Region | Title | System | Version | Edition | Languages | Serial | Status |
| Scarface: The World Is Yours | PC | 1.00.1 | Rerelease | | S1004045 | |
| Schizm: Mysterious Journey (Side B) | PC | Build 744 | Original | | | |
| Schizm: Mysterious Journey (Side A) | PC | Build 744 | Original | | | |
| Scratches | PC | | Original | | | |
| Scratches: Director's Cut (Disc 1) | PC | | Original | | | |
| Scratches: Director's Cut (Disc 2) | PC | | Original | | | |
| Secret Mission | CDI | | Original | | 814 0133 | |
| The Secret of the Nautilus | PC | | Original | | JVEENCD1 | |
| Sherlock Holmes Trilogy | PC | | Original | | | |
| Sherlock Holmes Versus Jack the Ripper | PC | 1.00.0777 | Original | | | |
| Sherlock Holmes: The Awakened | PC | 1.00.0000 | Original | | | |
| Sherlock Holmes: The Mystery of the Mummy Sherlock Holmes: Het Mysterie van de Mummie | PC | 1.000.0000 | Rerelease | | | |
| Simon the Sorcerer 3D (Disc 1) | PC | | Original | | | |
| Simon the Sorcerer 3D (Disc 2) | PC | | Original | | | |
| Simon the Sorcerer 4: Chaos Happens | PC | 1.01.0000 | Original | | | |
| Sinking Island | PC | | Original | | | |
| Star Trek: Klingon (Disc 1) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | 1.0 | Original | | | |
| Star Trek: Klingon (Disc 2) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | 1.0 | Original | | | |
| Strong Bad's Cool Game for Attractive People | PC | 1.5.0.0 | Original | | | |
| Syberia II (Disc 1) | PC | 1.0 | Original | | 71702102/1 | |
| Syberia II (Disc 2) | PC | 1.0 | Original | | 71702102/2 | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl | PC | | Original, Radiation Edition | | | |
| Sacred Plus (Disc 1) | PC | 1.8.30 | Original | | | |
| Sacred Plus (Disc 2) | PC | 1.8.30 | Original | | | |
| Safecracker | PC | | Original, Gamez Classic / PC Zone Benelux Klassieker | | | |
| SaGa Frontier 2 | PSX | | Original | | SLES-02112 | |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | |
| Sam & Max: Season One | PC | 1.0 | Original | | | |
| Sam & Max: Season Two | PC | 1.5.0.0 | Original | | | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| Samurai Warriors 2 | PS2 | 1.01 | Original | | SLES-54340 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Dice | | DMM 011143 | |
| Secret Files: Tunguska | PC | 1.03 | Original, Xplosiv | | ECD008099M 00060722-01, XP-2221 3026412 | |
| Shadow of Memories | PC | | Original | | | |
| Shin Megami Tensei: Digital Devil Saga | PS2 | 1.00 | Original | | SLES-53458 | |
| Shin Megami Tensei: Persona 2: Innocent Sin | PSP | 1.00 | Original | | ULUS-10584 | |
| Sign of the Sun | PC | | | | | |
| Silent Hill | PSX | | Original, Platinum | | SLES-01514 … | |
| The Sims: Deluxe Edition (Disc 1) | PC | 1.6 | EA Most Wanted, OEM, The Black Box PC Collection | | MXH08803907BD1, MXX08805130D/GER | |
| Space Quest 6: Roger Wilco: The Spinal Frontier Space Quest 6: Roger Wilco in The Spinal Frontier | PC | 1.0 | Original | | S329430 | |
| Space Quest Collection | PC | 1.0 | Original, Sierra Classic Collection | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | SoftKey, SierraOriginals | | CDRM SQU344AE-CD, S4840220012ZZ | |
| Space Quest: Collector's Edition Space Quest: 15th Anniversary Collector's Edition | PC | 1.032 | Original | | S343BBZZ12ZZZ | |
| Star Trek: Judgment Rites | PC | | White Label, White Label: Doubles | | | |
| Star Trek: Klingon (Disc 3) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | 1.0 | Original | | | |
| Star Wars: Rebel Assault: Special Edition | PC | | The LucasArts Archives Vol. I | | 636130 | |
| Star Wars: Screen Entertainment | PC | | Original, The LucasArts Archives Vol. I | | 633630 | |
| Starship Titanic (Disc 1) Douglas Adams: Starship Titanic | PC | 1.00.42 | Original | | | |
| Starship Titanic (Disc 2) Douglas Adams: Starship Titanic | PC | 1.00.42, 1.00.42b | Original, Rerelease | | | |
| Starship Titanic (Disc 3) Douglas Adams: Starship Titanic | PC | 1.00.42, 1.00.42b | Original, Rerelease | | | |
| Suikoden | PSX | | Original | | SLES-00527 | |
| Syberia (Disc 1) | PC | 1.0 | Original | | 64702102/1 | |
| Syberia (Disc 2) | PC | 1.0 | Original | | 64702102/2 | |
| Syberia Collectors Edition: I & II | PC | | Original | | 16660-DVD | |