Region | Title | System | Version | Edition | Languages | Serial | Status |
| Saban's Power Rangers: Time Force | PSX | | Original | | SLUS-01351 | |
| Sammy Sosa High Heat Baseball 2001 | PSX | | Original | | SLUS-01063 | |
| San Francisco Rush: Extreme Racing | PSX | | Original | | SLUS-00505 | |
| Scooby-Doo and the Cyber Chase | PSX | | Original, Greatest Hits | | SLUS-01396 … | |
| Simple 1500 Series Vol. 14: The Block Kuzushi SIMPLE1500シリーズ Vol.14 THE ブロックくずし | PSX | | Culture Publishers | | SLPS 02227 | |
| Soul Blade | PSX | | Original | | SLUS-00240 | |
| Spec Ops: Stealth Patrol | PSX | | Original | | SLUS-01131 | |
| Spectral Force スペクトラルフォース | PSX | | Shokai Gentei Box | | SLPS 00969 | |
| Speed Punks | PSX | | Original | | SCUS-94563 | |
| Spider-Man 2: Enter: Electro | PSX | Rev 1 | Original, Greatest Hits | | SLUS-01378 … | |
| Sports Car GT | PSX | | Original | | SLUS-00655 | |
| Spyro the Dragon | PSX | | Original, Greatest Hits, Collectors' Edition | | SCUS-94228 … | |
| Square's Preview 2 | PSX | | Demo | | SLPS 00771 | |
| Star Fighter | PSX | | Original | | SLUS-00241 | |
| Streak Hoverboard Racing | PSX | | Original | | SLUS-00629 | |
| Street Fighter Alpha 2 | PSX | | Original | | SLUS-00258 | |
| Street Sk8er 2 | PSX | | Original | | SLUS-01083 | |
| Strike Point | PSX | | Original | | SLUS-00139 | |
| Strikers 1945 | PSX | | Original | | SLUS-01337 | |
| Super Adventure Rockman (Disc 1) (Episode 1 "Tsuki no Shinden") スーパーアドベンチャーロックマン | PSX | | Original | | SLPS 01051 | |
| Super Adventure Rockman (Disc 2) (Episode 2 "Shitou! Wily Numbers") スーパーアドベンチャーロックマン | PSX | | Original | | SLPS 01052 | |
| Super Adventure Rockman (Disc 3) (Episode 3 "Saigo no Tatakai!!") スーパーアドベンチャーロックマン | PSX | | Original | | SLPS 01053 | |
| Superstar Dance Club: #1 Hits!!! | PSX | | Original | | SLUS-01493 | |
| The Simpsons Skateboarding | PS2 | 1.01 | Original | | SLUS-20114 | |
| ShellShock: Nam '67 | PS2 | 2.00 | Original | | SLUS-20828 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.001 | Tokubetsu-ban (Standalone, Bundled with Mogitate SegaSaturn Vol. 2) | | 610-6864 | |
| SegaColle Sega Bible Mogitate SegaSaturn Soukan-gou セガコレセガバイブルモギタテセガサターン。 創刊号 1997.11 | SS | 1.000 | Hibaihin | | 610-6805-01 | |
| Sonic Adventure 2: Battle | GC | | Original, Player's Choice | | DL-DOL-GSNE-USA | |
| Sonic Heroes | GC | | Original, Player's Choice | | DL-DOL-G9SE-USA | |
| Sonic Mega Collection | GC | | Original, Player's Choice | | DL-DOL-GSOE-USA | |
| Super Smash Bros. Melee | GC | Rev 2 | Original, Player's Choice, Original (Best Seller) | | DL-DOL-GALE-USA | |
| Sonic Colors | WII | | Original | | RVL-SNCE-USA-B0 | |
| Super Paper Mario | WII | Rev 2 | Original, Nintendo Selects | | RVL-R8PE-USA, RVL-R8PE-USA-B0 | |
| Shock Wave | 3DO | RE2 | Original, Not for Resale | | | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |