| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Second Sight | GC | | Original |  | DL-DOL-GISE-USA |  |
| Second Sight | PS2 | 1.00 | Original | | SLUS-21033 | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Secret Agent Clank | PSP | .01 | Beta |     | UCUS-98697 | |
| Secret Agent Clank | PSP | 1.00 | Demo | | UCUS 98707 | |
| Secret Agent Clank | PS2 | 1.00 | Original | | SCUS 97623 | |
| Secret Agent Clank | PSP | 1.01 | Original, Greatest Hits, Secret Agent Clank + Daxter UMD Dual Pack | | UCUS 98697 … | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| The Secret of the Silver Earring
Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| The Secret Saturdays: Beasts of the 5th Sun | PSP | 1.00 | Original | | ULUS-10443 | |
| The Secret Saturdays: Beasts of the 5th Sun | PS2 | 1.01 | Original | | SLUS-21896 | |
| Secret Service | PS2 | 1.01 | Original | | SLUS 21836 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Secret Weapons over Normandy | PS2 | 1.00 | Review Build | | SLUS-20762 | |
| Secret Weapons over Normandy | PS2 | 1.01 | Original | | SLUS 20762 | |
| Section 8 | PC | | Original | | 50027-LBL | |
| Seek & Find Adventures | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek and Destroy | PS2 | 1.01 | Original | | SLUS 20606 | |
| Sega Bass Fishing | WII | | Original | | RVL-RBTE-USA, RVL-RBTE-USA-B0 | |
| Sega Bass Fishing 2 | DC | 1.080 | Original | | 51166 | |
| Sega Classics Collection | PS2 | 1.01 | Original | | SLUS 21009 | |
| Sega Genesis Collection | PS2 | 1.01 | Original | | SLUS 21542 | |
| Sega Genesis Collection | PSP | 1.01 | Original, SEGA Fun Pack | | ULUS-10192 | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega GT 2002 | XBOX | | Original |  | SE-003 | |
| Sega GT 2002 / JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega GT Online | XBOX | | Original | | SE-033 | |
| Sega Rally Revo | PS3 | 01.00 | Original | | BLUS-30068 | |
| Sega Rally Revo | PSP | 1.00 | Original | | ULUS-10311 | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| Sega Soccer Slam | GC | | Original | | DL-DOL-GSSE-USA | |
| Sega Soccer Slam | PS2 | 1.00 | Original | | SLUS-20509 | |
| Sega Superstars Tennis | WII | | Original | | RVL-RT5E-USA | |
| Sega Superstars Tennis | PS3 | 01.01 | Original | | BLUS-30123 | |
| Sega Superstars Tennis | PS2 | 1.01 | Original | | SLUS 21733 | |
| Sengoku Basara: Samurai Heroes | WII | | Original | | RVL-SB3E-USA-B0 | |
| Sengoku Rance
戦国ランス | PC | 1.07 | Limited Edition | | MG-AS-RE-004 | |
| Serious Sam | XBOX | | Original | | TT-004 | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| Serious Sam: Next Encounter | PS2 | 1.01 | Original | | SLUS-20907 | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS4E-USA-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | PC | | Original | | | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS3E-USA-B0 | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Learn, Play and Grow Preschool / Sesame Street: Let's Go to Preschool / Sesame Street: First Steps | PC | | Southwestern Kids' Collection | | 05SS3-R01 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| The Settlers: Heritage of Kings | PC | 1.01.0163 | Original | | 682011-DVD | |
| The Settlers: Rise of an Empire | PC | 1.0.4140 | Original | | | |
| The Settlers: Rise of an Empire | PC | 1.0.4140.0 | Scholastic | | P/N DVD5107350 | |
| The Settlers: Rise of an Empire: Gold Edition
The Settlers: Bâtisseurs d'Empire: Gold Edition | PC | 1.6.4287 | | | 684596-DVD | |
| Seven Kingdoms: Conquest | PC | 1.00 | Original | | DVD580CD | |
| Seven Samurai 20XX | PS2 | 1.00 | Original | | SLUS 20621 | |
| Seventh Cross Evolution | DC | 1.000 | Original | | T-41301N | |
| Shadow Hearts | PS2 | 1.00 | Original | | SLUS 20347 | |
| Shadow Hearts: Covenant (Disc 1) | PS2 | 1.00 | Original | | SLUS 21041 | |
| Shadow Hearts: Covenant (Disc 2) | PS2 | 1.00 | Original | | SLUS 21044 | |
| Shadow Hearts: From the New World | PS2 | 1.01 | Original | | SLUS 21326 | |
| Shadow Man | DC | 1.001 | Original | | T-8106N | |
| Shadow of Destiny | PSP | 1.00 | Original | | ULUS-10459 | |
| Shadow of Destiny | PS2 | 1.10 | Original | | SLUS-20146 | |
| Shadow of Rome | PS2 | 1.00 | Demo | | SLUS 29139 | |
| Shadow of Rome | PS2 | 1.03 | Original | | SLUS 20902 | |
| Shadow of the Beast | PCE | | Original | | TGXCD1018 | |
| Shadow of the Colossus | PS2 | 1.00 | Demo | | SCUS 97505 | |
| Shadow of the Colossus | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97472 | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-037 | |
| Shadow President
Shadow President: The Simulation of Presidential World Power! | PC | | Gold Medal 12 CD Pack | | MQ 13-004-116 | |
| Shadow the Hedgehog | XBOX | | Original | | SE-134 | |
| Shadow the Hedgehog | GC | | Original | | DL-DOL-GUPE-USA | |
| Shadow the Hedgehog | PS2 | 1.02 | Original, Greatest Hits | | SLUS 21261 … | |
| Shadow Wolf Mysteries: Curse of the Full Moon / Bane of the Family | PC | | | | 33425010US | |
| Shadowgrounds Survivor | PC | 1.0 | Original | | 000152 DVD | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| Shadowrun | PC | 1.1.1.0 | Original | | 0307 Part No. X13-37194-01 | |
| Shadowrun Chronicles: Boston Lockdown | PC | 12.0.10093 | Cosmi | | DVDC6251 | |
| Shadowrun Returns (Game Disc) | PC | | Original | | | |
| Shakedown: Hawaii | PS3 | 01.01 | Original | | BLUS-31622 | |
| Shattered Horizon | PC | | Premium Edition | | | |
| Shattered Suns | PC | 1.0 | Original | | Part # CCS00003-1 | |
| Shattered Union | XBOX | | Original | | TT-131 | |
| Shaun Palmer's Pro Snowboarder | PS2 | 1.00 | Original | | SLUS-20199 | |
| Shaun White Skateboarding | WII | | Original | | RVL-SHNE-USA-B0 | |
| Shaun White Skateboarding | PS3 | 01.02 | Original | | BLUS-30303 | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| Shaun White Snowboarding | PS3 | 01.01 | Target Limited Edition | | BLUS-30233 | |
| Shaun White Snowboarding | PS3 | 01.01 | Original | | BLUS-30223 | |
| Shaun White Snowboarding | PS2 | 1.01 | Original | | SLUS 21853 | |
| Shaun White Snowboarding | PSP | 1.01 | Original | | ULUS 10399 | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Shaun White Snowboarding: Road Trip | WII | | Target Limited Edition | | RVL-RW7E-USA | |
| Shaun White Snowboarding: Road Trip | WII | | Original | | RVL-RDFE-USA | |
| Shaun White Snowboarding: World Stage | WII | | Original, Target Exclusive | | RVL-R6NE-USA-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| ShellShock 2: Blood Trails | PS3 | 01.01 | Original | | BLUS-30225 | |
| ShellShock 2: Blood Trails | PC | 1.0 | Original | | 5000026211 | |
