Region | Title | System | Version | Edition | Languages | Serial | Status |
| The Sacred Amulet | PC | | Original | | | |
| Sangokushi Tai Sen: Dairyuusei 三国志戴閃-大流星- | PC | 1.01 | Original | | | |
| Schizm: Mysterious Journey (Disc 1) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 2) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 3) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 4) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 5) | PC | 1.0.0.744 | Original | | | |
| Shaftdiver | PC | 0.1 | Taikenban | | | |
| Shindou Shippuu Monogatari Mousou Gaiden: Mahou Shoujo Magical Iorin: First Magic: "Mahou Shoujo ni Natchatta!?" 神動疾風物語妄想外伝 魔法少女マジカルいおりん ~First Magic゛魔法少女になっちゃった!?゛~ | PC | 1.00 | Original | | | |
| Shindou Shippuu Monogatari Mousou Gaiden: Mahou Shoujo Magical Iorin: Second Magic: "Watashi Stalking Hajimemashita!" 神動疾風物語妄想外伝 魔法少女マジカルいおりん ~Second Magic゛私ストーキングはじめました!゛~ | PC | 1.01 | | | | |
| Shivers | PC | 1.02 | Rerelease | | | |
| Shogo: Mobile Armor Division 昇剛 | PC | 1.0 | Original | | | |
| Silverload | PC | | | | | |
| Smart Steps: Kindergarten | PC | 1.0 | Original | | | |
| sourirE | PC | 1.00 | Original | | | |
| Soushun: Tsutaetai Koto 想瞬 ーつたえたいことー | PC | | Original | | | |
| Splatt! | PC | | Original | | | |
| SportzFreakz | PC | 1.0 | Original | | | |
| Star Crusader | PC | | Original | | | |
| Star Trek: Klingon (Disc 1) (Installation) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Star Trek: Klingon (Disc 2) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Star Trek: Klingon (Disc 3) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | 1.0 | Original | | | |
| Star Wars: X-Wing Alliance (Disc 1) | PC | 1.0 | Original | | | |
| Star Wars: X-Wing Alliance (Disc 2) | PC | 1.0 | Original | | | |
| Steal! (Shokai Genteiban Tokuten Data File) | PC | | Shokai Genteiban | | | |
| Steal! (Game Disc) スティール! | PC | | Shokai Genteiban | | | |
| Stronghold Crusader FireFly Studios' Stronghold Crusader | PC | 1.1 | Rerelease | | | |
| Sugu Tsukaeru Sei-Komoku Jouseki すぐ使える星・小目定石 | PC | | Taikenban | | | |
| Suguri スグリ | PC | 2005 8 / 9 | Trial Edition | | | |
| Super Heroine Taisen Vol. 5 スーパーヒロイン大戦vol.5 | PC | | Original | | | |
| Super Heroine Taisen: Touhou Start-ban スーパーヒロイン大戦 東方スタート版 | PC | | Original | | | |
| Sid Meier's Railroad Tycoon | PC | 455.03 | RomZōn! | | 0-447-40-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Scholastic's The Magic School Bus Explores the Solar System | PC | 1.0 | Original | | 0396 Part No. 90618, Disc Assy. 296-052-002 | |
| Same or Different | PC | | Book Bundle | | 08028 | |
| The Sims: Livin' Large (Expansion Pack) | PC | 1.0 | Original | | 1422707 | |
| The Sims: Deluxe Edition (Disc 1) | PC | 1.0 | Original, Double Deluxe, Mega Deluxe | | 1457647 | |
| The Sims: Deluxe Edition (Disc 2) | PC | 1.0 | Original, Double Deluxe, Mega Deluxe | | 1457657 | |
| Silent Steel | PC | 1.24.18.121 | Bundle Version Packard Bell OEM: Demo | | 170308 | |
| Schoolhouse Rock! Math Rock | PC | | Original | | 21010CD | |
| Star Wars: Yoda Stories | PC | 1.0 | Original | | 3111830 | |
| ShadowCaster | PC | | CD-ROM Classics, Electronic Arts Presents | | 5393 | |
| Star Wars: Rebel Assault | PC | 1.7 | White Label, Rerelease | | 632630, CDRM1151470, CDRS1151470 | |
| Sonic & Knuckles Collection | PC | 1.0 | Expert Software, Sonic Action 4 Pack | | 6820 01, T-6820-02 | |
| Starflight II Starflight 2: Trade Routes of the Cloud Nebula | PC | | Top Ten Pak II | | 7588 | |
| Sid Meier's Civilization IV (Disc 1) | PC | 1.61 | Game of the Year Edition | | 77875-1.1REA | |
| Sid Meier's Civilization IV (Disc 2) | PC | 1.61 | Game of the Year Edition | | 77875-1.2REA | |
| Star Wars: Dark Forces | PC | 1.0L Build 1 | Super Sampler Edition: LucasArts Archives Vol. II, The: Star Wars Collection | | 8031831 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | | The LucasArts Archives Vol. II: Star Wars Collection | | 8031832 | |
| Star Wars: Rebel Assault | PC | 1.72 | The LucasArts Archives Vol. II: Star Wars Collection | | 8031833 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | PC | | The LucasArts Archives Vol. II: Star Wars Collection | | 8031834 | |
| Star Wars: Making Magic | PC | QA1.03 | Original, LucasArts Archives Vol. II, The: Star Wars Collection | | 8031835 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | PC | | The LucasArts Archives Vol. II: Star Wars Collection | | 8031836 | |
| Sega Puzzle Pack | PC | | Rerelease | | 85091 / FS22923 | |
| Sid Meier's Civilization III | PC | 1.07f | Small Box Release | | BIPCIV3CDRV1 | |
| Sengoku Basara: Samurai Heroes | PS3 | 01.00 | Original | | BLES-00832 … | |
| Soulcalibur IV | PS3 | 01.00 | Original, Greatest Hits | | BLUS-30160 … | |
| Suzumiya Haruhi no Gyakuten! 2+1 涼宮ハルヒの逆転2+1 | PC | | Original | | CBT-0002 | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | CD 7011 SPI | |
| Star Trek: Starfleet Command II: Empires at War (Disc 1) | PC | 1.0.0.2 | Original | | CD-C95-1185-0 | |
| Star Trek: Starfleet Command II: Empires at War (Disc 2) | PC | 1.0.0.2 | Original | | CD-C95-1185-1 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 2 | Original | | CDRM 770000 | |
| Software JukeBox: Home & Entertainment Edition: Vol. 1 No. 1 | PC | | Original | | CDRM1006830 | |
| Sakura Taisen (Disc 1) サクラ大戦 | SS | 1.005 | Original | | GS-9037 | |
| Sakura Taisen (Disc 2) サクラ大戦 | SS | 1.005 | Original, Tokubetsu Genteiban A type | | GS-9037, GS-9115 | |
| Shin Seiki Evangelion: 2nd Impression 新世紀エヴァンゲリオン ~セカンド・インプレッション~ | SS | 1.012 | Original | | GS-9129 | |
| Shoot the Bullet for Busy Person. Tengu Without Increased Scarlet Devil Mansion 忙しい人のための文花帖 ~紅魔館マシマシ天狗ヌキ~ | PC | | Original | | KSG-0005 | |
| Sorcerian Forever ソーサリアン・フォーエバー | PC | | Ultra 2000/Ultra Series | | MKW-274 | |
| Sora ソラ | PC | 1.0 | Original | | ORDD-0009 | |
| Scrabble: Crossword Game | MAC | 1.0.0.52 | Original | | P/N 10328-5 | |
| Star Wars: Math: Jabba's Game Galaxy | PC | | Original, Scholastic | | P/N CDR5077850 | |
| StarCraft: Brood War (Expansion Set) | PC | 1.05 | StarCraft Battle Chest | | S02416 | |
| Space Quest 6: Roger Wilco: The Spinal Frontier Space Quest 6: Roger Wilco in The Spinal Frontier | PC | 1.0 | Original | | S329430 | |
| StarCraft | PC | 1.05 | StarCraft Battle Chest, Rerelease | | S7154910 | |
| Shadow of the Colossus | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97472 | |
| Shadow Force: Razor Unit | PC | | Special Forces Pack | | SFRU-0414 | |
| Shakugan no Shana 灼眼のシャナ | PS2 | 1.01 | Original, Dengeki SP | | SLPS 25599 … | |
| Simoun: Ibara Sensou: Fuuin no Ri Maajon シムーン 異薔薇戦争 ~封印のリ・マージョン~ | PS2 | 1.02 | Shokai Genteiban | | SLPS 25688 | |
| Silpheed: The Lost Planet | PS2 | 1.20 | Original | | SLUS 20085 … | |
| Star Ocean: Till the End of Time (Disc 1) | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20488 … | |
| Soulcalibur II | PS2 | 1.00 | Original, Greatest Hits, Namco Classic Fighter Collection | | SLUS 20643 … | |
| Star Ocean: Till the End of Time (Disc 2) | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20891 … | |
| Shinji Sougeki Carnival 神事双劇カーニバル | PC | 1.1 | Original | | TTCA-0902 | |