| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | SimCity 3000 Korea | PC | | Original |  | |  |
 | SimCity 3000 | PC | | Pre-Order Bonus |  | 4083407 | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Linux | | | |
| Shrak
Shrak for Quake | PC | 1.0 | Original | | | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | 831744330/S174150 | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.00 | Original | | | |
| Sherlock Holmes: Consulting Detective: Vol. I
Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | Original, 5 ft. 10 PAK Vol. 2 | | CDRM1011460 | |
 | Shanghai: Second Dynasty | PC | | Xplosiv | | EI-1588 ENGLISH | |
 | Shadowlands | PC | | Original, 10 Pack CD-ROM Series, Action CD-ROM 5 Pak | | | |
| Shadow Warrior
Lo Wang is Shadow Warrior | PC | 1.2 | Original, East Meets West | | 04-12539CD | |
| Shadow President
Shadow President: The Simulation of Presidential World Power! | PC | 1.0b | CD-ROM Ten Pak | | | |
| Shadoan | PC | | Demo | | CD-ICD-228-P | |
| Sesame Street Toddler | PC | | Adventure Workshop Tots | | 32180-CD1 v1.0 | |
| The Secret Island of Dr. Quandary | PC | | CD-ROM Ten Pak | | | |
 | Scholastic's The Magic School Bus Explores the Rainforest | PC | 1.0 | Original, Bundle Version OEM | | 0297 Part No. 91323, 1001 Part No. X08-50154, CD SET 420-056-001 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Bundle Version OEM | | 0396 Part No. 90626 | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Spot Goes to Hollywood | SS | 1.000 | Original | | T-7001H | |
| Sega Rally Championship | SS | 1.006 | Original, Sega Saturn NetLink Bundle | | 80012, 81207 | |
| Stellar-Fire | MCD | | Original | | T-110025 | |
| Sonic CD | MCD | | Original | | | |
| Start the Party! | PS3 | 01.01 | Original |    | BCUS-98220 | |
| Suzuki TT Superbikes: Real Road Racing | PS2 | 1.01 | Original | | SLUS 20912 | |
| The Sopranos: Road to Respect | PS2 | 1.01 | Original, Limited Edition | | SLUS 21388 … | |
| Silent Hill 4: The Room | PS2 | 1.00 | Original |  | SLUS 20873 … | |
| The Shield: The Game | PS2 | 1.01 | Original | | SLUS 21040 | |
| Samurai Shodown Anthology | PS2 | 1.01 | Original | | SLUS 21629 | |
| Samurai Champloo: Sidetracked | PS2 | 1.00 | Original | | SLUS 21343 | |
| Street Fighter EX3 | PS2 | 1.00 | Original | | SLUS-20130 | |
 | Stepping Selection (Disc 2)
ステッピングセレクション | PS2 | 1.20 | Original | | SLPS 20019 | |
| Stepping Selection (Disc 1)
ステッピングセレクション | PS2 | 1.20 | Original | | SLPS 20018 | |
