Region | Title | System | Version | Edition | Languages | Serial | Status |
| Stickybear Preschool | CDI | 1.05 | Original | | 810 0218 | |
| Stickybear Preschool | CDI | | Pre-Release Demonstration Disc | | 310-690-257-2 | |
| Stickybear Preschool | CDI | | Original, Demonstration Disc | | 310-690-257-2, 310690257-2 | |
| Stickybear Reading Stickybear Leyendo | CDI | | Original, Demonstration Disc | | 310-690-083-2, 310690083-2, 816 0040 | |
| Sting: Ten Summoner's Tales | CDI | 1.03 | Original | | 089 5664 | |
| Stomach in Motion | CDI | | Original | | WIM 060792 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2, 699 025-2 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Story Maschine: Galaxis | CDI | | Original | | 813 0032 | |
| Story Maschine: Märchenzauber | CDI | | Original | | 813 0026 | |
| The Story of Jonah | CDI | 2.04 | Original, FPD | | 310-690-067-2, 310690067-2 | |
| The Story of Samson | CDI | | Original, Demonstration Disc | | 310-690-190-2, 310690190-2 | |
| Stretch-Top System: Wasserbett-Information Stretch-Top System: Waterbed-Information | CDI | | Original | | | |
| Striker Pro | CDI | 1.14 | Original | | 810 0186, 810 0187, 811 0044 | |
| Striker Pro | CDI | | Original, Demonstration Disc | | 310-690-143-2, 310690143-2 | |
| Strip Poker Live | CDI | 1.04 | Original | | 810 0257 | |
| Strip Poker Live | CDI | | Original | | IM99002 | |
| Strip-Poker Pro | CDI | | Original | | 8120142 | |
| Die Stunde der Patrioten (Disc 1) | CDI | | Original | | 813 1004 | |
| Die Stunde der Patrioten (Disc 2) | CDI | | Original | | 813 1004 | |
| Super Mario's Wacky Worlds | CDI | 0.11 | Prototype | | | |
| Super Stories: Mom is Going to Stop It | CDI | | | | | |
| Super Stories: My Favorite Things | CDI | | | | | |
| SuperTest | CDI | 1.01 | Beta | | 810 0168 | |
| SuperTest | CDI | 1.03 | Original | | 810 0168 | |
| Surf City | CDI | 1.07 | Original | | 810 0091 | |
| Surf City | CDI | | Original, Demonstration Disc | | 310-690-131-2, 310690131-2 | |
| SVO: Opleiding voor de Vleessector: Het Bewerken van Varkensvlees SVO Opleiding voor de Vleessector te Utrecht | CDI | | Original | | | |
| SVO: Opleiding voor de Vleessector: Hygiëne en Verse Voeding SVO Opleiding voor de Vleessector te Utrecht | CDI | | Original | | | |
| Swiss Click | CDI | | Original | | | |
| Synthelabo: Cardio-Vasculaire Dausse 1995: Cours de Perfectionnement en Imagerie Cardiaque | CDI | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Space Ace | AJCD | | Original | | | |
| Sakura Taisen: Teigeki Secret File サクラ大戦 ~帝劇シークレット・ファイル~ | PHOTO-CD | | Magazine Bundle | | SSMP-00001 | |
| Sangaku Shashin Photo CD Series Vol. 1: Shirouma Takeshi Ushiro Tateyama Renpou 山岳写真フォトCDシリーズVol.1 白馬岳・後立山連峰 | PHOTO-CD | | Original | | AS 0001 | |
| Sangaku Shashin Photo CD Series Vol. 2: Hotaka Kamikochi 山岳写真フォトCDシリーズVol.2 穂高・上高地 | PHOTO-CD | | Original | | AS 0004 | |
| Sangaku Shashin Photo CD Series Vol. 3: Yatsugatake 山岳写真フォトCDシリーズVol.3[八ケ岳] | PHOTO-CD | | Original | | AS 0005 | |
| Sangaku Shashin Photo CD Series Vol. 4: Tateyama 山岳写真フォトCDシリーズVol.4[立山] | PHOTO-CD | | Original | | AS 0006 | |
| Sangaku Shashin Photo CD Series Vol. 5: Oze 山岳写真フォトCDシリーズVol.5[尾瀬] | PHOTO-CD | | Original | | AS 0007 | |
| Schoenbrunn | PHOTO-CD | | Original | | | |
| Die Schönsten Hotels der Welt | PHOTO-CD | | Original | | 813 0060 | |
| School Mates Collection | PHOTO-CD | | Original | | SJ-0001 | |
| Seikaku Shindan Game: Ukiyo-e Sumo-hen 性格診断ゲーム 浮世絵相撲編 | PHOTO-CD | | Original | | NPCD-1005 | |
| Sexy Bytes: Housewives 2 | PHOTO-CD | | Original | | | |
| Sexy Bytes: Lacquer & Leather | PHOTO-CD | | Original | | | |
| Sexy Bytes: Office Sex | PHOTO-CD | | Original | | | |
| Sexy Bytes: Outside Dreams | PHOTO-CD | | Original | | | |
| Sexy Bytes: Rolling Mountains | PHOTO-CD | | Original | | | |
| Sexy Bytes: Studio Girls 1 | PHOTO-CD | | Original | | | |
| Shiho Shashin-shuu SHIHO写真集 | PHOTO-CD | | Original | | FZ-JJ1YP0401 | |
| Shimada Youko: Quatre 島田陽・子カトル | PHOTO-CD | | Original | | FZ-JJ1YP0501 | |
| Shinpi no Sekai: El Hazard 神秘の世界 エルハザード | PHOTO-CD | | Original | | PIRW-1010 | |
| Snowboard "Trick x Trick" スノーボード”トリック×トリック” | PHOTO-CD | | Original | | AS 0003 | |
| Sotsugyou Genga-shuu 卒業原画集 | PHOTO-CD | | Original | | CRMP-1001 | |
| Souzou Sozai: Europe no Mado Vol. 2 創造素材 ヨーロッパの窓 Vol.2 | PHOTO-CD | | Original | | ERV2 | |
| Souzou Sozai: Umi Vol. 1 創造素材 海 Vol.1 | PHOTO-CD | | Original | | SEVI-1049 | |
| Space Shuttle スペースシャトル | PHOTO-CD | 1.1 | Original | | C02H | |
| Starry the Universe 大宇宙 遥かなる大星雲 | PHOTO-CD | | Original | | PLP-5003 | |
| Steelwood: Private Eye 名探偵スチールウッド | PHOTO-CD | | Original | | PX-001 | |
| Steelwood: Private Eye II 名探偵スチールウッドⅡ | PHOTO-CD | | Original | | PX-006 | |
| Sumida Yuki: Photo CD Portfolio 墨田ユキ フォトCDポートフォリオ | PHOTO-CD | | Original | | GLS-PH-08 | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |
| The Super Model Vol. 1: Gail McKenna ゲイル・マッケンナ | PHOTO-CD | | | | TPS-19011 | |
| Suppin Bishoujo Vol. 3 すっぴん美少女 vol.3 | PHOTO-CD | | Original | | SPN-003 | |
| Snake II | FPP | | Service Release Update 2001 | | 7710117 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Serious Sam: The First Encounter | PALM | | Original | | | |
| Shanghai for Palm 上海 for Palm | PALM | 1.0 | Original | | | |
| Shooting Gallery | PALM | | Original | | | |
| SimCity for Palm OS Handhelds シムシティー フォーパーム | PALM | 1.5 | Original | | 42-031-003-01 | |
| SocketScan | PALM | Release 108K | Original | | P/N 6210-00108 K | |
| Star Soldier for Palm OS スターソルジャー for Palm OS | PALM | | Original | | HMGOT060015 | |
| Street Maps & Vacation Planner | PALM | | Cosmi | | PDA051501, PDA631D1 | |
| Strike It Rich! $trike It Rich! | PALM | 1.00 Build 0524c | Original | | | |
| Sucharaka Salaryman: Deai-kei スチャラカサラリーマン 出会い系 | PALM | | Original | | | |
| Sudoku Deluxe Sudoku Pack | PALM | 2.1 | Original | | P/N: 750-3009-CD-B | |
| Sudoku Master | PALM | | Original | | 3340R-2006-03-CDA-US | |
| Super Game Pak | PALM | | Ultimate Game Collection, Cosmi | | PDA102501, PDA634D1 | |
| Super Solitaire 15 | PALM | | Rerelease | | 332-0204-10 | |
| SwiftWare | PALM | | Cosmi | | PDA060501, PDAMC1 | |
| ShadowGate Classic | PPC | 1.0.0.4 | Original | | 5053626 | |
| SimCity 2000 for Pocket PC | PPC | 1.0 | Original | | | |
| Soccer Addict: 2002 International Cup | PPC | 1.0.3b | Original | | | |
| Socket Low Power SDIO WLAN | PPC | Release 142 D | Original | | P/N 6210-00142 D | |
| Surasura Gaikokugo Kaiwa for Pocket PC すらすら外国語会話 for Pocket PC | PPC | | Original | | | |
| Secret of Video Architecture X68000画面表示仕様の秘密 | X68K | | Original | | | |
| Sugoi Dennou Club すごい電脳倶楽部 | X68K | | Original | | MKCD-0002 | |
| Suteki na Dennou Club すてきな電脳倶楽部 | X68K | | Original | | MKCD-0001 | |
| Science & Nature: Elements Science 1: Elements | ARCH | 1.00 | Original | | | |
| Science & Nature: Materials Science Series II: Materials | ARCH | 1.00 | Original | | | |
| Science: Electricity and Magnetism: Secondary Edition Science 3: Electricity and Magnetism | ARCH | 1.0 | Original | | | |
| Seashore Life | ARCH | 1.0 | Original | | | |
| Simon the Sorcerer | ARCH | | Original | | | |
| The Soft Rock Games Collection CD | ARCH | | Original | | | |
| The Soft Rock Software Collection | ARCH | Edition 1 | Original | | | |
| The StrongARM CD-ROM | ARCH | | Original | | | |
| Scooby-Doo: Viaje al Pasado | VFLASH | | Original | | 093087(SP) | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | Rev 1 | Original | | 093080(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093083(UK) | |
| Scooby-Doo! Les Civilisations Perdues | VFLASH | | Original | | 093085(FR) | |
| Shrek der Dritte: Die Suche nach Arthus | VFLASH | | Original | | 093144(GER) | |
| Shrek Le Troisième: En quête d'Artur | VFLASH | | Original | | 093145(FR) | |
| Shrek Tercero: ¿Dónde Está Arturo? | VFLASH | | Original | | 093147(SP) | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093140(US) | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093143(UK) | |
| Spider-Man Course-Poursuite à Manhattan | VFLASH | | Original | | 093065(FR) | |
| Spider-Man: Angriff der Super-Schurken | VFLASH | | Original | | 093064(GER) | |
| Space Invaders XL | NUON | | Original | | 11109 | |
| Sudoku | GAMEWAVE | | Original | | G230 | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |
| A Survey of Western Art: The Electronic Library of Art | VIS | | Original | | 25-6153 | |
| Salaryman Champ: Tatakau Salaryman サラリーマンチャンプ たたかうサラリーマン | KS573 | | Original | | A18 JA A02 | |
| Session Power Up Kit for DrumMania 2nd Mix / PercussionFreaks 2nd Mix | KS573 | | Original | | 912 *Z A01 | |
| Susume! Taisen Puzzle-dama 進め!対戦ぱずるだま | KSGV | | Original | | GV027-J1 | |
| Susume! Taisen Puzzle-dama 進め!対戦ぱずるだま | KSGV | Rev A | Original | | GV027-J1 | |
| Soulcalibur II ソウルキャリバーⅡ | NS246 | | Original | | SC21 DVD0D | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 4.000 | Original | | GDX-0006C | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 5.000 | Original | | GDX-0006D | |
| Sega Network Taisen Mahjong MJ3 セガ・ネットワーク対戦麻雀MJ3 | CHIHIRO | 5.000 | Original | | GDX-0017D | |
| Sega Network Taisen Mahjong MJ3 Evolution セガ・ネットワーク対戦麻雀MJ3 EVOLUTION | CHIHIRO | 2.000 | Original | | GDX-0021A | |
| Sega Network Taisen Mahjong MJ3 Evolution-you Firmware Koushin Program セガ・ネットワーク対戦麻雀MJ3 EVOLUTION用ファームウェア更新プログラム | CHIHIRO | 1.000 | Original | | GDX-0023 | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 7.000 | Lindbergh Red EX | | DVP-0049F | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 8.003 | Lindbergh Red EX | | DVP-0049G | |
| Sega Network Taisen Mahjong MJ4 Evolution セガネットワーク対戦麻雀MJ4 Evolution | LINDBERGH | 1.001 | Lindbergh Red EX | | DVP-0081 | |
| Sega-Race TV セガ-レースTV | LINDBERGH | 1.002 | Lindbergh Yellow | | DVP-0044 | |
| StarHorse 2: Final Destination | LINDBERGH | 5.000 | Lindbergh StarHorse 2 | | DVP-0086D | |
| Senko no Ronde 旋光の輪舞 | NAOMI | 1.001 | Original | | GDL-0030 | |
| Shikigami no Shiro II 式神の城II | NAOMI | 1.000 | Original | | GDL-0021 | |
| Slashout | NAOMI | 1.000 | Original | | GDS-0004 | |
| Sports Jam スポーツ・ジャム | NAOMI | 1.005 | Original | | GDS-0003 | |
| Street Fighter Zero 3 Upper | NAOMI | 1.001 | Original | | GDL-0002 | |
| Super Shanghai 2005 スーパー上海2005 | NAOMI | 1.001 | Original | | GDL-0031 | |
| Super Shanghai 2005 スーパー上海2005 | NAOMI | 2.001 | Original | | GDL-0031A | |
| Sega Network Taisen Mahjong MJ5 セガネットワーク対戦麻雀MJ5 | SRE | | Original | | DVR-0027 | |
| Sega Network Taisen Mahjong MJ5 Evolution セガネットワーク対戦麻雀MJ5 EVOLUTION | SRE | | Original | | DVR-0071 | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083D | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083 | |
| Sega Racing Classic | SRE | | RingWide | | DVR-0009A | |
| Sega Net Mahjong MJ Arcade セガNET麻雀MJ Arcade | SRE | | Original | | DVR-5055D | |