Region | Title | System | Version | Edition | Languages | Serial | Status |
| S.C.A.R.S. | PC | | Original | | | |
| S.T.A.L.K.E.R.: Call of Pripyat (Soundtrack CD) | PC | | Special Edition | | | |
| S²: Silent Storm (Disc 1) | PC | | Gold Edition | | ROSILENTST0007lab1 | |
| S²: Silent Storm (Disc 1) | PC | | Gold Edition | | ROSILENTST0006lab1 | |
| S²: Silent Storm (Disc 2) | PC | | Gold Edition | | ROSILENTST0006lab2 | |
| Sacred Plus (Disc 1) | PC | | Big Bytes | | | |
| Sacrifice (Editors Press Kit) | PC | | Press Kit | | | |
| Saga: Siegeszug der Wikinger | PC | | Original | | SAGER-CD-B | |
| Sage: Rage of Kings | PC | | Covermount | | | |
| Sail to Win! A Rules and Tactics Challenge | CDI | | Original | | 819 0042 | |
| Saint Eyes セイントアイズ | PC | | Shokai Genteiban | | | |
| The Saint: Abgrund der Verzweiflung | PC | | Original | | | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 4) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | 1.0.0.0 | Original, Shokai Genteiban | | 673-02560 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 5) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | 1.0.0.0 | Original, Shokai Genteiban | | 673-02561 | |
| Sakura Taisen: Teigeki Secret File サクラ大戦 ~帝劇シークレット・ファイル~ | PHOTO-CD | | Magazine Bundle | | SSMP-00001 | |
| Salaryman Champ: Tatakau Salaryman サラリーマンチャンプ たたかうサラリーマン | KS573 | | Original | | A18 JA A02 | |
| Sälis Cirkus Äventyr | CDI | | Original | | 817 0011 | |
| Salt Lake 2002 | PC | | Original | | MSALTPGE81 | |
| Salvat Enciclopedia Interactiva: Nueva Versión '98 | CDI | L.01.01 | Original | | | |
| Samba de Amigo | DC | 1.002 | Bundled with Maracas Controller | | MK-51092-50 | |
| Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| Sandy's Circus Adventure | CDI | | Original | | 690 0222 | |
| Sangaku Shashin Photo CD Series Vol. 1: Shirouma Takeshi Ushiro Tateyama Renpou 山岳写真フォトCDシリーズVol.1 白馬岳・後立山連峰 | PHOTO-CD | | Original | | AS 0001 | |
| Sangaku Shashin Photo CD Series Vol. 2: Hotaka Kamikochi 山岳写真フォトCDシリーズVol.2 穂高・上高地 | PHOTO-CD | | Original | | AS 0004 | |
| Sangaku Shashin Photo CD Series Vol. 3: Yatsugatake 山岳写真フォトCDシリーズVol.3[八ケ岳] | PHOTO-CD | | Original | | AS 0005 | |
| Sangaku Shashin Photo CD Series Vol. 4: Tateyama 山岳写真フォトCDシリーズVol.4[立山] | PHOTO-CD | | Original | | AS 0006 | |
| Sangaku Shashin Photo CD Series Vol. 5: Oze 山岳写真フォトCDシリーズVol.5[尾瀬] | PHOTO-CD | | Original | | AS 0007 | |
| Sanguo Qunyingzhuan IV (Disc 3) (Yinyuepan) 三国群英传Ⅳ | PC | | Luanshi-Yingxiongbao | | | |
| Sanrio Puroland Carnival サンリオピューロランド カーニバル | PC | | | | RS-13 | |
| Sargon Chess | CDI | | Original, Original: Longbox | | 310690030-2 | |
| SAT.1 Superball | PC | | Original | | | |
| Saturday Night Speedway | PS2 | 1.00 | Original | | SLUS 20640 | |
| Savage: The Battle for Newerth | PC | | Bundle Version ASUS OEM | | V471 | |
| Say What You Want | CDI | | Original | | | |
| Scan & Teach: Thema 1-6: Klasse 3 | CDI | | Original | | | |
| Scan & Teach: Thema 7-12: Klasse 3 | CDI | | Original | | | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scenariomania Scenariomania Vol. 1 | PC | | Original | | | |
| The Scene Archive: 1988-1998 | ACD | | Original | | | |
| Scene Storm | ACD | | | | | |
| Der Schatz der Versunkenen Brigantine | PC | | Original | | | |
| Der Schatz von El Dorado | PC | | Original | | | |
| Schiene & Strasse: Der 3D-Transport-Manager: 1820-2020 | PC | | Original | | | |
| Schiff-Simulator 2008 Ship Simulator 2008 | PC | | Original | | | |
| Schmidt Interaktivspaß: Brettspiele | PC | | Original | | S0022616 | |
| Schmidt Interaktivspaß: Mahjong | PC | | Original | | S0023095 | |
| Schmidt Interaktivspaß: Skat | PC | | Original | | S0022595 | |
| Schoenbrunn | PHOTO-CD | | Original | | | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | Beta | | | | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original | | Disc Assy. 451-052-012 0396 Part No. 90626 | |
| Die Schönsten Hotels der Welt | PHOTO-CD | | Original | | 813 0060 | |
| Schoolhouse Rock! 1st & 2nd Grade (Disc 2) (2nd Grade) | PC | | Original | | 21330CD-2, SGE744AE-CD2 | |
| Schoolhouse Rock! 1st & 2nd Grade Essentials (Disc 1) | PC | | Original | | 21330CD-1 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! Grammar Rock | PC | | SmartSaver | | SGR744AE-CD | |
| Schoolmates: The Mystery of the Magical Bracelet | PC | | Original | | | |
| Der Schuh des Manitu Der Schuh des Manitu: Das Computerspiel zum Film | PC | | Original | | | |
| Das Schwarze Auge: Die Schicksalsklinge | PC | | Das Schwarze Auge: Die Nordlandtrilogie | | SPI042 | |
| Das Schwarze Auge: Schatten über Riva | PC | | Das Schwarze Auge: Die Nordlandtrilogie | | SPI042 | |
| Das Schwarze Auge: Sternenschweif (Disc 1) | PC | | Das Schwarze Auge: Die Nordlandtrilogie | | SPI042 | |
| Das Schwarze Auge: Sternenschweif (Disc 2) | PC | | Das Schwarze Auge: Die Nordlandtrilogie | | SPI042 | |
| SCI Media Kit: Version: 2 | PC | | Press Kit | | | |
| SCI Media Kit: Version: 4 SCI Media Kit: Version: 4.0 | PC | | Press Kit | | | |
| Science Fiction: The Ultimate Collection (Disc 1) | PC | | | | 11014 | |
| Scooby-Doo! | IXL | 1.0.0 | Original | | R9709 | |
| Scooby-Doo! | IXL | 2.0.0 | Original | | R9709 | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.01 | Original | | 380849A-CD | |
| SCOP | PC | | Original | | SPR-1405 | |
| Scorcher | SS | 1.008 | Original | | 81214 | |
| Scotland Yard | PC | | Original | | | |
| Scotland Yard Interactif | CDI | 1.04 | Original | | 812 0070 | |
| Scotland Yard Interactive | CDI | 1.03 | Original | | 810 0139 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble | PC | | General Mills | | AM0703R72 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Screen Fighter Screen Saver スクリーンファイター スクリーンセーバー | PC | | Original | | SRC-00001 | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Seafight II | PC | | Original | | | |
| Seasons Greetings from Philips Media | CDI | | Original | | | |
| The Second AMUC CD | ACD | | | | CDRM1251610 | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Secret Mission | CDI | 1.01 | Beta | | 810 0272 | |
| Secret Mission | CDI | 1.07 | Original | | 812 0053 | |
| Secret Mission | CDI | | Original | | 814 0133 | |
| The Secret of Googol 1: Reshaping Googol: Submarine / Tower | PC | 2.0 | Original | | | |
| The Secret of Googol 2: Reshaping Googol: Castle / Ocean | PC | 2.0 | Original | | | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PC | 2.0 | Original | | | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PC | 2.0 | Original | | | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PC | 2.0 | Original | | | |
| The Secret of the Nautilus | PC | | Original | | JVEENCD1 | |
| Secret Service CD 36 | PC | | | | | |
| Secret Service CD 37 | PC | | | | | |
| Secret Service CD 38 | PC | | | | | |
| Secret Service CD 39 | PC | | | | | |
| Secret Service CD 40 | PC | | | | | |
| Secret Service CD 41 | PC | | | | | |
| Secret Service CD 43 | PC | | | | | |
| Secret Service CD 44 (Strona A) | PC | | | | | |
| Secret Service CD 44 (Strona B) | PC | | | | | |
| Secret Service CD 45 | PC | | | | | |
| Secret Service CD 46 | PC | | | | | |
| Secret Service CD 47 (Strona A) | PC | | | | | |
| Secret Service CD 47 (Strona B) | PC | | | | | |
| Secret Service CD 48 (Strona A) | PC | | | | | |
| Secret Service CD 48 (Strona B) | PC | | | | | |
| Secret Service CD 49 (Strona A) | PC | | | | | |
| Secret Service CD 49 (Strona B) | PC | | | | | |
| Secret Service CD 50 (Strona A) | PC | | | | | |
| Secret Service CD 50 (Strona B) | PC | | | | | |
| Secret Service CD 51 (Strona B) | PC | | | | | |
| Secret Service CD 51 (Strona A) | PC | | | | | |
| Secret Service CD 52 (Strona A) | PC | | | | | |
| Secret Service CD 52 (Strona B) | PC | | | | | |
| Secret Service CD 53 (Strona A) | PC | | | | | |
| Secret Service CD 53 (Strona B) | PC | | | | | |
| Secret Service CD 54 (Strona A) | PC | | | | | |
| Secret Service CD 54 (Strona B) | PC | | | | | |
| Secret Service CD 55 (Strona A) | PC | | | | | |
| Secret Service CD 55 (Strona B) | PC | | | | | |
| Secret Service CD 56 (Strona A) | PC | | | | | |
| Secret Service CD 56 (Strona B) | PC | | | | | |
| Secret Service CD 57 (Strona A) | PC | | | | | |
| Secret Service CD 57 (Strona B) | PC | | | | | |
| Secret Service CD 58 (Strona A) | PC | | | | | |
| Secret Service CD 58 (Strona B) | PC | | | | | |
| Secret Service CD 59 (Strona A) | PC | | | | | |
| Secret Service CD 59 (Strona B) | PC | | | | | |
| Secret Service CD 61 | PC | | | | | |
| Secret Service CD 64 | PC | | | | | |
| Secret Service CD 87 | PC | | | | | |
| Secret Service CD 88 | PC | | | | | |
| Secret Service CD 89 | PC | | | | | |
| Secret Service CD 90 | PC | | | | | |
| Secret Service CD 91 | PC | | | | | |
| Secret Service: Wydanie Specjalne Alone in the Dark | PC | | | | | |
| Secret Weapons over Normandy (Disc 1) | PC | | Original | | 32609.101.GM | |
| Secret Weapons over Normandy (Disc 2) | PC | | Original | | 32609.102.GM | |
| Secret Weapons over Normandy (Disc 3) | PC | | Original | | 32609.103.GM | |
| Secret Weapons over Normandy (Disc 4) (Spiel-CD) | PC | | Original | | 32609.104.GM | |
| The Secrets of Da Vinci: The Forbidden Manuscript (Disc 2) | PC | 1.02 | Original | | | |
| Secrets of the Dark: Der finstere Berg | PC | | Original | | | |
| Seek and Destroy | PC | | Original | | CDR3015 | |
| Sega Ages 2500 Series Vol. 8: Virtua Racing: FlatOut セガ・エイジス2500シリーズVol.8 ~V.R. バーチャレーシング フラットアウト~ | PS2 | 1.03 | Original | | SLPM 62443 | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Sega PC Greatest Hits Series Vol. 3 | PC | | PC Game Bundle | | 670-11970 | |
| Sega Rally 2: Sega Rally Championship (Install Disc) セガラリー2 | PC | | DigiCube PC | | DWRPD-00081 | |
| Sega Rally 2: Sega Rally Championship (Play Disc) セガラリー2 | PC | | DigiCube PC | | DWRPD-00081 | |
| Sega Sports Tennis | PS2 | 1.01 | Original | | SLUS 20480 | |
| Sega Superstars Exclusive Sonic Sega Superstars Demo | PS2 | 1.01 | Demo | | SLED-52875 | |
| Sega Superstars | PS2 | 1.00 | Original | | SLUS 20999 | |
| Sega Worldwide Soccer 2000 | DC | 1.200 | Sample | | 952-0007-50 | |
| Seikaku Shindan Game: Ukiyo-e Sumo-hen 性格診断ゲーム 浮世絵相撲編 | PHOTO-CD | | Original | | NPCD-1005 | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Self Selling Disc | CDI | 3.1 | | | 310-690-049-2 | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Sell It to Me! Part One: Preparing The Way | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Handling Telephone Sales Enquiries and Making Appraisals Pay | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Paperwork, Bloody Paperwork and Selling to Women | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Selling You to You and Taking Personal Control | CDI | | Original | | | |
| Senkaku Mondai o Yatchimasu 2 尖閣問題を殺っちます2 | PC | | Original | | | |
| Sensible World of Soccer | PC | 1.0 | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Rerelease | | CD-W58-1103-1 | |
| Serie Privélessen: Klassieke Gitaar: Handleiding voor Beginners | CDI | 1.06 | Original | | 814 0067 | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Serious Sam: The First Encounter | PC | 1.02 | Bundle Version Gainward OEM | | | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Serum-Werk Bernburg AG: Veterinärpharmaka: Vol. 1 | CDI | | Original | | | |
| Session Power Up Kit for DrumMania 2nd Mix / PercussionFreaks 2nd Mix | KS573 | | Original | | 912 *Z A01 | |
| Sethi und das Geheimnis der Neandertaler | PC | | Rerelease | | | |
| The Settlers III (Disc 1) | PC | | Revival | | REV036 | |
| The Settlers III (Disc 2) | PC | | Revival | | REV036 | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| The Settlers IV: Gold Edition (Disc 1) | PC | | Original | | | |
| The Settlers IV: Gold Edition (Disc 2) | PC | | Gold Edition | | | |
| The Settlers | PC | | PC Best Buy Pocket | | 900813 | |
| The Settlers: Heritage of Kings: Gold Edition (Legends Expansion Disc) | PC | | That's Hot! | | 5004531 | |
| Seven Kingdoms: Artwork | MAC | | Art Assets | | | |
| Seven Kingdoms: The Fryhtan Wars / Shadow Company: Left for Dead | PC | | Demo | | 5051859 | |
| Sex | 3DO | | Original | | | |
| Shade: Wrath of Angels (Press Disc) | PC | | Press Kit | | | |
| Shadoan Kingdom II: Shadoan | CDI | 1.03 | Original | | 810 0280 | |
| Shadow Force: Razor Unit | PC | | Original | | 30851.101.US | |
| Shadow Man | PC | | Demo | | | |
| Shadow Man | DC | 1.001 | Original | | T-8106N | |
| Shadow Man: 2econd Coming | PS2 | 1.03 | Original | | SLUS-20413 | |
| Shadow Vault Bonus CD Extra 1/2008 | PC | | | | | |
| Shadow Vault: Demos and Materials | PC | | Original | | | |
| Shadowbane | PC | | Taikenban | | | |
| Shamrock's Fall '96 Demo CD | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shanggu Juanzhou III: Chenfeng (Disc B) 上古卷轴Ⅲ:晨风 | PC | | Zhima Kai Men | | | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Shanghai: Dynasty 上海ダイナスティ | PC | 1.2 | DigiCube PC | | DWRPS-00055 | |
| Shanghai: Dynasty 上海ダイナスティ | PC | 1.2 | PC Game Best Series Mega Hit | | | |
| Shape Shifter | PCE | | Original | | TGXCD1021 | |
| Shareware CD Compilation n.40: Doom 1800 Niveaux | PC | | | | 1634 | |
| Shareware Games: The Best of 1996: Luglio/Agosto 1996 | PC | | | | | |
| Shareware Gold: PC Software | PC | | Original | | SGCD-01 | |
| Shari Lewis Lamb Chop's Play-Along! Action Songs | CDI | | Original | | 310690289-2 | |
| SharkPort: Code and Save Transfer Kit | PC | 1.04 | Original | | | |
| SharkPort: Code and Save Transfer Kit | PS2 | 2.21 | Unlicensed | | | |
| Sheep | PC | | Megapak 10 | | EI-1420 GERMAN | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| Sherlock Holmes: The Case of the Silver Earring (Disc 1) | PC | | Reload / White Label | | 1480A1 | |
| Sherlock Holmes: The Case of the Silver Earring (Disc 2) | PC | | Reload / White Label | | 1480A2 | |
| Sherlock Holmes: The Mystery of the Mummy | PC | | Original, Reload / White Label | | 1564A | |
| Shi Naki Shijin no Gogo 詩なき詩人の午後 | PC | | Original | | | |
| Shifters | PS2 | 1.02 | Original | | SLUS 20271 | |
| Shiken ni Deru!? Haruno-chan 試験に出る!?はるのちゃん | PC | | Original | | MAY-20112 | |
| Shin Theme Park: Yuuenchi o Tsukurou 新テーマパーク 遊園地をつくろう | PC | | EA Best Selections | | EMWB-7007 | |
| Shining Soul II + Shining Force Assets Shining Soul 2 + Shining Force Assets | PC | | Press Kit | | | |
| Shinjuwan Kougeki Taiheiyou Sensen 3: For Combat Flight Simulator 真珠湾攻撃 太平洋戦線3 For Combat Flight Simulator | PC | | Original | | | |
| Shinouken 神凰拳 | SS | 1.003 | Original | | T-3113G | |
| Shinpi no Sekai: El Hazard 神秘の世界 エルハザード | PHOTO-CD | | Original | | PIRW-1010 | |
| Shinsetsu Kamiya Ukyo 3: Missing Link 真説 神谷右京3 ~Missing Link~ | PC | | Original | | | |
| Ship Simulator 2008 | PC | 1.1 | Original | | | |
| Shivers | PC | | Demo | | | |
| Shivers / Torin's Passage | PC | | | | | |
| Shkola dressirovki Школа дрессировки | PC | | Original | | | |
| Shock Price 500 Game Series: Hyakunin Isshu SHOCK PRICE 500 GAME SERIES 百人一首 | PC | 1.00 | Original | | SSRX 3060 | |
| Shock Price 500 Game Series: Volleyball SHOCK PRICE 500 GAME SERIES バレーボール | PC | | Original | | SSRW 30032 | |
| Shock Wave | 3DO | | Original | | | |
| Shogo: Mobile Armor Division | PC | | TF1 Video Multimedia | | | |
| Shogun: Total War (Disc 1) | PC | | Original | | EAG08801965D1 | |
| Shogun: Total War (Disc 2) | PC | | Original | | EAG08801965D2 | |
| Shogun: Total War: The Mongol Invasion | PC | | Original | | EAD08803486D | |
| Shogun: Total War: Warlord Edition (Disc 1) | PC | | Original | | EAD08803525D | |
| Shogun: Total War: Warlord Edition (Disc 2) | PC | | Original | | EAD08803525D1 | |
| Shorelines | CDI | | | | | |
| Shrek 2 | PC | | Original | | 32585.101.GM | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| Shrek der Dritte: Die Suche nach Arthus | VFLASH | | Original | | 093144(GER) | |
| Shrek Super Party | PS2 | 1.00 | Original | | SLUS 20516 | |
| Shrek Swamp Fun with Early Math | PC | | | | 30993.101.AU | |
| Shrine Circus Tycoon | PC | | | | 31933.101.US | |
| Si Balla! | CDI | 1.03 | Original | | 815 0066 | |
| Sid Meier's Alien Crossfire | PC | | Original | | 1405807 | |
| Sid Meier's Alpha Centauri: Kanzenban シド・マイヤーズ アルファ・ケンタウリ 完全版 | PC | | EA Best Selections | | EMWB-7057 | |
| Sid Meier's Civilization | PC | | Rerelease | | | |
| Sid Meier's Civilization II | PC | | Total Heaven 1 | | | |
| Sid Meier's Civilization II | PC | | Original | | MP391260DO1R | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization IV (Disc 2) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.7 | |
| Sid Meier's CivNet | PC | | Original | | MP191226DOIR | |
| Sid Meier's CivNet | PC | 1.0 | Original | | MP391226DO1R | |
| Sid Meier's Colonization | MAC | | Original | | CLMC-60 | |
| Sid Meier's Railroad Tycoon | PC | | Action Sixteen | | | |
| Sid Meier's SimGolf | PC | | Original | | EAX08803576D | |
| Sid Meier's SimGolf | PC | | Rerelease | | 1641547 | |
| Siedler II, Die: Veni, Vidi, Vici | PC | | Total Heaven 1 | | | |
| Die Siedler | PC | | Blue Byte Classics | | | |
| Sierra Holiday Software Sampler | PC | | | | | |
| Sierra Pro Pilot (Disc 1) (Europa-Scenery) | PC | | Original | | S0010346 | |
| Sierra Pro Pilot (Disc 1) (Amerika-Scenery) | PC | | Original | | S0010344 | |
| Sierra Products Demo America Online featuring Sierra Online | PC | | | | R00482 | |
| Sierra Super Sampler Sierra On-Line Demos | PC | | | | | |
| Sierra's School House: Math (Disc 1) | PC | | Original | | | |
| Sierra's School House: Math (Disc 2) | PC | | Original | | | |
| Sierra's Sneak Peeks 2 | PC | | Demo | | | |
| Sierra/Coktel Multimedia Katalog | PC | | | | DEUTSCH PZZZ0520Z01Z1 | |
| Silent Hunter | PC | 1.11 | Original | | CS090398 | |
| Silent Hunter II | PC | | Original | | | |
| Silent Hunter: Patrol Disk | PC | | Original | | CS090338 | |
| Silent Scope | PS2 | 1.00 | Review Code | | SLES-50037 | |
| Silent Scope サイレント スコープ | DC | 1.002 | Original | | T-9513M | |
| Silent Scream II: Die Braut | PC | | Purple Hills Games³ Megabox Vol. 13 | | | |
| Silent Steel (Disc 1) | PC | | Original | | STEEL 1 | |
| Silent Steel (Disc 2) | PC | | Original | | STEEL 2 | |
| Silent Steel (Disc 3) | PC | | Original | | STEEL 3 | |
| Silent Steel (Disc 4) | PC | | Original | | STEEL 4 | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| Silhouette: CD-i Demo Version | CDI | | Original | | | |
| Silmarils Collection | PC | | Original | | EuroVideo-Artikel-Nummer: 502063 | |
| Silver Gene: The Mutia Chronicle 1 シルバージーン the mutia chronicle 1 | PC | | Original | | CNDL-0002 | |
| Sim City 4: Rush Hour (Expansion Pack) | PC | | Original | | MXX08804109D/GER | |
| Sim Earth: Der lebende Planet | PC | | Classics | | 3010-030-0601-A | |
| Sim Explosion: Extra Levels for Sim City & Sim City 2000 | PC | | Original | | | |
| SimCity 2000 | SS | 1.401 | Original | | T-12601H | |
| SimCity 2000 Netzwerkversion | PC | | Megapak 8 | | 03130-059-0601 | |
| SimCity 2000 Special Edition | PC | | Original | | 0126-000-0601-A | |
| SimCity 3000 Deutschland | PC | | EA Games Powerpack Vol. 1 | | MXG08903180D | |
| SimCity 3000 Deutschland (Manuals) | PC | | EA Games Powerpack Vol. 1 | | MXD08903897D2 | |
| SimCity 3000 Holiday Edition | PC | | Original | | MXG08801496D | |
| SimCity Enhanced CD-ROM | PC | | White Label | | | |
| SimCoaster: Bonus Disk SimCoaster Extra Value Pack | PC | | | | 4002307 | |
| SimCopter | PC | | Original | | | |
| SimEarth | PC | | Dual Jewel, 10 Sims for $20 | | 1111507 | |
| SimEarth: The Living Planet | PCE | | Original | | TGXCD1036 | |
| SimGolf | PC | | Dice | | DCG 007107 | |
| SimGolf | PC | 1.0 | Original | | 0093-000-0601-A | |
| SimLife | PC | | Maxis ReCreation | | | |
| SimLife SimLife: The Genetic Playground | PC | | Scholastic Clubs and Fairs | | 1111707, P1 | |
| Simon the Sorcerer II | PC | | PC Games Collection Vol. 1 | | | |
| Simon the Sorcerer's Pinball | PC | | Original | | | |
| SimPeople シムピープル | MAC | | Original, EA Best Selections | | EAM-7020, EAMD-702 | |
| SimPeople Kanzenban (Disc 1) シムピープル 完全版 | PC | 1.44 | SimPeople Kanzenban 3, SimPeople Kanzenban | | EMW-4110, EMW-4160 | |
| SimPeople Kanzenban (Disc 2) シムピープル 完全版 | PC | 1.44 | SimPeople Kanzenban 3, SimPeople Kanzenban | | EMW-4110, EMW-4160 | |
| SimPeople: Magical Dream! (Data Set) (Disc 1) シムピープル マジカルドリーム!データセット | PC | 1.1 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Magical Dream! (Data Set) (Disc 2) シムピープル マジカルドリーム!データセット | PC | 1.1 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Pets & Gardening! (Data Set) (Disc 1) シムピープル ペット&ガーデニング!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Pets & Gardening! (Data Set) (Disc 2) シムピープル ペット&ガーデニング!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Star Paradise! (Data Set) (Disc 1) シムピープル スター・パラダイス!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Star Paradise! (Data Set) (Disc 2) シムピープル スター・パラダイス!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Vacation! (Data Set) シムピープル バケーション!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| The Simpsons Skateboarding | PS2 | 1.01 | Original | | SLUS-20114 | |
| The Simpsons: Hit & Run (Disc 1) | PC | | Original | | S0029195 | |
| The Simpsons: Hit & Run (Disc 1) | PC | | Rerelease | | | |
| The Simpsons: Hit & Run (Disc 2) | PC | | Rerelease | | | |
| The Simpsons: Hit & Run (Disc 3) | PC | | Rerelease | | | |
| The Sims 2 (Disc 2) เดอะซิมส์ 2 | PC | | Original | | | |
| The Sims 2 (Disc 3) เดอะซิมส์ 2 | PC | | Original | | | |
| The Sims 2 (Disc 4) เดอะซิมส์ 2 | PC | | Original | | | |
| The Sims 2 | PC | | Press Kit | | | |
| The Sims 2: Christmas Party Pack The Sims 2: Holiday Party Pack | PC | | Original | | MXX08005018D | |
| The Sims 2: Family Fun Stuff | PC | | Original | | MXX08005080D | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 2) | PC | | | | 1497037 | |
| The Sims 2: Open for Business (Expansion Pack) | PC | | Original | | MXX08004985D | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | | Original | | MXX08004661D | |
| The Sims 2: University (Expansion Pack) (Disc 2) | PC | | Original | | MXX08004661D2 | |
| The Sims 2: University (Expansion Pack) (Disc 1) เดอะ ซิมส์ 2: มหา'ลัย วัยฝัน: มหา'ลัย วัยฝัน | PC | | Original | | 1491707 | |
| The Sims 2: University (Expansion Pack) (Disc 2) เดอะ ซิมส์ 2: มหา'ลัย วัยฝัน: มหา'ลัย วัยฝัน | PC | | Original | | | |
| The Sims 2: Winter Pack ザ・シムズ2 ウィンターパック | PC | | Original | | 15277EPWNJP | |
| Les Sims Magazine #25 | PC | | | | | |
| Les Sims Magazine #26 | PC | | Original | | | |
| Les Sims: Superstar (Disc 1) (Disque Additionnel) | MAC | | Original | | | |
| Les Sims: Superstar (Disc 2) (Disque Additionnel) | MAC | | Original | | | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims: Hot Date (Expansion Pack) | MAC | | Original | | 10150-1CDA | |
| The Sims: House Party (Expansion Pack) | PC | | Double Deluxe | | MXX08803522D | |
| The Sims: Livin' Large (Expansion Disc) | PC | | Original | | MXX08903305D | |
| The Sims: Livin' Large (Expansion Pack) | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | MAC | | Original | | 10430-1CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | MAC | | Original | | 10430-2CDA | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | | Original | | 1640617 | |
| SimTown: The Town You Build Yourself! シムタウン | MAC | | Original | | MMC-4093 | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| SimTunes | PC | | Original | | 0135-000-0601-A | |
| Simulation Eikaiwa: CD-I Taiken America Ryokou シュミレーション英会話 CD-I体験アメリカ旅行 | CDI | | Original | | | |
| Simulmondo Interactive: Little Computer People n. 1 | PC | | | | | |
| Simulmondo Interactive: Little Computer People n. 4 | PC | | | | | |
| SiN | PC | | Original | | 1000076.101.GM | |
| SiN | PC | 1.01 | Rerelease | | 6236-01 | |
| SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| Singles 2: Lyubov' vtroem Singles 2: Любовь втроем | PC | | Original | | | |
| Singles 2: Wilde Zeiten | PC | | Original | | ECD008010M | |
| Singles: Flirt Up Your Life! | PC | 1.2 | | | | |
| Singles: Flirt Up Your Life! | PC | | Original | | ECD000808K | |
| Singles: Flirt Up Your Life! | PC | 1.2 | Original | | | |
| Sinkha | MAC | | Original | | | |
| Skateboard Park Tycoon: Back in the USA 2004 | PC | | Original | | | |
| Ski Park Manager 2003: Gold Edition Val d'Isère Ski Park Manager 2003: Gold Edition | PC | | | | 71102221 | |
| Skin Style | CDI | | Original | | | |
| Skylanders: Spyro's Adventure | PC | | Press Kit | | | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slingo Deluxe Slingo Deluxe Bundle | PC | | Original | | | |
| Slingo Mystery: Who's Gold | PC | | Big Fish Games Backup CD | | | |
| Slot Shite kara ne スロットしてからね | PC | | Original | | ZPG-1003 | |
| Sly 2: Band of Thieves | PS2 | 1.00 | Demo | | SCUS 97415 | |
| Small Pak | PC | | | | | |
| Small Soldiers: Globaltech Design Lab | PC | | | | Product# 99144 | |
| Small Soldiers: Squad Commander | PC | | | | Product# 99264 | |
| I Smart Kids: Ik ziek zie... Beeldraadsels 1 | PC | | Original | | | |
| Smash Cars | PS2 | 1.03 | Original | | SLUS 20620 | |
| Smashdown: Boxsport Manager | PC | | SevenGames Extended | | | |
| SMBX + Tak 2 Art | PC | | Press Kit | | | |
| Smilde | CDI | | Original | | | |
| The Smithsonian Presents the Riches of Coins | CDI | | Original, Demonstration Disc | | 310-690-088-2, 310690088-2 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| Smok Wawelski | PC | | Covermount | | SELL 0132 | |
| Smoking Guns Smoking Guns: Shooting Gallery! | PC | 1.0 | Cosmi | | 02-2503-10 | |
| Snakebyte Special Spiele | PC | | Original | | Kat.-Nr. 6007 | |
| Sniper: Path of Vengeance | PC | | Original | | | |
| SNK NeoGeo USA Consumer Corporation: E3 2004 Games | PC | | Press Kit | | | |
| SNK Playmore E3 2006 Games | PC | | Press Kit | | | |
| Snowboard "Trick x Trick" スノーボード”トリック×トリック” | PHOTO-CD | | Original | | AS 0003 | |
| Snowboard Heaven スノーボードヘヴン | PS2 | 1.03 | Original, CapKore | | SLPM 62027 … | |
| Snowmobile Racing | PC | | Original | | | |
| Soccer Compilation | PC | | | | | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.00 | Beta Trial Code | | TCES-51904 | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.00 | Beta | | SCUS 97366 | |
| SOCOM Intel Disc | PC | | Press Kit | | | |
| Soft Kill | PC | | Original | | | |
| Soft-World Magazine No. 139: November 2000 軟體世界雜誌社 MegaDisc 第139期 | PC | | | | | |
| Softgold Presents: LucasArts Top Adventures CD-ROM Edition | PC | | Original | | | |
| Softgold: World of Business | PC | | Original | | | |
| SOFTline hiGames n. 17: Novembre 1996 | PC | | | | | |
| SOFTline hiGames n. 21: Aprile 1997 | PC | | | | | |
| SOFTline hiGames n. 22: Maggio 1997 | PC | | | | | |
| SOFTline hiGames n. 23: Giugno 1997 | PC | | | | | |
| SOFTline hiGames n. 24: Luglio/Agosto 1997 | PC | | | | | |
| SOFTline hiGames n. 25: Settembre 1997 | PC | | | | | |
| SOFTline hiGames n. 26: Novembre 1997 | PC | | | | | |
| Softline Software World: Novembre 2000 (Disc A) | PC | | | | | |
| Software 2000: Volume 1 (Disc 1) | ACD | | Original | | | |
| Software 2000: Volume 1 (Disc 2) | ACD | | Original | | | |
| Softwarehits Made in Germany 94/95 | PC | | Original | | | |
| Sol-Feace | MCD | | Bundled with Mega-CD (Sol-Feace / Cobra Command Bundle) | | 4130 | |
| Solar Crusade | CDI | | Original | | SOLARGB5511 | |
| Soldier Force ソルジャーフォース | PC | 1.00 | Original | | | |
| Soldier of Fortune II: Double Helix (Disc 2) 傭兵戰場Ⅱ | PC | | Original, Bundle Version Creative Labs OEM | | 3002648AU, 31147.102.US | |
| Soldiers of Anarchy | PC | | Original | | S5280010 | |
| Söldner: Gold Edition | PC | | | | | |
| Soldner: Morskaya pexota Soldner: Морская пехота | PC | | Original | | | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | PC | | Rerelease | | 517-05-232 | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | MAC | | Original | | | |
| Solitaire | CDI | | Prototype | | | |
| Solitaire Antics | PC | 1.0 | Original | | | |
| Solitaire Games | PC | | GSP | | 92534-A | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| Sonic & Knuckles Collection | PC | | Audio CD Bundle | | MK-85037-50D | |
| Sonic & Knuckles Collection ソニック&ナックルズ コレクション | PC | | Ultra 2000/Ultra Series | | MKW-051 | |
| Sonic 3D Blast | PC | | Expert Software | | 6822 01 | |
| Sonic Adventure | DC | 1.004 | Original | | 51000 | |
| Sonic Heroes (Disc 1) 소닉 히어로즈 | PC | 1.0 | Original | | | |
| Sonic Heroes (Disc 2) 소닉 히어로즈 | PC | 1.0 | Original | | | |
| Sonic R | PC | | Xplosiv | | EI-1263 | |
| Sonic R ソニックR | PC | | Ultra 2000/Ultra Series | | MKW-111 | |
| Sonic the Hedgehog CD ソニック・ザ・ヘッジホッグCD | MCD | | Sample | | SG-6021 | |
| Sony E3 2004: Press Information | PC | | Press Kit | | | |
| Sony Image Converter 2: Ver.2.1 | PC | 2.1.00.14241 | Original | | MSSW-IC2 | |
| Sony PlayStation 2: SCEA Santa Monica Studios: 2004 Press Information: Press Print | PC | | Press Kit | | | |
| Sonya | PC | | Original | | | |
| Sotsugyou Genga-shuu 卒業原画集 | PHOTO-CD | | Original | | CRMP-1001 | |
| Soukoku no Kusabi: Hiiro no Kakera 3 Portable: Genteiban Tokuten Desktop Accessory-shuu 蒼黒の楔 緋色の欠片3 ポータブル 限定版特典 デスクトップアクセサリー集 | PC | | PSP Game Bundle | | | |
| Sounds Best on Sound Blaster Every Game Sounds Best on Sound Blaster: 24-bit Advanced HD | PC | | | | | |
| Soundtrap | CDI | 1.06 | Original | | 811 0032 | |
| SouthPeak Interactive E3 2000 Electronic Press Kit | PC | | Press Kit | | | |
| Souzou Sozai: Europe no Mado Vol. 2 創造素材 ヨーロッパの窓 Vol.2 | PHOTO-CD | | Original | | ERV2 | |
| Souzou Sozai: Umi Vol. 1 創造素材 海 Vol.1 | PHOTO-CD | | Original | | SEVI-1049 | |
| Space Ace | CDI | | Original, Demonstration Disc | | 310-690-059-2, 310690059-2 | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Space Bunnies Must Die! | PC | | Demo | | MSDE-37216 | |
| Space Quest 6: Roger Wilco in the Spinal Frontier | PC | | Original | | S4330520Z12ZZ | |
| Space Quest 6: Roger Wilco in the Spinal Frontier | PC | | | | S6460520212ZZ | |
| Space Quest I: Roger Wilco in the Sarien Encounter | PC | | Kixx XL | | | |
| Space Ranger | CDI | | Unlicensed | | OGCDI-1180 | |
| Space Shuttle スペースシャトル | PHOTO-CD | 1.1 | Original | | C02H | |
| SpaceHaste BGamer 070 (Disc 2) | PC | | Covermount | | | |
| Spaceship Warlock | MAC | | Original | | CDRM 403300 | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-36816D-50 | |
| Special Permit for Cabela's Big Game Hunter | PC | | Original | | | |
| Special Secret Data Disc | PC | | PSP Game Bundle | | | |
| Spectrobes: Beyond the Portals (Electronic Press Kit) | PC | | Press Kit | | | |
| Speed Busters | PC | | Ubi Soft Classique | | | |
| Speed Freaks (Misc Artwork: PC-CD 2nd July '99) | PC | | Press Kit | | | |
| Speel Bridge 4 | PC | | Original | | | |
| Speel Bridge 5 | PC | | Original | | | |
| SpellForce: The Order of Dawn (Disc 1) (Install CD1 / Play CD) | PC | | Limited Edition | | ROSPELLFOR0012LAB1 | |
| SpellForce: The Order of Dawn (Disc 1) (Install CD1 / Play CD) | PC | 1.52.61407 | Hammerpreis | | ROSPELLFOR0024lab1 | |
| SpellForce: The Order of Dawn (Disc 2) (Install CD2) | PC | | Limited Edition | | ROSPELLFOR0012LAB2 | |
| SpellForce: The Order of Dawn (Disc 2) (Install CD2) | PC | 1.52.61407 | Hammerpreis | | ROSPELLFOR0024lab2 | |
| SpellForce: The Order of Dawn (Disc 3) (Install CD3) | PC | | Limited Edition | | ROSPELLFOR0012LAB3 | |
| SpellForce: The Order of Dawn (Disc 1) | PC | | Covermount | | ROSPELLFOR0003LAB1 | |
| SpellForce: The Order of Dawn (Disc 2) | PC | | Covermount | | ROSPELLFOR0003LAB2 | |
| SpellForce: The Order of Dawn: Songs of Winter SpellForce: The Order of Dawn: Songs of Winter: The Official Soundtrack to Breath of Winter | PC | | Limited Edition | | ROSPELLFOR0012LABST | |
| Spelling Home Tutor | PC | | | | | |
| Sphinix Gold | PC | | Original | | ROK 04 Art.-Nr. 6623 | |
| Spider-Man | MAC | | Original | | | |
| Spider-Man 2 Человек-паук 2 | PC | | 1C: Kollekciya igrushek | | | |
| Spider-Man 2: The Game | PC | | Original | | 32581.101.GM | |
| Spider-Man Course-Poursuite à Manhattan | VFLASH | | Original | | 093065(FR) | |
| Spider-Man: Angriff der Super-Schurken | VFLASH | | Original | | 093064(GER) | |
| Spider-Man: Web of Shadows (Final Press Kit) | PC | | Press Kit | | | |
| Spielbare Cheats Volume 16 | PS2 | 1.00 (European) | Unlicensed | | | |
| Spine Sense: The Interactive Back Protection Program | CDI | | Original | | | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| SpyHunter | PS2 | 1.00 | Demo | | SLED-50488 | |
| Square Enix E3 2004 Media CD | PC | | Press Kit | | | |
| Square Europe: Press Kit: E3 2000 | PC | | Press Kit | | | |
| SquareSoft: E3 2001 Media CD | PC | | Press Kit | | | |
| SSI Strategy Collection: Critic's Choice Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| SSX 3 | PS2 | 1.01 | Cheheompan | | SLKA 90502 | |
| St. Jeremiah Gakuen for Windows 聖エレミヤ学園 FOR WINDOWS | PC | | Original | | LNR0001 | |
| St. Shirobara Gakuen Petit Mahjong: Enami Rina no Maki 聖白薔薇学園プチ★MAHJONG ~江波理菜の巻~ | PC | | Original | | FIVD-002 | |
| Stable Masters 2 | PC | | Original | | | |
| Stalingrad スターリングラード | PC | | Original | | GLA-00370 | |
| Standard 1500: The Pinball: Golden Logres スタンダード1500 The ピンボール① ゴールデンログレス | PC | | Original | | SD-100041 | |
| Star Defender III | PC | | Original | | CD001697 | |
| Star Rangers スターレンジャーズ | PC | | Original | | | |
| Star Trek Pinball | PC | | Bundle Version OEM | | CD-C95-675-UNU | |
| Star Trek Pinball | PC | 1.00 | Original | | CD-C95-675-0 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 811 1007 | |