Region | Title | System | Version | Edition | Languages | Serial | Status |
| En Route: Beginners' French CD-ROM | ARCH | | Original | | | |
| EFF1 Professional Typography 1997 | ARCH | | Original | | | |
| EasiWriter Pro | ARCH | 8.64 | Original | | | |
| End of Eternity エンド オブ エタニティ | XBOX360 | | Original | | SE-2098 | |
| The Elder Scrolls V: Skyrim | XBOX360 | | Original, Legendary Edition (Disc 1), The Elder Scrolls V: Skyrim / BioShock Infinite Bundle | | BS-2022 | |
| Emerald Dragon エメラルド・ドラゴン | PCE | | Original, Tentou Demo-you | | HECD3005 | |
| EverQuest II (Disc 2) | PC | | Original | | 5003644-2 (DVD2) | |
| EverQuest II (Disc 1) | PC | | Original | | 5003644-1 (DVD1) | |
| Europa Universalis IV | PC | | Original | | PDX10507EU | |
| Endless Space | PC | 1.0.30 | Original | | | |
| Empire Earth II: Bonus DVD Exclusive Empire Earth II Bonus DVD | PC | | Pre-Order Bonus | | | |
| The Elder Scrolls IV: Shivering Isles | PC | | Original | | 5052740/OBL | |
| The Elder Scrolls III: Morrowind: Game of the Year Edition | PC | 1.6.1820 | PC Gamer Presents | | 062 MT v.2d.5.4.1 | |
| The Elder Scrolls III: Morrowind: Game of the Year Edition | PC | 1.2.0812 | Green Pepper | | 300011063 | |
| Eye Training | PC | | GSP | | 2031A | |
| Expendable Lite | PC | | Demo | | | |
| EverQuest | PC | | Covermount | | | |
| Evel Knievel Interactive Stunt Game Evel Knievel 3D Stunt Game | PC | | All in One | | | |
| European Racers Build & Race: Motor Stars | PC | 1.0 for DOS | Original | | | |
| Europe Racer | PC | 1.0.0.31 | Driving Collection | | CL-1718 COLLECTIONS | |
| Europa Universalis III: Chronicles | PC | 1.3 | GSP | | 2707A | |
| Etherlords II (Disc 2) | PC | 1.03 | Original | | | |
| Etherlords II (Disc 1) | PC | 1.03 | Original | | | |
| Escape from Monkey Island (Disc 2) | PC | | Original | | 41022.102.UK | |
| Escape from Monkey Island (Disc 1) | PC | 1.2 | Original | | 41022.101.UK | |
| Enemy Engaged: RAH-66 Comanche Versus KA-52 Hokum | PC | 1.0.1C | Grabit | | GDL014 | |
| Empress of the Deep 2: Le Chant de la Baleine Bleue | PC | r1150 (SE-FR) | Just For Fun | | JFF-10-EOTD-OBL | |
| Empire Earth II (Disc 2) | PC | | Original, Best Seller Series | | S1002684, S1003816 | |
| Empire Earth II (Disc 1) | PC | | Original | | S1002683 | |
| Empire Earth II (Playable Demo) Empire Earth II Single Player Demo | PC | | Demo | | S1002622 | |
| Empire Earth | PC | 1.0 | Sold Out Software | | | |
| The Emperor's Mahjong | PC | 1.0.2 | Focus Multimedia | | ESS640 | |
| The Elder Scrolls III: Morrowind (TES Construction Set) | PC | 1.20 | Original, PC Gamer Presents, Game of The Year Edition, Game of the Year Edition (Ubisoft eXclusive Collection) | | 5004125 | |
| The Elder Scrolls III: Morrowind | PC | 1.2.0722 | PC Gamer Presents | | | |
| eGames Strategy Multi-Pack | PC | 1.2 | | | | |
| eGames Galaxy of Games: Blue e2 Games: Blue Edition | PC | 1.2g | Original | | 02-9406-10 | |
| EF2000 | PC | | Wireplay Multi-Player Edition | | PCF62 1296-2 | |
| Edge of Chaos: Independence War 2 (Play Disc) | PC | F8.0 | GSP | | 0998A2 | |
| Edge of Chaos: Independence War 2 (Install Disc) | PC | F8.0 | GSP | | 0998A1 | |
| Edge CD4 | PC | | | | EDGE/54/01/98 | |
| Edge CD3 | PC | | | | EDG/52/12/97 | |
| Edge CD2 | PC | | | | EDG/50/10/97 | |
| Edge CD1 | PC | | | | EDG/47/07/97 | |
| Earthworm Jim: Special Edition | PC | | Covermount | | CDD-3114-01-U3 | |
| Earth Quest | PC | 1.0 | | | | |
| Earth 2150 (Disc 1) | PC | 2.8.7 | Bundle Version Tiny OEM | | KDGT1A | |
| Earth 2150 (Disc 2) 地球2150 | PC | 2.8.7 | Original, Bundle Version Tiny OEM | | KDGT1B | |
| The Early Years of Flight Sternstunden der Luftfahrt | PC | | Original | | | |
| Elansar | DC | 1.000 | Unlicensed | | | |
| EyePet: Move Edition | PS3 | 01.00 | Original, Promo | | BCES-00864 | |