trojanie i Eliksir Mocy | PC | 2.4.1090.0 | Original | | | |
| The Settlers: Narodziny Kultur The Settlers: Rise of Cultures | PC | 1.0 | Original | | 300026608 | |
| The Settlers: Rise of an Empire | PC | 1.0.4140 | Original | | | |
| Setup Utility for DTL-H1500 (Version 1.1) | PSX | | Original | | | |
| Seven Kingdoms | PC | 1.0 | Original | | 04033 CD | |
| The Seventh Seal: The Resurrection of the Dark Lord (Anzhuang Cidie 1) 第七封印:魔神甦醒 | PC | | Original | | | |
| The Seventh Seal: The Resurrection of the Dark Lord (Anzhuang Cidie 2) 第七封印:魔神甦醒 | PC | | Original | | | |
| The Seventh Seal: The Resurrection of the Dark Lord (Anzhuang Cidie 3) 第七封印:魔神甦醒 | PC | | Original | | | |
| Sewer Shark | MCD | Rev 1 | Original | | T-6201 | |
| Sex Sensou: Aiaru H wa Kinshi desu! H-na Hiyakeato Patch SEX戦争~愛あるHは禁止ですっ!~Hな日焼け跡パッチ | PC | | Original | | | |
| Sexy Bytes: Housewives 2 | PHOTO-CD | | Original | | | |
| Sexy Bytes: Lacquer & Leather | PHOTO-CD | | Original | | | |
| Sexy Bytes: Office Sex | PHOTO-CD | | Original | | | |
| Sexy Bytes: Rolling Mountains | PHOTO-CD | | Original | | | |
| Sexy Bytes: Studio Girls 1 | PHOTO-CD | | Original | | | |
| Sexy Idol Mahjong: Yakyuuken no Uta セクシー・アイドル麻雀 ~野球拳の詩~ | PCE | | Original | | NBCD4007 | |
| Sexy in the Hawaii: Nice Gal Hawaii-hen Sexy in The Hawaii ~ナイス・ギャル ハワイ編~ | FMT | | Original | | | |
| SFT 01/2005 | PC | | Original | | SFTDVD0105 | |
| SFT 02/2005 | PC | | Original | | SFTDVD0205 | |
| SFT 04/2005 | PC | | Original | | SFTDVD0405 | |
| Shadoan (Disc 1) | PC | | Original | | CD-ICD-228-UK1 | |
| Shadoan (Disc 2) | PC | | Original | | CD-ICD-228-UK2 | |
| Shadoan (Disc 1) | PC | | Original | | CD-ICD-228-0 | |
| Shadoan (Disc 2) | PC | | Original | | CD-ICD-228-1 | |
| Les Shadoks: Le Jeu: La Promenade | PC | | Original | | PCMCSHAD97FCD1 | |
| Shadow Company: Left for Dead | PC | 1.0 | Original | | 5051802 | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow of Memories | XBOX | | Original | | KN-014 | |
| Shadow of Memories | PSP | 1.02 | Original | | ULJM-05512 | |
| The Shadow of the Third Moon | ACD | 1.1 | Original | | | |
| Shadow Ops: Red Mercury | PC | | Original | | 1019185 | |
| Shadow Vault: Demos and Materials | PC | | Original | | | |
| Shadow Watch | PC | 1.0 | Original | | RED142Y010-0039-0004-01 | |
| Shadow Watch | PC | | Original | | | |
| Shadow Watch | PC | 1.0 | Original | | | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| Shadowrun Returns (Game Disc) | PC | | Original | | | |
| Shaftdiver シャフトダイバー | PC | 1.0 | Original | | DNAS-SDVR | |
| Shangdi Ye Fengkuang 上帝也疯狂 | PC | 1.01 | Original | | | |
| Shanghai 上海 | FMT | | Original | | HMB-192 | |
| Shanghai Double Pack | PC | | Original | | | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shanghai: Dynasty | PC | 1.0 | Original | | 1000053.101.UK | |
| Shannara 沙拉那之劍 | PC | 1.0.0 | Original | | | |
| Shaolin Shiba Tongren 少林十八銅人 | PC | | Original | | | |
| Shaolin Zuqiu (Disc 1) 少林足球 | PC | 1.00 | Original | | | |
| Shaolin Zuqiu (Disc 2) 少林足球 | PC | 1.00 | Original | | | |
| Shape Shifter | PC | | Original | | | |
| Shaqiu Mobao: Huangquan Zhengba (Disc 1) (Anzhuang Guangdie) 沙丘魔堡:皇權爭霸 | PC | 1.04 | Original | | | |
| Shaqiu Mobao: Huangquan Zhengba (Disc 2) (Atreides Jiazu) 沙丘魔堡:皇權爭霸 | PC | 1.04 | Original | | | |
| Shaqiu Mobao: Huangquan Zhengba (Disc 3) (Harkonnen Jiazu) 沙丘魔堡:皇權爭霸 | PC | 1.04 | Original | | | |
| Shaqiu Mobao: Huangquan Zhengba (Disc 4) (Ordos Jiazu) 沙丘魔堡:皇權爭霸 | PC | 1.04 | Original | | | |
| Shareware Gold: PC Software | PC | | Original | | SGCD-01 | |
| Shareware Magazine No. 1 | PC | 1.00 | Original | | | |
| Shareware-Hits zum Superpreis: Top 100 Spiele | PC | | Original | | | |
| Sharks! An Interactive Journey An Interactive Journey With... Sharks! | PC | | Original | | | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-M9 | |
| Shattered Suns | PC | 1.0 | Original | | Part # CCS00003-1 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shaun White Snowboarding | PS3 | 01.01 | Original | | BLUS-30223 | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NE-USA-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| Shediao Yingxiongzhuan 射鵰英雄傳 | PSX | | Original | | SCPS 45510 | |
| Sheer Delight | CD32 | | Original | | | |
| Shen Hua 神話 | PC | | Original | | | |
| Shendiao Xialü 神鵰俠侶 | PC | | Original | | | |
| Shendiao Xialü 神鵰俠侶 | PC | | Original | | | |
| Shengui Yuyan: Shiluo Zhi Zhang (Disc 1) 神鬼寓言:失落之章 | PC | 25.7.13.149 | Original | | 0905 Part No. X11-42711 | |
| Shengui Yuyan: Shiluo Zhi Zhang (Disc 2) 神鬼寓言:失落之章 | PC | 25.7.13.149 | Original | | 0905 Part No. X11-42714 | |
| Shengui Yuyan: Shiluo Zhi Zhang (Disc 3) 神鬼寓言:失落之章 | PC | 25.7.13.149 | Original | | 0905 Part No. X11-42716 | |
| Shengui Yuyan: Shiluo Zhi Zhang (Disc 4) 神鬼寓言:失落之章 | PC | 25.7.13.149 | Original | | 0905 Part No. X11-42718 | |
| Shenhai Zhengba 深海争霸 | PC | 1.1.0 | Original | | | |
| Shenlong Shaonian 神龙少年 | PC | | Original | | | |
| Shenying Tujidui 神鹰突击队 | PC | | Original | | GD94-18 | |
| Shepherd's Crossing | PSP | 1.00 | Original | | ULUS-10499 | |
| Sherlock Holmes Versus Jack the Ripper | XBOX360 | | Original | | FE-2003 | |
| Sherlock Holmes: Consulting Detective シャーロック・ホームズの探偵講座 | PCE | | Original | | JCCD1004 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 2 | Original | | CDRM 770000 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. III | PC | 4 | Original | | CDRM1061930 | |
| Shiji Diguo III (Disc 1) (Anzhuang Guangdie) 世紀帝國Ⅲ | PC | 1.0 | Original | | 1005 Part No. X11-47252 | |
| Shiji Diguo III (Disc 2) (Youxi Guangdie) 世紀帝國Ⅲ | PC | 1.0 | Original | | 1005 Part No. X11-47255 | |
| Shiji Diguo III (Disc 3) (Youxi Guangdie) 世紀帝國Ⅲ | PC | 1.0 | Original | | 1005 Part No. X11-47258 | |
| Shiki no Kyouken 四季の狂剣 | PC | | Original | | | |
| Shikigami no Shiro II 式神の城II | NAOMI | 1.000 | Original | | GDL-0021 | |
| Shiluo Dadi 失落大地 | PC | 1.00.000 | Original | | | |
| Shimano Extreme Fishing | WII | | Original | | RVL-R39P-EUR-B0 | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shin Master of Monsters Final EX: Mukunaru Nageki, Tenmei no Saika 真・マスターオブモンスターズ Final EX ~無垢なる嘆き、天冥の災禍~ | PSP | 1.01 | Original | | ULJS 00282 | |
| Shin Megami Tensei: Digital Devil Saga 2 | PS2 | 1.01 | Original | | SLES-54555 | |
| Shin Megami Tensei: Persona | PSP | 1.00 | Original | | ULUS-10432 | |
| Shin Seiki Evangelion 2: Tsukurareshi Sekai: Another Cases 新世紀エヴァンゲリオン2 造られしセカイ -another cases- | PSP | 1.01 | Original | | ULJS 00064 | |
| Shin Seiki Evangelion: Ayanami Ikusei Keikaku 新世紀エヴァンゲリオン 綾波育成計画 | DC | 1.002 | Original | | T-46303M | |
| Shin Seiki Evangelion: Koutetsu no Girlfriend 2nd Portable 新世紀エヴァンゲリオン 鋼鉄のガールフレンド2nd ポータブル | PSP | 1.01 | Original | | ULJM 05477 | |
| Shin-ou Densetsu Crystania DX 神王伝説クリスタニアDX | PC-98 | CDX-V1.00 | Original | | 001J291TA | |
| Shindou Shippuu Monogatari Mousou Gaiden: Mahou Shoujo Magical Iorin: First Magic: "Mahou Shoujo ni Natchatta!?" 神動疾風物語妄想外伝 魔法少女マジカルいおりん ~First Magic゛魔法少女になっちゃった!?゛~ | PC | 1.00 | Original | | | |
| Shinigami to Shoujo 死神と少女 | PSP | 1.01 | Original | | ULJS 00403 | |
| Shining Force III: Scenario 1: Outo no Kyoshin シャイニング・フォースⅢ シナリオ1 ~王都の巨神~ | SS | 2.005 | Original | | GS-9175 | |
| Shining Force III: Scenario 2: Nerawareta Miko シャイニング・フォースⅢ シナリオ2 ~狙われた神子~ | SS | 2.000 | Original | | GS-9188 | |
| Shinji Sougeki Carnival 神事双劇カーニバル | PC | 1.1 | Original | | TTCA-0902 | |
| Shinjuwan Kougeki Taiheiyou Sensen 3: For Combat Flight Simulator 真珠湾攻撃 太平洋戦線3 For Combat Flight Simulator | PC | | Original | | | |
| Shinki Sekai Evolutia 神機世界エヴォルシア | GC | | Original | | DL-DOL-GEVJ-JPN | |
| Shinkyoku Soukai Polyphonica: 0~4 wa Full Pack 神曲奏界ポリフォニカ 0~4話フルパック | PSP | 1.02 | Original | | ULJM-05347 | |
| The Shinri Game ザ・心理ゲーム | DC | 1.004 | Original | | T-43403M | |
| The Ship | PC | | Original | | | |
| Shirotsumesouwa: Episode of the Clovers: Extra Compact Disc 『白詰草話 -Episode of the Clovers-』エクストラCD | PC | | Original | | | |
| Shisan Zhiju 十三支局 | PC | | Original | | 917311 | |
| Shisenfuu Gekikara Mahjong 四川風激辛麻雀 | PC | 3.0 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | 831744330/S174150 | |
| Shobi University: Geijutsu Jouhou Gakubu Jouhou Hyougen Gakka: Gakusei Game & CG Eizou Sakuhinshuu 尚美学園大学 芸術情報学部情報表現学科 学生ゲーム&CG映像作品集 | PC | | Original | | | |
| Shock Price 500 Game Series: Cankeri: Kick Kick Kick SHOCK PRICE 500 GAME SERIES 缶蹴り~KICKKICKKICK~ | PC | | Original | | SRRW 69 | |
| Shock Price 500 Game Series: Chu-Chu Tataki SHOCK PRICE 500 GAME SERIES チュウチュウたたき | PC | | Original | | SSRX 3016 | |
| Shock Price 500 Game Series: Doki-Doki Mouse SHOCK PRICE 500 GAME SERIES ドキドキマウス | PC | | Original | | SSRX 3011 | |
| Shock Price 500 Game Series: Go Fish SHOCK PRICE 500 GAME SERIES ゴーフィッシュ | PC | | Original | | SSRX 3005 | |
| Shock Price 500 Game Series: Shooting Machine SHOCK PRICE 500 GAME SERIES シューティングマシーン | PC | | Original | | SSRX 3010 | |
| Shock Price 500 Game Series: Smash Hockey SHOCK PRICE 500 GAME SERIES スマッシュホッケー | PC | | Original | | SSRX 3084 | |
| Shock Price 500 Game Series: Space Hockey SHOCK PRICE 500 GAME SERIES スペースホッケー | PC | | Original | | SSRX 3019 | |
| Shock Price 500 Game Series: The Room SHOCK PRICE 500 GAME SERIES ザ・ルーム | PC | | Original | | SSRX 3050 | |
| Shock Price 500 Game Series: Volleyball SHOCK PRICE 500 GAME SERIES バレーボール | PC | | Original | | SSRW 30032 | |
| Shock Wave 지구공습 2019 | 3DO | | Original | | GDT-GA 101 | |