Region | Title | System | Version | Edition | Languages | Serial | Status |
| Scrabble Interactive: 2003 Edition | PC | | Focus Essential | | ESS493 | |
| Scrabble Interactive: 2005 Edition | PC | 1.0 | Covermount: Special Edition | | | |
| Scrabble Interactive: 2007 Edition | PC | 1.1.0 | Ubisoft eXclusive / Focus Essential | | ESS760 | |
| Scrabble: Champion Edition | PC | | Original | | 11191A-CD v1.0 S | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble: Champion Edition | PC | 1.0S | Rerelease | | 11191B-CD | |
| Scratches | PC | | Original | | | |
| Scratches | PC | | Original | | | |
| Scratches: Dans l'Antre de la Peur | PC | 0.92 Build 109 | Original | | 7816 | |
| Scratches: Director's Cut (Disc 1) | PC | | Original | | | |
| Scratches: Director's Cut (Disc 2) | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scratches: Graffi Mortali | PC | | Original | | | |
| Screamball: The Ultimate Pinball Experience | PC | | Original | | | |
| Screamer | PC | | Original, White Label | | | |
| Screamer | PC | | Sold Out Software | | | |
| Screamer | PC | | Screamer Injection | | | |
| Screamer | PC | | Award Winners No. 1 | | EI-1041 | |
| Screamer | PC | | Original | | | |
| Screamer | PC | | Sold Out Extreme | | | |
| Screamer | PC | | Original | | | |
| Screamer | PC | | White Label | | | |
| Screamer | PC | | White Label | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer 2 | PC | | Megapak 8 | | | |
| Screamer 2 | PC | | Sold Out Software | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer 2 | PC | | eXtra Klasyka | | | |
| Screamer 2 Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| Screamer 4x4 | PC | | Original | | CD-W95-V008-M24 | |
| Screamer 4x4 | PC | | Sold Out Software | | | |
| Screamer 4x4 | PC | 1.0 | Original | | CHA-004 | |
| Screamer 4x4 | PC | | Covermount | | | |
| Screamer Rally | PC | | Original, Screamer Injection | | | |
| Screamer Rally | PC | | Sold Out Software | | | |
| Screamer Rally | PC | sov 2.1 | Sold Out Software | | sov. 2.1 | |
| Screamer Rally | PC | | Covermount | | G02 | |
| Screaming Skies | PC | | Tewi | | Bestell-Nr. 27669 | |
| Screen Club: Pocket Monsters スクリーンクラブ ポケットモンスター | PC | | Original | | | |
| Screen Fighter Screen Saver スクリーンファイター スクリーンセーバー | PC | | Original | | SRC-00001 | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| Scribblenauts Unlimited (Asset Disc) | PC | | Press Kit | | | |
| The Scroll | PC | | | | | |
| The Scroll Daughter of Serpents | PC | | Original | | | |
| Scubeginners: I Misteri di Dive Island | PC | 1.1 | Original | | | |
| Scudetto 2 | PC | 1.48 | CD-ROM Classic Collection 3 | | | |
| Scudetto 4: Championship Manager: Stagione 2002-2003 | PC | 4.0.4 | Original | | MCHM4PIT81 | |
| SD Gundam: GGeneration SD 건담: G-제네레이션 | PC | 1.0.0.1 | Original | | | |
| SD Gundam: GGeneration DA SDガンダム GジェネレーションDA | PC | 1.00 | DigiCube PC Series | | DWRMS-00158 | |
| SD Gundam: GGeneration DA SDガンダム GジェネレーションDA | PC | 1.1.0.29 | Original | | BSE-2002 | |
| SD Qlympics Olympic Challenge | PC | | Grabit | | GDL031 | |
| SDevTC: Version 2 | PC | 2 | Original | | | |
| SDevTC: Version 2.4 | PC | 2.4 | Original | | DTL-S2200 | |
| SDS Star Divers スターダイバーズ | PC | | Original | | CS001 | |
| Sea Adventures | PC | | Microforum | | | |
| Sea Battle | PC | | Original | | | |
| Sea Dogs | PC | 1.06 | Green Pepper | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.06 | Sold Out Software | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.06 | Original | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.0 | Original | | | |
| Sea Dogs: Piraci | PC | 1.06 | Nowa eXtra Klasyka | | | |
| Sea Dogs: Piraci | PC | 1.06 | Original | | | |
| Sea Plane Adventures Sea Plane Adventures for FS2002/2004 | PC | | Original | | | |
| Sea Rescue | PC | | Nestlé Corn Flakes | | | |
| Sea War Sea War: Entscheidungsschlacht im Pazifik | PC | | Original | | SPI 023 | |
| Seafight II | PC | | Original | | | |
| Seal: Travelers of Destiny SEAL~運命の旅人~ | PC | | Original | | MKD-1390 | |
| SeaMail: Baby Gillman-hen: Ningen Kankei Shuufuku Hozen Pet シーメール 〈ベビーギルマン編〉 人間関係修復保全ペット | PC | 1.0 | Original | | VPC-0100 | |
| Search & Rescue 3 | PC | 1.0.0.0 | Original | | | |
| Search & Rescue 3 | PC | | Original | | ASS256A181-0001-0001-02 | |
| Search and Rescue Air Rescue | PC | | Grabit | | GDL024 | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Season Ticket Baseball 2003 | PC | 1.0 | Original | | 04-23416CDSL | |
| SeaWorld Adventure Parks Tycoon | PC | | Original | | 31711.101.US | |
| SeaWorld Adventure Parks Tycoon 2 SeaWorld Adventure Parks Tycoon 3D | PC | 1.0 | Original | | 35077.101.US | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| The Second Guest | PC | | Original | | | |
| Second Sight | PC | | Original | | | |
| Second Sight | PC | | Bundle Version ASUS OEM | | V468 | |
| Secret Agent Barbie | PC | 1.0c | Original | | S7127810 | |
| Secret Files: Tunguska (Disc 1) (Play Disc) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 2) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 3) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 4) | PC | 1.0 | Original | | | |
| Secret Game: Code:Revise: Trial Version シークレットゲーム CODE:Revise 体験版 | PC | | Demo | | | |
| The Secret Island of Dr. Quandary | PC | | Softkey | | PDQ944AB-CD | |
| The Secret Island of Dr. Quandary | PC | 1.0 | SoftKey | | PDQ944AE-CD | |
| The Secret of Googol 1: Reshaping Googol: Submarine / Tower | PC | 2.0 | Original | | | |
| The Secret of Googol 2: Reshaping Googol: Castle / Ocean | PC | 2.0 | Original | | | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PC | 2.0 | Original | | | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PC | 2.0 | Original | | | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 7: Eggs All Around: Egg Trek / Balloon Picnic | PC | 2.0 | Original | | | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PC | 2.0 | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| The Secret of Monkey Island | PC | 2.3 | Original, Bundle Version OEM | | 2147010-590001 / I 042 | |
| The Secret of Monkey Island | PC | 2.3 | Original | | 2147010-590001 / I 042 | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | | White Label: Doubles | | | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge The Monkey Island Bounty Pack: The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | 1.0 | LucasArts Classics: The Monkey Island Bounty Pack | | 3000012.101.UK | |
| The Secret of the Nautilus | PC | | Original | | JVEENCD1 | |
| The Secret of the Silver Earring (Disc 1) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of the Silver Earring (Disc 2) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| Secret Safari シークレットサファリ | PC | | Original | | VIRL-8 | |
| Secret Service CD 36 | PC | | | | | |
| Secret Service CD 37 | PC | | | | | |
| Secret Service CD 38 | PC | | | | | |
| Secret Service CD 39 | PC | | | | | |
| Secret Service CD 40 | PC | | | | | |
| Secret Service CD 41 | PC | | | | | |
| Secret Service CD 43 | PC | | | | | |
| Secret Service CD 44 (Strona A) | PC | | | | | |
| Secret Service CD 44 (Strona B) | PC | | | | | |
| Secret Service CD 45 | PC | | | | | |
| Secret Service CD 46 | PC | | | | | |
| Secret Service CD 47 (Strona A) | PC | | | | | |
| Secret Service CD 47 (Strona B) | PC | | | | | |
| Secret Service CD 48 (Strona A) | PC | | | | | |
| Secret Service CD 48 (Strona B) | PC | | | | | |
| Secret Service CD 49 (Strona A) | PC | | | | | |
| Secret Service CD 49 (Strona B) | PC | | | | | |
| Secret Service CD 50 (Strona A) | PC | | | | | |
| Secret Service CD 50 (Strona B) | PC | | | | | |
| Secret Service CD 51 (Strona B) | PC | | | | | |
| Secret Service CD 51 (Strona A) | PC | | | | | |
| Secret Service CD 52 (Strona A) | PC | | | | | |
| Secret Service CD 52 (Strona B) | PC | | | | | |
| Secret Service CD 53 (Strona A) | PC | | | | | |
| Secret Service CD 53 (Strona B) | PC | | | | | |
| Secret Service CD 54 (Strona A) | PC | | | | | |
| Secret Service CD 54 (Strona B) | PC | | | | | |
| Secret Service CD 55 (Strona A) | PC | | | | | |
| Secret Service CD 55 (Strona B) | PC | | | | | |
| Secret Service CD 56 (Strona A) | PC | | | | | |
| Secret Service CD 56 (Strona B) | PC | | | | | |
| Secret Service CD 57 (Strona A) | PC | | | | | |
| Secret Service CD 57 (Strona B) | PC | | | | | |
| Secret Service CD 58 (Strona A) | PC | | | | | |
| Secret Service CD 58 (Strona B) | PC | | | | | |
| Secret Service CD 59 (Strona A) | PC | | | | | |
| Secret Service CD 59 (Strona B) | PC | | | | | |
| Secret Service CD 60 | PC | | | | | |
| Secret Service CD 61 | PC | | | | | |
| Secret Service CD 64 | PC | | | | | |
| Secret Service CD 87 | PC | | | | | |
| Secret Service CD 88 | PC | | | | | |
| Secret Service CD 89 | PC | | | | | |
| Secret Service CD 90 | PC | | | | | |
| Secret Service CD 91 | PC | | | | | |
| Secret Service: Security Breach | PC | 1.1 | Original | | 31035.101.US | |
| Secret Service: Wydanie Specjalne Alone in the Dark | PC | | | | | |
| Secret Weapons of the Luftwaffe | PC | | Collezione CD-Rom by C.T.O. | | | |
| Secret Weapons of the Luftwaffe | PC | | Original | | 2156010-590001/I042, CDRM1003790 | |
| Secret Weapons over Normandy (Disc 1) | PC | 1.0 | Original | | 32609.101.UK | |
| Secret Weapons over Normandy (Disc 2) | PC | 1.0 | Original | | 32609.102.UK | |
| Secret Weapons over Normandy (Disc 3) | PC | 1.0 | Original | | 32609.103.UK | |
| Secret Weapons over Normandy (Disc 4) (Play Disc) | PC | 1.0 | Original | | 32609.104.UK | |
| Secret Weapons over Normandy (Disc 1) | PC | | Original | | 32609.101.GM | |
| Secret Weapons over Normandy (Disc 2) | PC | | Original | | 32609.102.GM | |
| Secret Weapons over Normandy (Disc 3) | PC | | Original | | 32609.103.GM | |
| Secret Weapons over Normandy (Disc 4) (Spiel-CD) | PC | | Original | | 32609.104.GM | |
| Secret Weapons over Normandy (Disco 1) | PC | 1.0 | Original | | 32609.101.IT | |
| Secret Weapons over Normandy (Disco 2) | PC | 1.0 | Original | | 32609.102.IT | |
| Secret Weapons over Normandy (Disco 3) | PC | 1.0 | Original | | 32609.103.IT | |
| Secret Weapons over Normandy (Disco 4) (Disco di Gioco) | PC | 1.0 | Original | | 32609.104.IT | |
| Secret Weapons over Normandy (Disc 1) | PC | 1.0 | Original | | 2101830 | |
| Secret Weapons over Normandy (Disc 2) | PC | 1.0 | Original | | 2101831 | |
| Secret Weapons over Normandy (Disc 3) | PC | 1.0 | Original | | 2101832 | |
| Secret Weapons over Normandy (Disc 4) (Play Disc) | PC | 1.0 | Original | | 2101833 | |
| Les Secrets d'Alamut (Disc 1) | PC | | Original | | ALAFR1P | |
| Les Secrets d'Alamut (Disc 2) | PC | | Original | | ALAFR2P | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Atlantis (Disc 1) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 2) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 3) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Da Vinci: Il Manoscritto Proibito (Disc 1) | PC | 1.02 | Original | | | |
| The Secrets of Da Vinci: The Forbidden Manuscript (Disc 2) | PC | 1.02 | Original | | | |
| The Secrets of Da Vinci: The Forbidden Manuscript (Disc 1) Sekrety Leonarda Da Vinci: Zakazany Manuskrypt | PC | | | | | |
| Secrets of Great Art | PC | 1.1 | Original | | P/N 61218-CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 1) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 2) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 3) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Dark: Der finstere Berg | PC | | Original | | | |
| Secrets of the East | PC | | Scholastic | | P/N CDR9909538 | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Section Z Capcom Classics: Section Z | PC | 1.0 | PDA | | | |
| SeeIn Ao SeeIn青 | PC | 1.00 | Original | | ALS-0040 | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Seek and Destroy | PC | | Original | | CDR3015 | |
| Seek and Destroy Seek & Destroy | PC | | Original | | EPSAD01 | |
| Seek and Destroy Seek & Destroy | PC | 1.0 | Original | | J230D | |
| Sega Bass Fishing 钓鱼高手 | PC | 1.0 | Original | | | |
| Sega Bass Fishing | PC | | Sega Bass Fishing & Sega Marine Fishing: Xplosiv | | EI-1607 | |
| Sega Bass Fishing | PC | | Original | | EI-1269 | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Sega E3 Press Kit 2005 2005 E3 Press Kit | PC | | Press Kit | | | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega Game Honpo: Puyo Puyo セガゲーム本舗 ぷよぷよ | PC | | Original | | | |
| Sega Game Honpo: Wonder Boy V, Monster World III セガゲーム本舗 ワンダーボーイⅤ モンスターワールドⅢ | PC | | Original | | SGH-013 | |
| Sega Genesis Classic Collection: Gold Edition | PC | 1.0.019 | Original | | | |
| Sega GT (Disc 1) (Installation Disc) | PC | | Original, Xplosiv | | EI-1266-1, EI-1266-1 ENGLISH | |
| Sega GT (Disc 2) (Play Disc) | PC | | Original | | EI-1266-2 | |
| Sega GT (Disc 1) (Installation Disc) | PC | | Original | | EI-1266-1 | |
| Sega GT (Disc 2) (Play Disc) | PC | | Original | | EI-1266-2 | |
| Sega Marine Fishing | PC | | Sega Bass Fishing & Sega Marine Fishing: Xplosiv | | EI-1606 | |
| Sega Mega Drive Classic Collection Volume 1 | PC | | Original | | SEGA-PC118 | |
| Sega Mega Drive Classic Collection Volume 2 | PC | | Original | | SEGA-PC119 | |
| Sega Mega Drive Classic Collection Volume 3 | PC | | Original | | SEGA-PC120 | |
| Sega Mega Drive Classic Collection Volume 4 | PC | | Original | | SEGA-PC121 | |
| Sega Mega Drive Classic Collection: Złota Edycja | PC | 1.0.019 | Platynowa Kolekcja | | P_37010_04A_PL | |
| Sega Memorial Selection: Dear 80's Videogame Best 3 | PC | | Ultra 2000/Ultra Series | | MKW-183 | |
| Sega PC Greatest Hits Series Vol. 2 | PC | | Taikenban, PC Game Bundle | | 670-10528 | |
| Sega PC Greatest Hits Series Vol. 3 | PC | | PC Game Bundle | | 670-11970 | |
| Sega PC Greatest Hits Series Vol. 3 | PC | | Demo | | 670-11970 | |
| Sega PC Greatest Hits Series Vol. 3 | PC | | Demo | | 670-11877 | |
| Sega PC Special Trydisc Vol. 1 Sega PC すべしゃる トライディスク Vol.1 | PC | | PC Game Bundle | | 670-9986 | |
| Sega Press Materials | PC | | Press Kit | | | |
| Sega Puzzle Pack | PC | | Original | | 673-01815 | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Sega Puzzle Pack | PC | | Rerelease | | 85091 / FS22923 | |
| Sega Puzzle Pack | PC | | Expert Software | | 682701.101.US | |
| Sega Rally (Uaktualnienie Wersji Polskiej) | PC | | Original, TopSeller | | | |
| Sega Rally 2 (Install Disc) Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sega Rally 2 (Play Disc) Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sega Rally 2 (Disc 1) (Install Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-1 | |
| Sega Rally 2 (Disc 2) (Play Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-2 | |
| Sega Rally 2 (Disc 1) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0919 | |
| Sega Rally 2 (Disc 2) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally 2: Sega Rally Championship (Install Disc) セガラリー2 | PC | | DigiCube PC | | DWRPD-00081 | |
| Sega Rally 2: Sega Rally Championship (Play Disc) セガラリー2 | PC | | DigiCube PC | | DWRPD-00081 | |
| Sega Rally Championship Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 | |
| Sega Rally Championship | PC | 1.0 | Original | | 85048 | |
| Sega Rally Championship PC | PC | 1.0 | Original | | MK 85048-50 | |
| Sega Rally Championship PC | PC | 1.0 | Expert Software | | XP 202022 01 | |
| Sega Rally Championship PC | PC | 2.11 | Original | | MK 85048MX-50 | |
| Sega Rally Championship PC | PC | 2.11 | Fair Game, Grabit | | FG-1282, GDL016 | |
| Sega Rally Championship PC | PC | | Green Pepper | | | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | MKW-031 | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Mihon-hin | | 670-10314 | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Original | | 670-9827 | |
| Sega Saturn Development Tool Kit | PC | | Original | | 610-5750 | |
| Sega Screenshots 2000 Sega E3 2000 | PC | | Press Kit | | | |
| Sega Smash Pack | PC | | Original | | 673-01668 | |
| Sega Smash Pack | PC | | Original | | 85087 | |
| Sega Smash Pack | PC | 1.0 | Expert Software | | 682601.101.US | |
| Sega Smash Pack 2 | PC | | Original | | 673-01986 | |
| Sega Smash Pack 2 | PC | | Original, Sonic Action 4 Pack | | 30107.101.US | |
| Sega Smash Pack II | PC | | Bundle Version Tiny OEM | | KDGT44 | |
| Sega Smash Pack Twin Pack | PC | | Original | | 30884.101.US | |
| Sega Touring Car Championship 世嘉巡回车大赛 | PC | | Original | | | |
| Sega Touring Car Championship | PC | | Fair Game: Quality Value | | FG-1306 EUROPEAN | |
| Sega Touring Car Championship | PC | 1.0 | Original | | MK 85067-50 | |
| Sega Touring Car Championship | PC | 1.0 | Xplosiv | | EI-1306 | |
| Sega Touring Car Championship | PC | 1.0 | Expert Software | | 681301.201.UK 01 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | 85067 | |
| Sega Worldwide Soccer PC | PC | | Original | | MK 85056-50 | |
| Sega Worldwide Soccer PC | PC | | Fair Game | | FG-1281 | |
| Sega Worldwide Soccer PC | PC | | 3D Power Pack | | 500-0009-50 | |
| Sega Worldwide Soccer PC セガワールドワイドサッカーPC | PC | 1.09J | PCHome | | 506-9781 | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| SegaKara for PC セガカラ for PC | PC | 4.0.100 | Original | | | |
| Segata Sanshirou: Choujin Densetsu せがた三四郎 超人伝説 | PC | | Original | | HCJ-0346 | |
| Sei Shirasagi Jogakuen Vol. 2: Tsukahara Shiho-hen 聖シラサギ女学園 Vol.2 塚原 シホ編 | PC | | Original | | SCR-1997-02 | |
| Sei Shirasagi Jogakuen Vol. 3: Sunada Misaki-hen 聖シラサギ女学園 Vol.3 砂田 ミサキ編 | PC | | Original | | SCR-1997-03 | |
| Seijo Vampire 聖女ヴァンパイア | PC | | Original | | MMM-7881 | |
| Seikai Risshiden: Kimi wa Nihon no Leader ni Nareru ka! 政界立志伝~君は日本のリーダーになれるか!~ | PC | | | | MSDJ-99094 | |
| Seikimatsu Taimaden Tsumugi-chan SOS 世紀末退魔伝つむぎちゃんSOS | PC | | Original | | EXC-0011 | |
| Seiyuu Kantoku Simulation: Standby Say You! (Disc 1) 声優監督シミュレーション スタンバイSay You! | PC | | | | HMW-1 | |
| Seiyuu Kantoku Simulation: Standby Say You! (Disc 2) 声優監督シミュレーション スタンバイSay You! | PC | | | | HMW-1 | |
| Sekai Saikyou Ginsei Igo 世界最強銀星囲碁 | PC | 2.2 | Great Series | | MKW-161 | |
| Sekai Saikyou Ginsei Igo 2 世界最強銀星囲碁2 | PC | 3.0 | Yuuyuu 1,980-yen | | | |
| Selection 2000 Dai-10-Dan: Osaka Ennichi セレクション2000 第10弾 大阪縁日 | PC | OE1-2V1.00 | Selection 2000 | | SSA0010 | |
| Sem' Samuraev (Disc 1) Семь Самураев | PC | | Original | | | |
| Sem' Samuraev (Disc 2) Семь Самураев | PC | | Original | | | |
| Semper Fi | PC | | Original | | | |
| Sengoku Bishoujo Emaki: Kuu o Kiru!! 戦国美少女絵巻 空を斬る!! | PC | | Original | | TGL-98 0220 | |
| Sengoku Bishoujo Emaki: Kuu o Kiru!! Harukaze no Shou 戦国美少女絵巻 空を斬る!! ~春風の章~ | PC | | Original | | | |
| Sengoku Shougi 戦国将棋 | PC | | Power Game 1800 Series | | GA-0001 | |
| Senha N. 1 | PC | | | | | |
| Senjou de Shoujo wa Karada o Kakeru: Briefing Disc 戦場デ少女ハ躰ヲカケル ブリーフィングDISC | PC | | Demo | | | |
| Senkaku Mondai o Yatchimasu 2 尖閣問題を殺っちます2 | PC | | Original | | | |
| Sensei 2 Запретное влечение | PC | | Original | | | |
| Sensei 2 | PC | | Original | | GC-007 | |
| Senshi no Ketsudan: Combat Force 戦士の決断 コンバット フォース | PC | 1.0 | Original | | KN12-12201 | |
| Sensible Golf | PC | | Original | | | |
| Sensible Soccer '98 | PC | | Original | | | |
| Sensible Soccer 2006 | PC | 1.00.0000 | Original | | MSS1CDEU00 | |
| Sensible Soccer 2006 | PC | 0.0.0.1 | Original | | | |
| Sensible Soccer: European Club Edition | PC | | Original | | | |
| Sensible World of Soccer | PC | 1.0 | Original | | | |
| Sensible World of Soccer '96/'97 (Upgrade PC CD-ROM Disc) | PC | | Original | | | |
| Sensible World of Soccer '96/'97 | PC | 2.0 | Original | | | |
| Sensible World of Soccer '96/'97 | PC | 2.0 | Replay | | | |
| Sensible World of Soccer: European Championship Edition | PC | 1.2 | White Label | | | |
| Sentient | PC | 1.4.0.124 | Original | | | |
| Sentient | PC | | Original | | | |
| Sentimental Graffiti (Disc 1) センチメンタルグラフティ | PC | | Original | | ID NO.9718-X8-01A | |
| Sentimental Graffiti (Disc 2) センチメンタルグラフティ | PC | | Original | | ID NO.9718-X8-01B | |
| Sentimental Graffiti 2 (Disc 1) 青澀寶貝2:青澀之戀 | PC | 1.00 | Original | | | |
| Sentimental Graffiti 2 (Disc 2) 青澀寶貝2:青澀之戀 | PC | 1.00 | Original | | | |
| Sentinel Returns | PC | | Original | | | |
| Sentinel Returns | PC | 1.0 | Original | | CDAC-148200 | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Sentinel: Il Regno delle Illusioni (Disc 1) | PC | 1.0 | | | | |
| Sentinel: Il Regno delle Illusioni (Disc 2) | PC | 1.0 | | | | |
| Sentinel: Strazh vremeni (Disc 1) Sentinel: Страж времени | PC | 1.0 | Original | | | |
| Sentinel: Strazh vremeni (Disc 2) Sentinel: Страж времени | PC | 1.0 | Original | | | |
| Sento Monogatari: Sono I 「占都物語」 そのI | PC | | Original | | | |
| Sentou Yousei Yukikaze: Yousei no Mau Sora (Disc 1) (Installation CD-ROM) 戦闘妖精雪風~妖精の舞う空~ | PC | | Original | | SYYi-V1.00 | |
| Sentou Yousei Yukikaze: Yousei no Mau Sora (Disc 2) (Game CD-ROM) 戦闘妖精雪風~妖精の舞う空~ | PC | | Original | | SYYg-V1.00 | |
| Septerra Core: Legacy of the Creator 赛普特拉战记 | PC | 1.02 | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Original | | | |
| Septerra Core: Legacy of the Creator | PC | | Covermount | | ADB 0103 | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Original | | TWI011 | |
| Septerra Core: Legacy of the Creator | PC | 1.02 | Gold Strategy Games, Rerelease | | TWI011 | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Covermount | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Covermount | | | |
| Septerra Core: Legacy of the Creator | PC | | Original | | 1CSP OR03 0020 IR | |
| Septerra Core: Legacy of the Creator | PC | 1.02 | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Rerelease | | CD-W58-1103-1 | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Original | | CD-W58-1103-0 | |
| Septerra Core: Legacy of the Creator | PC | 1.02 | Dual Jewel | | CD-C95-1298-1 | |
| Sequence Palladium シークエンス パラディウム | PC | | Original | | KGDP004 | |
| Sequence Palladium シークエンス パラディウム | PC | | DigiCube, Media Kite Great Series | | DWRPM-00089, MKW-182 | |
| Sequence Palladium シークエンス パラディウム | PC | 1.0.0.1 | Original | | WIC-5952 | |
| Sequence Palladium 2 Mania Kit | PC | | Original | | KGD-0060 | |
| Sequence Palladium 2: Yami no Shousei シークエンス・パラディウム2 ~闇の笑声~ | PC | 1.0 Build 1049 | Original | | KGD-9990 | |
| Sequence Palladium 3: Utakata no Ametsuchi (Disc 1) シークエンス・パラディウム3 ~泡沫の天地~ | PC | | Original | | KGD-04060 | |
| Sequence Palladium 3: Utakata no Ametsuchi (Disc 2) シークエンス・パラディウム3 ~泡沫の天地~ | PC | | Original | | KGD-04061 | |
| Sequence Palladium Mania Kit: Desktop Accessory シークエンス・パラディウム マニアキット デスクトップアクセサリ | PC | | Original | | WIC-6346 | |
| Sequence Palladium Premium Digital Novel | PC | | PC Game Bundle | | KGD-06021 | |
| Seraphim: Saigo no Tenshi セラフィム 最後の天使 | PC | | Original | | SCR-003 | |
| Serious Sam Gold (Disc 1) | PC | 1.05 | Original | | | |
| Serious Sam Gold (Disc 2) | PC | 1.05 | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Serious Sam: Drugie Starcie Serious Sam: The Second Encounter | PC | 1.05 | Original | | | |
| Serious Sam: Pierwsze Starcie Serious Sam: The First Encounter | PC | 1.00b | Original | | | |
| Serious Sam: The First Encounter | PC | | | | | |
| Serious Sam: The First Encounter 英雄萨姆 | PC | 1.00 | Original, Zhima Kai Men | | | |
| Serious Sam: The First Encounter | PC | 1.00a | Original, TakeAdvantage | | | |
| Serious Sam: The First Encounter | PC | 1.05 | Gold Edition (PC Gamer Presents) | | | |
| Serious Sam: The First Encounter | PC | 1.05 | Gold Edition | | | |
| Serious Sam: The First Encounter | PC | 1.00a | Software Pyramide | | | |
| Serious Sam: The First Encounter | PC | 1.00a | Covermount | | | |
| Serious Sam: The First Encounter シリアス サム | PC | 1.00 | Original | | | |
| Serious Sam: The First Encounter Крутой Сэм: Первая Кровь | PC | 1.00b | 1C: Kollekciya igrushek | | | |
| Serious Sam: The First Encounter | PC | 1.00 | Original | | | |
| Serious Sam: The First Encounter | PC | 1.02 | Bundle Version Gainward OEM | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| Serious Sam: The Second Encounter 英雄萨姆2 | PC | 1.05 | Original | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Original, TakeAdvantage | | | |
| Serious Sam: The Second Encounter | PC | 1.07 | Gold Edition (PC Gamer Presents) | | | |
| Serious Sam: The Second Encounter | PC | 1.07 | Gold Edition, Covermount | | | |
| Serious Sam: The Second Encounter | PC | | Rerelease | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Software Pyramide | | | |
| Serious Sam: The Second Encounter シリアス サム:ザ セカンド エンカウンター | PC | 1.05 | Original | | | |
| Serious Sam: The Second Encounter Крутой Сэм: Второе пришествие | PC | 1.05 | 1C: Kollekciya igrushek | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Original | | | |
| Serp i Molot (Disc 1) Серп и Молот | PC | | 1C: Igroteka | | | |
| Serp i Molot (Disc 2) Серп и Молот | PC | | 1C: Igroteka | | | |
| Serp i Molot (Disc 3) Серп и Молот | PC | | 1C: Igroteka | | | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Serve & Volley | PC | | Telstar Fun & Games | | TFGD 2178/4 | |
| Sesame Street Reading is Fun! Toddler (Disc 1) (Grover's Travels) | PC | 2.0 | Original | | SRF844AE-CD-1 | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Sesame Street Search & Learn Adventures | PC | | Original, Software for the fun of it | | EOA844AE-CD, KES005 | |
| Sesame Street Toddler: Elmo's Art Workshop (Disc 2) | PC | 3.0 | Rerelease | | STL744AE-CD2 | |
| Sesame Street: Art Workshop | PC | | Original | | 9369 | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Elmo's Art Workshop | PC | | Original | | EAW844AE-CD | |
| Sesame Street: Elmo's Preschool | PC | | | | 11040CD | |
| Sesame Street: Elmo's Preschool (Disc 1) (Elmo's Preschool) | PC | 3.1 | Original | | P/N 379663-CD1 | |
| Sesame Street: Elmo's Preschool (Disc 2) (Search & Learn Adventures) | PC | 3.1 | Original | | P/N 379663-CD2 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 1) (Elmo's Preschool) | PC | 2.0 | | | SPC844AE-CD-1 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 2) (Search & Learn Adventures) | PC | 2.0 | | | SPC844AE-CD-2 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 1) (Reading Basics) | PC | | Original | | EPK-744AE-CD1 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| Sesame Street: Let's Make a Word! | PC | | Bundle Version Creative Labs OEM | | 1713310119-1 | |
| Sesame Street: Let's Make a Word! | PC | | Original, Software for the fun of it | | KES006 | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: Letters | PC | | | | 9367A | |
| Sesame Street: My Baby & Me (Disc 1) (Baby & Me) | PC | 1.0 | Original | | SSY744AE-CD1 | |
| Sesame Street: My Baby & Me (Disc 2) (Sesame Street Greatest Hits Sampler) | PC | 1.0 | Original | | SSY744AE-CD2 | |
| Sesame Street: Numbers Улица Сезам: Учись считать | PC | | Original | | | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Preschool Улица Сезам: Элмо готовит в школу | PC | | Original | | | |
| Sesame Street: Reading Basics | PC | | Encore | | 10200 | |
| Sesame Street: Toddlers Deluxe (Disc 1) (Art Workshop) | PC | 2.0 | Original | | STO844AE-CD-1 | |
| Sesame Street: Toddlers Deluxe (Disc 2) (Letters) | PC | 2.0 | Original | | STO844AE-CD-2 | |
| Sesame Street: Toddlers Deluxe (Disc 3) (Numbers) | PC | 2.0 | Original | | STO844AE-CD-3 | |
| Sesamstrasse: Auf die Krümel, fertig, los! | PC | | Rerelease | | GSL854AG-CD | |
| Sethi und das Geheimnis der Neandertaler | PC | | Rerelease | | | |
| Sethi: Abenteuer im Mittelalter National Geographic: Sethi: Abenteuer im Mittelalter | PC | | Original | | | |
| The Settlers II | PC | | Demo | | | |
| The Settlers II | PC | 1.02 | Dice | | DCG 901570 | |
| The Settlers II | PC | 1.51 | Strefa Niskich Cen | | | |
| The Settlers II: 10-lecie The Settlers II: 10th Anniversary | PC | | eXtra Klasyka Next | | | |
| The Settlers II: 10th Anniversary | PC | | Original | | 5004880 | |
| The Settlers II: 10th Anniversary Die Siedler II: Die nächste Generation | PC | | Gold Edition (Software Pyramide) | | 300025385 | |
| The Settlers II: 10th Anniversary: Vikings Die Siedler II: Die nächste Generation: Wikinger | PC | | Gold Edition (Software Pyramide) | | 300025389 | |
| The Settlers II: Nowe Misje | PC | 1.51 | Strefa Niskich Cen | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.02 | Original | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | Rerelease | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | | Budget | | MMICDR 5803 | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | PC Best Buy | | | |
| The Settlers II: Złota Edycja | PC | 1.51 | eXtra Klasyka | | | |
| The Settlers III (Disc 1) 工人物語III | PC | 1.23 | Original | | | |
| The Settlers III (Disc 1) | PC | 0.0.0.91 | Original | | | |
| The Settlers III (Disc 1) | PC | 0.0.0.123 | | | | |
| The Settlers III (Disc 2) | PC | 0.0.0.123 | Original | | | |
| The Settlers III (Disc 1) | PC | 1.54 | PC Best Buy | | 900562a | |
| The Settlers III (Disc 2) | PC | 1.54 | PC Best Buy | | 900562b | |
| The Settlers III (Disc 2) | PC | 0.0.0.91 | Original | | | |
| The Settlers III (Disc 1) | PC | | Revival | | REV036 | |
| The Settlers III (Disc 1) | PC | | Revival | | REV036 | |
| The Settlers III (Disc 2) | PC | | Revival | | REV036 | |
| The Settlers III (Disc 2) | PC | | Revival | | REV036 | |
| The Settlers III: Gold Edition (Disc 1) | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Gold Edition (Disc 2) | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Misja Amazonek | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Nowe Misje (Disc 1) | PC | 1.25.0.125 | | | | |
| The Settlers III: Nowe Misje (Disc 2) | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| The Settlers III: Złota Edycja (Disc 1) | PC | | Nowa eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 1) | PC | 1.25.0.125 | | | | |
| The Settlers III: Złota Edycja (Disc 1) | PC | 1.25.0.125 | Nowa eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 2) | PC | | Nowa eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 2) | PC | 1.25.0.125 | | | | |
| The Settlers III: Złota Edycja (Disc 2) | PC | 1.25.0.125 | Nowa eXtra Klasyka | | | |
| The Settlers IV 工人物语IV | PC | 1.09.876 | Original | | | |
| The Settlers IV | PC | 1.01.761 | Original | | | |
| The Settlers IV | PC | | Original | | | |
| The Settlers IV | PC | 1.06.815 | Original | | | |
| The Settlers IV ザ・セトラーズ4 | PC | 2.04.1090 | | | | |
| The Settlers IV | PC | 1.06.811 | Original | | | |
| The Settlers IV | PC | 1.02.764 | | | | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| The Settlers IV: Gold Edition (Disc 1) | PC | | Original | | | |
| The Settlers IV: Gold Edition (Disc 1) | PC | | Focus Essential | | ESS565 | |
| The Settlers IV: Gold Edition (Disc 2) | PC | | Gold Edition | | | |
| The Settlers IV: Gold Edition (Disc 2) | PC | | Focus Essential | | ESS565 | |
| The Settlers IV: Misje Dodatkowe | PC | 1.10.908 | | | | |
| The Settlers IV: Mission CD | PC | 1.10.908 | Original | | | |
| The Settlers IV: The Trojans and the Elixir of Power | PC | 2.01.1056 | Original | | | |
| The Settlers IV: Trojanie i Eliksir Mocy | PC | 2.4.1090.0 | Original | | | |
| The Settlers IV: Złota Edycja | PC | | Nowa eXtra Klasyka | | | |
| The Settlers IV: Złota Edycja | PC | 2.50.1516.0 | eXtra Klasyka Next | | | |
| The Settlers IV: The Trojans and the Elixir of Power The Settlers IV: A Trójaiak és a Hatalom Elixírje | PC | 2.50.1508 | Original | | | |
| The Settlers | PC | | Rerelease | | | |
| The Settlers | PC | | Strefa Niskich Cen | | | |
| The Settlers | PC | | Strefa Niskich Cen | | | |
| The Settlers | PC | | eXtra Klasyka | | | |
| The Settlers | PC | | PC Best Buy Pocket | | 900813 | |
| The Settlers: Dziedzictwo Królów (Disc 1) The Settlers: Heritage of Kings | PC | 1.01.0163 | Original | | | |
| The Settlers: Dziedzictwo Królów (Disc 2) The Settlers: Heritage of Kings | PC | 1.01.0163 | Original | | | |
| The Settlers: Heritage of Kings (Disc 1) The Settlers: Dědictví Králů | PC | 1.03.0190 | Original | | | |
| The Settlers: Heritage of Kings (Disc 2) The Settlers: Dědictví Králů | PC | 1.03.0190 | Original | | | |
| The Settlers: Heritage of Kings (Disc 1) | PC | 1.1.163.0 | Original | | 5003818-1 | |
| The Settlers: Heritage of Kings (Disc 2) | PC | 1.1.163.0 | Original | | 5003818-2 | |
| The Settlers: Heritage of Kings: Expansion Disc | PC | 1.3.190.0 | Original | | 5004043 | |
| The Settlers: Heritage of Kings: Gold Edition (Legends Expansion Disc) | PC | | That's Hot! | | 5004531 | |
| The Settlers: Nasledie korolej (Disc 1) The Settlers: Наследие королей | PC | 1.03.0190 | Original | | | |
| The Settlers: Nasledie korolej (Disc 2) The Settlers: Наследие королей | PC | 1.03.0190 | Original | | | |
| Seven Games of the Soul (Disc 1) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 2) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 3) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 4) Faust | PC | | Original | | | |
| Seven Kingdoms | PC | 1.1 | Colección 'Juega y Aprende' | | | |
| Seven Kingdoms | PC | | Play the Games Vol. 1 | | | |
| Seven Kingdoms | PC | 1.0 | Original | | 04033 CD | |
| Seven Kingdoms II: The Fryhtan Wars 七国演义II:群魔乱舞 | PC | 1.0 | Rerelease | | | |
| Seven Kingdoms II: The Fryhtan Wars | PC | | Original | | | |
| Seven Kingdoms II: The Fryhtan Wars | PC | | Cool Games | | | |
| Seven Kingdoms: Ancient Adversaries | PC | 2.00 | Original, 2in1 Pack | | | |
| Seven Kingdoms: Ancient Adversaries | PC | | | | | |
| Seven Kingdoms: The Fryhtan Wars / Shadow Company: Left for Dead | PC | | Demo | | 5051859 | |
| Seven Years War 2 セブン イヤーズ ウォー 2 | PC | 1.101 | Original | | SUNC-W1004E1 | |
| Seven Years War 2 決戰王朝 | PC | 1.090ER | Original | | | |
| Seven Years War 2 + Joseonui Bangyeok 임진록 2 + 조선의 반격 | PC | | Hapbon | | | |
| The Seventh Seal: The Resurrection of the Dark Lord (Disc 2) 第七封印 魔神苏醒第七封印:魔神甦醒 | PC | 2.0.0.0 | Original, Limited Edition | | | |
| The Seventh Seal: The Resurrection of the Dark Lord (Anzhuang Cidie 1) 第七封印:魔神甦醒 | PC | | Original | | | |
| The Seventh Seal: The Resurrection of the Dark Lord (Anzhuang Cidie 2) 第七封印:魔神甦醒 | PC | | Original | | | |